Click modification in the N 6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition

Bioconjugate Chemistry

Volumn 23, Issue 2, 2012, Pages 232-247

  Tosh, Dilip K ^a   Phan, Khai ^a   Deflorian, Francesca ^a   Wei, Qiang ^a   Yoo, Lena S ^a   Gao, Zhan Guo ^a   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOMOLECULES; CHAINS; COPPER COMPOUNDS;

ADENOSINE RECEPTOR; ALKYNYL GROUPS; AZIDO DERIVATIVES; BENZYL GROUP; CARBOCYCLIC NUCLEOSIDES; CLICK CHEMISTRY; PHARMACOPHORES; PROPARGYL; RING SYSTEMS; TERMINAL ALKYNYL GROUPS;

SYNTHESIS (CHEMICAL);

ADENOSINE RECEPTOR; AZIDE; CARBOCYCLIC NUCLEOSIDE; N6 (4 FLUORO 3 NITROPHENYL) TRIAZOLYLMETHYL DERIVATIVE; POLYAMIDOAMINE; TRIAZOLE; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; DENDRIMER; DRUG DERIVATIVE; LIGAND; NUCLEOSIDE; POLYAMINE; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; NUCLEOPHILICITY; PHARMACOPHORE; CELL CULTURE; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; CLICK CHEMISTRY; DRUG POTENTIATION; HUMAN; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ADENOSINE A3 RECEPTOR AGONISTS; CELLS, CULTURED; CLICK CHEMISTRY; DENDRIMERS; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; NUCLEOSIDES; POLYAMINES; RECEPTOR, ADENOSINE A3; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856904025     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200526c     Document Type: Article

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