Involvement of the extracellular signal-regulated kinase 1/2 signaling pathway in amylin's eating inhibitory effect

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 302, Issue 3, 2012, Pages

  Potes, Catarina Soares ^a   Boyle, Christina Neuner ^a   Wookey, Peter John ^b   Riediger, Thomas ^a   Lutz, Thomas Alexander ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Amylin receptor; Area postrema; ERK; MAPK; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AMYLIN; CALCITONIN 1A RECEPTOR; CALCITONIN 1B RECEPTOR; CALCITONIN RECEPTOR; DOPAMINE BETA MONOOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANOREXIA; APPETITE; AREA POSTREMA; ARTICLE; BRAIN FOURTH VENTRICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEEDING BEHAVIOR; FOOD INTAKE; HORMONE ACTION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NORADRENERGIC NERVE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; ANOREXIA; APPETITE REGULATION; AREA POSTREMA; BUTADIENES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FOURTH VENTRICLE; ISLET AMYLOID POLYPEPTIDE; MALE; MAP KINASE SIGNALING SYSTEM; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ISLET AMYLOID POLYPEPTIDE; TIME FACTORS;

EID: 84856981878     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00380.2011     Document Type: Article

References (71)

1. Aksamitiene E, Kholodenko BN, Kolch W, Hoek JB, Kiyatkin A. PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. Cell Signal 22: 1369-1378, 2010.
2. Armstrong DM, Pickel VM, Joh TH, Reis DJ, Miller RJ. Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in area postrema and medial nucleus tractus solitarius of rat brain. J Comp Neurol 196: 505-517, 1981.
3. Armstrong DM, Ross CA, Pickel VM, Joh TH, Reis DJ. Distribution of dopamine-, noradrenaline-, and adrenaline-containing cell bodies in the rat medulla oblongata: demonstrated by the immunocytochemical localization of catecholamine biosynthetic enzymes. J Comp Neurol 212: 173-187, 1982.
4. Arnelo U, Reidelberger R, Adrian TE, Larsson J, Permert J. Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats. Am J Physiol Regul Integr Comp Physiol 275: R1537-R1542, 1998.
5. Aronne L, Fujioka K, Aroda V, Chen K, Halseth A, Kesty NC, Burns C, Lush CW, Weyer C. Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study. J Clin Endocrinol Metab 92: 2977-2983, 2007.
6. Asarian L. Loss of cholecystokinin and glucagon-like peptide-1-induced satiation in mice lacking serotonin 2C receptors. Am J Physiol Regul Integr Comp Physiol 296: R51-R56, 2009.
7. Barth SW, Riediger T, Lutz TA, Rechkemmer G. Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat. Brain Res 997: 97-102, 2004.
8. Becskei C, Grabler V, Edwards GL, Riediger T, Lutz TA. Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK. Brain Res 1162: 76-84, 2007.
9. Becskei C, Riediger T, Zund D, Wookey P, Lutz TA. Immunohistochemical mapping of calcitonin receptors in the adult rat brain. Brain Res 1030: 221-233, 2004.
10. Bhavsar S, Watkins J, Young A. Synergy between amylin and cholecystokinin for inhibition of food intake in mice. Physiol Behav 64: 557-561, 1998.
11. Bonaz B, Taylor I, Tache Y. Peripheral peptide YY induces c-fos-like immunoreactivity in the rat brain. Neurosci Lett 163: 77-80, 1993.
12. Butler PC, Chou J, Carter WB, Wang YN, Bu BH, Chang D, Chang JK, Rizza RA. Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans. Diabetes 39: 752-756, 1990.
13. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001.
14. Chien WL, Liang KC, Teng CM, Kuo SC, Lee FY, Fu WM. Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole. Mol Pharmacol 63: 1322-1328, 2003.
15. Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM. Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol Pharmacol 56: 235-242, 1999.
16. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930, 2006.
17. Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol 164: 509-514, 2004.
18. Diaz-Ruiz O, Navarro L, Mendez-Diaz M, Galicia O, Elder JH, Sanna PP, Drucker-Colin R, Prospero-Garcia O. Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase. Brain Res 913: 78-81, 2001.
19. Endo S, Launey T. Nitric oxide activates extracellular signal-regulated kinase 1/2 and enhances declustering of ionotropic glutamate receptor subunit 2/3 in rat cerebellar Purkinje cells. Neurosci Lett 350: 122-126, 2003.
20. Fuentes EN, Bjornsson BT, Valdes JA, Einarsdottir IE, Lorca B, Alvarez M, Molina A. IGF-I/PI3K/Akt and IGF-I/MAPK/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder. Am J Physiol Regul Integr Comp Physiol 300: R1532-R1542, 2011.
21. Gantke T, Sriskantharajah S, Ley SC. Regulation and function of TPL-2, an IB kinase-regulated MAP kinase kinase kinase. Cell Res 21: 131-145, 2011.
22. Gibbs J, Young RC, Smith GP. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 84: 488-495, 1973.
23. Grewal SS, York RD, Stork PJ. Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9: 544-553, 1999.
24. Hilton JM, Chai SY, Sexton PM. In vitro autoradiographic localization of the calcitonin receptor isoforms, C1a and C1b, in rat brain. Neuroscience 69: 1223-1237, 1995.
25. Hunyady B, Krempels K, Harta G, Mezey E. Immunohistochemical signal amplification by catalyzed reporter deposition and its application in double immunostaining. J Histochem Cytochem 44: 1353-1362, 1996.
26. Lin HY, Harris TL, Flannery MS, Aruffo A, Kaji EH, Gorn A, Kolakowski LF Jr, Lodish HF, Goldring SR. Expression cloning of an adenylate cyclase-coupled calcitonin receptor. Science 254: 1022-1024, 1991.
27. Lutz TA. Pancreatic amylin as a centrally acting satiating hormone. Curr Drug Targets 6: 181-189, 2005.
28. Lutz TA, Geary N, Szabady MM, Del Prete E, Scharrer E. Amylin decreases meal size in rats. Physiol Behav 58: 1197-1202, 1995.
29. Lutz TA, Mollet A, Rushing PA, Riediger T, Scharrer E. The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema/nucleus of the solitary tract (AP/NTS) lesioned rats. Int J Obes Relat Metab Disord 25: 1005-1011, 2001.
30. Lutz TA, Senn M, Althaus J, Del Prete E, Ehrensperger F, Scharrer E. Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats. Peptides 19: 309-317, 1998.
31. Mack C, Wilson J, Athanacio J, Reynolds J, Laugero K, Guss S, Vu C, Roth J, Parkes D. Pharmacological actions of the peptide hormone amylin in the long-term regulation of food intake, food preference, and body weight. Am J Physiol Regul Integr Comp Physiol 293: R1855-R1863, 2007.
32. 2+ and calmodulin/MAP kinase kinase/extracellular signal-regulated protein kinase signalling pathway in the mitogenic and antimitogenic effect of nitric oxide in glia-and neurone-derived cell lines. Eur J Neurosci 23: 1690-1700, 2006.
33. Metzger BL, Hansen BC. Cholecystokinin effects on feeding, glucose, and pancreatic hormones in rhesus monkeys. Physiol Behav 30: 509-518, 1983.
34. Michel S, Becskei C, Erguven E, Lutz TA, Riediger T. Diet-derived nutrients modulate the effects of amylin on c-Fos expression in the area postrema and on food intake. Neuroendocrinology 86: 124-135, 2007.
35. Mollet A, Gilg S, Riediger T, Lutz TA. Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats. Physiol Behav 81: 149-155, 2004.
36. Mollet A, Meier S, Grabler V, Gilg S, Scharrer E, Lutz TA. Endogenous amylin contributes to the anorectic effects of cholecystokinin and bombesin. Peptides 24: 91-98, 2003.
37. Monnikes H, Lauer G, Arnold R. Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicinsensitive vagal afferents and CCK-A receptors in the rat. Brain Res 770: 277-288, 1997.
38. Morfis M, Tilakaratne N, Furness SG, Christopoulos G, Werry TD, Christopoulos A, Sexton PM. Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology 149: 5423-5431, 2008.
39. Muff R, Buhlmann N, Fischer JA, Born W. An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3. Endocrinology 140: 2924-2927, 1999.
40. Nishimoto S, Nishida E. MAPK signalling: ERK5 versus ERK1/2. EMBO Rep 7: 782-786, 2006.
41. Ogawa A, Harris V, McCorkle SK, Unger RH, Luskey KL. Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment. J Clin Invest 85: 973-976, 1990.
42. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Oxford, UK: Academic, 2007.
43. Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3: 639-650, 2002.
44. Potes CS, Lutz TA. Brainstem mechanisms of amylin-induced anorexia. Physiol Behav 100: 511-518, 2010.
45. Potes CS, Lutz TA, Riediger T. Identification of central projections from amylin-activated neurons to the lateral hypothalamus. Brain Res 1334: 31-44, 2010.
46. Potes CS, Turek VF, Cole RL, Vu C, Roland BL, Roth JD, Riediger T, Lutz TA. Noradrenergic neurons of the area postrema mediate amylin's hypophagic action. Am J Physiol Regul Integr Comp Physiol 299: R623-R631, 2010.
47. Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. J Clin Invest 114: 652-658, 2004.
48. Rice PL, Peters SL, Beard KS, Ahnen DJ. Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMPdependent protein kinase signaling pathways. Mol Cancer Ther 5: 746-754, 2006.
49. Riediger T, Schmid HA, Lutz T, Simon E. Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP. Am J Physiol Regul Integr Comp Physiol 281: R1833-R1843, 2001.
50. Riediger T, Zuend D, Becskei C, Lutz TA. The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis. Am J Physiol Regul Integr Comp Physiol 286: R114-R122, 2004.
51. Rinaman L. Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. J Neurosci 23: 10084-10092, 2003.
52. Rinaman L, Verbalis JG, Stricker EM, Hoffman GE. Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin. J Comp Neurol 338: 475-490, 1993.
53. Ritter RC, Slusser PG, Stone S. Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213: 451-452, 1981.
54. Roth JD, Hughes H, Kendall E, Baron AD, Anderson CM. Antiobesity effects of the β-cell hormone amylin in diet-induced obese rats: effects on food intake, body weight, composition, energy expenditure, and gene expression. Endocrinology 147: 5855-5864, 2006.
55. Rowland NE, Crews EC, Gentry RM. Comparison of Fos induced in rat brain by GLP-1 and amylin. Regul Pept 71: 171-174, 1997.
56. Rowland NE, Richmond RM. Area postrema and the anorectic actions of dexfenfluramine and amylin. Brain Res 820: 86-91, 1999.
57. Smith SR, Blundell JE, Burns C, Ellero C, Schroeder BE, Kesty NC, Chen KS, Halseth AE, Lush CW, Weyer C. Pramlintide treatment reduces 24-h caloric intake and meal sizes and improves control of eating in obese subjects: a 6-wk translational research study. Am J Physiol Endocrinol Metab 293: E620-E627, 2007.
58. Sutton GM, Duos B, Patterson LM, Berthoud HR. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 146: 3739-3747, 2005.
59. Sutton GM, Patterson LM, Berthoud HR. Extracellular signal-regulated kinase 1/2 signaling pathway in solitary nucleus mediates cholecystokinininduced suppression of food intake in rats. J Neurosci 24: 10240-10247, 2004.
60. Sweatt JD. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76: 1-10, 2001.
61. Thammacharoen S, Lutz TA, Geary N, Asarian L. Hindbrain administration of estradiol inhibits feeding and activates estrogen receptor-α-expressing cells in the nucleus tractus solitarius of ovariectomized rats. Endocrinology 149: 1609-1617, 2008.
62. Tikellis C, Xuereb L, Casley D, Brasier G, Cooper ME, Wookey PJ. Calcitonin receptor isoforms expressed in the developing rat kidney. Kidney Int 63: 416-426, 2003.
63. Torack RM, Stranahan P, Hartman BK. The role of norepinephrine in the function of the area postrema. I. Immunofluorescent localization of dopamine-β-hydroxylase and electron microscopy. Brain Res 61: 235-252, 1973.
64. Torii S, Nakayama K, Yamamoto T, Nishida E. Regulatory mechanisms and function of ERK MAP kinases. J Biochem (Tokyo) 136: 557-561, 2004.
65. Valjent E, Caboche J, Vanhoutte P. Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain: a molecular substrate for learning and memory? Mol Neurobiol 23: 83-99, 2001.
66. Wang G, Achim CL, Hamilton RL, Wiley CA, Soontornniyomkij V. Tyramide signal amplification method in multiple-label immunofluorescence confocal microscopy. Methods 18: 459-464, 1999.
67. Wang Y, Prywes R. Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites. Oncogene 19: 1379-1385, 2000.
68. Wielinga PY, Alder B, Lutz TA. The acute effect of amylin and salmon calcitonin on energy expenditure. Physiol Behav 91: 212-217, 2007.
69. Woods SC, Seeley RJ, Cota D. Regulation of food intake through hypothalamic signaling networks involving mTOR. Annu Rev Nutr 28: 295-311, 2008.
70. + channels in hippocampus involves a mitogenactivated protein kinase pathway. J Neurosci 22: 4860-4868, 2002.
71. Züger D, Forster K, Lutz TA, Riediger T. The sensitivity of AP neurons to amylin and GLP-1 is modulated by the feeding status. Appetite 57: S48-S49, 2011.