-
1
-
-
78751607023
-
Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota
-
Hesdorffer DC, Logroscino G, Benn EK, Katri N, Cascino G, Hauser WA. Estimating risk for developing epilepsy: a population-based study in Rochester, Minnesota. Neurology. 2011;76:23-27.
-
(2011)
Neurology
, vol.76
, pp. 23-27
-
-
Hesdorffer, D.C.1
Logroscino, G.2
Benn, E.K.3
Katri, N.4
Cascino, G.5
Hauser, W.A.6
-
2
-
-
0032806451
-
Incidence of epileptic syndromes in Rochester, Minnesota
-
Zarrelli MM, Beghi E, Rocca WA, Hauser WA. Incidence of epileptic syndromes in Rochester, Minnesota. Epilepsia. 1999;40:1708-1714.
-
(1999)
Epilepsia
, vol.40
, pp. 1708-1714
-
-
Zarrelli, M.M.1
Beghi, E.2
Rocca, W.A.3
Hauser, W.A.4
-
3
-
-
33644781763
-
Mortality of epilepsy in developed countries: A review
-
Forsgren L, Hauser WA, Olafsson E, Sander JWAS, Sillanpaa M, Tomson T. Mortality of epilepsy in developed countries: a review. Epilepsia. 2005;46(Suppl 11):18-27.
-
(2005)
Epilepsia
, vol.46
, Issue.SUPPL. 11
, pp. 18-27
-
-
Forsgren, L.1
Hauser, W.A.2
Olafsson, E.3
Sander, J.W.A.S.4
Sillanpaa, M.5
Tomson, T.6
-
4
-
-
21844467976
-
Psychological distress, comorbidities, and health behaviors among U S adults with seizures: Results from the 2002 national health interview survey
-
Strine TW, Kobau R, Chapman DP, Thurman DJ, Price P, Balluz LS. Psychological distress, comorbidities, and health behaviors among U S adults with seizures: results from the 2002 national health interview survey. Epilepsia. 2005;46:1133-1139.
-
(2005)
Epilepsia
, vol.46
, pp. 1133-1139
-
-
Strine, T.W.1
Kobau, R.2
Chapman, D.P.3
Thurman, D.J.4
Price, P.5
Balluz, L.S.6
-
5
-
-
0034598762
-
Early identification of refractory epilepsy
-
Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342:314-319.
-
(2000)
N Engl J Med
, vol.342
, pp. 314-319
-
-
Kwan, P.1
Brodie, M.J.2
-
6
-
-
21444436318
-
Outcomes in newly diagnosed localizationrelated epilepsies
-
Mohanraj R, Brodie MJ. Outcomes in newly diagnosed localizationrelated epilepsies. Seizure. 2005;14:318-323.
-
(2005)
Seizure
, vol.14
, pp. 318-323
-
-
Mohanraj, R.1
Brodie, M.J.2
-
7
-
-
0030668611
-
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells
-
Rundfelt C. The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells. Eur J Pharmacol. 1997;336:243-249.
-
(1997)
Eur J Pharmacol
, vol.336
, pp. 243-249
-
-
Rundfelt, C.1
-
8
-
-
0033862433
-
Retigabine, a novel anticonvulsant, enhances activation of KCNQ2/Q3 potassium channels
-
Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK. Retigabine, a novel anticonvulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol. 2000;58:591-600.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 591-600
-
-
Wickenden, A.D.1
Yu, W.2
Zou, A.3
Jegla, T.4
Wagoner, P.K.5
-
9
-
-
0033916576
-
Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine
-
Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA. Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol Pharmacol. 2000;58:253-262.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 253-262
-
-
Main, M.J.1
Cryan, J.E.2
Dupere, J.R.3
Cox, B.4
Clare, J.J.5
Burbidge, S.A.6
-
10
-
-
19044386394
-
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine
-
Schenzer A, Friedrich T, Pusch M, et al. Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine. J Neurosci. 2005;25:5051-5060.
-
(2005)
J Neurosci
, vol.25
, pp. 5051-5060
-
-
Schenzer, A.1
Friedrich, T.2
Pusch, M.3
-
11
-
-
15744400656
-
The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate
-
Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol. 2005;67:1009-1017.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1009-1017
-
-
Wuttke, T.V.1
Seebohm, G.2
Bail, S.3
Maljevic, S.4
Lerche, H.5
-
12
-
-
59449092002
-
Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels
-
Lange W, Geissendorfer J, Schenzer A, et al. Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels. Mol Pharmacol. 2009;75:272-280.
-
(2009)
Mol Pharmacol
, vol.75
, pp. 272-280
-
-
Lange, W.1
Geissendorfer, J.2
Schenzer, A.3
-
13
-
-
0034677733
-
The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits
-
Rundfeldt C, Netzer R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci Lett. 2000;282:73-76.
-
(2000)
Neurosci Lett
, vol.282
, pp. 73-76
-
-
Rundfeldt, C.1
Netzer, R.2
-
14
-
-
0035425653
-
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine
-
Tatulian L, Delmas P, Abogadie FC, Brown DA. Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci. 2001;21:5535-5545.
-
(2001)
J Neurosci
, vol.21
, pp. 5535-5545
-
-
Tatulian, L.1
Delmas, P.2
Abogadie, F.C.3
Brown, D.A.4
-
15
-
-
0034533728
-
Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels
-
Rundfeldt C, Netzer R. Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung.2000;50:1063-1070.
-
(2000)
Arzneimittelforschung
, vol.50
, pp. 1063-1070
-
-
Rundfeldt, C.1
Netzer, R.2
-
16
-
-
0037454126
-
Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex
-
van Rijn CM, Willems-van Bree E. Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex. Eur J Pharmacol. 2003;464:95-100.
-
(2003)
Eur J Pharmacol
, vol.464
, pp. 95-100
-
-
van Rijn, C.M.1
Willems-van Bree, E.2
-
17
-
-
0029969951
-
D-23129: A new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures
-
Rostock A, Tober C, Rundfeldt C, et al. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Res. 1996;23:211-223.
-
(1996)
Epilepsy Res
, vol.23
, pp. 211-223
-
-
Rostock, A.1
Tober, C.2
Rundfeldt, C.3
-
18
-
-
0035111693
-
Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
-
De Sarro G, Di Paola ED, Conte G, Pasculli MP, De Sarro A. Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice. Naynyn Schmiedebergs Arch Pharmacol. 2001;363:330-336.
-
(2001)
Naynyn Schmiedebergs Arch Pharmacol
, vol.363
, pp. 330-336
-
-
de Sarro, G.1
di Paola, E.D.2
Conte, G.3
Pasculli, M.P.4
de Sarro, A.5
-
19
-
-
58149237124
-
Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: An ontogenic study
-
Mazarati A, Wu J, Shin D, Kwon YS, Sankar R. Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study. Epilepsia. 2008;49:1777-1786.
-
(2008)
Epilepsia
, vol.49
, pp. 1777-1786
-
-
Mazarati, A.1
Wu, J.2
Shin, D.3
Kwon, Y.S.4
Sankar, R.5
-
20
-
-
0032536030
-
A potassium channel mutation in neonatal human epilepsy
-
Biervert C, Schroeder BC, Kubisch C, et al. A potassium channel mutation in neonatal human epilepsy. Science. 1998;279:403-406.
-
(1998)
Science
, vol.279
, pp. 403-406
-
-
Biervert, C.1
Schroeder, B.C.2
Kubisch, C.3
-
21
-
-
0031974209
-
A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family
-
Charlier C, Singh NA, Ryan SG, et al. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet. 1998;18:53-55.
-
(1998)
Nat Genet
, vol.18
, pp. 53-55
-
-
Charlier, C.1
Singh, N.A.2
Ryan, S.G.3
-
22
-
-
17344372328
-
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns
-
Singh NA, Charlier C, Stauffer D, et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet. 1998;18:25-29.
-
(1998)
Nat Genet
, vol.18
, pp. 25-29
-
-
Singh, N.A.1
Charlier, C.2
Stauffer, D.3
-
23
-
-
34247252905
-
Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures
-
Porter RJ, Partiot A, Sachedo R, Nohria C, Alves WM. Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures. Neurology. 2007;68:1197-1204.
-
(2007)
Neurology
, vol.68
, pp. 1197-1204
-
-
Porter, R.J.1
Partiot, A.2
Sachedo, R.3
Nohria, C.4
Alves, W.M.5
-
24
-
-
78649984382
-
Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
-
Brodie MJ, Lerche H, Gil-Nagel A, et al. Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy. Neurology. 2010;75:1817-1824.
-
(2010)
Neurology
, vol.75
, pp. 1817-1824
-
-
Brodie, M.J.1
Lerche, H.2
Gil-Nagel, A.3
-
25
-
-
79955592696
-
Randomized, doubleblind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
-
French JA, Abou-Khalil BW, Leroy RF, et al. Randomized, doubleblind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology. 2011;76:1555-1563.
-
(2011)
Neurology
, vol.76
, pp. 1555-1563
-
-
French, J.A.1
Abou-Khalil, B.W.2
Leroy, R.F.3
-
26
-
-
5444225675
-
Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats
-
Streng T, Christoph T, Andersson KE. Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats. J Urol. 2004;172:2054-2058.
-
(2004)
J Urol
, vol.172
, pp. 2054-2058
-
-
Streng, T.1
Christoph, T.2
Andersson, K.E.3
-
27
-
-
77953536118
-
Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder
-
Rode F, Svalo J, Sheykhzade M, Ronn LCB. Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder. Eur J Pharmacol. 2010;638:121-127.
-
(2010)
Eur J Pharmacol
, vol.638
, pp. 121-127
-
-
Rode, F.1
Svalo, J.2
Sheykhzade, M.3
Ronn, L.C.B.4
-
28
-
-
0030991641
-
In vitro glucuronidation of D-23129, a novel anticonvulsant, by human liver microsomes and liver slices
-
McNeilly RJ, Torchin CD, Anderson LW, Kapetanovic IM, Kupferberg HJ, Strong JM. In vitro glucuronidation of D-23129, a novel anticonvulsant, by human liver microsomes and liver slices. Xenobiotica. 1997;27:431-441.
-
(1997)
Xenobiotica
, vol.27
, pp. 431-441
-
-
McNeilly, R.J.1
Torchin, C.D.2
Anderson, L.W.3
Kapetanovic, I.M.4
Kupferberg, H.J.5
Strong, J.M.6
-
29
-
-
0032930073
-
Metabolism of retigabine (D-23129), a novel anticonvulsant
-
Hempel R, Schupke H, McNeilly PJ, et al. Metabolism of retigabine (D-23129), a novel anticonvulsant. Drug Metab Dispos. 1999;27: 613-622.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 613-622
-
-
Hempel, R.1
Schupke, H.2
McNeilly, P.J.3
-
30
-
-
0032906655
-
Retigabine N-glucuronidation and its potential role in enterohepatic circulation
-
Hiller A, Nguyen N, Strassburg C, et al. Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999;27:605-612.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 605-612
-
-
Hiller, A.1
Nguyen, N.2
Strassburg, C.3
-
31
-
-
33646497843
-
N-glucuronidation of the antiepileptic drug retigabine: Results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler Najjar type II
-
Borlak J, Gasparic A, Locher M, Schupke H, Hermann R. N-glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler Najjar type II. Metabolism. 2006;5:711-721.
-
(2006)
Metabolism
, vol.5
, pp. 711-721
-
-
Borlak, J.1
Gasparic, A.2
Locher, M.3
Schupke, H.4
Hermann, R.5
-
32
-
-
0036152375
-
Multiple-dose, linear, doseproprotional, pharmacokinetics of retigabine in healthy volunteers
-
Ferron GM, Paul J, Fruncillo R, et al. Multiple-dose, linear, doseproprotional, pharmacokinetics of retigabine in healthy volunteers. J Clin Pharmacol. 2002;42:175-182.
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 175-182
-
-
Ferron, G.M.1
Paul, J.2
Fruncillo, R.3
-
33
-
-
0037261396
-
Effects of age and sex on the disposition of retigabine
-
Hermann R, Ferron GM, Erb K, et al. Effects of age and sex on the disposition of retigabine. Clin Pharmacol Ther. 2003;73:61-70.
-
(2003)
Clin Pharmacol Ther
, vol.73
, pp. 61-70
-
-
Hermann, R.1
Ferron, G.M.2
Erb, K.3
-
34
-
-
0038293217
-
Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects
-
Hermann R, Knebel NG, Niebch G, Richards L, Borlak J, Locher M. Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects. Eur J Clin Pharmacol. 2003;58:795-802.
-
(2003)
Eur J Clin Pharmacol
, vol.58
, pp. 795-802
-
-
Hermann, R.1
Knebel, N.G.2
Niebch, G.3
Richards, L.4
Borlak, J.5
Locher, M.6
-
35
-
-
0037660846
-
Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects
-
Ferron GM, Patat A, Parks V, Rolan P, Troy SM. Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. Br J Clin Pharmacol. 2003;56:39-45.
-
(2003)
Br J Clin Pharmacol
, vol.56
, pp. 39-45
-
-
Ferron, G.M.1
Patat, A.2
Parks, V.3
Rolan, P.4
Troy, S.M.5
-
36
-
-
57849141134
-
Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
-
Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009;83:1-43.
-
(2009)
Epilepsy Res
, vol.83
, pp. 1-43
-
-
Bialer, M.1
Johannessen, S.I.2
Levy, R.H.3
Perucca, E.4
Tomson, T.5
White, H.S.6
-
37
-
-
0028882747
-
Acquired neuromyotonia: Evidence for autoantibodies directed against K+ channels of peripheral nerves
-
Shillito P, Molenaar PC, Vincent A, et al. Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerves. Ann Neurol. 1995;38:714-722.
-
(1995)
Ann Neurol
, vol.38
, pp. 714-722
-
-
Shillito, P.1
Molenaar, P.C.2
Vincent, A.3
-
38
-
-
0021336274
-
Hereditary form of sustained muscle activity of peripheral nerve origin causing generalized myokymia and muscle stiffness
-
Auger RG, Daube JR, Gomez MR, Lambert EH. Hereditary form of sustained muscle activity of peripheral nerve origin causing generalized myokymia and muscle stiffness. Ann Neurol. 1984:15:13-21.
-
(1984)
Ann Neurol
, vol.15
, pp. 13-21
-
-
Auger, R.G.1
Daube, J.R.2
Gomez, M.R.3
Lambert, E.H.4
-
39
-
-
0035834007
-
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel
-
Dedek K, Kunath B, Kananura C, Reuner U, Jentsch TJ, Steinlein OK. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc Natl Acad Sci U S A. 2001;98:12272-12277.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12272-12277
-
-
Dedek, K.1
Kunath, B.2
Kananura, C.3
Reuner, U.4
Jentsch, T.J.5
Steinlein, O.K.6
-
40
-
-
36448983645
-
Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations
-
Wuttke TV, Jurkat-Rott K, Paulus W, Garnkarek M, Lehrman-Horn F, Lerche H. Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations. Neurology. 2007;69:2045-2053.
-
(2007)
Neurology
, vol.69
, pp. 2045-2053
-
-
Wuttke, T.V.1
Jurkat-Rott, K.2
Paulus, W.3
Garnkarek, M.4
Lehrman-Horn, F.5
Lerche, H.6
-
41
-
-
0037462422
-
The anticonvulsant retigabine attenuates nociceptive behaviors in rat models of persistent and neuropathic pain
-
Blackburn-Munro G, Jensen BS. The anticonvulsant retigabine attenuates nociceptive behaviors in rat models of persistent and neuropathic pain. Eur J Pharmacol. 2003;460:109-116.
-
(2003)
Eur J Pharmacol
, vol.460
, pp. 109-116
-
-
Blackburn-Munro, G.1
Jensen, B.S.2
-
42
-
-
34848923432
-
Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety
-
Munro G, Erichsen HK, Mirza NR. Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety. Neuropharmacology. 2007;53:609-618.
-
(2007)
Neuropharmacology
, vol.53
, pp. 609-618
-
-
Munro, G.1
Erichsen, H.K.2
Mirza, N.R.3
-
43
-
-
37049038680
-
Effect of the new antiepileptic drug retigabine in a rodent model of mania
-
Dencker D, Dias R, Pedersen ML, Husum H. Effect of the new antiepileptic drug retigabine in a rodent model of mania. Epilepsy Behav. 2008;12:49-53.
-
(2008)
Epilepsy Behav
, vol.12
, pp. 49-53
-
-
Dencker, D.1
Dias, R.2
Pedersen, M.L.3
Husum, H.4
-
44
-
-
34547841517
-
The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine
-
Hansen HH, Andreasen JT, Weikop P, Mirza M, Scheel-Kruger J, Mikkelsen JD. The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine. Eur J Pharmacol. 2007;570:77-88.
-
(2007)
Eur J Pharmacol
, vol.570
, pp. 77-88
-
-
Hansen, H.H.1
Andreasen, J.T.2
Weikop, P.3
Mirza, M.4
Scheel-Kruger, J.5
Mikkelsen, J.D.6
-
45
-
-
33750999596
-
Antidystonic effects of Kv7 (KCNQ) channel openers in the dtsz mutant, an animal model of primary paroxysmal dystonia
-
Richter A, Sander SE, Rundfelt C. Antidystonic effects of Kv7 (KCNQ) channel openers in the dtsz mutant, an animal model of primary paroxysmal dystonia. Br J Pharmacol. 2006;149:747-753.
-
(2006)
Br J Pharmacol
, vol.149
, pp. 747-753
-
-
Richter, A.1
Sander, S.E.2
Rundfelt, C.3
-
46
-
-
23044477292
-
Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels
-
Korsgaard MP, Hartz BP, Brown WD, Ahring PK, Strobaek D, Mirza NR. Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J Pharmacol Exp Ther. 2005; 314:282-292.
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(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 282-292
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Korsgaard, M.P.1
Hartz, B.P.2
Brown, W.D.3
Ahring, P.K.4
Strobaek, D.5
Mirza, N.R.6
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