Small molecule antagonists of CCR8 inhibit eosinophil and T cell migration

Biochemical and Biophysical Research Communications

Volumn 407, Issue 4, 2011, Pages 764-771

  Karlsson, Anna K C ^a   Walles, Katarina ^a   Bladh, Håkan ^a   Connolly, Stephen ^b   Skrinjar, Marco ^a   Rosendahl, Alexander ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Antagonist; CCR8; Chemokine; Eosinophil; GPCR; T cell

Indexed keywords

ANTIINFLAMMATORY AGENT; BENZYLBIPIPERIDINE; CCL1 CHEMOKINE; CHEMOKINE RECEPTOR CCR ANTAGONIST; CHEMOKINE RECEPTOR CCR8; DIAZASPIROUN DECANE; DIAZASPIROUNDECANE 2,4 DIONE; N BENZYLPIPERAZINE; N BENZYLPYRROLIDINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CALCIUM MOBILIZATION; CELL CLONE; CELL MATURATION; CHEMOTAXIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG STRUCTURE; EOSINOPHIL; EOSINOPHIL CHEMOTAXIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL;

ANTI-ASTHMATIC AGENTS; CELL LINE; CELL SEPARATION; CHEMOKINE CCL1; CHEMOTAXIS; EOSINOPHILS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; RECEPTORS, CCR8; SMALL MOLECULE LIBRARIES; T-LYMPHOCYTES;

EID: 79954990988     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.097     Document Type: Article

References (23)

1. Anderskewitz R., Bauer R., Bodenbach G., Gester D., Gramlich B., Morschhauser G., Birke F.W. Pyrrolidinohydroquinazolines - a novel class of CCR3 modulators. Bioorg. Med. Chem. Lett. 2005, 15:669-673.
2. Baumann M.A., Paul C.C. The AML14 and AML14.3D10 cell lines: a long-overdue model for the study of eosinophils and more. Stem Cells 1998, 16:16-24.
3. Broekema M., Volbeda F., Timens W., Dijkstra A., Lee N.A., Lee J.J., Lodewijk M.E., Postma D.S., Hylkema M.N., ten Hacken N.H. Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1). Respir. Med. 2010, 104:1254-1262.
4. Colantonio L., Recalde H., Sinigaglia F., D'Ambrosio D. Modulation of chemokine receptor expression and chemotactic responsiveness during differentiation of human naive T cells into Th1 or Th2 cells. Eur. J. Immunol. 2002, 32:1264-1273.
5. Coward P., Chan S.D., Wada H.G., Humphries G.M., Conklin B.R. Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors. Anal. Biochem. 1999, 270:242-248.
6. D'Ambrosio D., Iellem A., Bonecchi R., Mazzeo D., Sozzani S., Mantovani A., Sinigaglia F. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 1998, 161:5111-5115.
7. Fuentes-Beltran A., Montes-Vizuet R., Valencia-Maqueda E., Negrete-Garcia M.C., Garcia-Cruz M.L., Teran L.M. Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients. Clin. Exp. Allergy 2009, 39:491-499.
8. Gombert M., Dieu-Nosjean M.C., Winterberg F., Bunemann E., Kubitza R.C., Da C.L., Haahtela A., Lehtimaki S., Muller A., Rieker J., Meller S., Pivarcsi A., Koreck A., Fridman W.H., Zentgraf H.W., Pavenstadt H., Amara A., Caux C., Kemeny L., Alenius H., Lauerma A., Ruzicka T., Zlotnik A., Homey B. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J. Immunol. 2005, 174:5082-5091.
9. Gonzalo J.A., Qiu Y., Lora J.M., Al-Garawi A., Villeval J.L., Boyce J.A., Martinez A., Marquez G., Goya I., Hamid Q., Fraser C.C., Picarella D., Cote-Sierra J., Hodge M.R., Gutierrez-Ramos J.C., Kolbeck R., Coyle A.J. Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis. J. Immunol. 2007, 179:1740-1750.
10. Hamid Q., Tulic M. Immunobiology of asthma. Annu. Rev. Physiol. 2009, 71:489-507.
11. Inngjerdingen M., Al-Aoukaty A., Damaj B., Maghazachi A.A. Differential utilization of cyclic ADP-ribose pathway by chemokines to induce the mobilization of intracellular calcium in NK cells. Biochem. Biophys. Res. Commun. 1999, 262:467-472.
12. Jakubzick C., Tacke F., Llodra J., van Rooijen N., Randolph G.J. Modulation of dendritic cell trafficking to and from the airways. J. Immunol. 2006, 176:3578-3584.
13. Maghazachi A.A. Intracellular signaling events at the leading edge of migrating cells. Int. J. Biochem. Cell Biol. 2000, 32:931-943.
14. Meyer zu H.D., Lass H., Alemany R., Laser K.T., Neumann E., Zhang C., Schmidt M., Rauen U., Jakobs K.H., van Koppen C.J. Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. EMBO J. 1998, 17:2830-2837.
15. Montes-Vizuet R., Vega-Miranda A., Valencia-Maqueda E., Negrete-Garcia M.C., Velasquez J.R., Teran L.M. CC chemokine ligand 1 is released into the airways of atopic asthmatics. Eur. Respir. J. 2006, 28:59-67.
16. Oliveira S.H., Lira S., Martinez A., Wiekowski M., Sullivan L., Lukacs N.W. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. J. Leukoc. Biol. 2002, 71:1019-1025.
17. Panina-Bordignon P., Papi A., Mariani M., Di L.P., Casoni G., Bellettato C., Buonsanti C., Miotto D., Mapp C., Villa A., Arrigoni G., Fabbri L.M., Sinigaglia F. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J. Clin. Invest. 2001, 107:1357-1364.
18. Pease J.E., Williams T.J. Chemokines and their receptors in allergic disease. J. Allergy Clin. Immunol. 2006, 118:305-318.
19. Roos R.S., Loetscher M., Legler D.F., Clark-Lewis I., Baggiolini M., Moser B. Identification of CCR8, the receptor for the human CC chemokine I-309. J. Biol. Chem. 1997, 272:17251-17254.
20. Soler D., Chapman T.R., Poisson L.R., Wang L., Cote-Sierra J., Ryan M., McDonald A., Badola S., Fedyk E., Coyle A.J., Hodge M.R., Kolbeck R. CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J. Immunol. 2006, 177:6940-6951.
21. Tuteja N. Signaling through G protein coupled receptors. Plant Signal. Behav. 2009, 4:942-947.
22. Wise E.L., Duchesnes C., da Fonseca P.C., Allen R.A., Williams T.J., Pease J.E. Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. J. Biol. Chem. 2007, 282:27935-27943.
23. Zimmermann N., Daugherty B.L., Stark J.M., Rothenberg M.E. Molecular analysis of CCR-3 events in eosinophilic cells. J. Immunol. 2000, 164:1055-1064.