Cyclization of conotoxins to improve their biopharmaceutical properties

Toxicon

Volumn 59, Issue 4, 2012, Pages 446-455

  Clark, Richard J ^a   Akcan, Muharrem ^a   Kaas, Quentin ^a   Daly, Norelle L ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Conotoxins; Cyclic peptides; Cyclization; Cyclotides; Drug design; Marine toxins

Indexed keywords

ALPHA CONOTOXIN; ALPHA CONOTOXIN CYCLIC VC1.1; ALPHA CONOTOXIN IMI; ALPHA CONOTOXIN MII; CONOTOXIN; CONOTOXIN MRIA; CYCLOSPORIN; GABAPENTIN; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ANALGESIC ACTIVITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL PROCEDURES; CYCLIZATION; DISULFIDE BOND; DRUG DESIGN; DRUG TARGETING; HUMAN; NATIVE CHEMICAL LIGATION; NEUROPATHIC PAIN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL AGENTS; CONOTOXINS; CYCLIZATION; DISULFIDES; HUMANS; ION CHANNELS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEOLYSIS; SNAILS;

GASTROPODA;

EID: 84857048280     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.12.003     Document Type: Review

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