Cell permeation of a Trypanosoma brucei aldolase inhibitor: Evaluation of different enzyme-labile phosphate protecting groups

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3440-3443

  Azéma, Laurent ^a   Lherbet, Christian ^b   Baudoin, Cécile ^a   Blonski, Casimir ^a  

^a UPS)   (France)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Aldolase; Drug delivery; Enzyme labile protecting group; Inhibitor; Phosphate; Trypanosoma brucei

Indexed keywords

ENZYME INHIBITOR; FRUCTOSE BISPHOSPHATE ALDOLASE; THIOESTER;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG SYNTHESIS; IC 50; NONHUMAN; TRYPANOSOMA BRUCEI;

ALDEHYDE-LYASES; ANIMALS; CELL MEMBRANE PERMEABILITY; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; PARASITIC SENSITIVITY TESTS; PHOSPHORIC ACID ESTERS; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 33646849429     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.010     Document Type: Article

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