VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 5, 2006, Pages 1813-1822

  Lin, Kai ^a   Perni, Robert B ^a   Kwong, Ann D ^a   Lin, Chao ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CILUPREVIR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; VX 950;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REPLICON; VIRUS RESISTANCE;

ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; HEPACIVIRUS; HEPATOCYTES; HUMANS; INHIBITORY CONCENTRATION 50; INTERFERON TYPE I, RECOMBINANT; LEUKOCYTES, MONONUCLEAR; LIVER NEOPLASMS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEIN BINDING; RATS; REPLICON; RNA, VIRAL;

EID: 33646446894     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.5.1813-1822.2006     Document Type: Article

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