Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration

Biochemical Pharmacology

Volumn 83, Issue 6, 2012, Pages 778-787

  Connolly, Stephen ^a   Skrinjar, Marco ^b   Rosendahl, Alexander ^b  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Asthma; Chemokine; Dendritic cell; Mode of binding; Receptor inhibitor

Indexed keywords

AMIDE; AZ 084; AZ 133; AZ 435; AZ 442; AZ 463; AZ 491; AZ 760; CCL1 CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR8; LIGAND; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL FUNCTION; CELL LINE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STABILITY; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO CULTURE; LIPOPHILICITY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SINGLE DRUG DOSE; T LYMPHOCYTE;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BIOLOGICAL AVAILABILITY; CELL LINE; CELL MOVEMENT; CHEMOKINE CCL1; CHEMOTAXIS; DENDRITIC CELLS; DOGS; EOSINOPHILS; FEMALE; HALF-LIFE; HUMANS; MALE; MICE; PIPERIDINES; PROTEIN BINDING; PYRIDAZINES; RATS; RECEPTORS, CCR8; SMALL MOLECULE LIBRARIES; SPIRO COMPOUNDS; T-LYMPHOCYTES;

EID: 84857057985     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.12.021     Document Type: Article

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