Conformational dynamics of abasic DNA upon interactions with AP endonuclease 1 revealed by stopped-flow fluorescence analysis

Biochemistry

Volumn 51, Issue 6, 2012, Pages 1306-1321

  Kanazhevskaya, Lyubov Yu ^a   Koval, Vladimir V ^a,b   Vorobjev, Yury N ^a,b   Fedorova, Olga S ^a,b  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

2-AMINOPURINE; ALKYLATING AGENTS; AMINO ACID RESIDUES; AP-SITES; CATALYTIC CYCLES; CONFORMATIONAL DYNAMICS; CONFORMATIONAL FLEXIBILITY; CONFORMATIONAL TRANSITIONS; DNA LESIONS; DNA SUBSTRATES; ENDONUCLEASES; FLUORESCENCE ANALYSIS; FLUORESCENCE INTENSITIES; HUMAN CELLS; KINETIC SCHEME; MOLECULAR DYNAMICS SIMULATIONS; OXYGEN RADICAL; PHOSPHODIESTERS; REACTION STEPS; REAL TIME; SPECIFIC BINDING; STOPPED FLOW; STOPPED-FLOW TECHNIQUES; STRUCTURAL DISTORTIONS; TRP-FLUORESCENCE;

AMINO ACIDS; FLUORESCENCE; IONIZING RADIATION; MOLECULAR DYNAMICS; RATE CONSTANTS; SUBSTRATES;

DNA;

2 AMINOPURINE; APURINIC APYRIMIDINIC DEOXYRIBONUCLEASE I; DEOXYRIBONUCLEASE I; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA BINDING; DNA CONFORMATION; DNA DAMAGE; DNA PROTEIN COMPLEX; FLUORESCENCE ANALYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; STEADY STATE;

2-AMINOPURINE; CATALYSIS; DNA; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FLUORESCENT DYES; HUMANS; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID HETERODUPLEXES; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

EID: 84856939661     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201444m     Document Type: Article

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