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503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders.
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Sarrazin C, Rouzier R, Wagner F, Forestier N, Larrey D, Gupta SK, Hussain M, Shah A, Cutler D, Zhang J, Zeuzem S : SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders. Gastroenterology 2007 132 : 1270 1278
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Kwo P, Lawitz E, McCone J, Schiff ER, Vierling JM, Pound D, Davis M, Galati JS, Gordon SC, Ravendhran N, Rossaro L, Anderson FH, Jacobson I, Rubin R, Koury K, Chaudhri EI, Albrecht JK : HCV SPRINT-1: boceprevir plus peginterferon-alfa-2b/ribavirin for treatment of genotype 1 chronic hepatitis C in previously untreated patients. Presented at the 59th Annual Meeting of the American Association for the Study of Liver Diseases October 31-November 4, 2008; San Francisco, CA.
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HCV SPRINT-1: Boceprevir Plus peginterferon-alfa-2b/ribavirin for Treatment of Genotype 1 Chronic Hepatitis C in Previously Untreated Patients
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36
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Schiff ER, Poordad F, Jacobson I, Flamm S, Bacon B, Lawitz E, Gordon SC, Mchutchison JG, Ghalib R, Poynard T, Sulkowski M, Trepo C, Rizzetto M, Zeuzem S, Marcellin P, Mendez P, Brass C, Albrecht JK : Boceprevir (B) combination therapy in null responders (NR): Response dependent on interferon responsiveness. Presented at the 41st Annual Meeting of the European Association for the Study of the Liver April 23-27, 2008; Milan, Italy.
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Boceprevir (B) Combination Therapy in Null Responders (NR): Response Dependent on Interferon Responsiveness
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Schiff, E.R.1
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37
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67650380159
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Presented at the 41st Annual Meeting of the European Association for the Study of the Liver. April 23-27, 2008; Milan, Italy.
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Reesink H, Verloes R, Abou Farha K, Van Vliet A, Weegink C, van't Klooster G, Aharchi F, Marien K, Van Remoortere P, de Kock H, Broeckaert F, Fanning G, Meyvisch P, Van Beirendonck E, Simmen K : Safety of the HCV protease inhibitor TMC435350 in healthy volunteers and safety and activity in chronic hepatitis C infected individuals: A phase 1 study. Presented at the 41st Annual Meeting of the European Association for the Study of the Liver April 23-27, 2008; Milan, Italy.
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Safety of the HCV Protease Inhibitor TMC435350 in Healthy Volunteers and Safety and Activity in Chronic Hepatitis C Infected Individuals: A Phase 1 Study
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Reesink, H.1
Verloes, R.2
Abou Farha, K.3
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Robust antiviral activity of R1626, a novel nucleoside analog: A randomized, placebo-controlled study in patients with chronic hepatitis C
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R1626 plus peginterferon Alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin
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High relapse rate seen at week 72 for patients treated with R1626 combination therapy
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Pockros P, Nelson D, Godofsky E, Rodriguez-Torres M, Everson GT, Fried MW, Ghalib R, Harrison S, Nyberg L, Shiffman ML, Chan A, Hill G : High relapse rate seen at week 72 for patients treated with R1626 combination therapy. Hepatology 2008 48 : 1349 1350
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41
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Reddy R, Rodriguez-Torres M, Gane E, Robson R, Lalezari J, Everson GT, DeJesus E, Mchutchison JG, Vargas HE, Beard A, Rodriguez CA, Hill G, Symonds W, Berrey M : Antiviral activity, pharmacokinetics, safety, and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy. Presented at the 57th Annual Meeting of the American Association for the Study of Liver Diseases October 27-31, 2006, Boston, MA.
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Antiviral Activity, Pharmacokinetics, Safety, and Tolerability of R7128, A Novel Nucleoside HCV RNA Polymerase Inhibitor, Following Multiple, Ascending, Oral Doses in Patients with HCV Genotype 1 Infection Who Have Failed Prior Interferon Therapy
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Reddy, R.1
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Gane E, Rodriguez-Torres M, Nelson D, Jacobson I, Mchutchison JG, Jeffers L, Beard A, Walker S, Shulman N, Symonds W, Albanis E, Berrey M : Antiviral activity of the HCV nucleoside polymerase inhibitor R7128 in HCV genotype 2 and 3 prior non-responders: interim results of R7128 1500 mg bid with peg-IFN and ribavirin for 28 days. Presented at the 59th Annual Meeting of the American Association for the Study of Liver Diseases October 31-November 4, 2008; San Francisco, CA.
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Antiviral Activity of the HCV Nucleoside Polymerase Inhibitor R7128 in HCV Genotype 2 and 3 Prior Non-responders: Interim Results of R7128 1500 Mg Bid with Peg-IFN and Ribavirin for 28 Days
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Gane, E.1
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Standring DN, Lanford R, Cretton-Scott E, Licklider L, Larsson M, Pierra C, Gosselin G, Perigaud C, Surleraux D, Mayes B, Moussa A, Selden J : Potent antiviral activity of second generation nucleoside inhibitors, IDX102 and IDX 184, in HCV-infected chimpanzees. Presented at the 41st Annual Meeting of the European Association for the Study of the Liver April 23-27, 2008; Milan, Italy.
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Potent Antiviral Activity of Second Generation Nucleoside Inhibitors, IDX102 and IDX 184, in HCV-infected Chimpanzees
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Standring, D.N.1
Lanford, R.2
Cretton-Scott, E.3
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45
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67650362027
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Nettles R, Chien C, Persson A, Min Gao Belema M, Meanwell NA, DeMicco M, Marbury TC, Goldwater R, Northup P, Coumbis J, Kraft WK, Charlton M, Lopez-Talavera JC, Grasela D : BMS-790052 is a first-in-class potent hepatitis C virus (HCV) NS5A inhibitor for patients with chronic HCV infection: Results from a proof-of-concept study. Presented at the 59th Annual Meeting of the American Association for the Study of Liver Diseases October 31-November 4, 2008, San Francisco, CA.
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BMS-790052 Is A First-in-class Potent Hepatitis C Virus (HCV) NS5A Inhibitor for Patients with Chronic HCV Infection: Results from A Proof-of-concept Study
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Nettles, R.1
Chien, C.2
Persson, A.3
Min Gao Belema, M.4
Meanwell, N.A.5
Demicco, M.6
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Flisiak R, Horban A, Gallay P, Bobardt M, Selvarajah S, Wiercinska-Drapalo A, Siwak E, Cielniak I, Higersberger J, Kierkus J, Aeschlimann C, Grosgurin P, Nicolas-Metral V, Dumont JM, Porchet H, Crabbe R, Scalfaro P : The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology 2008 47 : 817 826
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Dumont, J.M.14
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47
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Presented at the 41st Annual Meeting of the European Association for the Study of the Liver. April 23-27, 2008; Milan, Italy.
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Flisiak R, Feinman SV, Jablowski M, Horban A, Kryczka W, Halota W, Heathcote JE, Mazzella G, Vandelli C, Liz JS, Crabbz R, Scalfaro P, Porchet H : Efficacy and safety of increasing doses of the cyclophilin inhibitor Debio 025 in combination with pegylated interferon alpha-2a in treatment naïve chronic HCV patients. Presented at the 41st Annual Meeting of the European Association for the Study of the Liver April 23-27, 2008; Milan, Italy.
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Efficacy and Safety of Increasing Doses of the Cyclophilin Inhibitor Debio 025 in Combination with Pegylated Interferon alpha-2a in Treatment Naïve Chronic HCV Patients
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Flisiak, R.1
Feinman, S.V.2
Jablowski, M.3
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Rossignol JF, Kabil SM, El-Gohary Y, Elfert A, Keeffe EB : Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4. Aliment Pharmacol Ther 2008 April 23-27, 2008 28 : 574 580
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Randomized Controlled Trial of Nitazoxanide-peginterferon-ribavirin, Nitazoxanide-peginterferon and Peginterferon-ribavirin in the Treatment of Patients with Chronic Hepatitis C Genotype 4
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Rossignol, J.F.1
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