Local renin-angiotensin systems in the genitourinary tract

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 1, 2012, Pages 13-26

  Comiter, Craig ^a  

^a Department of Urology ^*  (United States)

Author keywords

Angiotensin II; Nitric oxide; Oxidative stress

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN 1B RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; CAPTOPRIL; COLLAGEN; CYCLIC GMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENDOTHELIN 1; EPROSARTAN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LOSARTAN; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO KINASE; TRANSFORMING GROWTH FACTOR BETA; VALSARTAN;

ADENOHYPOPHYSIS; APOPTOSIS; BIOSYNTHESIS; BLADDER; BLOOD PRESSURE REGULATION; CLITORIS; CONGESTIVE HEART FAILURE; CORPUS CAVERNOSUM; DETRUSOR MUSCLE; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; EXTRACELLULAR MATRIX; FEMALE SEXUAL DYSFUNCTION; FIBROSING ALVEOLITIS; HEART LEFT VENTRICLE HYPERTROPHY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HORMONE RECEPTOR INTERACTION; HUMAN; HYPERPLASIA; HYPERTENSION; HYPERTROPHY; INTERSTITIAL CYSTITIS; KIDNEY DEVELOPMENT; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SPHINCTER; T LYMPHOCYTE ACTIVATION; URETERAL SPASM; URETHRA; UROGENITAL SYSTEM; VASODILATATION;

ANGIOTENSIN II; ANIMALS; HUMANS; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM; UROGENITAL SYSTEM;

EID: 84857032218     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0706-y     Document Type: Review

References (171)

1. PM Abadir A Periasamy RM Carey HM Siragy 2006 Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization Hypertension 48 316 322 16754789 1:CAS:528:DC%2BD28XmvFaltbc%3D 10.1161/01.HYP.0000228997.88162. a8 (Pubitemid 44309829)
2. KE Anderson K Persson 1995 Nitric oxide synthase and the lower urinary tract: possible implication for physiology and pathophysiology Scand J Urol Nephrol 29 43 53
3. K-E Andersson 2003 Erectile physiological and pathophysiological pathways involved in erectile dysfunction J Urol 170 S6 S14 12853766 10.1097/01.ju.0000075362.08363.a4
4. KE Andersson H Hedlund M Stahl 1992 Contractions induced by angiotensin I, angiotensin II, and bradykinin in isolated muscle from the human detrusor Acta Physiol Scand 145 253 259 1519483 1:CAS:528:DyaK38Xlt1Ggtro%3D 10.1111/j.1748-1716.1992.tb09362.x
5. R Ardaillo D Chansel 1997 Synthesis and effects of active fragments of angiotensin II Kidney Int 52 1458 1468 10.1038/ki.1997.476 (Pubitemid 28032049)
6. S Ayan JA Roth MR Freeman SH Bride CA Peters 2001 Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney Urology 58 301 306 11489731 1:STN:280:DC%2BD3MvksVCisA%3D%3D 10.1016/S0090-4295(01)01156-6 (Pubitemid 32728085)
7. KM Azadzoi VK Keim T Tarcan MB Siroky 2004 Alteration of urothelial-mediated tone in the ischemic bladder: role of eicosanoids Neurourol Urodyn 23 258 264 15098224 1:CAS:528:DC%2BD2cXkvF2jtrc%3D 10.1002/nau.20029 (Pubitemid 39549987)
8. M Bader D Ganten 2008 Update on tissue renin-angiotensin systems J Mol Med 86 615 621 18414822 1:CAS:528:DC%2BD1cXls1Klt70%3D 10.1007/s00109-008-0336-0
9. WW Batenburg IM Garrelds CC Bernasonic, et al. 2004 Angiotensin II type 2 receptor-mediated vasodilation in human coronary microareteries Circulation 109 2296 2301 15117835 1:CAS:528:DC%2BD2cXjslOru7c%3D 10.1161/01.CIR.0000128696. 12245.57 (Pubitemid 38656868)
10. AJ Becker S Uckert CG Stief, et al. 2001 Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction Urology 58 805 810 11711372 1:STN:280:DC%2BD3Mnms1alsQ%3D%3D 10.1016/S0090-4295(01)01312-7
11. AJ Becker S Ückert CG Stief MC Truss S Machtens F Scheller WH Knapp U Hartmann U Jonas 2001 Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence Urology 57 193 198 11164180 1:STN:280:DC%2BD3M3is1ertw%3D%3D 10.1016/S0090-4295(00)00881-5 (Pubitemid 32065855)
12. D Boivin D Bilodeau R Beliveau 1996 Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells Can J Physiol Pharmacol 74 801 810 8946066 1:CAS:528:DyaK28Xnt1yis7o%3D 10.1139/y96-083 (Pubitemid 26426569)
13. WA Border NA Noble 1998 Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis Hypertension 31 181 188 9453300 1:CAS:528:DyaK1cXptF2iug%3D%3D
14. H Brasch L Sieroslawski P Dominiak 1993 Angiotensin II increases norepinephrine release from atria by acting on angiotensin subtype 1 receptors Hypertension 22 699 704 8225530 1:CAS:528:DyaK2cXisValuw%3D%3D (Pubitemid 23326217)
15. CG Brilla GP Reams B Maisch KT Weber 1993 Renin angiotensin system and myocardial fibrosis in hypertension: regulation of the myocardial collagen matrix Eur Heart J 14 S57 S61 10.1093/eurheartj/14.1.57
16. AD Bullock MJ Becich CG Klutke TL Ratliff 1992 Experimental autoimmune cystitis: a potential murine model for ulcerative interstitial cystitis J Urol 148 1951 1956 1433651 1:STN:280:DyaK3s%2FlvFyksw%3D%3D
17. AL Burnett 1997 Nitric oxide in the penis: physiology and pathology J Urol 157 320 324 8976289 1:CAS:528:DyaK2sXivFarsQ%3D%3D 10.1016/S0022-5347(01) 65369-2 (Pubitemid 26414983)
18. AL Burnett B Msicki L Jin TJ Bivalacqua 2006 Nitric oxide/redox-based signaling as a therapeutic target for penile disorders Expert Opin Ther Targets 10 445 457 16706684 1:CAS:528:DC%2BD28XltVOgtLw%3D 10.1517/14728222.10.3.445 (Pubitemid 43949958)
19. A Butkus A Albiston D Alcorn, et al. 1997 Ontogeny of angiotensin II receptors, types 1 and 2, in ovine mesonephros and metanephros Kidney Int 51 628 636 10.1038/ki.1997.376 (Pubitemid 27402360)
20. H Cai DG Harrison 2000 Endothelial dysfunction in cardiovascular disease: the role of oxidative stress Circ Res 87 840 844 11073878 1:CAS:528: DC%2BD3cXoslygsrk%3D
21. RM Carey HM Siragy 2003 Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation Endocr Rev 24 261 271 12788798 1:CAS:528:DC%2BD3sXlsFWqs7w%3D 10.1210/er.2003-0001 (Pubitemid 36733542)
22. AF Celik P Katsinelos NW Read MI Khan TC Donnelly 1995 Hereditary proctalgia fugax and constipation: report of a second family Gut 36 581 584 7737568 1:STN:280:DyaK2M3lsFOhsw%3D%3D 10.1136/gut.36.4.581
23. Y Chen SX Li LS Yao R Wang YT Dai 2006 Valsartan treatment reverses erectile dysfunction in diabetic rats Int J Impot Res 19 366 370 17183345 10.1038/sj.ijir.3901534 1:CAS:528:DC%2BD2sXntFymsL8%3D
24. EY Cheng T Grammatopoulos C Lee R Decker J Sensibar WE Kaplan M Maizels CF Firlit 1996 Angiotensin II and basic fibroblast growth factor induce neonatal bladder stromal cell mitogenesis J Urol 156 593 597 8683740 1:CAS:528:DyaK28XkvFaqtbw%3D 10.1016/S0022-5347(01)65759-8 (Pubitemid 126444883)
25. EY Cheng L Chung RS Decker, et al. 1997 Captopril (an inhibitor of angiotensin converging enzyme) inhibits obstructive changes in the neonatal rabbit bladder Urology 50 465 471 9301722 1:STN:280:DyaK2svkslaksw%3D%3D 10.1016/S0090-4295(97)00266-5 (Pubitemid 27428135)
26. ME Chicurel CS Chen DE Ingber 1998 Cellular control lies in the balance of forces Curr Opin Cell Biol 10 232 239 9561847 1:CAS:528:DyaK1cXisFyntLg%3D 10.1016/S0955-0674(98)80145-2 (Pubitemid 28174765)
27. JN Cohn 2006 What is the role of angiotensin-receptor blockade in cardiovascular protection? Am Heart J 152 859 e.1 e.8
28. Comiter CV, Phull HS (2011) Angiotensin II type 1 (AT1) receptor inhibition prevents the urodynamic and detrusor changes associated with bladder outlet obstruction-a mouse model. BJU Int. doi: 10.1111/j.1464-410X.2011.10580.x
29. CV Comiter MP Sullivan SV Yalla, et al. 1997 Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: in vitro studies in canines Int J Impot Res 9 135 140 9315490 1:STN:280: DyaK2svmtFWhsQ%3D%3D 10.1038/sj.ijir.3900261 (Pubitemid 27427269)
30. GLV Cooper WE Mercer JK Hoober, et al. 1986 Load regulation of the properties of adult feline cardiocytes. The role of substrate adhesion Circ Res 58 692 705 3708766 (Pubitemid 16088291)
31. MC Cruzado NR Risler RM Miatello, et al. 2005 Vasclar smooth muscle cell SNDPH activity during the development of hypertension: effect of angiotensin II and role of inslinlike growth factor-1 receptor transactivation Am J Hypertens 18 81 87 15691621 1:CAS:528:DC%2BD2MXit1Wms7s%3D 10.1016/j.amjhyper.2004.09.001 (Pubitemid 40187353)
32. IA Darby M Congiu RT Fernley 1994 Cellular and ultrastructural location of antiotensinogen in rat and sheep kidney Kidney Int 46 1557 1560 7700005 1:CAS:528:DyaK2MXis1Glsro%3D 10.1038/ki.1994.445 (Pubitemid 24370461)
33. M de Gasparo 2002 Angiotensin II and nitric oxide interaction Heart Fail Rev 7 347 358 12379820 10.1023/A:1020714518246 (Pubitemid 35396467)
34. MAF De Godoy S Rattan 2005 Autocrine regulation if internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle Am J Physiol 289 G1164 G1175
35. MAF De Godoy S Rattan 2006 Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive rats JPET 318 725 734 10.1124/jpet.106.103366 1:CAS:528:DC%2BD28XnslOlsbc%3D (Pubitemid 44061247)
36. MAF De Godoy AM de Oliveira S Rattan 2004 Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of At2 receptor associated with nitric-oxide synthase pathway JPET 311 394 401 10.1124/jpet.104.069856 1:CAS:528:DC%2BD2cXosVKrtbg%3D (Pubitemid 39287821)
37. AM Dorrance RW Lewis TM Mills 2002 Captopril treatment reverses erectile dysfunction in male stroke prone spontaneously hypertensive rats Int J Impot Res 14 494 497 12494284 1:STN:280:DC%2BD38jjtVOitg%3D%3D 10.1038/sj.ijir.3900915 (Pubitemid 36068427)
38. Dzau VJ, Pratt RE (1993) Cardiac, vascular and intrarenal rennin angiotensin system in normal physiology and disease. In: Robertson JIS, Nicholls MG (eds) The renin-angiotensin system. Gower, London, pp 1-11
39. DJ Dzielak 1992 The immune system and hypertension Hypertension 19 Suppl I36 I44 1730453 1:STN:280:DyaK387ht1altg%3D%3D
40. SS El Dahr J Gee S Dipp, et al. 1993 Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy Am J Physiol 264 F874 F881 8498541 1:CAS:528:DyaK3sXkvFejsLo%3D
41. NT El Melegy ME Ali EM Awad 2005 Plasma levels of endothelin-1, angiotensin II, nitric oxide and prostaglandin E in the venous and cavernosal blood of patients with erectile dysfunction BJU Int 96 1079 1086 16225532 1:CAS:528:DC%2BD2MXht1amtLbN 10.1111/j.1464-410X.2005.05780.x (Pubitemid 41531418)
42. CR Esther Jr TE Howard EM Marino JM Goddard MR Capecchi KE Bernstein 1996 Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility Lab Invest 7 953 965 (Pubitemid 26152664)
43. Y-P Fan RN Pri S Rattan 2002 Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action Am J Physiol 282 G462 G469
44. RJ Fern CM Vesko BA Thornhill, et al. 1999 Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice J Clin Invest 103 39 46 9884332 1:CAS:528:DyaK1MXjsl2msA%3D%3D 10.1172/JCI4236 (Pubitemid 29031161)
45. EJ Freeman EA Tallant 1994 Vasclar smooth-muscle cells contain AT1 angiotensin receptors coupled to phospholipase D activation Biochem J 304 543 548 7998990 1:CAS:528:DyaK2MXitlCntr8%3D (Pubitemid 24368236)
46. H Fujinaka Y Miyazaki T Matsusaka H Yoshida AB Fogo T Inagami, et al. 2000 Salutary role for angiotensin in partial urinary tract obstruction Kidney Int 58 2018 2017 11044222 1:STN:280:DC%2BD3M%2FivFSksQ%3D%3D 10.1111/j.1523-1755.2000.00374.x
47. JM Gase S Shanmugam M Sibony P Corvol 1994 Tissue-specific expression of type 1 angiotensin II receptor subtypes. An in situ hybridization study Hypertension 24 531 537 (Pubitemid 24337821)
48. RF Gilmom AE Khoury EJ Macarak GA McLorie RE Steckler BA Kogan 1994 Loss of elasticity in dysfunctional bladders: urodynamic and histochemical correlation J Urol 152 702 705 (Pubitemid 24235886)
49. R Gobet JM Park HT Nguyen, et al. 1999 Renal renin-angiotensin system dysregulation casued by partial bladder outlet obstruction in fetal sheep Kidney Int 56 1654 1661 10571773 1:CAS:528:DyaK1MXnslWqurk%3D 10.1046/j.1523-1755. 1999.00732.x (Pubitemid 29518165)
50. I Goldstein JR Berman 1998 Vasculogenic female sexal dysfnction: vaginal engorgement and clitoral erectile insufficiency syndromes Int J Impot Res 10 S84 S90 9647967
51. JE Greenland AF Brading 1997 The in vivo and in vitro effects of hypoxia on pig urethral smooth muscle BJU Int 79 525 531 1:STN:280:DyaK2s3ntFWhug%3D%3D 10.1046/j.1464-410X.1997.00068.x (Pubitemid 28321092)
52. JE Greenland JJ Hvistendahl H Andersen, et al. 2000 The effect of bladder outlet obstruction on tissue oxygen tension and blood flow in the pig bladder BJU Int 85 1109 1114 10848706 1:STN:280:DC%2BD3czos1SjtQ%3D%3D 10.1046/j.1464-410x.2000.00611.x (Pubitemid 30348810)
53. JP Habashi DP Judge TM Holm RD Cohn BL Loeys TK Cooper, et al. 2006 Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome Science 312 117 121 16601194 1:CAS:528:DC%2BD28XjtFalsLk%3D 10.1126/science.1124287
54. L Hansson LH Lindholm T Ekbom, et al. 1999 Randomized trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 Study Lancet 354 1751 1756 10577635 1:CAS:528:DC%2BD3cXhtVan 10.1016/S0140-6736(99)10327-1
55. L Hansson LH Lindholm L Niskanen, et al. 1999 Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomized trial Lancet 353 611 616 10030325 1:CAS:528:DyaK1MXivVCls78%3D 10.1016/S0140-6736(98)05012-0 (Pubitemid 29087980)
56. F Holmquist K Persson A Garcia-Pascual, et al. 1992 Phospholipase C activation by endothelin-1 and noradrenaline in isolated penile erectile tissue from rabbit J Urol 147 1632 1635 1593712 1:STN:280:DyaK383nslOkuw%3D%3D
57. S Ishidoya J Morrissey R McCracken A Reyes S Klahr 1995 Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction Kidney Int 47 1285 1294 7637258 1:CAS:528:DyaK2MXmsV2mtLo%3D 10.1038/ki.1995.183
58. S Ishidoya J Morrissey R McCracken S Klahr 1996 Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats with obstructive nephropathy Kidney Int 49 1110 1119 8691732 1:CAS:528:DyaK28XkslSht7s%3D 10.1038/ki.1996.161 (Pubitemid 26122714)
59. Y Iwamoto K Song S Takai, et al. 2001 Multiple pathways of angiotensin I conversion and their functional role in the canine penile corpus cavernosum J Pharmacol Exp Ther 298 43 48 11408523 1:CAS:528:DC%2BD3MXksFCht7g%3D (Pubitemid 32574508)
60. L-M Jin 2009 Angiotensin II signaling and its implication in erectile dysfunction J Sex Med 6 suppl 3 302 210 19267853 1:CAS:528:DC%2BD1MXktlKrtL4%3D 10.1111/j.1743-6109.2008.01188.x
61. L Jin Z Ying RC Webb 2004 Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta Am J Physiol Heart Circ Physiol 287 H1495 H1500 15371261 1:CAS:528:DC%2BD2cXptFansLs%3D 10.1152/ajpheart.01006.2003 (Pubitemid 39313251)
62. L Jin Z Ying RH Hilgers, et al. 2006 Increased Rhoa/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats J Pharmacol Exp Ther 318 288 295 16569756 1:CAS:528:DC%2BD28XmsFymt7o%3D 10.1124/jpet.105.100735
63. L Jin G Lagoda R Leite RC Webb AL Burnett 2008 NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction J Sex Med 5 544 551 18208505 1:CAS:528:DC%2BD1cXksFSks7k%3D 10.1111/j.1743-6109.2007.00733.x (Pubitemid 351337880)
64. H Kaneto J Morrissey R McCracken A Reyes S Klahr 1994 Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney Kidney Int 45 1637 1647 7933811 1:CAS:528:DyaK2cXlslSisbY%3D 10.1038/ki.1994.215 (Pubitemid 24207499)
65. K Kato F Monson P Longhurst A Wein N Haugaard R Levin 1990 The functional effects of long-term outlet obstruction on the rabbit urinary bladder J Urol 143 600 606 1968106 1:STN:280:DyaK3c7ls1KjsA%3D%3D (Pubitemid 20108174)
66. H Kato H Suzuki S Tajima Y Ogata T Tominaga A Sato T Saruta 1991 Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells J Hypertens 9 17 22 1848253 1:CAS:528:DyaK3MXltVKqurw%3D
67. T Kawazoe H Kosaka H Yoneyama, et al. 2000 Acute production of vascular speroxide by Ang-II but not by catecholamines J Hypertens 18 179 185 10694186 1:CAS:528:DC%2BD3cXhsFahsLk%3D 10.1097/00004872-200018020-00008 (Pubitemid 30114064)
68. I Kifor G Williams M Vickers, et al. 1997 Tissue angiotensin II as a modulator of erectile function. 1. Angiotensin peptide content, secretion and effects in the corpus cavernosum J Urol 157 1920 1925 9112563 1:CAS:528:DyaK2sXmtVGjtrY%3D 10.1016/S0022-5347(01)64901-2 (Pubitemid 27171811)
69. KM Kim BA Kogan CA Massad YC Huang 1991 Collagen and elastin in the obstructed fetal bladder J Urol 146 528 531 1861293 1:STN:280: DyaK3MzhvVCrug%3D%3D
70. S Klahr JJ Morrissey 1997 Comparative study of ACE inhibitors and angiotensin II receptor antagonists in interstitial scarring Kidney Int 52 S111 S114 10.1038/ki.1997.296
71. CP Klett MP Printz M Bader D Ganten P Eggena 1996 Angiotensinogen messenger RNA stabilization by angiotensin II J Hypertens Suppl 14 S25 S36 9120681 1:STN:280:DyaK2s7nsleisw%3D%3D
72. DSH Lam LS Dias KH Moore, et al. 2000 Angiotensin II in child urinary bladder: functional and autoradiographic studies Br J Urol 86 494 501 1:CAS:528:DC%2BD3cXntFKrs7k%3D 10.1046/j.1464-410X.2000.00771.x
73. VC Lee DC Rhew M Dylan, et al. 2004 Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction Ann Intern Med 141 693 704 15520426 1:CAS:528:DC%2BD2cXhtVams7rN (Pubitemid 39434842)
74. SR Leiblum RM Bame SH Croog 1994 The sexual functioning of elderly hypertensive women J Sex Marital Ther 20 250 270 10.1080/00926239408404377
75. BF Lindberg LG Nillson H Hedlund M Stahl KE Andersson 1994 Angiotensin I is converted to angiotensin II by a serine protease in human detrusor smooth muscle Am J Physiol 266 R1861 R1867 8024040 1:CAS:528:DyaK2cXlt1Kju7Y%3D
76. H Lithell L Hansson I Skoog, et al. 2003 The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial J Hypertens 21 875 886 12714861 1:CAS:528: DC%2BD3sXjtFGmtbc%3D 10.1097/00004872-200305000-00011 (Pubitemid 36677151)
77. EM Lonn S Yusuf P Jha, et al. 1994 Emerging role of angiotensin- converting enzyme inhibitors in cardiac and vascular protection Circulation 90 2056 2069 7923694 1:CAS:528:DyaK2MXhvFOgtrw%3D (Pubitemid 24320959)
78. J Ma NH Fogo KV Inagami, et al. 1998 Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction Kidney Int 53 937 944 9551401 1:CAS:528:DyaK1cXisVKmtr0%3D 10.1111/j.1523-1755.1998.00893.x (Pubitemid 28155667)
79. DL Mann RL Kent G Cooper 1989 Load regulation of the properties of adult feline cardiocytes: growth induction by cellular deformation Circ Res 64 1079 1090 2470528 1:CAS:528:DyaL1MXktlOisLg%3D (Pubitemid 19155778)
80. ON Mazza M Angerosa E Becher JE Toblli 2006 Differences between Candesartan and Hydralazine in the protection of penile structures in spontaneously hypertensive rats J Sex Med 3 604 611 16839316 1:CAS:528:DC%2BD28XnsVWitbo%3D 10.1111/j.1743-6109.2006.00235.x
81. N Mikata N Iwai T Inagami, et al. 1992 Two distinct pathways in the downregulation of type 1 angiotensin receptor gene in rat glomerular mesangial cells Biochem Biophy Res Commun 185 142 146 10.1016/S0006-291X(05)80967-2
82. MA Millan DM Jacobowitz G Aguilera KJ Catt 1991 Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development Proc Natl Acad Sci U S A 88 11440 11444 1763058 1:CAS:528: DyaK38Xlt1egsw%3D%3D 10.1073/pnas.88.24.11440 (Pubitemid 21916057)
83. TM Mills K Chitaley RW Lewis RC Webb 2002 Nitric oxide inhibits RhoA/Rho-kinase signaling to case penile erection Eur J Pharmacol 439 173 174 11937108 1:CAS:528:DC%2BD38XisV2rs7o%3D 10.1016/S0014-2999(02)01408-5 (Pubitemid 34286622)
84. Y Miyazaki S Tsuchida H Nishimura, et al. 1998 Angiotensin induces the urinary peristaltic machinery during the perinatal period J Clin Invest 102 1489 1497 9788961 1:CAS:528:DyaK1cXmvVygurc%3D 10.1172/JCI4401 (Pubitemid 28492215)
85. K Mizuno M Tani S Hashimoto, et al. 1992 Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats Life Sci 51 367 374 1385640 1:CAS:528:DyaK38Xks1ektLs%3D 10.1016/0024-3205(92)90589-H
86. JJ Morrissey S Klahr 1997 Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction Kidney Int 52 926 933 9328931 1:CAS:528:DyaK2sXmslOmsLs%3D 10.1038/ki.1997.414 (Pubitemid 27435825)
87. M Mukoyama M Nakajima M Horiuchi, et al. 1993 Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors J Biol Chem 268 24539 24542 8227010 1:CAS:528:DyaK2cXisVahtw%3D%3D (Pubitemid 23335456)
88. M Nagata K Tanimoto A Fukamizu Y Kon F Sugiyama K Yagami K Murakami T Watanabe 1996 Nephrogenesis and renovascular development in angiotensinogen- deficient mice Lab Invest 75 745 753 8941219 1:STN:280:DyaK2s%2Fps1Wqtw%3D%3D (Pubitemid 26392804)
89. R Nakasawa M Tanaka T Takahashi, et al. 2007 Effects of castration and testosterone administration on angiotensin II receptor mRNA expression and apoptosis-related proteins in rat urinary bladder Endocr J 54 211 219 10.1507/endocrj.K06-134 (Pubitemid 46798642)
90. H Nakashima H Suzuki H Ohtsu, et al. 2006 Angiotensin II regulates vascular and endothelial dysfunction: recent topics of angiotensin Ii type-1 signaling in the vasculature Curr Vasc Pharmacol 4 67 78 16472178 1:CAS:528:DC%2BD28XitlGhuw%3D%3D 10.2174/157016106775203126 (Pubitemid 46785183)
91. LG Navar EW Inscho SA Majid, et al. 1996 Paracrine regulation of the renal microcirclation Physiol Rev 76 425 536 8618962 1:CAS:528: DyaK28XivFWlsLY%3D
92. G Nguyen C Burckle JD Sraer 2003 The renin receptor: the facts, the promise and the hope Curr Opin Nephrol Hypertens 12 51 55 12496666 1:CAS:528:DC%2BD2cXps1Cn 10.1097/00041552-200301000-00009 (Pubitemid 36092315)
93. F Niimura PA Labosky J Kakuchi S Okubo H Yoshida T Oikawa T Ichiki AJ Naftilan A Fogo T Inagami 1995 Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation J Clin Invest 96 2947 2954 8675666 1:CAS:528: DyaK28XmtVenug%3D%3D 10.1172/JCI118366
94. M Noda R Fukuda T Matsui, et al. 1997 Effects of candesartan cilexetil and enalapril in 5/6 nephrectomized rats Kidney Int 63 Suppl S136 S139 1:CAS:528:DyaK2sXotVKgtrY%3D
95. S Nouet C Nahamias 2000 Signal transduction from the angiotensin II AT2 receptor Trends Endocrinol Metab 11 1 6 10652498 1:CAS:528: DC%2BD3cXpsFanug%3D%3D 10.1016/S1043-2760(99)00205-2 (Pubitemid 30395452)
96. MI Oliverio HS Kim M Ito T Le L Audoly CF Best S Hiller K Kluckman N Maeda O Smithies TM Coffman 1998 Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice 1118 Pediatr Nephrol 24 1113 1120
97. LS Palmer C Lee RS Decker, et al. 1997 The effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on obstructed rat bladder J Urol 158 1100 1104 9258150 1:CAS:528:DyaK1cXmsVyju7s%3D 10.1016/S0022-5347(01)64397-0 (Pubitemid 27340242)
98. JK Park SZ Kim SH Kim, et al. 1997 Renin angiotensin system in rabbit corpus cavernosm: functional characterization of angiotensin II receptors J Urol 158 653 658 9224386 1:CAS:528:DyaK1cXmsVCrsrc%3D 10.1016/S0022-5347(01)64577-4 (Pubitemid 27327741)
99. JM Park JG Borer MR Freeman, et al. 1998 Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells Am J Physiol 275 C1247 C1254 9814973 1:CAS:528:DyaK1cXns1aitbw%3D
100. JK Park SZ Kim SH Kim, et al. 2000 Renin angiotensin system of rabbit clitoral cavernosum: interaction with nitric oxide J Urol 164 556 561 10893643 1:CAS:528:DC%2BD3cXlsFyqtr4%3D 10.1016/S0022-5347(05)67422-8 (Pubitemid 30481983)
101. JK Park SO Lee YG Kim, et al. 2002 Role of rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle Int J Impot Res 14 472 477 12494280 1:STN:280:DC%2BD38jjtVOisg%3D%3D 10.1038/sj.ijir.3900911 (Pubitemid 36068423)
102. JK Park SO Lee WS Cui, et al. 2005 Activity of angiotensin peptides in clitoral cavernosum of alloxan induced diabetic rabbit Eur Urol 48 1042 1050 16084009 1:CAS:528:DC%2BD2MXhtlCjtL%2FI 10.1016/j.eururo.2005.06.017 (Pubitemid 41641662)
103. K Park JW Shin JK Oh, et al. 2005 Restoration of erectile capacity in normotensive aged rats by modulation of angiotensin receptor type 1 J Androl 26 123 128 15611576 1:CAS:528:DC%2BD2MXmsFWntg%3D%3D (Pubitemid 39665285)
104. K Persson JJ Sando JB Tuttle, et al. 1995 Protein kinase C in cyclic stretch-induced nerve growth factor production by urinary tract smooth muscle cells Am J Physiol 269 C1018 C1024 7485441 1:CAS:528:DyaK2MXptVaisrk%3D
105. K Persson RK Pandita K Waldeck K-E Andersson 1996 Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility Am J Physiol 271 R1186 R1192 8945952 1:CAS:528:DyaK28XntFyqs74%3D
106. CA Peters MC Carr A Lais, et al. 1992 The response of the fetal kidney to obstruction J Urol 148 503 509 1640511 1:STN:280:DyaK38zkvFCqsA%3D%3D
107. CA Peters S Vasavada D Dator M Carr E Shapiro H Lepor J McConnell AB Retik J Mandell 1992 The effect of obstruction on the developing bladder J Urol 148 491 496 1640508 1:STN:280:DyaK38zkvFCruw%3D%3D
108. MI Phillips EA Speakman B Kimura 1993 Levels of angiotensin and molecular biology of the tissue renin angiotensin system Regul Pept 43 1 20 8426906 1:CAS:528:DyaK3sXhtFKrtrs%3D 10.1016/0167-0115(93)90403-U
109. H Phull M Salkini C Escobar, et al. 2007 The role of angiotensin II in stress urinary incontinence: a rat model Neurourol Urodyn 26 81 88 17029249 1:CAS:528:DC%2BD2sXhvVansLs%3D 10.1002/nau.20339 (Pubitemid 46175452)
110. H Phull M Salkini T Purves, et al. 2007 Angiotensin II plays a role in acute murine experimental autoimmune cystitis BJU Int 100 664 667 17550411 1:CAS:528:DC%2BD2sXhtVynsb7O 10.1111/j.1464-410X.2007.07035.x (Pubitemid 47205478)
111. JL Pimentel M Martinez-Maldonado JN Wilcox S Wang C Luo 1993 Regulation of renin-angiotensin system in unilateral ureteral obstruction Kidney Int 44 390 400 8397317 1:CAS:528:DyaK2cXhtlWgurw%3D 10.1038/ki.1993.257 (Pubitemid 23228696)
112. JL Pimentel Jr S Wang M Martinez-Maldonado 1994 Regulation of the renal angiotensin II receptor gene in acute unilateral ureteral obstruction Kidney Int 45 1614 1621 7933808 1:CAS:528:DyaK2cXlsFCrs7g%3D 10.1038/ki.1994.212 (Pubitemid 24207496)
113. JL Pimentel Jr A Montero S Wang I Yosipiv S El-Dahr M Martinez-Maldonado 1995 Sequential changes in renal expression of renin-angiotensin system genes in acute unilateral ureteral obstruction Kidney Int 48 1247 1253 8569086 1:CAS:528:DyaK2MXpsVSisbg%3D 10.1038/ki.1995.408
114. JL Pimentel Jr CL Sundell S Wang JB Kopp A Montero M Martinez-Maldonado 1995 Role of angiotensin II in the expression and regulation of transforming growth factor-beta in obstructive nephropathy Kidney Int 48 1233 1246 8569085 1:CAS:528:DyaK2MXpsVSisbs%3D 10.1038/ki.1995.407
115. VO Puntmann MB Hussain M Mayr, et al. 2005 Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease Vascul Pharmacol 43 277 282 16243586 10.1016/j.vph.2005. 08.015 1:CAS:528:DC%2BD2MXhtFyksbjL (Pubitemid 41586215)
116. Purves J, Do R, Heimark R et al (2004) Discovery and population characterization of angiotensin receptors in the proximal urethra of the male mouse. Presented at the Western Section. American Urological Association, San Diego
117. D Rees R Palmer S Moncada 1989 Role of endothelium-derived nitric oxide in the regulation of blood pressure Proc Natl Acad Sci 86 3375 3378 2497467 1:CAS:528:DyaL1MXit12hsbo%3D 10.1073/pnas.86.9.3375 (Pubitemid 19129614)
118. JE Robillard WV Page MS Mathews, et al. 1995 Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep Pediatr Res 38 896 904 8618791 1:CAS:528: DyaK28XmslOqtw%3D%3D 10.1203/00006450-199512000-00012
119. J Rodriguez-Vita E Sanchez-Lopez V Esteban M Ruperez J Egido M Ruiz-Ortega 2005 Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism Circulation 111 2509 2517 15883213 1:CAS:528:DC%2BD2MXjvFOisro%3D 10.1161/01.CIR.0000165133.84978.E2 (Pubitemid 40696140)
120. M Rossi LC Peres 1992 Effect of captopril on the prevention and regression of myocardial cell hypertrophy and interstitial fibrosis in pressure overload cardiac hypertrophy Am Heart J 124 700 709 1387507 1:CAS:528: DyaK38XmsVGhsLs%3D 10.1016/0002-8703(92)90281-Y
121. B Rubin MJ Antonaccio ME Goldberg, et al. 1978 Chronic antihypertensives effects of captopril and orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive rats Eur J Pharmacol 51 592 594 10.1016/0014-2999(78)90429-6 (Pubitemid 9202891)
122. J Sadjadi GL Kramer CH Yu MB Welborn 3rd JG Modrall 2005 Angiotensin II exerts positive feedback on the intrarenal renin-angiotensin system by an angiotensin converting enzyme-dependent mechanism J Surg Res 129 272 277 15992826 1:CAS:528:DC%2BD2MXhtlWqu7rF 10.1016/j.jss.2005.04.044 (Pubitemid 41797063)
123. J Sadoshima S Izumo 1993 Molecular characterization of angiotensin 11-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype Circ Res 73 413 423 8348686 1:CAS:528:DyaK3sXmtFygs74%3D (Pubitemid 23238726)
124. J Sadoshima Y Xu HS Slayter S Izumo 1993 Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro Cell 75 977 984 8252633 1:CAS:528:DyaK2cXks1Gkuw%3D%3D 10.1016/0092-8674(93)90541-W (Pubitemid 24014554)
125. CT Sangaleti A Crescenzi LC Michelini 2004 Endogenous angiotensin and pressure modulate brain angiotensinogen and AT1A mRNA expression Hypertension 43 317 323 14732738 1:CAS:528:DC%2BD2cXitVajsLo%3D 10.1161/01.HYP.0000112030. 79692.21 (Pubitemid 38174132)
126. WF Santis MP Sullivan R Gobet, et al. 2000 Characterization of ureteral dysfunction in an experimental model of congenital bladder outlet obstruction J Urol 163 980 984 10688035 1:STN:280:DC%2BD3c7ltVOnsQ%3D%3D 10.1016/S0022- 5347(05)67868-8 (Pubitemid 30091674)
127. WF Santis CA Peters AV Yalla MP Sullivan 2003 Ureteral function is modulated by a local renin-angiotensin system J Urol 170 259 263 12796700 1:CAS:528:DC%2BD3sXks1yqsrY%3D 10.1097/01.ju.0000060848.61864.e1 (Pubitemid 36734473)
128. S Shanmugam C Lorens-Cortes E Clauser P Corvol JM Gasc 1995 Expression of angiotensin II AT2 receptor mRNA during development of rat kidney and adrenal gland Am J Physiol Renal Physiol 268 F922 F930 1:CAS:528:DyaK2MXlvVajsLc%3D
129. E Shapiro MJ Becich E Perlman H Lepor 1991 Bladder wall abnormalities in myelodysplastic bladders: a computer assisted morphometric analysis J Urol 145 1024 1029 2016785 1:STN:280:DyaK3M3gt1Knsw%3D%3D
130. M Shirazi A Noorafshan MA Bahri A Hassanpoor 2008 Captopril reduces deposition of collagen in lamina propria and muscular layers of the bladder and ureter in neonatal dogs with partial urethral obstruction Scand J Urol Nephrol 42 324 329 19230165 1:CAS:528:DC%2BD1cXhtFaisr7I 10.1080/00365590801905984
131. MK Sim WS Chen 2006 Effects of losartan on angiotensin receptors in the hypertrophic rat heart Regul Pept 137 140 146 16928404 1:CAS:528: DC%2BD28Xht12rsLvF 10.1016/j.regpep.2006.07.002 (Pubitemid 44838979)
132. G Simon S Altman 1992 Subpressor angiotensin I1 is a bifunctional growth factor of vascular muscle in rat J Hypertens 10 1165 1171 1334997 1:CAS:528:DyaK3sXhsVSls74%3D 10.1097/00004872-199210000-00009
133. G Simon G Abraham S Altman 1994 Stimulation of vascular glycosaminoglycan synthesis by subpressor angiotensin II in rats Hypertension 23 1148 1151
134. R Singh I Mackraj R Naidoo P Gathiram 2006 Sanguinarine downregulates AT1a gene expression in a hypertensive rat model J Cardiovasc Pharmacol 48 14 21 16954816 1:CAS:528:DC%2BD28XptVGrt7g%3D 10.1097/01.fjc.0000238590.82438.64 (Pubitemid 44358889)
135. HM Siragy M de Gasparo RM Carey 2006 Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization Hypertension 48 316 322 16754789 10.1161/01.HYP.0000228997.88162.a8 1:CAS:528: DC%2BD28XmvFaltbc%3D (Pubitemid 44309829)
136. CP Steidle ML Cohen BL Neubauer 1990 Bradykinin-induced contractions of canine prostate and bladder: effect of angiotensin-converting enzyme inhibition J Urol 144 390 392 2165184 1:STN:280:DyaK3czisFelsw%3D%3D (Pubitemid 20255147)
137. N Takahashi ML Lopez JE Cowhig Jr MA Taylor T Hatada E Riggs G Lee RA Gomez HS Kim O Smithies 2005 Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type J Am Soc Nephrol 16 125 132 15563565 10.1681/ASN.2004060490 (Pubitemid 43073164)
138. C Talaia G Queiroz H Pinheiro D Moura J Gonçalves 2006 Involvement of G-protein [beta] [gamma] subunits on the influence of inhibitory [alpha]2-autoreceptors on the angiotensin AT1- receptor modulation of noradrenaline release in the rat vas deferens Neurochem Int 49 698 707 16962210 1:CAS:528:DC%2BD28XhtFSlu7zP 10.1016/j.neuint.2006.07.002 (Pubitemid 44572573)
139. N Tanabe A Ueno G Tsujimoto 1993 Angiotensin II receptors in the rat urinary bladder smooth muscle: type 1 subtype receptors mediate contractile responses J Urol 150 1056 1059 8345584 1:STN:280:DyaK3szksleisQ%3D%3D (Pubitemid 23241334)
140. H Thai J Wollmuth S Goldman M Gaballa 2003 Angiotensin subtype 1 receptor (AT1) blockade imporves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor J Pharmacol Exp Ther 307 1171 1178 14560036 1:CAS:528:DC%2BD3sXpslSht7w%3D 10.1124/jpet.103.054916 (Pubitemid 37494239)
141. Anonymous 1991 Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD investigators N Engl J Med 325 293 302 10.1056/NEJM199108013250501
142. SR Tipnis NM Hooper R Hyde, et al. 2000 A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase J Biol Chem 275 33238 33243 10924499 1:CAS:528:DC%2BD3cXnvVOqtbw%3D 10.1074/jbc.M002615200
143. JE Toblli I Stella F Inserra L Ferder F Zeller ON Mazza 2000 Morphological changes in cavernous tissue in spontaneously hypertensive rats Am J Hypertens 13 686 692 10912754 1:STN:280:DC%2BD3M%2FivVyjtA%3D%3D 10.1016/S0895-7061(99)00268-X (Pubitemid 30459881)
144. JE Toblli I Stella ON Mazza L Ferder F Inserra 2004 Candesartan cilexetil protects cavernous tissue in spontaneously hypertensive rats Int J Impot Res 16 305 312 15103316 1:CAS:528:DC%2BD2cXlvVens7s%3D 10.1038/sj.ijir.3901146 (Pubitemid 39273755)
145. JE Toblli I Stella ON Mazza L Ferder F Inserra 2004 Different effect of losartan and amlodipine on penile structures in male spontaneously hypertensive rats Am J Nephrol 24 614 623 15591797 1:CAS:528:DC%2BD2MXnvVCnsg%3D%3D 10.1159/000082598 (Pubitemid 40187019)
146. JE Toblli G Cao A Lombrana M Rivero 2007 Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan J Sex Med 4 1291 1303 17727350 1:CAS:528:DC%2BD2sXhtFantbnO 10.1111/j.1743-6109.2007.00567.x (Pubitemid 47337673)
147. RM Touyz C Berry 2002 Recent advances in angiotensin II signaling Braz J Med Biol Res 35 1001 1015 12219172 1:CAS:528:DC%2BD3sXmvVWhsA%3D%3D 10.1590/S0100-879X2002000900001 (Pubitemid 35452880)
148. RM Touyz EL Schiffrin 2001 Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypotensive patients: role of phospholipase D-dependent NADPH oxidase-sensitive pathways J Hypertens 19 1245 1254 11446714 1:CAS:528:DC%2BD3MXltVGktrs%3D 10.1097/00004872-200107000-00009 (Pubitemid 32595280)
149. F Trigo-Rocha GL Hsu CF Donatucci, et al. 1993 The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection J Urol 149 872 877 8384275 1:STN:280:DyaK3s3gsVeisg%3D%3D (Pubitemid 23111103)
150. S Tsuchida T Matsusaka X Chen S Okubo F Niimura H Nishimura A Fogo H Utsunomiya T Inagami I Ichikawa 1998 Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes J Clin Invest 101 755 760 9466969 1:CAS:528:DyaK1cXht1WrsbY%3D 10.1172/JCI1899 (Pubitemid 28096071)
151. Y Tsutsumi H Matsubara H Masaki, et al. 1999 Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation J Clin Invest 104 925 935 10510333 1:CAS:528:DyaK1MXmsVClsbs%3D 10.1172/JCI7886 (Pubitemid 29536342)
152. AG Tulloch 1974 The vascular contribution to intraurethral pressure BJU Int 46 659 664 1:CAS:528:DyaE2MXlsVait7s%3D 10.1111/j.1464-410X.1974.tb08901.x
153. B Uvelius P Lindner A Mattiasson 1991 Collagen content of the rat urinary bladder following removal of an experimental infravesical outlet obstruction Urol Int 47 245 249 1781110 1:STN:280:DyaK387kt1eluw%3D%3D 10.1159/000282230
154. K Waldeck BF Lindberg K Persson, et al. 1997 Characterization of angiotensin II formation in human isolated bladder by selective inhibitors of ACE and human chymase: a functional and biochemical study Br J Pharmacol 121 1081 1086 9249242 1:CAS:528:DyaK2sXkvFeqs78%3D 10.1038/sj.bjp.0701240 (Pubitemid 27303575)
155. HD Wang DG Johns S Xu, et al. 2002 Role of superoxide anion in regulating pressor and vascular hypertrophic responses to Ang-II Am J Physiol Heart Circ Physiol 282 H1697 H1702 11959633 1:CAS:528:DC%2BD38XjslWmtr8%3D
156. KT Weber CG Brilla 1991 Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensinaldosteronesystem Circulation 83 1849 1865 1828192 1:STN:280:DyaK3M3kvFChtg%3D%3D
157. CR White TA Brock LY Chang 1994 Superoxide and peroxynitrite in atherosclerosis Proc Natl Acad Sci U S A 91 1044 1048 8302829 1:CAS:528:DyaK2cXhs1Snuro%3D 10.1073/pnas.91.3.1044 (Pubitemid 24048505)
158. MK Wong W Ge NY Woo 2007 Positive feedback of hepatic angiotensinogen expression in silver sea bream (Sparus sarba) Mol Cell Endocrinol 263 103 111 17027145 1:CAS:528:DC%2BD28Xht1Kgur%2FI 10.1016/j.mce.2006.09.001 (Pubitemid 44828235)
159. T Yamada M Horiuchi VJ Dzau 1996 Angiotensin II type 2 receptor mediates programmed cell death Proc Natl Acad Sci U S A 93 156 160 8552595 1:CAS:528:DyaK28Xjslyisg%3D%3D 10.1073/pnas.93.1.156 (Pubitemid 26038119)
160. S Yamada C Takeuchi L Oyunsul Y Ito 2009 Bladder angiotensin-II receptors: characterization and alteration I bladder outlet obstruction Eur Urol 55 482 490 18378069 1:CAS:528:DC%2BD1MXislGitr4%3D 10.1016/j.eururo.2008.03.015
161. O Yamaguchi 2004 Response of bladder smooth muscle cells to obstruction: signal transduction and the role of mechanosensors Urology 63 Suppl 3A 11 16 15013647 10.1016/j.urology.2003.12.002 (Pubitemid 38317357)
162. C Yan D Kim T Aizawa, et al. 2003 Functional interplay between angiotensin II and nitric oxide Arterioscler Thromb Vasc Biol 23 26 36 12524221 1:CAS:528:DC%2BD3sXhvF0%3D 10.1161/01.ATV.0000046231.17365.9D (Pubitemid 36091622)
163. R Yang B Yang Y Wen, et al. 2009 Losartan, an angiotensin type I receptor, restores erectile function by downregulation of cavernous renin-angiotensin system in streptozocin-induced diabetic rats J Sex Med 6 696 707 19175863 1:CAS:528:DC%2BD1MXktlKrtLk%3D 10.1111/j.1743-6109.2008.01054.x
164. K Yayam H Hiyoshi D Imazu H Okamoto 2006 Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor Hypertension 48 958 964 10.1161/01.HYP. 0000244108.30909.27 1:CAS:528:DC%2BD28XhtVKjtLrN (Pubitemid 44611011)
165. G Ye X Jin 1997 Action of autonomic drugs on the in vivo bladder base and proximal urethra in dog Chin Med J (Engl) 110 173 176 1:CAS:528: DyaK2sXlslOlsbg%3D (Pubitemid 27207238)
166. KH Yoo VF Norwood SS El-Dahr, et al. 1997 Regulation of angiotensin II, AT1 and AT2 receptors in neonatal ureteral obstruction Am J Physiol 273 R503 R509 9277532 1:CAS:528:DyaK2sXls12gtL4%3D
167. IV Yospiv 2009 Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis Pediatr Nephrol 24 1113 1120 10.1007/s00467-008-1021-9
168. IV Yosypiv 2004 Hypothesis: a novel role for the renin angiotensin system in ureteric bud branching Organogenesis 1 26 32 19521557 1:CAS:528: DC%2BD2MXnslyhtr4%3D 10.4161/org.1.1.1071 (Pubitemid 40754309)
169. X Yuan S Wu T Lin, et al. 2011 Role of nitric oxide synthase in bladder pathologic remodeling and dysfunction resulting from partial outlet obstruction Urology 77 1008.e1 1008.e8 10.1016/j.urology.2010.11.018
170. YC Zhu YZ Zhu N Lu, et al. 2003 Role of angiotensin AT1 and AT2 receptor in cardiac hypertrophy and cardiac remodeling Clin Exp Pharmacol Physiol 30 911 918 14678229 1:CAS:528:DC%2BD2cXpvVyh 10.1111/j.1440-1681.2003.03942.x (Pubitemid 38037279)
171. J Zimpelmann KD Burns 2001 Angiotensin II AT2 receptors inhibit growth responses in proximal tubule cells Am J Physiol Renal Physiol 281 F300 F308 11457722 1:CAS:528:DC%2BD3MXmtVCksr0%3D