Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: Class II fructose-1,6-bis-phosphate aldolases, type i phosphomannose isomerase, and phosphoglucose isomerase

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 4, 2012, Pages 1511-1520

  Desvergnes, Stéphanie ^a,b   Courtiol Legourd, Stéphanie ^a,b   Daher, Racha ^a,b   Dabrowski, MacIej ^a,b   Salmon, Laurent ^a,b   Therisod, Michel ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

Author keywords

Enzyme inhibitor; Hydroxamate; Malonate; Monosaccharide; Phosphate

Indexed keywords

5 DEOXY 5 MALONATE ARABINONOHYDROXAMIC ACID; 5 DEOXY HYDROGENOMALONATE DEXTRO ARABINONOHYDROXAMIC ACID; 5 PHOSPHO DEXTRO ARABINONOHYDROXAMIC ACID; ANTIBIOTIC AGENT; CLASS II FRUCTOSE 1,6 BISPHOSPHATE ALDOLASE INHIBITOR; ENZYME INHIBITOR; HYDROXAMIC ACID DERIVATIVE; MALONIC ACID DERIVATIVE; PHOSPHATE; PHOSPHOGLUCOSE ISOMERASE INHIBITOR; SODIUM 2 [2 [HYDROXY[4 (HYDROGENPHOSPHONATOOXY)BUTYL]AMINO] 2 OXOETHYL]MALONATE; SODIUM 2 CARBOXY 6 [2 (HYDROGENPHOSPHONATOOXY) N HYDROXYACETAMIDO]HEXANOATE; TYPE 1 PHOSPHOMANNOSE ISOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHOSPHORYLATION; STRUCTURE ANALYSIS; YEAST;

ANIMALS; CATALYTIC DOMAIN; ENZYME ACTIVATION; ENZYME INHIBITORS; ESCHERICHIA; FRUCTOSE-BISPHOSPHATE ALDOLASE; GLUCOSE-6-PHOSPHATE ISOMERASE; HUMANS; INHIBITORY CONCENTRATION 50; MALONATES; MANNOSE-6-PHOSPHATE ISOMERASE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; YEASTS;

ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS;

EID: 84857031819     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.050     Document Type: Article

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