Conformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair

Biochemistry

Volumn 49, Issue 30, 2010, Pages 6451-6461

  Kanazhevskaya, Lyubov Yu ^a   Koval, Vladimir V ^a,b   Zharkov, Dmitry O ^a,b   Strauss, Phyllis R ^c   Fedorova, Olga S ^a,b  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AP-SITES; BASE EXCISION REPAIRS; BINDING AFFINITIES; CATALYTIC CYCLES; CATALYTIC PROCESS; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; CONFORMATIONAL TRANSITIONS; DNA DUPLEXES; ENDONUCLEASES; ENZYME ACTIVE SITES; FLUORESCENCE TITRATIONS; HIGH FLEXIBILITY; HUMAN CELLS; INTRINSIC TRYPTOPHAN FLUORESCENCES; NON-SPECIFIC INTERACTIONS; PHOSPHODIESTERS; STOPPED FLOW; STOPPED FLOW EXPERIMENTS; SUBSTRATE RECOGNITION; TETRA-HYDROFURAN; TWO-STEP KINETICS; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; DNA; ENZYMES; EQUILIBRIUM CONSTANTS; FLUORESCENCE; GENES; LIGANDS; PHOSPHATASES; RATE CONSTANTS; SUBSTRATES;

CONFORMATIONS;

DEOXYGUANOSINE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE 1; DOUBLE STRANDED DNA; LIGAND; OLIGODEOXYRIBONUCLEOTIDE; PHENYLALANINE; TETRAHYDROFURAN DERIVATIVE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE; EQUILIBRIUM CONSTANT; EXCISION REPAIR; FLUORESCENCE; HUMAN; MOLECULAR RECOGNITION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TURNOVER TIME; WILD TYPE;

CATALYSIS; CATALYTIC DOMAIN; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; KINETICS; MUTATION, MISSENSE; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 77955016886     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100769k     Document Type: Article

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