-
1
-
-
0033786776
-
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
-
Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, Eaton J, Antel J, Frank JA, McFarland HF, Martin R (2000) Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 6:1167-1175
-
(2000)
Nat Med
, vol.6
, pp. 1167-1175
-
-
Bielekova, B.1
Goodwin, B.2
Richert, N.3
Cortese, I.4
Kondo, T.5
Afshar, G.6
Gran, B.7
Eaton, J.8
Antel, J.9
Frank, J.A.10
McFarland, H.F.11
Martin, R.12
-
2
-
-
0023248694
-
A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis
-
Bornstein MB, Miller A, Slagle S, Weitzman M, Crystal H, Drexler E, Keilson M, Merriam A, Wassertheil-Smoller S, Spada V, et al. (1987) A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. New Engl J Med 317:408-414
-
(1987)
New Engl J Med
, vol.317
, pp. 408-414
-
-
Bornstein, M.B.1
Miller, A.2
Slagle, S.3
Weitzman, M.4
Crystal, H.5
Drexler, E.6
Keilson, M.7
Merriam, A.8
Wassertheil-Smoller, S.9
Spada, V.10
-
3
-
-
0037180468
-
A randomized, double-blind, dose-comparison study of weekly interferon beta-1a in relapsing MS
-
Clanet M, Radue EW, Kappos L, Hartung HP, Hohlfeld R, Sandberg-Wollheim M, Kooijmans-Coutinho MF, Tsao EC, Sandrock AW; European IFNbeta-1a (Avonex®) Dose-Comparison Study Investigators (2002) A randomized, double-blind, dose-comparison study of weekly interferon beta-1a in relapsing MS. Neurology 59:1507-1517
-
(2002)
Neurology
, vol.59
, pp. 1507-1517
-
-
Clanet, M.1
Radue, E.W.2
Kappos, L.3
Hartung, H.P.4
Hohlfeld, R.5
Sandberg-Wollheim, M.6
Kooijmans-Coutinho, M.F.7
Tsao, E.C.8
Sandrock, A.W.9
-
4
-
-
0034122105
-
Why treat early multiple sclerosis patients?
-
Comi G (2000) Why treat early multiple sclerosis patients? Curr Opin Neurol 13:235-240
-
(2000)
Curr Opin Neurol
, vol.13
, pp. 235-240
-
-
Comi, G.1
-
5
-
-
0035912520
-
Effect of early interferon treatment on conversion to definite multiple sclerosis: A randomised study
-
Comi G, Filippi M, Barkhof F, Durelli L, Edan G, Fernandez O, Hartung H, Seeldrayers P, Sorensen PS, Rovaris M, Martinelli V, Hommes OR; Early Treatment of Multiple Sclerosis Study Group (2001) Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet 357:1576-1582
-
(2001)
Lancet
, vol.357
, pp. 1576-1582
-
-
Comi, G.1
Filippi, M.2
Barkhof, F.3
Durelli, L.4
Edan, G.5
Fernandez, O.6
Hartung, H.7
Seeldrayers, P.8
Sorensen, P.S.9
Rovaris, M.10
Martinelli, V.11
Hommes, O.R.12
-
6
-
-
0037181634
-
Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: Results of a 2-year prospective randomised multicentre study (INCOMIN)
-
Durelli L, Verdun E, Barbero P, Bergui M, Versino E, Ghezzi A, Montanari E, Zaffaroni M; Independent Comparison of Interferon (INCOMIN) Trial Study Group (2002) Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 359:1453-1460
-
(2002)
Lancet
, vol.359
, pp. 1453-1460
-
-
Durelli, L.1
Verdun, E.2
Barbero, P.3
Bergui, M.4
Versino, E.5
Ghezzi, A.6
Montanari, E.7
Zaffaroni, M.8
-
7
-
-
0032494792
-
Placebo controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis
-
European Study Group on Interferon β-1b in Secondary Progressive MS (1998) Placebo controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis. Lancet 352:1491-1497
-
(1998)
Lancet
, vol.352
, pp. 1491-1497
-
-
-
8
-
-
0022997935
-
Multiple sclerosis: Gadolinium enhancement in MR imaging
-
Grossman RI, Gonzalez-Scarano F, Atlas SW, Galetta S, Silberberg DH (1986) Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 161:721-725
-
(1986)
Radiology
, vol.161
, pp. 721-725
-
-
Grossman, R.I.1
Gonzalez-Scarano, F.2
Atlas, S.W.3
Galetta, S.4
Silberberg, D.H.5
-
9
-
-
0037153729
-
Mitoxantrone in progressive multiple sclerosis: A placebo-controlled, double-blind, randomized, multicentre trial
-
Hartung HP, Gonsette R, Konig N, Kwiecinski H, Guseo A, Morrissey SP, Krapf H, Zwingers T; Mitoxantrone in Multiple Sclerosis Study Group (MIMS) (2002) Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomized, multicentre trial. Lancet 360:2018-2025
-
(2002)
Lancet
, vol.360
, pp. 2018-2025
-
-
Hartung, H.P.1
Gonsette, R.2
Konig, N.3
Kwiecinski, H.4
Guseo, A.5
Morrissey, S.P.6
Krapf, H.7
Zwingers, T.8
-
10
-
-
0034121184
-
The prognostic value of MR and MTI findings at presentation in patients with clinically isolated syndromes suggestive of MS
-
Iannucci G, Tonorella C, Rovaris M, Sormani MP, Comi G, Filippi M (2000) The prognostic value of MR and MTI findings at presentation in patients with clinically isolated syndromes suggestive of MS. Am J Neuroradiol 21:1034-1038
-
(2000)
Am J Neuroradiol
, vol.21
, pp. 1034-1038
-
-
Iannucci, G.1
Tonorella, C.2
Rovaris, M.3
Sormani, M.P.4
Comi, G.5
Filippi, M.6
-
11
-
-
0027418515
-
Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
-
The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis (1993) I Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43:655-661
-
(1993)
Neurology
, vol.43
, pp. 655-661
-
-
-
12
-
-
0029161628
-
Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomised controlled trial
-
The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group (1995) Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomised controlled trial. Neurology 45:1277-1285
-
(1995)
Neurology
, vol.45
, pp. 1277-1285
-
-
-
13
-
-
0008678962
-
Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
-
The Multiple Sclerosis Collaborative Research Group (MSCRG)
-
rd, Priore RL, Pullicino PM, Scherokman BJ, Whitham RH, et al. (1996) Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 39:285-294
-
(1996)
Ann Neurol
, vol.39
, pp. 285-294
-
-
Jacobs, L.D.1
Cookfair, D.L.2
Rudick, R.A.3
Herndon, R.M.4
Richert, J.R.5
Salazar, A.M.6
Fischer, J.S.7
Goodkin, D.E.8
Granger, C.V.9
Simon, J.H.10
Alam, J.J.11
Bartoszak, D.M.12
Bourdette, D.N.13
Braiman, J.14
Brownscheidle, C.M.15
Coats, M.E.16
Cohan, S.L.17
Dougherty, D.S.18
Kinkel, R.P.19
Mass, M.K.20
Munschauer III, F.E.21
Priore, R.L.22
Pullicino, P.M.23
Scherokman, B.J.24
Whitham, R.H.25
more..
-
14
-
-
0034727059
-
Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis
-
CHAMPS Study Group
-
Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasor PJ, Sandrock AW (2000) Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Eng J Med 343:898-904
-
(2000)
N Eng J Med
, vol.343
, pp. 898-904
-
-
Jacobs, L.D.1
Beck, R.W.2
Simon, J.H.3
Kinkel, R.P.4
Brownscheidle, C.M.5
Murray, T.J.6
Simonian, N.A.7
Slasor, P.J.8
Sandrock, A.W.9
-
15
-
-
0029082566
-
Copolymer 1 reduces relapse rate and improves disability in relapsing remitting multiple sclerosis: Results of a phase III multicentre double-blind placebo-controlled trial
-
The Copolymer I Multiple Sclerosis Study Group
-
Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB (1995) Copolymer 1 reduces relapse rate and improves disability in relapsing remitting multiple sclerosis: results of a phase III multicentre double-blind placebo-controlled trial. The Copolymer I Multiple Sclerosis Study Group. Neurology 45:1268-1276
-
(1995)
Neurology
, vol.45
, pp. 1268-1276
-
-
Johnson, K.P.1
Brooks, B.R.2
Cohen, J.A.3
Ford, C.C.4
Goldstein, J.5
Lisak, R.P.6
Myers, L.W.7
Panitch, H.S.8
Rose, J.W.9
Schiffer, R.B.10
-
16
-
-
0033546665
-
TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
-
The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group (1999) TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 53:457-465
-
(1999)
Neurology
, vol.53
, pp. 457-465
-
-
-
17
-
-
0029913882
-
Defining the clinical course of multiple sclerosis: Results of an international survey
-
National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
-
Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907-911
-
(1996)
Neurology
, vol.46
, pp. 907-911
-
-
Lublin, F.D.1
Reingold, S.C.2
-
18
-
-
0031744008
-
The Mayo Clinic-Canadian Cooperative trial of sulfasalazine in active multiple sclerosis
-
Noseworthy JH, O'Brien P, Erickson BJ, Lee D, Sneve D, Ebers GC, Rice GP, Auty A, Hader WJ, Kirk A, Duquette P, Carter J, Francis G, Metz L, Shuster E (1998) The Mayo Clinic-Canadian Cooperative trial of sulfasalazine in active multiple sclerosis. Neurology 51:1342-1352
-
(1998)
Neurology
, vol.51
, pp. 1342-1352
-
-
Noseworthy, J.H.1
O'Brien, P.2
Erickson, B.J.3
Lee, D.4
Sneve, D.5
Ebers, G.C.6
Rice, G.P.7
Auty, A.8
Hader, W.J.9
Kirk, A.10
Duquette, P.11
Carter, J.12
Francis, G.13
Metz, L.14
Shuster, E.15
-
19
-
-
0034624942
-
Linomide in relapsing and secondary progressive MS: Part I: trial design and clinical results
-
North American Linomide Investigators
-
Noseworthy JH, Wolinsky JS, Lublin FD, Whitaker JN, Linde A, Gjorstrup P, Sullivan HC (2000) Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators. Neurology 54:1726-1733
-
(2000)
Neurology
, vol.54
, pp. 1726-1733
-
-
Noseworthy, J.H.1
Wolinsky, J.S.2
Lublin, F.D.3
Whitaker, J.N.4
Linde, A.5
Gjorstrup, P.6
Sullivan, H.C.7
-
20
-
-
0029751983
-
Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
-
van Oosten BW, Barkhof F, Truyen L, Boringa JB, Bertelsmann FW, von Blomberg BM, Woody JN, Hartung HP, Polman CH (1996) Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 47:1531-1534
-
(1996)
Neurology
, vol.47
, pp. 1531-1534
-
-
Van Oosten, B.W.1
Barkhof, F.2
Truyen, L.3
Boringa, J.B.4
Bertelsmann, F.W.5
Von Blomberg, B.M.6
Woody, J.N.7
Hartung, H.P.8
Polman, C.H.9
-
21
-
-
0037180479
-
Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE Trial
-
Panitch H, Goodin DS, Francis G, Chang P, Coyle PK, O'Connor P, Monaghan E, Li D, Weinshenker B; EVIDENCE Study Group. Evidence of Interferon Dose-response: European North American Comparative Efficacy; University of British Columbia MS/MRI Research Group (2002) Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE Trial. Neurology 59:1496-1506
-
(2002)
Neurology
, vol.59
, pp. 1496-1506
-
-
Panitch, H.1
Goodin, D.S.2
Francis, G.3
Chang, P.4
Coyle, P.K.5
O'Connor, P.6
Monaghan, E.7
Li, D.8
Weinshenker, B.9
-
22
-
-
8844222623
-
Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study
-
Panitch H, Miller A, Paty D, Weinshenker B, North American Study Group on Interferon beta-1b in Secondary Progressive MS (2004) Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 63:1788-1795
-
(2004)
Neurology
, vol.63
, pp. 1788-1795
-
-
Panitch, H.1
Miller, A.2
Paty, D.3
Weinshenker, B.4
-
23
-
-
0345601517
-
Randomized double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis
-
PRISMS (Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis) Study Group (1998) Randomized double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Lancet 352:1498-1504
-
(1998)
Lancet
, vol.352
, pp. 1498-1504
-
-
-
24
-
-
0034646216
-
Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial
-
Cladribine MRI Study Group
-
Rice GP, Filippi M, Comi G (2000) Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group. Neurology 54:1145-1155
-
(2000)
Neurology
, vol.54
, pp. 1145-1155
-
-
Rice, G.P.1
Filippi, M.2
Comi, G.3
-
25
-
-
25144519985
-
Randomized controlled trial of interferon-beta-1a in secondary progressive MS: Clinical results
-
in press
-
Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-beta-1 a (Serono) in MS (SPECTRIMS) Study Group. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: clinical results. Neurology (in press)
-
Neurology
-
-
-
26
-
-
0028988737
-
The effects of interferon beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis
-
Stone LA, Frank JA, Albert PS, Bash C, Smith ME, Maloni H, McFarland HF (1995) The effects of interferon beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Ann Neurol 37:611-619
-
(1995)
Ann Neurol
, vol.37
, pp. 611-619
-
-
Stone, L.A.1
Frank, J.A.2
Albert, P.S.3
Bash, C.4
Smith, M.E.5
Maloni, H.6
McFarland, H.F.7
-
27
-
-
0032576752
-
Axonal transection in the lesions of multiple sclerosis
-
Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285
-
(1998)
N Engl J Med
, vol.338
, pp. 278-285
-
-
Trapp, B.D.1
Peterson, J.2
Ransohoff, R.M.3
Rudick, R.4
Mork, S.5
Bo, L.6
-
28
-
-
0032796747
-
Axonal pathology in multiple sclerosis: Relationship to neurologic disability
-
Trapp BD, Ransohoff R, Rudick R (1999) Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr Opin Neurol 12:295-302
-
(1999)
Curr Opin Neurol
, vol.12
, pp. 295-302
-
-
Trapp, B.D.1
Ransohoff, R.2
Rudick, R.3
-
29
-
-
0027521002
-
Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
-
UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43:662-667
-
(1993)
Neurology
, vol.43
, pp. 662-667
-
-
-
30
-
-
17744367204
-
United States open-label glatiramer acetate trial for relapsing multiple sclerosis: MRI and clinical correlates
-
Multiple Sclerosis Study Group and MRI analysis Group
-
Wolinsky S, Narayana PA, Johnson KP (2001) United States open-label glatiramer acetate trial for relapsing multiple sclerosis: MRI and clinical correlates. Multiple Sclerosis Study Group and MRI analysis Group. Mutl Scler 7:33-41
-
(2001)
Mutl Scler
, vol.7
, pp. 33-41
-
-
Wolinsky, S.1
Narayana, P.A.2
Johnson, K.P.3
-
31
-
-
0019480344
-
Nuclear magnetic resonance imaging of the brain in multiple sclerosis
-
Young IR, Hall AS, Pallis CA, Legg NJ, Bydder GM, Steiner RE (1981) Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet 2:1063-1066
-
(1981)
Lancet
, vol.2
, pp. 1063-1066
-
-
Young, I.R.1
Hall, A.S.2
Pallis, C.A.3
Legg, N.J.4
Bydder, G.M.5
Steiner, R.E.6
|