The renin receptor: The facts, the promise and the hope

Current Opinion in Nephrology and Hypertension

Volumn 12, Issue 1, 2003, Pages 51-55

  Nguyen, Genevieve ^a,b   Burckle, Celine ^a   Sraer, Jean Daniel ^a  

^a INSERM   (France)

^b HÔPITAL TENON   (France)

Author keywords

Mannose 6 phosphate receptor; Renin receptor; Tissue renin angiotensin system

Indexed keywords

ANGIOTENSIN; ANGIOTENSINOGEN; CELL RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PRORENIN; RENIN; RENIN RECEPTOR; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

BLOOD PRESSURE REGULATION; CORONARY ARTERY; ENDOTHELIUM CELL; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; INFLAMMATION; KIDNEY ARTERY; MESANGIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SODIUM BALANCE; TISSUE DISTRIBUTION;

ANIMALS; CARBOHYDRATE EPIMERASES; CARRIER PROTEINS; HUMANS; RECEPTOR, IGF TYPE 2; RECEPTORS, CELL SURFACE; RENIN-ANGIOTENSIN SYSTEM; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 0037228799     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200301000-00009     Document Type: Review

References (31)

1. Tamura T, Said S, Harris J, et al. Reverse modeling of cardiac myocyte hypertrophy in hypertension and failure by targeting of the renin-angiotensin system. Circulation 2000; 102:253-259.
2. Guron G, Friberg P. An intact renin-angiotensin system is a prerequisite for renal development. J Hypertens 2000; 181:23-137.
3. Schieffer B, Schieffer E, Hilfiker-Kleiner D, et al. Expression of angiotensin II and interleukine 6 in human coronary atherosclerotic plaques. Potential implications for inflammation and plaque instability. Circulation 2000; 101:1372-1378.
4. Brown NJ, Vaughan DE. Prothrombotic effects of angiotensin. Adv Intern Med 2000; 45:419-429.
5. Sleight P, Yusuf S, Pogue J, et al. Blood-pressure reduction and cardiovascular risk in HOPE study. Lancet 2001; 358:2130-2131. This very important paper clearly establishes that the benefits of the blockade of the RAS (with an angiotensin converting enzyme inhibitor) on cardiac structure and function are independent of the blood pressure lowering effect. The authors also suggest that angiotensin converting enzyme inhibitors should be given to patients with cardiovascular diseases, even if they are normotensive, to improve the outcome.
6. Danser AHJ, Van Kats JP, Admiraal PJJ, et al. Cardiac renin and angiotensins: uptake from plasma versus in situ synthesis. Hypertension 1994; 24:37-48.
7. Müller DN, Fischli W, Clozel J-P, et al. Local angiotensin II generation in the rat heart. Role of renin uptake. Circ Res 1998; 82:13-20.
8. Methot D, Silversides DW, Reudelhuber TL. In vivo enzymatic assay reveals catalytic activity of the human renin precursor in tissues. Circ Res 1999; 84:1067-1072.
9. Prescott G, Silverside DW, Reudelhuber TL. Tissue activity of circulating prorenin. Am J Hypertens 2002; 13:280-285. This is a very interesting paper that confirms prorenin uptake by cardiac tissue and supports the existence of prorenin activity in tissue but not in the circulation.
10. Nguyen G, Delarue F, Berrou J, et al. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int 1996; 50:1897-1903.
11. Campbell DJ, Valentijn AJ. Identification of vascular renin binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors. J Hypertens 1994; 12:879-890.
12. Sealey JE, Catanzaro DF, Lavin TN, et al. Specific prorenin/renin binding (proBP). Identification and characterization of a novel membrane site. Am J Hypertens 1996; 9:491-502.
13. Maru I, Ohta Y, Murata K, Tsukada Y. Molecular cloning and identification of N-Aoyl-D-glucosamine 2-epimerase from porcine kidney as renin-binding protein. J Biol Chem 1996; 271:16294-16299.
14. Van Kesteren CAM, Danser AHJ, Derkx FH, et al. Mannose-6-phosphate receptor mediated internalization and activation of prorenin by cardiac cells. Hypertension 1997; 30:1389-1396.
15. Saris JJ, Derkx FHM, de Bruin RJA, et al. High-affinity protrenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Am J Physiol Heart Circ Physiol 2001; 280(4): H1706-H1715. This paper describes the characteristics of prorenin binding to the M6P receptor on cardiac cells and shows that internalized prorenin is activated by proteolytic cleavage.
16. Saris JJ, Derkx FHM, Lamers JMJ, et al. Cardiomyocytes bind and activate native human prorenin. Role of soluble mannose-6-phosphate receptor. Hypertension 2001; 37 (Pt 2):710-715.
17. Admiraal PJ, van Kesteren CA, Danser AHJ, et al. Uptake and proteolytic activation of prorenin by cultured human endothelial cells. J Hypertens 1999; 17:621-629.
18. van den Eijnden MMED, Saris JJ, de Bruin RJA, et al. Prorenin accumulation and activation in human endothelial cells. Importance of the mannose-6-phosphate receptors. Arterioscler Thromb Vasc Biol 2001; 21:911-916.
19. Saris JJ, van den Eijnden MMED, Lamers JMJ, et al. Prorenin-induced myocyte proliferation. No role for intracellular angiotensin II. Hypertension 2002; 39 (Pt 2):573-577. This is an interesting paper showing that prorenin alone has no functional effect on cardiac cell and confirming the absence of intracellular angiotensins generation. Cell-surface generated angiotensin II binds and activates angiotensin II type 1 receptor more efficiently than exogenous applied angiotensin II.
20. d gene. Nature 1990; 344:541-544.
21. Peters J, Farrenkopf R, Clausmeyer S, et al. Functional significance of prorenin internalization in the rat heart. Circ Res 2002; 90:1135-1141. This is an important paper demonstrating the existence of another prorenin binding and internalization pathway on cardiac cells, independent of the M6P receptor, not only in vitro, but also in vivo. Accumulation of prorenin within cardiac cells and intracellular angiotensin generation revives the possibility of an intracrine angiotensin system.
22. Sadoshima J, Xy Y, Slayter HS, Izumo S. Autocrine release of angiotensin II mediates strech-induced hyoertrophy of cardiac myocytes in vitro. Cell 1993; 75:977-984.
23. De Mello WC, Danser AHJ. Angiotensin II and the heart. On the intracrine renin-angiotensin system. Hypertension 2000; 35:1183-1188
24. Cook JL, Zhang Z, Re RN. In vitro evidence for intracellular site of angiotensin action. Circ Res 2001; 89:1138-1146
25. Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109:1417-1427. This important paper reports the cloning of a functional receptor of renin and describes the characteristics of renin binding (activation of MAP kinases, increased catalytic activity of receptor-bound (pro)renin). It also shows the localization of the receptor on vascular smooth-muscle cells, and its co-localization with renin.
26. Moravski CJ, Kelly DJ, Cooper ME, et al. Retinal neovascularization is prevented by blockade of the renin-angiotensin system. Hypertension 2000; 36:1099-1044.
27. Niimura F, Labosky P, Kakuchi J, et al. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 1995; 66:2947-2954.
28. Esther C, Howard T, Marino E, et al. Mice lacking angiotensin converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 1996; 74:953-965.
29. Tsuchida S, Matsusaka T, Chen X, et al. Murine double nullizygotes of the angiotensin type 1A and 1B receptors genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 1998; 101:755-760.
30. Yanai K, Saito T, Kakimuna Y, et al. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier function revealed by renin-deficient mice. J Biol Chem 2000; 275:5-8.
31. Véniant M, Ménard J, Bruneval P, et al. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 1996; 98:1966-1970.