메뉴 건너뛰기




Volumn 27, Issue 5, 1997, Pages 431-441

In vitro glucuronidation of D-23129, a new anticonvulsant, by human liver microsomes and liver slices

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; DRUG METABOLITE; RETIGABINE;

EID: 0030991641     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982597240424     Document Type: Article
Times cited : (36)

References (22)
  • 2
    • 0023475299 scopus 로고
    • Formation of a quaternary N-glucuronide of amitriptyline in human liver microsomes
    • DAHL-PUUSTINEN, M. and BERTILSSON, L., 1987, Formation of a quaternary N-glucuronide of amitriptyline in human liver microsomes. Pharmacology and Toxicology, 61, 342-346.
    • (1987) Pharmacology and Toxicology , vol.61 , pp. 342-346
    • Dahl-Puustinen, M.1    Bertilsson, L.2
  • 3
    • 0027327501 scopus 로고
    • Development of a simple incubation system for metabolism studies with precision-cut liver slices
    • DOGTEROM, P., 1993, Development of a simple incubation system for metabolism studies with precision-cut liver slices. Drug Metabolism and Disposition, 21, 699-703.
    • (1993) Drug Metabolism and Disposition , vol.21 , pp. 699-703
    • Dogterom, P.1
  • 4
    • 0028948889 scopus 로고
    • Expressed human UGT1·4 protein catalyzes the formation of quarternary ammonium linked glucuronides
    • GREEN, M. D., BISHOP, W. P. and TEPHLY, T. R., 1995, Expressed human UGT1·4 protein catalyzes the formation of quarternary ammonium linked glucuronides. Drug Metabolism and Disposition, 23, 299-302.
    • (1995) Drug Metabolism and Disposition , vol.23 , pp. 299-302
    • Green, M.D.1    Bishop, W.P.2    Tephly, T.R.3
  • 5
    • 0027957132 scopus 로고
    • Metabolism of taxol by human hepatic microsomes and liver slices: Participation of cytochrome P450 3A4 and an unknown P450 enzyme
    • HARRIS, J. W., RAHMAN, A., KIM, B., GUENGERICH, F. P. and COLLINS, J. M., 1994, Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. Cancer Research, 54, 4026-4035.
    • (1994) Cancer Research , vol.54 , pp. 4026-4035
    • Harris, J.W.1    Rahman, A.2    Kim, B.3    Guengerich, F.P.4    Collins, J.M.5
  • 6
    • 0021915908 scopus 로고
    • Untersuchungen zur Pharmakokinetik und Biotransformation des Analgetikums Flupirtin beim Menschen
    • HLAVICA, P. and NIEBCH, G., 1985, Untersuchungen zur Pharmakokinetik und Biotransformation des Analgetikums Flupirtin beim Menschen. Arzneim.-Forsch./Drug Research, 35, 67-74.
    • (1985) Arzneim.-Forsch./Drug Research , vol.35 , pp. 67-74
    • Hlavica, P.1    Niebch, G.2
  • 7
    • 0027980615 scopus 로고
    • N-glucuronidation reactions III: Regioselective N-glucuronidation of methylbiphenyl tetrazole, methylbiphenyl triazole and methylbiphenyl imidazole using human and rat recombinant UDP-glucuronosyl-transferases stably expressed in V79 cells
    • HUSKEY, S. W., MAGDALOU, J., OUZZINE, M., SIEST G. and CHIU, S. L., 1994, N-glucuronidation reactions III: regioselective N-glucuronidation of methylbiphenyl tetrazole, methylbiphenyl triazole and methylbiphenyl imidazole using human and rat recombinant UDP-glucuronosyl-transferases stably expressed in V79 cells. Drug Metabolism and Disposition, 22, 659-662.
    • (1994) Drug Metabolism and Disposition , vol.22 , pp. 659-662
    • Huskey, S.W.1    Magdalou, J.2    Ouzzine, M.3    Siest, G.4    Chiu, S.L.5
  • 8
    • 0027451525 scopus 로고
    • N-glucuronidation reactions. I. Tetrazole N-glucuronidation of selected angiotensin II receptor antagonists in hepatic microsomes from rats, dogs, monkeys and humans
    • HUSKEY, S. W., MILLER, R. R. and CHIU, S. L., 1993, N-glucuronidation reactions. I. Tetrazole N-glucuronidation of selected angiotensin II receptor antagonists in hepatic microsomes from rats, dogs, monkeys and humans. Drug Metabolism and Disposition, 21, 792-799.
    • (1993) Drug Metabolism and Disposition , vol.21 , pp. 792-799
    • Huskey, S.W.1    Miller, R.R.2    Chiu, S.L.3
  • 9
    • 0029003696 scopus 로고
    • Metabolism of taxol by human and rat liver in vitro: A screen for drug interactions and interspecies differences
    • JAMIS-DOW, C. A., KLECKER, R. W., KATKI, A. G. and COLLINS, J. M., 1995, Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences. Cancer Chemotherapy and Pharmacology, 36, 107-114.
    • (1995) Cancer Chemotherapy and Pharmacology , vol.36 , pp. 107-114
    • Jamis-Dow, C.A.1    Klecker, R.W.2    Katki, A.G.3    Collins, J.M.4
  • 10
    • 0029855407 scopus 로고    scopus 로고
    • D-23129 - A new anticonvulsant compound
    • KAPETANOVIC, I. M. and RUNDFELDT, C., 1996, D-23129 - A new anticonvulsant compound. CNS Drug Reviews, 2, 308-321.
    • (1996) CNS Drug Reviews , vol.2 , pp. 308-321
    • Kapetanovic, I.M.1    Rundfeldt, C.2
  • 11
    • 0028806375 scopus 로고
    • The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro
    • KAPETANOVIC, I. M., YONEKAWA, W. D. and KUPFERBERG, H. J., 1995, The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro. Epilepsy Research, 22, 167-173.
    • (1995) Epilepsy Research , vol.22 , pp. 167-173
    • Kapetanovic, I.M.1    Yonekawa, W.D.2    Kupferberg, H.J.3
  • 13
    • 0022004401 scopus 로고
    • Untersuchungen zur Pharmakokinetik und Biotransformation des Analgetikums Flupirtin bei Ratte und Hund
    • OBERMEIER, K., NIEBCH, G. and THIEMER, K., 1985, Untersuchungen zur Pharmakokinetik und Biotransformation des Analgetikums Flupirtin bei Ratte und Hund. Arzneim.-Forsch./Drug Research, 35, 60-67.
    • (1985) Arzneim.-Forsch./Drug Research , vol.35 , pp. 60-67
    • Obermeier, K.1    Niebch, G.2    Thiemer, K.3
  • 14
    • 0027978702 scopus 로고
    • Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferases of the UGT1 gene complex
    • ORZECHOWSKI, A., SCHRENK, D., BOCK-HENNING, B. S. and BOCK, K. W., 1994, Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferases of the UGT1 gene complex. Carcinogenesis, 15, 1549-1553.
    • (1994) Carcinogenesis , vol.15 , pp. 1549-1553
    • Orzechowski, A.1    Schrenk, D.2    Bock-Henning, B.S.3    Bock, K.W.4
  • 15
    • 0002718880 scopus 로고
    • Classification of epileptic seizures and epileptic syndromes
    • edited by J. Laidlaw and D. Chadwick (New York: Churchill Livingstone)
    • PORTER, R. J., 1993, Classification of epileptic seizures and epileptic syndromes. In A Textbook of Epilepsy, edited by J. Laidlaw and D. Chadwick (New York: Churchill Livingstone) pp. 1-22.
    • (1993) A Textbook of Epilepsy , pp. 1-22
    • Porter, R.J.1
  • 16
    • 0001974167 scopus 로고
    • Drugs effective in the therapy of the epilepsies
    • edited by A. Goodman Gilman, T. W. Rall, A. S. Niles and P. Taylor (New York: Pergamon)
    • RALL, T. W. and SCHLEIFER, L. S., 1990, Drugs effective in the therapy of the epilepsies. In The Pharmacological Basis of Therapeutics, 8th edition, edited by A. Goodman Gilman, T. W. Rall, A. S. Niles and P. Taylor (New York: Pergamon), pp. 436-462.
    • (1990) The Pharmacological Basis of Therapeutics, 8th Edition , pp. 436-462
    • Rall, T.W.1    Schleifer, L.S.2
  • 18
    • 0025893724 scopus 로고
    • A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs
    • REMEL, R. P. and SINZ, M. W., 1991, A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs. Drug Metabolism and Disposition, 19, 630-636.
    • (1991) Drug Metabolism and Disposition , vol.19 , pp. 630-636
    • Remel, R.P.1    Sinz, M.W.2
  • 21
    • 0028928220 scopus 로고
    • Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds
    • WORBOYS, P. D., BRADBURY, A. and HOUSTON, J. B., 1995, Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. Drug Metabolism and Disposition, 23, 393-397.
    • (1995) Drug Metabolism and Disposition , vol.23 , pp. 393-397
    • Worboys, P.D.1    Bradbury, A.2    Houston, J.B.3
  • 22
    • 0028843385 scopus 로고
    • The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro
    • YONEKAWA, W. D., KAPETANOVIC, I. M. and KUPFERBERG, H. J., 1995, The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro. Epilepsy Research, 20, 137-150.
    • (1995) Epilepsy Research , vol.20 , pp. 137-150
    • Yonekawa, W.D.1    Kapetanovic, I.M.2    Kupferberg, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.