-
1
-
-
0034094873
-
Glutamine repeats and neurodegeneration
-
Zoghbi, H.Y. and Orr, H.T. (2000) Glutamine repeats and neurodegeneration. Annu. Rev. Neurosci., 23, 217-247.
-
(2000)
Annu. Rev. Neurosci.
, vol.23
, pp. 217-247
-
-
Zoghbi, H.Y.1
Orr, H.T.2
-
2
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
Taylor, J.P., Hardy, J. and Fischbeck, K.H. (2002) Toxic proteins in neurodegenerative disease. Science, 296, 1991-1995.
-
(2002)
Science
, vol.296
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
3
-
-
65849122227
-
Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration
-
Garden, G.A. and La Spada, A.R. (2008) Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration. Cerebellum., 7, 138-149.
-
(2008)
Cerebellum
, vol.7
, pp. 138-149
-
-
Garden, G.A.1
La Spada, A.R.2
-
5
-
-
20844441094
-
Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity
-
McMahon, S.J., Pray-Grant, M.G., Schieltz, D., Yates, J.R. and Grant, P.A. (2005) Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. Proc. Natl Acad. Sci., 102, 8478-8482.
-
(2005)
Proc. Natl Acad. Sci.
, vol.102
, pp. 8478-8482
-
-
McMahon, S.J.1
Pray-Grant, M.G.2
Schieltz, D.3
Yates, J.R.4
Grant, P.A.5
-
6
-
-
33947532026
-
Histone acetyltransferase complexes: one size doesn't fit all
-
Lee, K.K. and Workman, J.L. (2007) Histone acetyltransferase complexes: one size doesn't fit all. Nat. Rev. Mol. Cell Biol., 8, 284-295.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 284-295
-
-
Lee, K.K.1
Workman, J.L.2
-
7
-
-
0032516156
-
Function of TAFII-containing complex without TBP in transcription by RNA polymerase II
-
Wieczorek, E., Brand, M., Jacq, X. and Tora, L. (1998) Function of TAFII-containing complex without TBP in transcription by RNA polymerase II. Nature, 393, 187-191.
-
(1998)
Nature
, vol.393
, pp. 187-191
-
-
Wieczorek, E.1
Brand, M.2
Jacq, X.3
Tora, L.4
-
8
-
-
0033603317
-
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction
-
Brand, M., Yamamoto, K., Staub, A. and Tora, L. (1999) Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J. Biol. Chem., 274, 18285-18289.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18285-18289
-
-
Brand, M.1
Yamamoto, K.2
Staub, A.3
Tora, L.4
-
9
-
-
0032508406
-
A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID
-
Martinez, E., Kundu, T.K., Fu, J. and Roeder, R.G. (1998) A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. J. Biol. Chem., 273, 23781-23785.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 23781-23785
-
-
Martinez, E.1
Kundu, T.K.2
Fu, J.3
Roeder, R.G.4
-
10
-
-
0032504040
-
Histone-like TAFs within the PCAF histone acetylase complex
-
Ogryzko, V.V., Kotani, T., Zhang, X., Schiltz, R.L., Howard, T., Yang, X.J., Howard, B.H., Qin, J. and Nakatani, Y. (1998) Histone-like TAFs within the PCAF histone acetylase complex. Cell, 94, 35-44.
-
(1998)
Cell
, vol.94
, pp. 35-44
-
-
Ogryzko, V.V.1
Kotani, T.2
Zhang, X.3
Schiltz, R.L.4
Howard, T.5
Yang, X.J.6
Howard, B.H.7
Qin, J.8
Nakatani, Y.9
-
11
-
-
34547864553
-
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation
-
Nagy, Z. and Tora, L. (2007) Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Oncogene, 26, 5341-5357.
-
(2007)
Oncogene
, vol.26
, pp. 5341-5357
-
-
Nagy, Z.1
Tora, L.2
-
12
-
-
0031876314
-
Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III
-
Tse, C., Sera, T., Wolffe, A.P. and Hansen, J.C. (1998) Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Mol. Cell. Biol., 18, 4629-4638.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 4629-4638
-
-
Tse, C.1
Sera, T.2
Wolffe, A.P.3
Hansen, J.C.4
-
13
-
-
32444434989
-
Histone H4-K16 acetylation controls chromatin structure and protein interactions
-
Shogren-Knaak, M., Ishii, H., Sun, J.M., Pazin, M.J., Davie, J.R. and Peterson, C.L. (2006) Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science, 311, 844-847.
-
(2006)
Science
, vol.311
, pp. 844-847
-
-
Shogren-Knaak, M.1
Ishii, H.2
Sun, J.M.3
Pazin, M.J.4
Davie, J.R.5
Peterson, C.L.6
-
14
-
-
0033639208
-
Distribution of Ataxin7 in normal human brain and retina
-
Cancel, G., Duyckaerts, C., Holmberg, M., Zander, C., Yvert, G., Lebre, A.S., Ruberg, M., Faucheux, B., Agid, Y., Hirsch, E. and Brice, A. (2000) Distribution of Ataxin7 in normal human brain and retina. Brain, 123, 2519-2530.
-
(2000)
Brain
, vol.123
, pp. 2519-2530
-
-
Cancel, G.1
Duyckaerts, C.2
Holmberg, M.3
Zander, C.4
Yvert, G.5
Lebre, A.S.6
Ruberg, M.7
Faucheux, B.8
Agid, Y.9
Hirsch, E.10
Brice, A.11
-
15
-
-
0033919033
-
Expression analysis of Ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulation
-
Lindenberg, K.S., Yvert, G., Müller, K. and Landwehrmeyer, G.B. (2000) Expression analysis of Ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulation. Brain Pathol., 10, 385-394.
-
(2000)
Brain Pathol
, vol.10
, pp. 385-394
-
-
Lindenberg, K.S.1
Yvert, G.2
Müller, K.3
Landwehrmeyer, G.B.4
-
16
-
-
0037138354
-
Cloning and expression analysis of the murine homolog of the spinocerebellar ataxia type 7 (SCA7) gene
-
Ströma, A.L., Jonassona, J., Harta, P., Brännströmb, T., Forsgrenc, L. and Holmberg, M. (2002) Cloning and expression analysis of the murine homolog of the spinocerebellar ataxia type 7 (SCA7) gene. Gene, 285, 91-99.
-
(2002)
Gene
, vol.285
, pp. 91-99
-
-
Ströma, A.L.1
Jonassona, J.2
Harta, P.3
Brännströmb, T.4
Forsgrenc, L.5
Holmberg, M.6
-
17
-
-
33646378692
-
Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal
-
Taylor, J., Grote, S.K., Xia, J., Vandelft, M., Graczyk, J., Ellerby, E.M., La Spada, A.R. and Truant, R. (2006) Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal. J. Biol. Chem., 281, 2730-2739.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2730-2739
-
-
Taylor, J.1
Grote, S.K.2
Xia, J.3
Vandelft, M.4
Graczyk, J.5
Ellerby, E.M.6
La Spada, A.R.7
Truant, R.8
-
18
-
-
14044266141
-
RNA association and nucleocytoplasmic shuttling by ataxin-1
-
Irwin, S., Vandelft, M., Pinchev, D., Howell, J.L., Graczyk, J., Orr, H.T. and Truant, R. (2005) RNA association and nucleocytoplasmic shuttling by ataxin-1. J. Cell Sci., 118, 233-242.
-
(2005)
J. Cell Sci.
, vol.118
, pp. 233-242
-
-
Irwin, S.1
Vandelft, M.2
Pinchev, D.3
Howell, J.L.4
Graczyk, J.5
Orr, H.T.6
Truant, R.7
-
19
-
-
3042771651
-
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
-
Helmlinger, D., Hardy, S., Sasorith, S., Klein, F., Robert, F., Weber, C., Miguet, L., Potier, N., Van-Dorsselaer, A., Wurtz, J.M. et al. (2004) Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum. Mol. Genet., 13, 1257-1265.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 1257-1265
-
-
Helmlinger, D.1
Hardy, S.2
Sasorith, S.3
Klein, F.4
Robert, F.5
Weber, C.6
Miguet, L.7
Potier, N.8
Van-Dorsselaer, A.9
Wurtz, J.M.10
-
20
-
-
78651093463
-
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia
-
Kahle, J.J., Gulbahce, N., Shaw, C.A., Lim, J., Hill, D.E., Barabási, A.L. and Zoghbi, H.Y. (2011) Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Hum. Mol. Genet., 20, 510-527.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 510-527
-
-
Kahle, J.J.1
Gulbahce, N.2
Shaw, C.A.3
Lim, J.4
Hill, D.E.5
Barabási, A.L.6
Zoghbi, H.Y.7
-
21
-
-
65249134306
-
Identification of microtubule-binding domains on microtubule-associated proteins by major coat phage display technique
-
Cao, B. and Mao, C. (2009) Identification of microtubule-binding domains on microtubule-associated proteins by major coat phage display technique. Biomacromolecules, 10, 555-564.
-
(2009)
Biomacromolecules
, vol.10
, pp. 555-564
-
-
Cao, B.1
Mao, C.2
-
22
-
-
0008538685
-
A protein factor essential for microtubule assembly
-
Weingarten, M.D., Lockwood, A.H., Hwo, S.Y. and Kirschner, M.W. (1975) A protein factor essential for microtubule assembly. Proc. Natl Acad. Sci., 72, 1858-1862.
-
(1975)
Proc. Natl Acad. Sci.
, vol.72
, pp. 1858-1862
-
-
Weingarten, M.D.1
Lockwood, A.H.2
Hwo, S.Y.3
Kirschner, M.W.4
-
23
-
-
0033152450
-
Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
-
Gleeson, J.G., Lin, P.T., Flanagan, L.A. and Walsh, C.A. (1999) Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron, 23, 257-271.
-
(1999)
Neuron
, vol.23
, pp. 257-271
-
-
Gleeson, J.G.1
Lin, P.T.2
Flanagan, L.A.3
Walsh, C.A.4
-
24
-
-
0032832998
-
Doublecortin, a stabilizer of microtubules
-
Horesh, D., Sapir, T., Francis, F., Wolf, S.G., Caspi, M., Elbaum, M., Chelly, J. and Reiner, O. (1999) Doublecortin, a stabilizer of microtubules. Hum. Mol. Genet., 8, 1599-1610.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1599-1610
-
-
Horesh, D.1
Sapir, T.2
Francis, F.3
Wolf, S.G.4
Caspi, M.5
Elbaum, M.6
Chelly, J.7
Reiner, O.8
-
25
-
-
0023293040
-
Microtubules containing acetylated alpha-tubulin in mammalian cells in culture
-
Piperno, G., LeDizet, M. and Chang, X.J. (1987) Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J. Biol. Chem., 104, 289-302.
-
(1987)
J. Biol. Chem.
, vol.104
, pp. 289-302
-
-
Piperno, G.1
LeDizet, M.2
Chang, X.J.3
-
26
-
-
0000297058
-
Taxol stabilizes microtubules in mouse fibroblast cells
-
Schiff, P.B. and Horwitz, S.B. (1980) Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl Acad. Sci., 77, 1561-1565.
-
(1980)
Proc. Natl Acad. Sci.
, vol.77
, pp. 1561-1565
-
-
Schiff, P.B.1
Horwitz, S.B.2
-
27
-
-
0017227021
-
Interaction of noncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin
-
Hoebeke, J., Nijena, G.V. and Brabanderb, M.D. (1976) Interaction of noncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin. Biochem. Biophys. Res. Commun., 69, 319-324.
-
(1976)
Biochem. Biophys. Res. Commun.
, vol.69
, pp. 319-324
-
-
Hoebeke, J.1
Nijena, G.V.2
Brabanderb, M.D.3
-
28
-
-
0037154229
-
Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment
-
Muchowski, P.J., Ning, K., D'Souza-Schorey, C. and Fields, S. (2002) Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment. Proc. Natl Acad. Sci., 99, 727-732.
-
(2002)
Proc. Natl Acad. Sci.
, vol.99
, pp. 727-732
-
-
Muchowski, P.J.1
Ning, K.2
D'Souza-Schorey, C.3
Fields, S.4
-
29
-
-
0038387873
-
Conserved microtubule-actin interactions in cell movement and morphogenesis
-
Rodriguez, O.C., Schaefer, A.W., Mandato, C.A., Forscher, P., Bement, W.M. and Waterman-Storer, C.M. (2003) Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat. Cell. Biol., 5, 599-609.
-
(2003)
Nat. Cell. Biol.
, vol.5
, pp. 599-609
-
-
Rodriguez, O.C.1
Schaefer, A.W.2
Mandato, C.A.3
Forscher, P.4
Bement, W.M.5
Waterman-Storer, C.M.6
-
30
-
-
77952328557
-
The spectraplakin short stop is an actin-microtubule cross-linker that contributes to organization of the microtubule network
-
Applewhite, D.A., Grode, K.D., Keller, D., Zadeh, A.D., Slep, K.C. and Rogers, S.L. (2010) The spectraplakin short stop is an actin-microtubule cross-linker that contributes to organization of the microtubule network. Mol. Biol. Cell., 21, 1714-1724.
-
(2010)
Mol. Biol. Cell.
, vol.21
, pp. 1714-1724
-
-
Applewhite, D.A.1
Grode, K.D.2
Keller, D.3
Zadeh, A.D.4
Slep, K.C.5
Rogers, S.L.6
-
31
-
-
33144469085
-
Glutamine-expanded Ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction
-
Helmlinger, D., Hardy, S., Abou-Sleymane, G., Eberlin, A., Bowman, A.B., Gansmüller, A., Picaud, S., Zoghbi, H.Y., Trottier, Y., Tora, L. et al. (2006) Glutamine-expanded Ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. PLoS Biol., 4, e67.
-
(2006)
PLoS Biol
, vol.4
-
-
Helmlinger, D.1
Hardy, S.2
Abou-Sleymane, G.3
Eberlin, A.4
Bowman, A.B.5
Gansmüller, A.6
Picaud, S.7
Zoghbi, H.Y.8
Trottier, Y.9
Tora, L.10
-
32
-
-
33748695582
-
Transcriptional alterations and chromatin remodeling in polyglutamine diseases
-
Helmlinger, D., Tora, L. and Devys, D. (2006) Transcriptional alterations and chromatin remodeling in polyglutamine diseases. Trends Genet., 22, 562-570.
-
(2006)
Trends Genet
, vol.22
, pp. 562-570
-
-
Helmlinger, D.1
Tora, L.2
Devys, D.3
-
33
-
-
3142636768
-
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
-
Gauthier, L.R., Charrin, B.C., Borrell-Pages, M., Dompierre, J.P., Rangone, H., Cordelieres, F.P., De Mey, J., MacDonald, M.E., Lessmann, V., Humbert, S. and Saudou, F. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell, 118, 127-138.
-
(2004)
Cell
, vol.118
, pp. 127-138
-
-
Gauthier, L.R.1
Charrin, B.C.2
Borrell-Pages, M.3
Dompierre, J.P.4
Rangone, H.5
Cordelieres, F.P.6
De Mey, J.7
MacDonald, M.E.8
Lessmann, V.9
Humbert, S.10
Saudou, F.11
-
34
-
-
67649826155
-
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
-
Morfini, G.A., You, Y.M., Pollema, S.L., Kaminska, A., Liu, K., Yoshioka, K., Bjorkblom, B., Coffey, E.T., Bagnato, C., Han, D. et al. (2009) Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat. Neurosci., 12, 864-871.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 864-871
-
-
Morfini, G.A.1
You, Y.M.2
Pollema, S.L.3
Kaminska, A.4
Liu, K.5
Yoshioka, K.6
Bjorkblom, B.7
Coffey, E.T.8
Bagnato, C.9
Han, D.10
-
35
-
-
0031867231
-
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
-
Velier, J., Kim, M., Schwarz, C., Kim, T.W., Sapp, E., Chase, K., Aronin, N. and DiFiglia, M. (1998) Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp. Neurol., 152, 34-40.
-
(1998)
Exp. Neurol.
, vol.152
, pp. 34-40
-
-
Velier, J.1
Kim, M.2
Schwarz, C.3
Kim, T.W.4
Sapp, E.5
Chase, K.6
Aronin, N.7
DiFiglia, M.8
-
36
-
-
29244462838
-
In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets
-
Zhai, Z., Jeong, H., Cui, L., Krainc, D. and Tjian, R. (2005) In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell, 123, 1241-1253.
-
(2005)
Cell
, vol.123
, pp. 1241-1253
-
-
Zhai, Z.1
Jeong, H.2
Cui, L.3
Krainc, D.4
Tjian, R.5
-
37
-
-
35648964788
-
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation
-
Young, J.E., Gouw, L., Propp, S., Sopher, B.L., Taylor, J., Lin, A., Hermal, E., Logvinova, A., Chen, S.F., Chen, S., Bredesen, D.E., Truant, R., Ptacek, L.J., La Spada, A.R. and Ellerby, L.M. (2007) Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J. Biol. Chem., 282, 30150-30160.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 30150-30160
-
-
Young, J.E.1
Gouw, L.2
Propp, S.3
Sopher, B.L.4
Taylor, J.5
Lin, A.6
Hermal, E.7
Logvinova, A.8
Chen, S.F.9
Chen, S.10
Bredesen, D.E.11
Truant, R.12
Ptacek, L.J.13
La Spada, A.R.14
Ellerby, L.M.15
-
38
-
-
0347287040
-
Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization
-
Chen, S., Peng, G.H., Wang, X., Smith, A.C., Grote, S.G., Sopher, B.L. and La Spada, A.R. (2004) Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization. Hum. Mol. Genet., 13, 53-67.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 53-67
-
-
Chen, S.1
Peng, G.H.2
Wang, X.3
Smith, A.C.4
Grote, S.G.5
Sopher, B.L.6
La Spada, A.R.7
-
39
-
-
0037223823
-
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
-
Hergovich, A., Lisztwan, J., Barry, R., Ballschmieter, P. and Krek, W. (2003) Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat. Cell. Biol., 5, 64-70.
-
(2003)
Nat. Cell. Biol.
, vol.5
, pp. 64-70
-
-
Hergovich, A.1
Lisztwan, J.2
Barry, R.3
Ballschmieter, P.4
Krek, W.5
-
40
-
-
17944370599
-
Polyglutamine-expanded ataxin-7 antagonizes CRX function and induced cone-rod dystrophy in a mouse model of SCA7
-
La Spada, A.R., Fu, Y.-H., Sopher, B.L., Libby, R.T., Wang, X., Li, L.Y., Einum, D.D., Huang, J., Possin, D.E., Smith, A.C. et al. (2001) Polyglutamine-expanded ataxin-7 antagonizes CRX function and induced cone-rod dystrophy in a mouse model of SCA7. Neuron, 31, 913-927.
-
(2001)
Neuron
, vol.31
, pp. 913-927
-
-
La Spada, A.R.1
Fu, Y.-H.2
Sopher, B.L.3
Libby, R.T.4
Wang, X.5
Li, L.Y.6
Einum, D.D.7
Huang, J.8
Possin, D.E.9
Smith, A.C.10
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