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Volumn 13, Issue 1, 2012, Pages 56-82

Review: New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy

Author keywords

Clinical trial; Hepatitis C virus (HCV); Review; Small molecular compounds

Indexed keywords

2' C METHYL 7 DEAZA ADENOSINE; 2' DEOXY 2' FLUORO 2' METHYLCYTIDINE; 2' METHYLCYTIDINE; 2' METHYLGUANOSINE MONOPHOSPHATE; 4' AZIDOCYTIDINE; ABT 072; ABT 333; ABT 450; ACH 1625; ALISPORIVIR; ALPHA INTERFERON; ALPHA1 INTERFERON; ANTIVIRUS AGENT; ASUNAPREVIR; AZD 7295; BALAPIRAVIR; BI 201335; BI 207127; BILB 1941; BMS 791325; BOCEPREVIR; DANOPREVIR; FILIBUVIR; GS 9256; GSK 625433; IDX 184; IDX 375; INX 189; MERICITABINE; MK 0608; MK 3281; NARLAPREVIR; NESBUVIR; PEGINTERFERON; PEGINTERFERON ALPHA2A; PLACEBO; PSI 7851; PSI 7977; PSI 938; RIBAVIRIN; RITONAVIR; SETROBUVIR; SIMEPREVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALOPICITABINE; VANIPREVIR; VBY 376; VCH 222; VCH 759; VCH 916; VIRUS RNA; VX 813; ENZYME INHIBITOR;

EID: 84856977406     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1100120     Document Type: Review
Times cited : (13)

References (150)
  • 1
    • 57049112290 scopus 로고    scopus 로고
    • Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
    • doi:10.1128/AAC.00444-08
    • Ali, S., Leveque, V., Le Pogam, S., Ma, H., Philipp, F., Inocencio, N., Smith, M., Alker, A., Kang, H., Najera, I., et al., 2008. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob. Agents Chemother., 52(12):4356-4369. [doi:10.1128/AAC.00444-08]
    • (2008) Antimicrob. Agents Chemother. , vol.52 , Issue.12 , pp. 4356-4369
    • Ali, S.1    Leveque, V.2    Le Pogam, S.3    Ma, H.4    Philipp, F.5    Inocencio, N.6    Smith, M.7    Alker, A.8    Kang, H.9    Najera, I.10
  • 2
    • 41749085866 scopus 로고    scopus 로고
    • Antiviral, pharmacokinetic and safety data for GS-9190, a non-nucleoside HCV NS5B polymerase inhibitor, in a phase-1 trial in HCV genotype 1 infected subjects
    • Bavisotto, L., Wang, C. C., Jacobson, I. M., Marcellin, P., Zeuzem, S., Lawitz, E. J., Lunde, M., Sereni, P., O'Brien, C., Oldach, D. W., et al., 2007. Antiviral, pharmacokinetic and safety data for GS-9190, a non-nucleoside HCV NS5B polymerase inhibitor, in a phase-1 trial in HCV genotype 1 infected subjects. Hepatology, 46(4):255A.
    • (2007) Hepatology , vol.46 , Issue.4
    • Bavisotto, L.1    Wang, C.C.2    Jacobson, I.M.3    Marcellin, P.4    Zeuzem, S.5    Lawitz, E.J.6    Lunde, M.7    Sereni, P.8    O'Brien, C.9    Oldach, D.W.10
  • 3
    • 77951297232 scopus 로고    scopus 로고
    • Identification and characterization of VCH-222, a novel potent and selective non-nucleoside HCV polymerase inhibitor
    • doi:10.1016/S0168-8278 09 60937-5
    • Bedard, J., Nicolas, O., Bilimoria, D., L'Heureux, L., Fex, P., David, M., Chan, L., 2009. Identification and characterization of VCH-222, a novel potent and selective non-nucleoside HCV polymerase inhibitor. J. Hepatol., 50 (S1): S340. [doi:10.1016/S0168-8278(09) 60937-5]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Bedard, J.1    Nicolas, O.2    Bilimoria, D.3    L'Heureux, L.4    Fex, P.5    David, M.6    Chan, L.7
  • 4
    • 84863059807 scopus 로고    scopus 로고
    • NIM811, a cyclophilin inhibitor, and NM107, an HCV polymerase inhibitor, synergistically inhibits HCV replication and suppresses the emergence of resistance in vitro
    • doi:10.1016/j.antiviral.2007.01.081
    • Boerner, J., Ma, S., Compton, T., Lin, K., 2007. NIM811, a cyclophilin inhibitor, and NM107, an HCV polymerase inhibitor, synergistically inhibits HCV replication and suppresses the emergence of resistance in vitro. Antivir. Res., 74(3):A57. [doi:10.1016/j.antiviral.2007.01.081]
    • (2007) Antivir. Res. , vol.74 , Issue.3
    • Boerner, J.1    Ma, S.2    Compton, T.3    Lin, K.4
  • 5
    • 67649625180 scopus 로고    scopus 로고
    • Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues
    • doi:10.1517/13543780902854194
    • Brown, N. A., 2009. Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues. Expert Opin. Inv. Drugs, 18(6):709-725. [doi:10.1517/ 13543780902854194]
    • (2009) Expert Opin. Inv. Drugs , vol.18 , Issue.6 , pp. 709-725
    • Brown, N.A.1
  • 6
    • 67650631316 scopus 로고    scopus 로고
    • HCV NS5B polymerase inhibitors
    • doi:10.1016/j.cld.2009.05.001
    • Burton, J. R., Everson, G. T., 2009. HCV NS5B polymerase inhibitors. Clin. Liver Dis., 13(3):453-465. [doi:10.1016/j.cld.2009.05.001]
    • (2009) Clin. Liver Dis. , vol.13 , Issue.3 , pp. 453-465
    • Burton, J.R.1    Everson, G.T.2
  • 7
    • 27644458571 scopus 로고    scopus 로고
    • Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells
    • DOI 10.1128/JVI.79.22.13963-13973.2005
    • Cai, Z., Zhang, C., Chang, K. S., Jiang, J., Ahn, B. C., Wakita, T., Liang, T. J., Luo, G., 2005. Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells. J. Virol., 79(22):13963-13973. [doi:10.1128/JVI.79.22.13963-13973.2005] (Pubitemid 41552695)
    • (2005) Journal of Virology , vol.79 , Issue.22 , pp. 13963-13973
    • Cai, Z.1    Zhang, C.2    Chang, K.-S.3    Jiang, J.4    Ahn, B.-C.5    Wakita, T.6    Liang, T.J.7    Luo, G.8
  • 9
    • 77951046665 scopus 로고    scopus 로고
    • HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors
    • doi:10.1016/j.jhep. 2010.01.041
    • Chatterji, U., Lim, P., Bobardt, M. D., Wieland, S., Cordek, D. G., Vuagniaux, G., Chisari, F., Cameron, C. E., Targett-Adams, P., Parkinson, T., et al., 2010. HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J. Hepatol., 53(1):50-56. [doi:10.1016/j.jhep. 2010.01.041]
    • (2010) J. Hepatol. , vol.53 , Issue.1 , pp. 50-56
    • Chatterji, U.1    Lim, P.2    Bobardt, M.D.3    Wieland, S.4    Cordek, D.G.5    Vuagniaux, G.6    Chisari, F.7    Cameron, C.E.8    Targett-Adams, P.9    Parkinson, T.10
  • 10
    • 84863020256 scopus 로고    scopus 로고
    • Preclinical pharmacokinetic and ADME characterization of VCH-222, a novel non-nucleoside HCV NS5B polymerase inhibitor
    • doi:10.1016/S0168-8278 09 60941-7
    • Chauret, N., Chagnon-Labelle, C., Diallo, M., Laquerre, J., Laterreur, J., May, S., Ste-Marie, L., 2009. Preclinical pharmacokinetic and ADME characterization of VCH-222, a novel non-nucleoside HCV NS5B polymerase inhibitor. J. Hepatol., 50 (S1): S341-S342. [doi:10.1016/S0168-8278(09) 60941-7]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Chauret, N.1    Chagnon-Labelle, C.2    Diallo, M.3    Laquerre, J.4    Laterreur, J.5    May, S.6    Ste-Marie, L.7
  • 11
    • 68649110912 scopus 로고    scopus 로고
    • A review of HCV protease inhibitors
    • Chen, K. X., Njoroge, F. G., 2009. A review of HCV protease inhibitors. Curr. Opin. Investig. Drugs, 10(8):821-837.
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , Issue.8 , pp. 821-837
    • Chen, K.X.1    Njoroge, F.G.2
  • 12
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo, Q. L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W., Houghton, M., 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 244(4902):359-362. [doi:10.1126/science. 2523562] (Pubitemid 19117877)
    • (1989) Science , vol.244 , Issue.4902 , pp. 359-362
    • Choo, Q.-L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 13
    • 84863076548 scopus 로고    scopus 로고
    • In vitro anti-hepatitis C virus (HCV) activities and resistance profile of Debio 025, a non-immunosuppressive cyclophilin binding molecule
    • doi: 10.1016/j.antiviral.2009.02.024
    • Coelmont, L., Gallay, P., Bobardt, M., Kaptein, S., Paeshuyse, J., Vliegen, I., Vuagniaux, G., Neyts, J., 2009a. In vitro anti-hepatitis C virus (HCV) activities and resistance profile of Debio 025, a non-immunosuppressive cyclophilin binding molecule. Antivir. Res., 82(2):A20. [doi: 10.1016/j.antiviral.2009.02.024]
    • (2009) Antivir. Res. , vol.82 , Issue.2
    • Coelmont, L.1    Gallay, P.2    Bobardt, M.3    Kaptein, S.4    Paeshuyse, J.5    Vliegen, I.6    Vuagniaux, G.7    Neyts, J.8
  • 14
    • 67650858129 scopus 로고    scopus 로고
    • Particular in vitro anti-HCV activities and resistance profile of the cyclophilin inhibitor Debio 025
    • doi:10.1016/S0168-8278 09 60090-8
    • Coelmont, L., Gallay, P., Bobardt, M., Kaptein, S., Paeshuyse, J., Vliegen, I., Vuagniaux, G., Neyts, J., 2009b. Particular in vitro anti-HCV activities and resistance profile of the cyclophilin inhibitor Debio 025. J. Hepatol., 50 (S1): S36. [doi:10.1016/S0168-8278(09) 60090-8]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Coelmont, L.1    Gallay, P.2    Bobardt, M.3    Kaptein, S.4    Paeshuyse, J.5    Vliegen, I.6    Vuagniaux, G.7    Neyts, J.8
  • 15
    • 78149434641 scopus 로고    scopus 로고
    • DEB025 (alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
    • doi:10.1371/journal.pone. 0013687
    • Coelmont, L., Hanoulle, X., Chatterji, U., Berger, C., Snoeck, J., Bobardt, M., Lim, P., Vliegen, I., Paeshuyse, J., Vuagniaux, G., et al., 2010. DEB025 (alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS ONE, 5(10): e13687. [doi:10.1371/journal.pone. 0013687]
    • (2010) PLoS ONE , vol.5 , Issue.10
    • Coelmont, L.1    Hanoulle, X.2    Chatterji, U.3    Berger, C.4    Snoeck, J.5    Bobardt, M.6    Lim, P.7    Vliegen, I.8    Paeshuyse, J.9    Vuagniaux, G.10
  • 16
    • 42349083141 scopus 로고    scopus 로고
    • Antiviral activity of the non-nucleoside polymerase inhibitor, VCH-759, in chronic hepatitis C patients: Results from a randomized, double-blind, placebo-controlled, ascending multiple dose study
    • Cooper, C., Lawitz, E. J., Ghali, P., Rodriguez-Torres, M., Anderson, F. H., Lee, S. S., Proulx, L., 2007. Antiviral activity of the non-nucleoside polymerase inhibitor, VCH-759, in chronic hepatitis C patients: Results from a randomized, double-blind, placebo-controlled, ascending multiple dose study. Hepatology, 46(4):864A.
    • (2007) Hepatology , vol.46 , Issue.4
    • Cooper, C.1    Lawitz, E.J.2    Ghali, P.3    Rodriguez-Torres, M.4    Anderson, F.H.5    Lee, S.S.6    Proulx, L.7
  • 17
    • 67650556130 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of the HCV polymerase inhibitor VCH-222 following single dose administration in healthy volunteers and antiviral activity in HCV-infected individuals
    • doi:10.1016/S0168-8278 09 60942-9
    • Cooper, C., Larouche, R., Bourgault, B., Chauret, N., Proulx, L., 2009a. Safety, tolerability and pharmacokinetics of the HCV polymerase inhibitor VCH-222 following single dose administration in healthy volunteers and antiviral activity in HCV-infected individuals. J. Hepatol., 50 (S1): S342. [doi:10.1016/S0168-8278(09) 60942-9]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Cooper, C.1    Larouche, R.2    Bourgault, B.3    Chauret, N.4    Proulx, L.5
  • 20
    • 67650489621 scopus 로고    scopus 로고
    • New developments in the antiviral treatment of hepatitis C
    • doi:10.1111/j. 1423-0410.2009.01187.x
    • de Bruijne, J., Weegink, C. J., Jansen, P. L. M., Reesink, H. W., 2009. New developments in the antiviral treatment of hepatitis C. Vox Sanguinis, 97(1):1-12. [doi:10.1111/j. 1423-0410.2009.01187.x]
    • (2009) Vox Sanguinis , vol.97 , Issue.1 , pp. 1-12
    • De Bruijne, J.1    Weegink, C.J.2    Jansen, P.L.M.3    Reesink, H.W.4
  • 21
    • 78149425102 scopus 로고    scopus 로고
    • Antiviral therapy for hepatitis C virus: Beyond the standard of care
    • doi:10.3390/v2040826
    • Delang, L., Coelmont, L., Neyts, J., 2010. Antiviral therapy for hepatitis C virus: beyond the standard of care. Viruses, 2(4):826-866. [doi:10.3390/v2040826]
    • (2010) Viruses , vol.2 , Issue.4 , pp. 826-866
    • Delang, L.1    Coelmont, L.2    Neyts, J.3
  • 22
    • 77954974327 scopus 로고    scopus 로고
    • Danoprevir, a small-molecule NS3/4A protease inhibitor for the potential oral treatment of HCV infection
    • Deutsch, M., Papatheodoridis, G. V., 2010. Danoprevir, a small-molecule NS3/4A protease inhibitor for the potential oral treatment of HCV infection. Curr. Opin. Investig. Drugs, 11(8):951-963.
    • (2010) Curr. Opin. Investig. Drugs , vol.11 , Issue.8 , pp. 951-963
    • Deutsch, M.1    Papatheodoridis, G.V.2
  • 23
    • 23944462641 scopus 로고    scopus 로고
    • Mechanism of action of interferon and ribavirin in treatment of hepatitis C
    • DOI 10.1038/nature04082
    • Feld, J. J., Hoofnagle, J. H., 2005. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature, 436(7053):967-972. [doi:10.1038/nature04082] (Pubitemid 41191673)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 967-972
    • Feld, J.J.1    Hoofnagle, J.H.2
  • 24
    • 77954999006 scopus 로고    scopus 로고
    • Cyclophilin inhibitors for the treatment of HCV infection
    • Fischer, G., Gallay, P., Hopkins, S., 2010. Cyclophilin inhibitors for the treatment of HCV infection. Curr. Opin. Investig. Drugs, 11(8):911-918.
    • (2010) Curr. Opin. Investig. Drugs , vol.11 , Issue.8 , pp. 911-918
    • Fischer, G.1    Gallay, P.2    Hopkins, S.3
  • 25
    • 52649164276 scopus 로고    scopus 로고
    • Efficacy and safety of increasing doses of the cyclophilin inhibitor Debio 025 in combination with pegylated interferon α-2a in treatment naive chronic HCV patients
    • doi: 10.1016/S0168-8278 08 60145-2
    • Flisiak, R., Feinman, S. V., Jablkowski, M., Horban, A., Kryczka, W., Halota, W., Heathcote, J. E., Mazzella, G., Vandelli, C., Liz, J. S., et al., 2008a. Efficacy and safety of increasing doses of the cyclophilin inhibitor Debio 025 in combination with pegylated interferon α-2a in treatment naive chronic HCV patients. J. Hepatol., 48 (S2): 62. [doi: 10.1016/S0168-8278(08) 60145-2]
    • (2008) J. Hepatol. , vol.48 , Issue.S2 , pp. 62
    • Flisiak, R.1    Feinman, S.V.2    Jablkowski, M.3    Horban, A.4    Kryczka, W.5    Halota, W.6    Heathcote, J.E.7    Mazzella, G.8    Vandelli, C.9    Liz, J.S.10
  • 29
    • 34247344418 scopus 로고    scopus 로고
    • Genetic and catalytic efficiency structure of an HCV protease quasispecies
    • DOI 10.1002/hep.21623
    • Franco, S., Parera, M., Aparicio, E., Clotet, B., Martinez, M. A., 2007. Genetic and catalytic efficiency structure of an HCV protease quasispecies. Hepatology, 45(4):899-910. [doi:10.1002/hep. 21623] (Pubitemid 46631559)
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 899-910
    • Franco, S.1    Parera, M.2    Aparicio, E.3    Clotet, B.4    Martinez, M.A.5
  • 30
    • 38649125211 scopus 로고    scopus 로고
    • A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals
    • DOI 10.1016/j.virusres.2007.10.003, PII S0168170207003632
    • Franco, S., Clotet, B., Martinez, M. A., 2008. A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals. Virus Res., 131(2):260-270. [doi:10.1016/j. virusres.2007.10.003] (Pubitemid 351173398)
    • (2008) Virus Research , vol.131 , Issue.2 , pp. 260-270
    • Franco, S.1    Clotet, B.2    Martinez, M.A.3
  • 31
    • 77956116880 scopus 로고    scopus 로고
    • Resistance analysis of the HCV NS5A inhibitor BMS-790052 in an in vitro replicon system
    • doi:10.1128/AAC.00556-10
    • Fridell, R. A., Qiu, D. K., Wang, C. F., Valera, L., Gao, M., 2010. Resistance analysis of the HCV NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob. Agents Chemother., 54(9):3641-3650. [doi:10.1128/AAC.00556- 10]
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.9 , pp. 3641-3650
    • Fridell, R.A.1    Qiu, D.K.2    Wang, C.F.3    Valera, L.4    Gao, M.5
  • 32
    • 0034747214 scopus 로고    scopus 로고
    • Sequences in the 5 nontranslated region of hepatitis C virus required for RNA replication
    • DOI 10.1128/JVI.75.24.12047-12057.2001
    • Friebe, P., Lohmann, V., Krieger, N., Bartenschlager, R., 2001. Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication. J. Virol., 75(24):12047-12057. [doi:10.1128/JVI.75.24.12047-12057. 2001] (Pubitemid 33115877)
    • (2001) Journal of Virology , vol.75 , Issue.24 , pp. 12047-12057
    • Friebe, P.1    Lohmann, V.2    Krieger, N.3    Bartenschlager, R.4
  • 35
    • 4043129511 scopus 로고    scopus 로고
    • Function-dependent clustering of orthologues and paralogues of cyclophilins
    • DOI 10.1002/prot.20156
    • Galat, A., 2004. Function-dependent clustering of orthologues and paralogues of cyclophilins. Prot. Struct. Funct. Bioinf., 56(4):808-820. [doi:10.1002/prot.20156] (Pubitemid 39063322)
    • (2004) Proteins: Structure, Function and Genetics , vol.56 , Issue.4 , pp. 808-820
    • Galat, A.1
  • 36
    • 78751609899 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, and tolerability of AZD7295, a novel NS5A inhibitor, in a placebo-controlled multiple ascending dose study in HCV genotype 1 and 3 patients
    • doi:10.1016/S0168-8278 10 61194-4
    • Gane, E., Foster, G. R., Cianciara, J., Stedman, C., Ryder, S., Buti, M., Clark, E., Tait, D., 2010a. Antiviral activity, pharmacokinetics, and tolerability of AZD7295, a novel NS5A inhibitor, in a placebo-controlled multiple ascending dose study in HCV genotype 1 and 3 patients. J. Hepatol., 52 (S1): S464. [doi:10.1016/S0168-8278(10) 61194-4]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Gane, E.1    Foster, G.R.2    Cianciara, J.3    Stedman, C.4    Ryder, S.5    Buti, M.6    Clark, E.7    Tait, D.8
  • 37
    • 77954992351 scopus 로고    scopus 로고
    • Early on-treatment responses during pegylated IFN plus ribavirin are increased following 13 days of combination nucleoside polymerase (RG7128) and protease (RG7227) inhibitor therapy (INFORM-1)
    • doi:10.1016/S0168-8278 10 60751-9
    • Gane, E., Roberts, S., Stedman, C., Angus, P., Ritchie, B., Elston, R., Ipe, D., Morcos, P., Baher, L., Najera, I., et al., 2010b. Early on-treatment responses during pegylated IFN plus ribavirin are increased following 13 days of combination nucleoside polymerase (RG7128) and protease (RG7227) inhibitor therapy (INFORM-1). J. Hepatol., 52 (S1): S291-S292. [doi:10.1016/S0168-8278(10) 60751-9]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Gane, E.1    Roberts, S.2    Stedman, C.3    Angus, P.4    Ritchie, B.5    Elston, R.6    Ipe, D.7    Morcos, P.8    Baher, L.9    Najera, I.10
  • 38
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebocontrolled, dose-escalation trial
    • doi:10.1016/S0140-6736 10 61384-0
    • Gane, E. J., Roberts, S. K., Stedman, C. A., Angus, P. W., Ritchie, B., Elston, R., Ipe, D., Morcos, P. N., Baher, L., Najera, I., et al., 2010c. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebocontrolled, dose-escalation trial. Lancet, 376(9751):1467-1475. [doi:10.1016/S0140-6736(10) 61384-0]
    • (2010) Lancet , vol.376 , Issue.9751 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.3    Angus, P.W.4    Ritchie, B.5    Elston, R.6    Ipe, D.7    Morcos, P.N.8    Baher, L.9    Najera, I.10
  • 39
    • 78649961533 scopus 로고    scopus 로고
    • Ritonavir boosting of low dose RG7227/ITMN-191, HCV NS3/4A protease inhibitor, results in robust reduction in HCV RNA at lower exposures than provided by unboosted regimens
    • doi:10.1016/S0168-8278 10 60039-6
    • Gane, E., Rouzier, R., Stedman, C., Wiercinska-Drapalo, A., Horban, A., Chang, L., Zhang, Y., Sampeur, P., Najera, I., Shulman, N., et al., 2010d. Ritonavir boosting of low dose RG7227/ITMN-191, HCV NS3/4A protease inhibitor, results in robust reduction in HCV RNA at lower exposures than provided by unboosted regimens. J. Hepatol., 52 (S1): S16-S17. [doi:10.1016/S0168-8278(10) 60039-6]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Gane, E.1    Rouzier, R.2    Stedman, C.3    Wiercinska-Drapalo, A.4    Horban, A.5    Chang, L.6    Zhang, Y.7    Sampeur, P.8    Najera, I.9    Shulman, N.10
  • 40
    • 77958162291 scopus 로고    scopus 로고
    • Sustained virologic response (SVR) following RG7128 1500 mg BID PEG-IFN/RBV for 28 days in HCV genotype 2/3 prior non-responders
    • doi:10.1016/S0168-8278 10 60039-6
    • Gane, E. J., Rodriguez-Torres, M., Nelson, D. E., Jacobson, I. M., McHutchison, J. G., Duca, A., Hyland, R., Hill, G., Albanis, E., Symonds, W. T., et al., 2010e. Sustained virologic response (SVR) following RG7128 1500 mg BID PEG-IFN/RBV for 28 days in HCV genotype 2/3 prior non-responders. J. Hepatol., 52 (S1): S16. [doi:10.1016/S0168-8278(10) 60039-6]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Gane, E.J.1    Rodriguez-Torres, M.2    Nelson, D.E.3    Jacobson, I.M.4    McHutchison, J.G.5    Duca, A.6    Hyland, R.7    Hill, G.8    Albanis, E.9    Symonds, W.T.10
  • 42
    • 33645911783 scopus 로고    scopus 로고
    • Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811
    • doi:10.1016/j.bbrc.2006.03.059
    • Goto, K., Watashi, K., Murata, T., Hishiki, T., Hijikata, M., Shimotohno, K., 2006. Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811. Biochem. Biophys. Res. Commun., 343(3):879-884. [doi:10.1016/j.bbrc.2006.03.059]
    • (2006) Biochem. Biophys. Res. Commun. , vol.343 , Issue.3 , pp. 879-884
    • Goto, K.1    Watashi, K.2    Murata, T.3    Hishiki, T.4    Hijikata, M.5    Shimotohno, K.6
  • 45
    • 33644547392 scopus 로고    scopus 로고
    • Antiviral therapy for chronic hepatitis C: Past, present, and future
    • doi:10.1007/s00535-005-1740-7
    • Hayashi, N., Takehara, T., 2006. Antiviral therapy for chronic hepatitis C: past, present, and future. J. Gastroenterol., 41(1):17-27. [doi:10.1007/s00535-005-1740-7]
    • (2006) J. Gastroenterol. , vol.41 , Issue.1 , pp. 17-27
    • Hayashi, N.1    Takehara, T.2
  • 46
    • 84856830842 scopus 로고    scopus 로고
    • PK-PD modeling of viral kinetics during treatment with Debio-025 plus pegylated interferon α-2a in treatment-naive HCV patients
    • doi:10.1016/S0168-8278 09 60948-X
    • Herrmann, E., Kafer, A., Flisiak, R., Nicolas-Metral, V., Zeuzem, S., Crabbe, R., 2009. PK-PD modeling of viral kinetics during treatment with Debio-025 plus pegylated interferon α-2a in treatment-naive HCV patients. J. Hepatol., 50 (S1): S344. [doi:10.1016/S0168-8278(09) 60948-X]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Herrmann, E.1    Kafer, A.2    Flisiak, R.3    Nicolas-Metral, V.4    Zeuzem, S.5    Crabbe, R.6
  • 48
    • 84863069199 scopus 로고    scopus 로고
    • Antiviral activity of the non-immunosuppressive cyclophilin inhibitor SCY-635 in combination with investigational and approved anti-HCV agents
    • Hopkins, S., Huang, Z. H., Scribner, A., Peel, M., 2009a. Antiviral activity of the non-immunosuppressive cyclophilin inhibitor SCY-635 in combination with investigational and approved anti-HCV agents. Hepatology, 50(4):1042A.
    • (2009) Hepatology , vol.50 , Issue.4
    • Hopkins, S.1    Huang, Z.H.2    Scribner, A.3    Peel, M.4
  • 49
    • 67650559141 scopus 로고    scopus 로고
    • Safety, plasma pharmacokinetics, and anti-viral activity of SCY-635 in adult patients with chronic hepatitis C virus infection
    • doi:10.1016/S0168-8278 09 60091-X
    • Hopkins, S., Heuman, D., Gavis, E., Lalezari, J., Glutzer, E., Di Massimo, B., Rusnak, P., Wring, S., Smitley, C., Ribeill, Y., 2009b. Safety, plasma pharmacokinetics, and anti-viral activity of SCY-635 in adult patients with chronic hepatitis C virus infection. J. Hepatol., 50 (S1): S36. [doi:10.1016/S0168-8278(09) 60091-X]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Hopkins, S.1    Heuman, D.2    Gavis, E.3    Lalezari, J.4    Glutzer, E.5    Di Massimo, B.6    Rusnak, P.7    Wring, S.8    Smitley, C.9    Ribeill, Y.10
  • 50
    • 75749110945 scopus 로고    scopus 로고
    • SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro
    • doi:10.1128/AAC.00660-09
    • Hopkins, S., Scorneaux, B., Huang, Z. H., Murray, M. G., Wring, S., Smitley, C., Harris, R., Erdmann, F., Fischer, G., Ribeill, Y., 2010. SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob. Agents Chemother., 54(2):660-672. [doi:10.1128/AAC.00660-09]
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.2 , pp. 660-672
    • Hopkins, S.1    Scorneaux, B.2    Huang, Z.H.3    Murray, M.G.4    Wring, S.5    Smitley, C.6    Harris, R.7    Erdmann, F.8    Fischer, G.9    Ribeill, Y.10
  • 51
    • 78751620386 scopus 로고    scopus 로고
    • Sustained virological response after 4-week treatment with Debio 025 monotherapy or coadministered with PEG-IFN α-2a in HCV genotype 1 and 3 patients
    • doi:10.1016/S0168-8278 10 60757-X
    • Horban, A., Berak, H., Kolakowska-Rzadzka, A., Patel, H., Flisiak, R., Crabbe, R., Liz, J. S., Heathcote, J. E., 2010. Sustained virological response after 4-week treatment with Debio 025 monotherapy or coadministered with PEG-IFN α-2a in HCV genotype 1 and 3 patients. J. Hepatol., 52 (S1): S294. [doi:10.1016/S0168-8278(10) 60757-X]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Horban, A.1    Berak, H.2    Kolakowska-Rzadzka, A.3    Patel, H.4    Flisiak, R.5    Crabbe, R.6    Liz, J.S.7    Heathcote, J.E.8
  • 52
    • 34848912104 scopus 로고    scopus 로고
    • Preclinical evaluation of SCY-635, a cyclophilin inhibitor with potent anti-HCV activity
    • Houck, D. R., Hopkins, S., 2006. Preclinical evaluation of SCY-635, a cyclophilin inhibitor with potent anti-HCV activity. Hepatology, 44 (S1): 534A-535A.
    • (2006) Hepatology , vol.44 , Issue.S1
    • Houck, D.R.1    Hopkins, S.2
  • 53
    • 23944452579 scopus 로고    scopus 로고
    • Prospects for a vaccine against the hepatitis C virus
    • DOI 10.1038/nature04081
    • Houghton, M., Abrignani, S., 2005. Prospects for a vaccine against the hepatitis C virus. Nature, 436(7053):961-966. [doi:10.1038/nature04081] (Pubitemid 41191672)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 961-966
    • Houghton, M.1    Abrignani, S.2
  • 54
    • 0038102952 scopus 로고    scopus 로고
    • Combined interferon α2b and cyclosporin A in the treatment of chronic hepatitis C: Controlled trial
    • Inoue, K., Sekiyama, K., Yamada, M., Watanabe, T., Yasuda, H., Yoshiba, M., 2003. Combined interferon α-2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial. J. Gastroenterol., 38(6):567-572. [doi:10.1007/s00535-002-1104-5] (Pubitemid 36857388)
    • (2003) Journal of Gastroenterology , vol.38 , Issue.6 , pp. 567-572
    • Inoue, K.1    Sekiyama, K.2    Yamada, M.3    Watanabe, T.4    Yasuda, H.5    Yoshiba, M.6
  • 55
    • 34247383488 scopus 로고    scopus 로고
    • Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo
    • DOI 10.1002/hep.21587
    • Inoue, K., Umehara, T., Ruegg, U. T., Yasui, F., Watanabe, T., Yasuda, H., Dumont, J. M., Scalfaro, P., Yoshiba, M., Kohara, M., 2007. Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo. Hepatology, 45(4):921-928. [doi:10.1002/hep. 21587] (Pubitemid 46631561)
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 921-928
    • Inoue, K.1    Umehara, T.2    Ruegg, U.T.3    Yasui, F.4    Watanabe, T.5    Yasuda, H.6    Dumont, J.-M.7    Scalfaro, P.8    Yoshiba, M.9    Kohara, M.10
  • 56
    • 67650511383 scopus 로고    scopus 로고
    • Antiviral activity of Filibuvir in combination with pegylated interferon α-2a and Ribavirin for 28 days in treatment naive patients chronically infected with HCV genotype 1
    • doi:10.1016/S0168-8278 09 61054-0
    • Jacobson, I., Pockros, P., Lalezari, J., Lawitz, E., Rodriguez-Torres, M., De Jesus, E., Haas, F., Martorell, C., Pruitt, R., Durham, K., et al., 2009. Antiviral activity of Filibuvir in combination with pegylated interferon α-2a and Ribavirin for 28 days in treatment naive patients chronically infected with HCV genotype 1. J. Hepatol., 50 (S1): S382-S383. [doi:10.1016/S0168-8278(09) 61054-0]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Jacobson, I.1    Pockros, P.2    Lalezari, J.3    Lawitz, E.4    Rodriguez-Torres, M.5    De Jesus, E.6    Haas, F.7    Martorell, C.8    Pruitt, R.9    Durham, K.10
  • 57
    • 78751620008 scopus 로고    scopus 로고
    • Virologic response rates following 4 weeks of Filibuvir in combination with pegylated interferon alfa-2a and Ribavirin in chronicallyinfected HCV genotype-1 patients
    • doi:10.1016/S0168-8278 10 61197-X
    • Jacobson, I., Pockros, P. J., Lalezari, J., Lawitz, E., Rodriguez-Torres, M., De Jesus, E., Haas, F., Martorell, C., Pruitt, R., Purohit, V., et al., 2010. Virologic response rates following 4 weeks of Filibuvir in combination with pegylated interferon alfa-2a and Ribavirin in chronicallyinfected HCV genotype-1 patients. J. Hepatol., 52 (S1): S465. [doi:10.1016/S0168-8278(10) 61197-X]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Jacobson, I.1    Pockros, P.J.2    Lalezari, J.3    Lawitz, E.4    Rodriguez-Torres, M.5    De Jesus, E.6    Haas, F.7    Martorell, C.8    Pruitt, R.9    Purohit, V.10
  • 59
    • 77954969479 scopus 로고    scopus 로고
    • Safety, and tolerability of NIM 811, a novel cyclophilin inhibitor for HCV, following single and multiple ascending doses in healthy volunteers and HCV-infected patients
    • doi:10.1016/S0168-8278 09 60624-3
    • Ke, J., Lawitz, E., Rozier, R., Marbury, T., Nguyen, N., Serra, D., Dole, K., Praestgaard, J., Huang, M., Evans, T., 2009. Safety, and tolerability of NIM 811, a novel cyclophilin inhibitor for HCV, following single and multiple ascending doses in healthy volunteers and HCV-infected patients. J. Hepatol., 50 (S1): S229. [doi:10.1016/S0168-8278(09) 60624-3]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Ke, J.1    Lawitz, E.2    Rozier, R.3    Marbury, T.4    Nguyen, N.5    Serra, D.6    Dole, K.7    Praestgaard, J.8    Huang, M.9    Evans, T.10
  • 60
    • 42349090663 scopus 로고    scopus 로고
    • ANA598, a novel nonnucleoside inhibitor of HCV NS5B polymerase, exhibits favorable pharmacokinetic properties in multiple preclinical species
    • Kirkovsky, L., Zhou, Y., Norris, D., Okamoto, E., Nolan, T. G., Bartkowski, D., Khandurina, J., Sergeeva, M., Murphy, D., Ayida, B., et al., 2007. ANA598, a novel nonnucleoside inhibitor of HCV NS5B polymerase, exhibits favorable pharmacokinetic properties in multiple preclinical species. Hepatology, 46 (S1): 858A.
    • (2007) Hepatology , vol.46 , Issue.S1
    • Kirkovsky, L.1    Zhou, Y.2    Norris, D.3    Okamoto, E.4    Nolan, T.G.5    Bartkowski, D.6    Khandurina, J.7    Sergeeva, M.8    Murphy, D.9    Ayida, B.10
  • 61
    • 36749074159 scopus 로고    scopus 로고
    • Design and characterization of R1626, a prodrug of the HCV replication inhibitor R1479 (4'-azidocytidine) with enhanced oral bioavailability
    • doi:10.1016/j.antiviral.2007.01.029
    • Klumpp, K., Smith, D., Brandl, M., Alfredson, T., Sarma, K., Smith, M., Najera, I., Jiang, W. R., Le Pogam, S., Leveque, V., et al., 2007. Design and characterization of R1626, a prodrug of the HCV replication inhibitor R1479 (4'-azidocytidine) with enhanced oral bioavailability. Antivir. Res., 74(3):A35. [doi:10.1016/j.antiviral.2007.01.029]
    • (2007) Antivir. Res. , vol.74 , Issue.3
    • Klumpp, K.1    Smith, D.2    Brandl, M.3    Alfredson, T.4    Sarma, K.5    Smith, M.6    Najera, I.7    Jiang, W.R.8    Le Pogam, S.9    Leveque, V.10
  • 62
    • 0033920304 scopus 로고    scopus 로고
    • Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
    • DOI 10.1128/JVI.74.4.2046-2051.2000
    • Kolykhalov, A. A., Mihalik, K., Feinstone, S. M., Rice, C. M., 2000. Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J. Virol., 74(4):2046-2051. [doi:10.1128/JVI.74.4.2046-2051.2000] (Pubitemid 30434065)
    • (2000) Journal of Virology , vol.74 , Issue.4 , pp. 2046-2051
    • Kolykhalov, A.A.1    Mihalik, K.2    Feinstone, S.M.3    Rice, C.M.4
  • 63
    • 67650529545 scopus 로고    scopus 로고
    • BI 201335, a potent HCV NS3 protease inhibitor, in treatment-naive and-experienced chronic HCV genotype-1 infection: Genotypic and phenotypic analysis of the NS3 protease domain
    • doi:10.1016/S0168-8278 09 60956-9
    • Kukolj, G., Benhamou, Y., Manns, M. P., Bourliere, M., Pol, S., Schuchmann, M., Cartier, M., Huang, D., Lagace, L., Steinmann, G., et al., 2009. BI 201335, a potent HCV NS3 protease inhibitor, in treatment-naive and-experienced chronic HCV genotype-1 infection: genotypic and phenotypic analysis of the NS3 protease domain. J. Hepatol., 50 (S1): S347. [doi:10.1016/S0168-8278(09) 60956-9]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Kukolj, G.1    Benhamou, Y.2    Manns, M.P.3    Bourliere, M.4    Pol, S.5    Schuchmann, M.6    Cartier, M.7    Huang, D.8    Lagace, L.9    Steinmann, G.10
  • 65
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon α-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An openlabel, randomised, multicentre phase 2 trial
    • doi:10.1016/S0140-6736 10 60934-8
    • Kwo, P. Y., Lawitz, E. J., McCone, J., Schiff, E. R., Vierling, J. M., Pound, D., Davis, M. N., Galati, J. S., Gordon, S. C., Ravendhran, N., et al., 2010. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon α-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an openlabel, randomised, multicentre phase 2 trial. Lancet, 376(9742):705-716. [doi:10.1016/S0140-6736(10) 60934-8]
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3    Schiff, E.R.4    Vierling, J.M.5    Pound, D.6    Davis, M.N.7    Galati, J.S.8    Gordon, S.C.9    Ravendhran, N.10
  • 66
    • 75149190736 scopus 로고    scopus 로고
    • Antiviral activity, safety and pharmacokinetics of IDX184, a liver-targeted nucleotide HCV polymerase inhibitor, in patients with chronic hepatitis C
    • Lalezari, J., Asmuth, D., Casiro, A., Vargas, H. E., Patrick, G. D., Liu, W., Pietropaolo, K., Zhou, X. J., Sullivan-Bolyai, J., Mayers, D. L., 2009. Antiviral activity, safety and pharmacokinetics of IDX184, a liver-targeted nucleotide HCV polymerase inhibitor, in patients with chronic hepatitis C. Hepatology, 50(6):11A-12A.
    • (2009) Hepatology , vol.50 , Issue.6
    • Lalezari, J.1    Asmuth, D.2    Casiro, A.3    Vargas, H.E.4    Patrick, G.D.5    Liu, W.6    Pietropaolo, K.7    Zhou, X.J.8    Sullivan-9    Bolyai, J.10    Mayers, D.L.11
  • 67
    • 77954697109 scopus 로고    scopus 로고
    • Combination of IDX184, a nucleotide prodrug polymerase inhibitor, with other classes of HCV inhibitors is additive to synergistic in the HCV replicon in vitro
    • Lallos, L., La Colla, M., Serra, I., Bilello, J. P., Soubasakos, M. A., Li, B., Panzo, R. J., Gillum, J. M., Bonin, A., Seifer, M., et al., 2009. Combination of IDX184, a nucleotide prodrug polymerase inhibitor, with other classes of HCV inhibitors is additive to synergistic in the HCV replicon in vitro. Hepatology, 50(4):1045A.
    • (2009) Hepatology , vol.50 , Issue.4
    • Lallos, L.1    La Colla, M.2    Serra, I.3    Bilello, J.P.4    Soubasakos, M.A.5    Li, B.6    Panzo, R.J.7    Gillum, J.M.8    Bonin, A.9    Seifer, M.10
  • 68
    • 33645967464 scopus 로고    scopus 로고
    • Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase
    • doi:10.1128/JVI.80.1.404-411.2006
    • Lam, A. M., Frick, D. N., 2006. Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase. J. Virol., 80(1):404-411. [doi:10.1128/JVI.80.1.404-411.2006]
    • (2006) J. Virol. , vol.80 , Issue.1 , pp. 404-411
    • Lam, A.M.1    Frick, D.N.2
  • 70
    • 72049107298 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and antiviral effect of BI 207127, a novel HCV RNA polymerase inhibitor, after 5 days oral treatment in patients with chronic hepatitis C
    • doi:10.1016/S0168-8278 09 61056-4
    • Larrey, D., Benhamou, Y., Lohse, A. W., Trepo, C., Moelleken, C., Bronowicki, J. P., Arasteh, K., Bourliere, M., Heim, M., Enriquez, J., et al., 2009b. Safety, pharmacokinetics and antiviral effect of BI 207127, a novel HCV RNA polymerase inhibitor, after 5 days oral treatment in patients with chronic hepatitis C. J. Hepatol., 50 (S1): S383-S384. [doi:10.1016/S0168-8278(09) 61056-4]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Larrey, D.1    Benhamou, Y.2    Lohse, A.W.3    Trepo, C.4    Moelleken, C.5    Bronowicki, J.P.6    Arasteh, K.7    Bourliere, M.8    Heim, M.9    Enriquez, J.10
  • 71
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • doi:10.1111/j.1478-3231.2008.01934.x
    • Lavanchy, D., 2009. The global burden of hepatitis C. Liver Int., 29(1):74-81. [doi:10.1111/j.1478-3231.2008.01934.x]
    • (2009) Liver Int. , vol.29 , Issue.1 , pp. 74-81
    • Lavanchy, D.1
  • 72
    • 67650535688 scopus 로고    scopus 로고
    • Safety and antiviral efficacy of 14 days of the cycophilin inhibitor NIM811 in combination with pegylated interferon α-2a in relapsed genotype 1 HCV infected patients
    • doi:10.1016/S0168-8278 09 61047-3
    • Lawitz, E., Rouzier, R., Nguyen, T., Huang, M., Ke, J., Praestgaard, J., Serra, D., Koziel, M., Evans, T., 2009. Safety and antiviral efficacy of 14 days of the cycophilin inhibitor NIM811 in combination with pegylated interferon α-2a in relapsed genotype 1 HCV infected patients. J. Hepatol., 50 (S1): S379. [doi:10.1016/S0168-8278(09) 61047-3]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Lawitz, E.1    Rouzier, R.2    Nguyen, T.3    Huang, M.4    Ke, J.5    Praestgaard, J.6    Serra, D.7    Koziel, M.8    Evans, T.9
  • 74
    • 79952148090 scopus 로고    scopus 로고
    • Safety and antiviral activity of ANA598 in combination with pegylated interferon α-2a plus ribavirin in treatment-naive genotype-1 chronic HCV patients
    • doi:10.1016/S0168-8278 10 61200-7
    • Lawitz, E., Rodriquez-Torres, M., Rustgi, V. K., Hassanein, T., Rahimy, M. H., Crowley, C. A., Freddo, J. L., Muir, A., McHutchison, J., 2010a. Safety and antiviral activity of ANA598 in combination with pegylated interferon α-2a plus ribavirin in treatment-naive genotype-1 chronic HCV patients. J. Hepatol., 52 (S1): S467. [doi:10.1016/S0168-8278(10) 61200-7]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Lawitz, E.1    Rodriquez-Torres, M.2    Rustgi, V.K.3    Hassanein, T.4    Rahimy, M.H.5    Crowley, C.A.6    Freddo, J.L.7    Muir, A.8    McHutchison, J.9
  • 75
    • 78349268362 scopus 로고    scopus 로고
    • RG7128 alone or in combination with pegylated interferon-α 2a and ribavirin pre-1vents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients
    • doi:10.1086/656774
    • Le Pogam, S., Seshaadri, A., Ewing, A., Kang, H. S., Kosaka, A., Yan, J. M., Berrey, M., Symonds, B., de la Rosa, A., Cammack, N., et al., 2010. RG7128 alone or in combination with pegylated interferon-α 2a and ribavirin pre-1vents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients. J. Infect. Dis., 202(10):1510-1519. [doi:10.1086/656774]
    • (2010) J. Infect. Dis. , vol.202 , Issue.10 , pp. 1510-1519
    • Le Pogam, S.1    Seshaadri, A.2    Ewing, A.3    Kang, H.S.4    Kosaka, A.5    Yan, J.M.6    Berrey, M.7    Symonds, B.8    De La Rosa, A.9    Cammack, N.10
  • 76
    • 84863073233 scopus 로고    scopus 로고
    • Bound structure and biochemical mechanism of action of BI 201335, a potent, non-covalent inhibitor of HCV NS3-NS4A protease
    • doi:10.1016/j. antiviral.2010.02.336
    • Lemke, C. T., Zhao, S. P., Goudreau, N., Hucke, O., Thibeault, D., Llinas-Brunet, M., White, P. W., 2010. Bound structure and biochemical mechanism of action of BI 201335, a potent, non-covalent inhibitor of HCV NS3-NS4A protease. Antivir. Res., 86(1):A20-A21. [doi:10.1016/j. antiviral.2010.02.336]
    • (2010) Antivir. Res. , vol.86 , Issue.1
    • Lemke, C.T.1    Zhao, S.P.2    Goudreau, N.3    Hucke, O.4    Thibeault, D.5    Llinas-Brunet, M.6    White, P.W.7
  • 78
    • 64349088294 scopus 로고    scopus 로고
    • Discovery of (R)-6-cyclopentyl-6-(2-(2, 6-diethylpyridin-4-yl) ethyl)-3-((5, 7-dimethyl-[1, 2, 4]triazolo [1, 5-a]pyrimidin-2-yl) methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
    • doi:10.1021/jm8014537
    • Li, H., Tatlock, J., Linton, A., Gonzalez, J., Jewell, T., Patel, L., Ludlum, S., Drowns, M., Rahavendran, S. V., Skor, H., et al., 2009. Discovery of (R)-6-cyclopentyl-6-(2-(2, 6-diethylpyridin-4-yl) ethyl)-3-((5, 7-dimethyl-[1, 2, 4]triazolo [1, 5-a]pyrimidin-2-yl) methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor. J. Med. Chem., 52(5):1255-1258. [doi:10.1021/jm8014537]
    • (2009) J. Med. Chem. , vol.52 , Issue.5 , pp. 1255-1258
    • Li, H.1    Tatlock, J.2    Linton, A.3    Gonzalez, J.4    Jewell, T.5    Patel, L.6    Ludlum, S.7    Drowns, M.8    Rahavendran, S.V.9    Skor, H.10
  • 79
    • 33744457959 scopus 로고    scopus 로고
    • Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease
    • Lin, C., Kwong, A. D., Perni, R. B., 2006. Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. Infect. Disord. Drug Targets, 6(1):3-16. [doi:10.2174/ 187152606776056706] (Pubitemid 43796632)
    • (2006) Infectious Disorders - Drug Targets , vol.6 , Issue.1 , pp. 3-16
    • Lin, C.1    Kwong, A.D.2    Perni, R.B.3
  • 80
    • 9644275435 scopus 로고    scopus 로고
    • Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells
    • DOI 10.1128/AAC.48.12.4784-4792.2004
    • Lin, K., Kwong, A. D., Lin, C., 2004. Combination of a hepatitis C virus NS3-NS4A protease inhibitor and α interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells. Antimicrob. Agents Chemother., 48(12):4784-4792. [doi:10.1128/AAC.48.12.4784- 4792.2004] (Pubitemid 39577685)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.12 , pp. 4784-4792
    • Lin, K.1    Kwong, A.D.2    Lin, C.3
  • 81
    • 33646446894 scopus 로고    scopus 로고
    • VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells
    • doi:10.1128/AAC.50.5.1813-1822.2006
    • Lin, K., Perni, R. B., Kwong, A. D., Lin, C., 2006. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells. Antimicrob. Agents Chemother., 50(5):1813-1822. [doi:10.1128/AAC.50.5.1813-1822.2006]
    • (2006) Antimicrob. Agents Chemother. , vol.50 , Issue.5 , pp. 1813-1822
    • Lin, K.1    Perni, R.B.2    Kwong, A.D.3    Lin, C.4
  • 84
    • 47949084830 scopus 로고    scopus 로고
    • Hepatitis C protease and polymerase inhibitors in development
    • doi:10.1089/apc.2007.0199
    • Liu-Young, G., Kozal, M. J., 2008. Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care St., 22(6):449-457. [doi:10.1089/apc.2007.0199]
    • (2008) AIDS Patient Care St. , vol.22 , Issue.6 , pp. 449-457
    • Liu-Young, G.1    Kozal, M.J.2
  • 86
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • DOI 10.1126/science.285.5424.110
    • Lohmann, V., Korner, F., Koch, J., Herian, U., Theilmann, L., Bartenschlager, R., 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science, 285(5424):110-113. [doi:10.1126/science.285.5424. 110] (Pubitemid 29307577)
    • (1999) Science , vol.285 , Issue.5424 , pp. 110-113
    • Lohmann, V.1    Korner, F.2    Koch, J.-O.3    Herian, U.4    Theilmann, L.5    Bartenschlager, R.6
  • 87
    • 78650928650 scopus 로고    scopus 로고
    • Combination therapy with BMS-790052 and BMS-650032 alone or with pegylated interferon and ribavirin (PEGIFN/RBV) results in undetectable HCV RNA through 12 weeks of therapy in HCV genotype 1 null responders
    • Lok, A. S., Gardiner, D. F., Lawitz, E., Martorell, C., Everson, G. T., Ghalib, R. H., Reindollar, R., Rustgi, V. K., Wendelburg, P., Zhu, K., et al., 2010. Combination therapy with BMS-790052 and BMS-650032 alone or with pegylated interferon and ribavirin (PEGIFN/RBV) results in undetectable HCV RNA through 12 weeks of therapy in HCV genotype 1 null responders. Hepatology, 52(4):877A.
    • (2010) Hepatology , vol.52 , Issue.4
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3    Martorell, C.4    Everson, G.T.5    Ghalib, R.H.6    Reindollar, R.7    Rustgi, V.K.8    Wendelburg, P.9    Zhu, K.10
  • 88
    • 33748687426 scopus 로고    scopus 로고
    • NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon
    • DOI 10.1128/AAC.00310-06
    • Ma, S., Boerner, J. E., TiongYip, C., Weidmann, B., Ryder, N. S., Cooreman, M. P., Lin, K., 2006. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with α interferon. Antimicrob. Agents Chemother., 50(9):2976-2982. [doi: 10.1128/AAC.00310-06] (Pubitemid 44396401)
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.9 , pp. 2976-2982
    • Ma, S.1    Boerner, J.E.2    TiongYip, C.3    Weidmann, B.4    Ryder, N.S.5    Cooreman, M.P.6    Lin, K.7
  • 90
    • 67650519838 scopus 로고    scopus 로고
    • Opera-1 Trial: Interim analysis of safety and antiviral activity of TMC435 in treatmentnaive genotype 1 HCV patients
    • doi:10.1016/S0168-8278 09 60013-1
    • Manns, M., Reesink, H., Moreno, C., Berg, T., Benhamou, Y., Horsmans, Y., Dusheiko, G., Flisiak, R., Meyvisch, P., Lenz, O., et al., 2009. Opera-1 Trial: interim analysis of safety and antiviral activity of TMC435 in treatmentnaive genotype 1 HCV patients. J. Hepatol., 50 (S1): S7. [doi:10.1016/S0168-8278(09) 60013-1]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Manns, M.1    Reesink, H.2    Moreno, C.3    Berg, T.4    Benhamou, Y.5    Horsmans, Y.6    Dusheiko, G.7    Flisiak, R.8    Meyvisch, P.9    Lenz, O.10
  • 91
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • DOI 10.1016/S0140-6736(01)06102-5
    • Manns, M. P., McHutchison, J. G., Gordon, S. C., Rustgi, V. K., Shiffman, M., Reindollar, R., Goodman, Z. D., Koury, K., Ling, M., Albrecht, J. K., 2001. Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet, 358(9286):958-965. [doi:10.1016/S0140-6736(01) 06102-5] (Pubitemid 32913521)
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.-H.9    Albrecht, J.K.10
  • 94
    • 42949167169 scopus 로고    scopus 로고
    • The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors
    • DOI 10.1128/AAC.01317-07
    • McCown, M. F., Rajyaguru, S., le Pogam, S., Ali, S., Jiang, W. R., Kang, H., Symons, J., Cammack, N., Najera, I., 2008. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors. Antimicrob. Agents Chemother., 52(5):1604-1612. [doi:10.1128/AAC. 01317-07] (Pubitemid 351614649)
    • (2008) Antimicrobial Agents and Chemotherapy , vol.52 , Issue.5 , pp. 1604-1612
    • McCown, M.F.1    Rajyaguru, S.2    Le Pogam, S.3    Ali, S.4    Jiang, W.-R.5    Kang, H.6    Symons, J.7    Cammack, N.8    Najera, I.9
  • 95
    • 78650968050 scopus 로고    scopus 로고
    • Identification and preclinical profile of the novel HCV NS3 protease inhibitor BMS-650032
    • doi:10.1016/S0168-8278 10 60763-5
    • McPhee, F., 2010. Identification and preclinical profile of the novel HCV NS3 protease inhibitor BMS-650032. J. Hepatol., 52 (S1): S296. [doi:10.1016/S0168-8278(10) 60763-5]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • McPhee, F.1
  • 96
    • 84856973586 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of samples from HCV-infected subjects treated with BMS-650032 in a single ascending dose study
    • doi:10.1002/hep. 23307
    • McPhee, F., Hernandez, D., Sheaffer, A., Lee, M., Falk, P., Yu, F., Zhai, G. Z., Chaniewski, S., Pasquinelli, C., 2009. Genotypic and phenotypic analysis of samples from HCV-infected subjects treated with BMS-650032 in a single ascending dose study. Hepatology, 50 (S4): 1048A. [doi:10.1002/hep. 23307]
    • (2009) Hepatology , vol.50 , Issue.S4
    • McPhee, F.1    Hernandez, D.2    Sheaffer, A.3    Lee, M.4    Falk, P.5    Yu, F.6    Zhai, G.Z.7    Chaniewski, S.8    Pasquinelli, C.9
  • 97
    • 83555163165 scopus 로고    scopus 로고
    • Genotypic characterisation of filibuvir (PF-00868554) resistance in patients receiving four weeks co-administration of filibuvir with PEGIFN/RBV (12 week analysis)
    • doi:10.1016/S0168-8278 10 60037-2
    • Mori, J., Hammond, J. L., Srinivasan, S., Jagannatha, S., van der Ryst, E., 2010. Genotypic characterisation of filibuvir (PF-00868554) resistance in patients receiving four weeks co-administration of filibuvir with PEGIFN/RBV (12 week analysis). J. Hepatol., 52 (S1): S15. [doi:10.1016/S0168-8278(10) 60037-2]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Mori, J.1    Hammond, J.L.2    Srinivasan, S.3    Jagannatha, S.4    Van Der Ryst, E.5
  • 98
    • 78649817575 scopus 로고    scopus 로고
    • Danoprevir, an HCV NS3/4A protease inhibitor, improves insulin sensitivity in patients with genotype 1 chronic hepatitis C
    • doi:10.1136/gut.2010.219089
    • Moucari, R., Forestier, N., Larrey, D., Guyader, D., Couzigou, P., Benhamou, Y., Voitot, H., Vidaud, M., Seiwert, S., Bradford, B., et al., 2010. Danoprevir, an HCV NS3/4A protease inhibitor, improves insulin sensitivity in patients with genotype 1 chronic hepatitis C. Gut, 59(12):1694-1698. [doi:10.1136/gut.2010.219089]
    • (2010) Gut , vol.59 , Issue.12 , pp. 1694-1698
    • Moucari, R.1    Forestier, N.2    Larrey, D.3    Guyader, D.4    Couzigou, P.5    Benhamou, Y.6    Voitot, H.7    Vidaud, M.8    Seiwert, S.9    Bradford, B.10
  • 99
    • 84863027569 scopus 로고    scopus 로고
    • Exposure-response relationship of Filibuvir in HCV infected patients: Application to dose selection for combination therapy
    • doi:10.1016/S0168-8278 10 60288-7
    • Neelakantan, S., Purohit, V. S., O'Gorman, M., Hammond, J., Tensfeldt, T. G., 2010. Exposure-response relationship of Filibuvir in HCV infected patients: application to dose selection for combination therapy. J. Hepatol., 52 (S1): S119-S120. [doi:10.1016/S0168-8278(10) 60288-7]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Neelakantan, S.1    Purohit, V.S.2    O'Gorman, M.3    Hammond, J.4    Tensfeldt, T.G.5
  • 100
    • 26444432835 scopus 로고    scopus 로고
    • Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6
    • DOI 10.1016/S1542-3565(05)00711-1, PII S1542356505007111
    • Nguyen, M. H., Keeffe, E. B., 2005. Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6. Clin. Gastroenterol. Hepatol., 3(10):S97-S101. [doi:10.1016/S1542-3565(05) 00711-1] (Pubitemid 41427738)
    • (2005) Clinical Gastroenterology and Hepatology , vol.3 , Issue.SUPPL. 2
    • Nguyen, M.H.1    Keeffe, E.B.2
  • 101
    • 55749098373 scopus 로고    scopus 로고
    • Genotypic analysis of HCV NS5B variants selected from patients treated with VCH-759
    • doi:10.1016/S0168-8278 08 60846-6
    • Nicolas, O., Boivin, I., St-Denis, C., Bedard, J., 2008. Genotypic analysis of HCV NS5B variants selected from patients treated with VCH-759. J. Hepatol., 48 (S2): S317. [doi:10.1016/S0168-8278(08) 60846-6]
    • (2008) J. Hepatol. , vol.48 , Issue.S2
    • Nicolas, O.1    Boivin, I.2    St-Denis, C.3    Bedard, J.4
  • 103
    • 77954233516 scopus 로고    scopus 로고
    • Excitement grows for potential revolution in hepatitis C virus treatment
    • doi:10.1038/nrd3214
    • Opar, A., 2010. Excitement grows for potential revolution in hepatitis C virus treatment. Nat. Rev. Drug Discov., 9(7):501-503. [doi:10.1038/nrd3214]
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.7 , pp. 501-503
    • Opar, A.1
  • 105
    • 33646015668 scopus 로고    scopus 로고
    • The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
    • doi:10.1002/hep. 21102
    • Paeshuyse, J., Kaul, A., de Clercq, E., Rosenwirth, B., Dumont, J. M., Scalfaro, P., Bartenschlager, R., Neyts, J., 2006. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology, 43(4):761-770. [doi:10.1002/hep. 21102]
    • (2006) Hepatology , vol.43 , Issue.4 , pp. 761-770
    • Paeshuyse, J.1    Kaul, A.2    De Clercq, E.3    Rosenwirth, B.4    Dumont, J.M.5    Scalfaro, P.6    Bartenschlager, R.7    Neyts, J.8
  • 106
    • 84863077979 scopus 로고    scopus 로고
    • In vitro combination studies of ANA598 with anti-HCV agents demonstrate enhanced anti-viral activity
    • doi:10.1016/j.antiviral.2010.02.397
    • Patel, R., Thompson, P., Showalter, R., Appleman, J., 2010. In vitro combination studies of ANA598 with anti-HCV agents demonstrate enhanced anti-viral activity. Antivir. Res., 86(1):A41-A42. [doi:10.1016/j.antiviral. 2010.02.397]
    • (2010) Antivir. Res. , vol.86 , Issue.1
    • Patel, R.1    Thompson, P.2    Showalter, R.3    Appleman, J.4
  • 107
    • 33644520948 scopus 로고    scopus 로고
    • Therapy of hepatitis C: From empiricism to eradication
    • doi:10.1002/hep. 21064
    • Pawlotsky, J. M., 2006. Therapy of hepatitis C: from empiricism to eradication. Hepatology, 43 (S1): S207-S220. [doi:10.1002/hep. 21064]
    • (2006) Hepatology , vol.43 , Issue.S1
    • Pawlotsky, J.M.1
  • 110
    • 49649125855 scopus 로고    scopus 로고
    • R1626 plus peginterferon α-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin
    • doi:10.1002/hep. 22357
    • Pockros, P. J., Nelson, D., Godofsky, E., Rodriguez-Torres, M., Everson, G. T., Fried, M. W., Ghalib, R., Harrison, S., Nyberg, L., Shiffman, M. L., et al., 2008b. R1626 plus peginterferon α-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin. Hepatology, 48(2):385-397. [doi:10.1002/hep. 22357]
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 385-397
    • Pockros, P.J.1    Nelson, D.2    Godofsky, E.3    Rodriguez-Torres, M.4    Everson, G.T.5    Fried, M.W.6    Ghalib, R.7    Harrison, S.8    Nyberg, L.9    Shiffman, M.L.10
  • 111
    • 78650971116 scopus 로고    scopus 로고
    • Once-daily NS5A inhibitor (BMS-790052) plus peginterferon α-2a and Ribavirin produces high rates of extended rapid virologic response in treatment-naive HCV-genotype 1 subjects: Phase 2a trial
    • doi:10.1016/S0168-8278 10 61190-7
    • Pol, S., Everson, G., Ghalib, R., Rustgi, V., Martorell, C., Tatum, H. A., Lim, J., Hezode, C., Diva, U., Yin, P. D., et al., 2010. Once-daily NS5A inhibitor (BMS-790052) plus peginterferon α-2a and Ribavirin produces high rates of extended rapid virologic response in treatment-naive HCV-genotype 1 subjects: phase 2a trial. J. Hepatol., 52 (S1): S462. [doi:10.1016/S0168- 8278(10) 61190-7]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Pol, S.1    Everson, G.2    Ghalib, R.3    Rustgi, V.4    Martorell, C.5    Tatum, H.A.6    Lim, J.7    Hezode, C.8    Diva, U.9    Yin, P.D.10
  • 112
    • 84863052853 scopus 로고    scopus 로고
    • Results of a phase I safety, tolerability and pharmacokinetic study of ANA598, a non-nucleoside NS5B polymerase inhibitor, in healthy volunteers
    • Rahimy, M. H., Crowley, C. A., Freddo, J. L., Sergeeva, M. V., Golec, B., 2008. Results of a phase I safety, tolerability and pharmacokinetic study of ANA598, a non-nucleoside NS5B polymerase inhibitor, in healthy volunteers. Hepatology, 48(4):1026A.
    • (2008) Hepatology , vol.48 , Issue.4
    • Rahimy, M.H.1    Crowley, C.A.2    Freddo, J.L.3    Sergeeva, M.V.4    Golec, B.5
  • 113
    • 41349083638 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, safety and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy
    • Reddy, R., Rodriguez-Torres, M., Gane, E., Robson, R., Lalezari, J., Everson, G. T., Dejesus, E., McHutchison, J. G., Vargas, H. E., Beard, A., et al., 2007. Antiviral activity, pharmacokinetics, safety and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy. Hepatology, 46(4):862A-863A.
    • (2007) Hepatology , vol.46 , Issue.4
    • Reddy, R.1    Rodriguez-Torres, M.2    Gane, E.3    Robson, R.4    Lalezari, J.5    Everson, G.T.6    Dejesus, E.7    McHutchison, J.G.8    Vargas, H.E.9    Beard, A.10
  • 115
    • 68249161340 scopus 로고    scopus 로고
    • Serine protease inhibitors as antihepatitis C virus agents
    • doi:10.1586/eri.09.30
    • Reiser, M., Timm, J., 2009. Serine protease inhibitors as antihepatitis C virus agents. Expert Rev. Anti.-Infect. Ther., 7(5):537-547. [doi:10.1586/eri.09.30]
    • (2009) Expert Rev. Anti.-Infect. Ther. , vol.7 , Issue.5 , pp. 537-547
    • Reiser, M.1    Timm, J.2
  • 116
    • 20144387727 scopus 로고    scopus 로고
    • Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C
    • DOI 10.1002/hep.20612
    • Reiser, M., Hinrichsen, H., Benhamou, Y., Reesink, H. W., Wedemeyer, H., Avendano, C., Riba, N., Yong, C. L., Nehmiz, G., Steinmann, G. G., 2005. Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology, 41(4):832-835. [doi:10.1002/hep. 20612] (Pubitemid 40462946)
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 832-835
    • Reiser, M.1    Hinrichsen, H.2    Benhamou, Y.3    Reesink, H.W.4    Wedemeyer, H.5    Avendano, C.6    Riba, N.7    Yong, C.-L.8    Nehmiz, G.9    Steinmann, G.G.10
  • 117
    • 49649094687 scopus 로고    scopus 로고
    • Robust antiviral activity of R1626, a novel nucleoside analog: A randomized, placebo-controlled study in patients with chronic hepatitis C
    • doi:10.1002/hep. 22321
    • Roberts, S. K., Cooksley, G., Dore, G. J., Robson, R., Shaw, D., Berns, H., Hill, G., Klumpp, K., Najera, I., Washington, C., 2008. Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C. Hepatology, 48(2):398-406. [doi:10.1002/hep. 22321]
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 398-406
    • Roberts, S.K.1    Cooksley, G.2    Dore, G.J.3    Robson, R.4    Shaw, D.5    Berns, H.6    Hill, G.7    Klumpp, K.8    Najera, I.9    Washington, C.10
  • 118
    • 17044415559 scopus 로고    scopus 로고
    • Liver disease as a major cause of death among HIV infected patients: Role of hepatitis C and B viruses and alcohol
    • DOI 10.1016/j.jhep.2005.01.022, PII S0168827805001820
    • Salmon-Ceron, D., Lewden, C., Morlat, P., Bevilacqua, S., Jougla, E., Bonnet, F., Heripret, L., Costagliola, D., May, T., Chene, G., 2005. Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol. J. Hepatol., 42(6):799-805. [doi:10.1016/j.jhep. 2005.01.022] (Pubitemid 40693195)
    • (2005) Journal of Hepatology , vol.42 , Issue.6 , pp. 799-805
    • Salmon-Ceron, D.1    Lewden, C.2    Morlat, P.3    Bevilacqua, S.4    Jougla, E.5    Bonnet, F.6    Heripret, L.7    Costagliola, D.8    May, T.9    Chene, G.10
  • 119
    • 34247205808 scopus 로고    scopus 로고
    • SCH 503034, a Novel Hepatitis C Virus Protease Inhibitor, Plus Pegylated Interferon α-2b for Genotype 1 Nonresponders
    • DOI 10.1053/j.gastro.2007.01.041, PII S0016508507001801
    • Sarrazin, C., Rouzier, R., Wagner, F., Forestier, N., Larrey, D., Gupta, S. K., Hussain, M., Shah, A., Cutler, D., Zhang, J., et al., 2007. SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon α-2b for genotype 1 nonresponders. Gastroenterology, 132(4):1270-1278. [doi:10.1053/j.gastro.2007.01.041] (Pubitemid 46627577)
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1270-1278
    • Sarrazin, C.1    Rouzier, R.2    Wagner, F.3    Forestier, N.4    Larrey, D.5    Gupta, S.K.6    Hussain, M.7    Shah, A.8    Cutler, D.9    Zhang, J.10    Zeuzem, S.11
  • 120
    • 67650533718 scopus 로고    scopus 로고
    • Role of interferon response during RE-Treatment of null responders with boceprevir combination therapy: Results of phase II trial
    • doi:10.1016/S0016-5085 08 63527-1
    • Schiff, E., Poordad, F. F., Jacobson, I. M., Flamm, S. L., Bacon, B. R., Lawitz, E. J., Gordon, S. R., McHutchison, J. G., Ghalib, R., Poynard, T., et al., 2008. Role of interferon response during RE-Treatment of null responders with boceprevir combination therapy: results of phase II trial. Gastroenterology, 134(4):A755. [doi:10.1016/S0016-5085(08) 63527-1]
    • (2008) Gastroenterology , vol.134 , Issue.4
    • Schiff, E.1    Poordad, F.F.2    Jacobson, I.M.3    Flamm, S.L.4    Bacon, B.R.5    Lawitz, E.J.6    Gordon, S.R.7    McHutchison, J.G.8    Ghalib, R.9    Poynard, T.10
  • 121
    • 52449124695 scopus 로고    scopus 로고
    • NS5A-from obscurity to new target for HCV therapy
    • doi:10.2174/157489108784746597
    • Schmitz, U., Tan, S. L., 2008. NS5A-from obscurity to new target for HCV therapy. Recent Pat. Anti-Infect. Drug Discov., 3(2):77-92. [doi:10.2174/ 157489108784746597]
    • (2008) Recent Pat. Anti-Infect. Drug Discov. , vol.3 , Issue.2 , pp. 77-92
    • Schmitz, U.1    Tan, S.L.2
  • 122
    • 32644456874 scopus 로고    scopus 로고
    • Antiviral innate immunity pathways
    • DOI 10.1038/sj.cr.7310019, PII 7310019
    • Seth, R. B., Sun, L., Chen, Z. J., 2006. Antiviral innate immunity pathways. Cell Res., 16(2):141-147. [doi:10.1038/sj.cr. 7310019] (Pubitemid 43247969)
    • (2006) Cell Research , vol.16 , Issue.2 , pp. 141-147
    • Seth, R.B.1    Sun, L.2    Chen, Z.J.3
  • 123
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • DOI 10.1016/S1473-3099(05)70216-4, PII S1473309905702164
    • Shepard, C. W., Finelli, L., Alter, M. J., 2005. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis., 5(9):558-567. [doi:10.1016/S1473-3099(05) 70216-4] (Pubitemid 41196755)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.9 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 124
    • 67049145581 scopus 로고    scopus 로고
    • Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    • doi: 10.1128/AAC.01599-08
    • Shi, S. T., Herlihy, K. J., Graham, J. P., Nonomiya, J., Rahavendran, S. V., Skor, H., Irvine, R., Binford, S., Tatlock, J., Li, H., et al., 2009. Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Antimicrob. Agents Chemother., 53(6):2544-2552. [doi: 10.1128/AAC.01599-08]
    • (2009) Antimicrob. Agents Chemother. , vol.53 , Issue.6 , pp. 2544-2552
    • Shi, S.T.1    Herlihy, K.J.2    Graham, J.P.3    Nonomiya, J.4    Rahavendran, S.V.5    Skor, H.6    Irvine, R.7    Binford, S.8    Tatlock, J.9    Li, H.10
  • 125
    • 56849119315 scopus 로고    scopus 로고
    • Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCV NS5B polymerase with potent antiviral activity and a unique mechanism of action
    • Shih, I. H., Vliegen, I., Peng, B., Yang, H., Paeshuyse, J., Purstinger, G., Fenaux, M., Mabery, E., Bahador, G., Lehman, L. S., et al., 2007. Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCV NS5B polymerase with potent antiviral activity and a unique mechanism of action. Hepatology, 46(4):859A.
    • (2007) Hepatology , vol.46 , Issue.4
    • Shih, I.H.1    Vliegen, I.2    Peng, B.3    Yang, H.4    Paeshuyse, J.5    Purstinger, G.6    Fenaux, M.7    Mabery, E.8    Bahador, G.9    Lehman, L.S.10
  • 126
    • 7444256169 scopus 로고    scopus 로고
    • Genetic diversity and evolution of hepatitis C virus - 15 years on
    • DOI 10.1099/vir.0.80401-0
    • Simmonds, P., 2004. Genetic diversity and evolution of hepatitis C virus-15 years on. J. Gen. Virol., 85(11):3173-3188. [doi:10.1099/vir.0.80401-0] (Pubitemid 39445434)
    • (2004) Journal of General Virology , vol.85 , Issue.11 , pp. 3173-3188
    • Simmonds, P.1
  • 127
    • 84863030243 scopus 로고    scopus 로고
    • Characterization of the hepatoselective distribution of ACH-1625, a potent, clinical stage HCV NS3 protease inhibitor
    • doi:10.1016/S0168-8278 10 60772-6
    • Stauber, K., Marlor, C. W., Mushtaq, G., Gadhachanda, V., Pais, G., Hashimoto, A., Phadke, A., Huang, M., Deshpande, M., 2010. Characterization of the hepatoselective distribution of ACH-1625, a potent, clinical stage HCV NS3 protease inhibitor. J. Hepatol., 52 (S1): S299. [doi:10.1016/S0168-8278(10) 60772-6]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Stauber, K.1    Marlor, C.W.2    Mushtaq, G.3    Gadhachanda, V.4    Pais, G.5    Hashimoto, A.6    Phadke, A.7    Huang, M.8    Deshpande, M.9
  • 129
    • 67749111896 scopus 로고    scopus 로고
    • Cellular and molecular biology of HCV infection and hepatitis
    • doi:10.1042/CS20080631
    • Tang, H., Grise, H., 2009. Cellular and molecular biology of HCV infection and hepatitis. Clin. Sci., 117(2):49-65. [doi:10.1042/CS20080631]
    • (2009) Clin. Sci. , vol.117 , Issue.2 , pp. 49-65
    • Tang, H.1    Grise, H.2
  • 130
    • 42949145532 scopus 로고    scopus 로고
    • Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    • DOI 10.1371/journal.ppat.1000032
    • Tellinghuisen, T. L., Foss, K. L., 2008. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog., 4(3): e1000032. [doi:10.1371/journal.ppat.1000032] (Pubitemid 351631090)
    • (2008) PLoS Pathogens , vol.4 , Issue.3
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.3
  • 131
    • 75149195123 scopus 로고    scopus 로고
    • In vitro studies demonstrate that combinations of antiviral agents that include HCV polymerase inhibitor ANA598 have the potential to overcome viral resistance
    • Thompson, P. A., Patel, R., Showalter, R. E., Li, C., Applemon, J. R., Steffy, K., 2008. In vitro studies demonstrate that combinations of antiviral agents that include HCV polymerase inhibitor ANA598 have the potential to overcome viral resistance. Hepatology, 48(4):1164A.
    • (2008) Hepatology , vol.48 , Issue.4
    • Thompson, P.A.1    Patel, R.2    Showalter, R.E.3    Li, C.4    Applemon, J.R.5    Steffy, K.6
  • 132
    • 77953409062 scopus 로고    scopus 로고
    • Preclinical studies of ANA598 combined with other anti-HCV agents demonstrate potential of combination treatment
    • doi:10.1016/S0168-8278 09 60092-1
    • Thompson, P., Patel, R., Steffy, K., Appleman, J., 2009. Preclinical studies of ANA598 combined with other anti-HCV agents demonstrate potential of combination treatment. J. Hepatol., 50 (S1): S37. [doi:10.1016/S0168-8278(09) 60092-1]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Thompson, P.1    Patel, R.2    Steffy, K.3    Appleman, J.4
  • 133
    • 84863064484 scopus 로고    scopus 로고
    • In vitro combination of ANA598 with other anti-HCV agents can eliminate the emergence of resistant colonies
    • doi:10.1016/j.antiviral.2010. 02.415
    • Thompson, P., Showalter, R., Patel, R., Appleman, J., 2010a. In vitro combination of ANA598 with other anti-HCV agents can eliminate the emergence of resistant colonies. Antivir. Res., 86(1):A48. [doi:10.1016/j.antiviral.2010. 02.415]
    • (2010) Antivir. Res. , vol.86 , Issue.1
    • Thompson, P.1    Showalter, R.2    Patel, R.3    Appleman, J.4
  • 134
    • 84961723672 scopus 로고    scopus 로고
    • Enhanced in vitro antiviral activity of ANA598 in combination with other anti-HCV Agents support combination treatment
    • doi:10.1016/S0168-8278 10 60675-7
    • Thompson, P. A., Showalter, R. E., Patel, R. A., Appleman, J. R., 2010b. Enhanced in vitro antiviral activity of ANA598 in combination with other anti-HCV Agents support combination treatment. J. Hepatol., 52 (S1): S262. [doi:10.1016/S0168-8278(10) 60675-7]
    • (2010) J. Hepatol. , vol.52 , Issue.S1
    • Thompson, P.A.1    Showalter, R.E.2    Patel, R.A.3    Appleman, J.R.4
  • 135
    • 77952602256 scopus 로고    scopus 로고
    • Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease
    • doi:10.1128/AAC. 00135-10
    • Tong, X., Arasappan, A., Bennett, F., Chase, R., Feld, B., Guo, Z., Hart, A., Madison, V., Malcolm, B., Pichardo, J., et al., 2010. Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease. Antimicrob. Agents Chemother., 54(6):2365-2370. [doi:10.1128/AAC. 00135-10]
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.6 , pp. 2365-2370
    • Tong, X.1    Arasappan, A.2    Bennett, F.3    Chase, R.4    Feld, B.5    Guo, Z.6    Hart, A.7    Madison, V.8    Malcolm, B.9    Pichardo, J.10
  • 136
    • 75149114907 scopus 로고    scopus 로고
    • Genotypic characterisation of HCV NS5B following 8-day monotherapy with the polymerase inhibitor PF-00868554 in HCV-infected subjects
    • doi:10.1016/S0168-8278 09 60970-3
    • Troke, P., Lewis, M., Simpson, P., van der Ryst, E., Hammond, J., Craig, C., Perros, M., Westby, M., 2009. Genotypic characterisation of HCV NS5B following 8-day monotherapy with the polymerase inhibitor PF-00868554 in HCV-infected subjects. J. Hepatol., 50 (S1): S351. [doi:10.1016/S0168-8278(09) 60970-3]
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Troke, P.1    Lewis, M.2    Simpson, P.3    Van Der Ryst, E.4    Hammond, J.5    Craig, C.6    Perros, M.7    Westby, M.8
  • 137
    • 42349106424 scopus 로고    scopus 로고
    • GS-9190, a novel substituted imidazopyridine analogue, is a potent inhibitor of hepatitis C virus replication in vitro and remains active against known drug resistant mutants
    • Vliegen, I., Paeshuyse, J., Marbery, E., Peng, B., Shih, H., Lehman, L. S., Dutartre, H., Selisko, B., Canard, B., Bondy, S., et al., 2007. GS-9190, a novel substituted imidazopyridine analogue, is a potent inhibitor of hepatitis C virus replication in vitro and remains active against known drug resistant mutants. Hepatology, 46(4):855A.
    • (2007) Hepatology , vol.46 , Issue.4
    • Vliegen, I.1    Paeshuyse, J.2    Marbery, E.3    Peng, B.4    Shih, H.5    Lehman, L.S.6    Dutartre, H.7    Selisko, B.8    Canard, B.9    Bondy, S.10
  • 140
    • 0036791538 scopus 로고    scopus 로고
    • HCV RNA-dependent RNA polymerase as a target for antiviral development
    • doi:10.1016/S1471-4892 02 00195-9
    • Walker, M. P., Hong, Z., 2002. HCV RNA-dependent RNA polymerase as a target for antiviral development. Cur. Opin. Pharmacol., 2(5):534-540. [doi:10.1016/S1471-4892(02) 00195-9]
    • (2002) Cur. Opin. Pharmacol. , vol.2 , Issue.5 , pp. 534-540
    • Walker, M.P.1    Hong, Z.2
  • 141
    • 0027153210 scopus 로고
    • Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism
    • Wang, C., Sarnow, P., Siddiqui, A., 1993. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J. Virol., 67(6):3338-3344. (Pubitemid 23143708)
    • (1993) Journal of Virology , vol.67 , Issue.6 , pp. 3338-3344
    • Wang, C.1    Sarnow, P.2    Siddiqui, A.3
  • 142
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin a suppresses replication of hepatitis c virus genome in cultured hepatocytes
    • DOI 10.1053/jhep.2003.50449
    • Watashi, K., Hijikata, M., Hosaka, M., Yamaji, M., Shimotohno, K., 2003. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology, 38(5):1282-1288. [doi:10.1053/jhep. 2003.50449] (Pubitemid 37314838)
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1282-1288
    • Watashi, K.1    Hijikata, M.2    Hosaka, M.3    Yamaji, M.4    Shimotohno, K.5
  • 143
    • 67650700013 scopus 로고    scopus 로고
    • Telaprevir: Hope on the horizon, getting closer
    • doi:10.1016/j.cld.2009.05.009
    • Weisberg, I. S., Jacobson, I. M., 2009. Telaprevir: hope on the horizon, getting closer. Clin. Liver Dis., 13(3):441-452. [doi:10.1016/j.cld.2009.05.009]
    • (2009) Clin. Liver Dis. , vol.13 , Issue.3 , pp. 441-452
    • Weisberg, I.S.1    Jacobson, I.M.2
  • 146
    • 0031850395 scopus 로고    scopus 로고
    • High prevalence of hepatitis C virus genotype 6 among certain risk groups in Hong Kong
    • DOI 10.1023/A:1007400304726
    • Wong, D. A., Tong, L. K., Lim, W., 1998. High prevalence of hepatitis C virus genotype 6 among certain risk groups in Hong Kong. Eur. J. Epidemiol., 14(5):421-426. [doi:10.1023/A:1007400304726] (Pubitemid 28370776)
    • (1998) European Journal of Epidemiology , vol.14 , Issue.5 , pp. 421-426
    • Wong, D.A.1    Tong, L.K.2    Lim, W.3
  • 147
    • 56849091583 scopus 로고    scopus 로고
    • Preclinical pharmacokinetic characterization of GS-9190, a novel non-nucleoside HCV NS5B polymerase inhibitor
    • Yang, C., Wang, Y., Wieman, L., Eisenberg, E., Lee, M., Murray, B., Tong, L., Ray, A., Bondy, S., Tse, W., et al., 2007. Preclinical pharmacokinetic characterization of GS-9190, a novel non-nucleoside HCV NS5B polymerase inhibitor. Hepatology, 46(4):860A-861A.
    • (2007) Hepatology , vol.46 , Issue.4
    • Yang, C.1    Wang, Y.2    Wieman, L.3    Eisenberg, E.4    Lee, M.5    Murray, B.6    Tong, L.7    Ray, A.8    Bondy, S.9    Tse, W.10
  • 148
    • 0037332361 scopus 로고    scopus 로고
    • 3 nontranslated RNA signals required for replication of hepatitis C virus RNA
    • DOI 10.1128/JVI.77.6.3557-3568.2003
    • Yi, M., Lemon, S. M., 2003. 3'-nontranslated RNA signals required for replication of hepatitis C virus RNA. J. Virol., 77(6):3557-3568. [doi:10.1128/JVI.77.6.3557-3568.2003] (Pubitemid 36297275)
    • (2003) Journal of Virology , vol.77 , Issue.6 , pp. 3557-3568
    • Yi, M.1    Lemon, S.M.2
  • 150
    • 67650538785 scopus 로고    scopus 로고
    • IDX184, a liver-targeted nucleotide HCV polymerase inhibitor: Results of a first-in-man safety and pharmacokinetic study
    • doi:10.1016/S0168-8278 09 60968-5
    • Zhou, X. J., Pietropaolo, K., Sullivan-Bolyai, J., Kuca, B., Liu, W., Xu, L., Belanger, B., Khan, S., Mayers, D., 2009. IDX184, a liver-targeted nucleotide HCV polymerase inhibitor: results of a first-in-man safety and pharmacokinetic study. J. Hepatol., 50 (S1): S351. [doi:10.1016/S0168-8278(09) 60968-5]X
    • (2009) J. Hepatol. , vol.50 , Issue.S1
    • Zhou, X.J.1    Pietropaolo, K.2    Sullivan-Bolyai, J.3    Kuca, B.4    Liu, W.5    Xu, L.6    Belanger, B.7    Khan, S.8    Mayers, D.9


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