The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/antidepressant drug

Neuropharmacology

Volumn 62, Issue 5-6, 2012, Pages 2034-2039

  Inta, Dragos ^a   Filipovic, Dragana ^a,b   Lima Ojeda, Juan M ^a   Dormann, Christof ^a   Pfeiffer, Natascha ^a   Gasparini, Fabrizio ^c   Gass, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antidepressants; Anxiolytics; c Fos; mGluR5; Neurotoxicity; Stress related areas

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; CASPASE 3; DIZOCILPINE; HEAT SHOCK PROTEIN 70; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN C FOS;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN MAPPING; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; DRUG TARGETING; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; RETROSPLENIAL CORTEX; STRIA TERMINALIS; TRANQUILIZING ACTIVITY;

AMYGDALA; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BRAIN; CELL COUNT; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; HSP72 HEAT-SHOCK PROTEINS; HYPOTHALAMUS; MALE; MICE; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; SEPTAL NUCLEI;

EID: 84857064144     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.12.035     Document Type: Article

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