Low hydrogen sulphide and chronic kidney disease: A dangerous liaison

Nephrology Dialysis Transplantation

Volumn 27, Issue 2, 2012, Pages 486-493

  Perna, Alessandra F ^a   Ingrosso, Diego ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

chronic kidney disease; chronic kidney failure; cysteine; homocysteine; hydrogen sulphide

Indexed keywords

3 MERCAPTOPYRUVATE SULPHURTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; HYDROGEN SULFIDE; TRANSFERASE; UNCLASSIFIED DRUG;

BLOOD CELL; BLOOD LEVEL; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CATALYSIS; CHEMICAL REACTION; CHRONIC KIDNEY DISEASE; COMPLICATION; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HUMAN; HYDROGEN SULFIDE BLOOD LEVEL; HYPERHOMOCYSTEINEMIA; INFLAMMATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RENOVASCULAR HYPERTENSION; REVIEW; TISSUE DISTRIBUTION; TISSUE LEVEL; UREMIA;

ANIMALS; HYDROGEN SULFIDE; KIDNEY FAILURE, CHRONIC; MALE; OXIDATIVE STRESS; THIOBARBITURATES;

EID: 84856886249     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr737     Document Type: Review

References (61)

1. Gadalla MM, Snyder SH. Hydrogen sulfide as a gasotransmitter. J Neurochem 2010; 113: 14-26
2. Olson KR. The therapeutic potential of hydrogen sulfide: separating hype from hope. Am J Physiol Regul Integr Comp Physiol 2011; 301: R297-R312
3. Yang G, Wu L, Jiang B et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 2008; 322: 587-590
4. Mathai JC, Missner A, Kugler P et al. No facilitator required for membrane transport of hydrogen sulfide. Proc Natl Acad Sci USA 2009; 106: 16633-16638
5. Kabil O, Vitvitski V, Xie P et al. The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues. Antioxid Redox Signal 2011; 15: 363-372
6. Tanizawa K. Production of H2S by 3-mercaptopyruvate sulphurtransferase. J Biochem 2011; 149: 357-359
7. Kabil O, Banerjee R. The redox biochemistry of hydrogen sulfide. J Biol Chem 2010; 285: 21903-21907
8. Whiteman M, Moore PK. Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? J Cell Mol Med 2009; 13: 488-507
9. Chen P, Poddar R, Tipa EV et al. Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease. Adv Enzyme Regul 1999; 39: 93-109
10. Chen X, Jhee K, Kruger WD. Production of the neuromodulator H2S by cystathionine ß-synthase via the condensation of cysteine and homocysteine. J Biol Chem 2004; 279: 52082-52086
11. Chiku T, Padovani D, Zhu W et al. H2S biogenesis by human cystathionine c-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem 2009; 284: 11601-11612
12. Renga B, Mencarelli A, Migliorati M et al. Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. World J Gastroenterol 2009; 15: 2097-2108
13. Shibuya N, Mikami Y, Kimura Y et al. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J Biochem 2009; 146: 623-626
14. Kimura H. Hydrogen sulfide: its production, release and functions. Amino Acids 2011; 41: 113-121
15. Benavides GA, Squadrito GL, Mills RW et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA 2007; 104: 17977-17982
16. Li L, Hsu A, Moore PK. Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation-a tale of three gases!. Pharmacol Ther 2009; 123: 386-400
17. Olson KR. Is hydrogen sulfide a circulating "gasotransmitter" in vertebrate blood? Biochim Biophys Acta 2009; 1787: 856-863
18. Shen X, Pattillo CB, Pardue S et al. Measurement of plasma hydrogen sulfide in vivo and in vivo. Free Radic Biol Med 2011; 50: 1021-1031
19. Mustafa AK, Gadalla MM, Sen N et al. H2S signals through protein S-sulfhydration. Sci Signal 2009; 2: ra72
20. Levitt MD, Abdel-Rehim MS, Furne J. Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue. Antioxid Redox Signal 2011; 15: 373-378
21. Bucci M, Papapetropulos A, Vellecco V et al. Hydrogen sulfide is an endogenous inhibitor of phophodiesterase activity. Arterioscler Thromb Vasc Biol 2010; 30: 1998-2004
22. Qiao W, Chaoshu T, Hongfang J et al. Endogenous hydrogen sulfide is involved in the pathogenesis of atherosclerosis. Biochem Biophys Res Commun 2010; 396: 182-186
23. Wang Y, Zhao X, Jin H et al. Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2008; 29: 173-179
24. Kimura Y, Kimura H. Hydrogen sulfide protects neurons from oxidative stress. FASEB J 2004; 18: 1165-1167
25. Geng B, Chang L, Pan C et al. Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun 2004; 318: 756-763
26. Whiteman M, Armstrong JS, Chu SH et al. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? J Neurochem 2004; 90: 765-768
27. Yang C, Yang Z, Zhang M et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-kB/COX-2 pathway. PLoS One 2011; 6: e21971. doi:10.1371/journal.pone. 0021971
28. Pan LL, Liu XH, Gong QH et al. Hydrogen sulfide attenuated tumor necrosis factor-a-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS One 2011; 6: e19766. doi:10.1371/journal.pone.0019766
29. Henderson PW, Singh SP, Belkin D et al. Hydrogen sulfide protects against ischemia-reperfusion injury in an in vitro model of cutaneous tissue transplantation. J Surg Res 2010; 159: 451-455
30. Elrod JW, Calvert JW, Morrison J et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci USA 2007; 104: 15560-15565
31. Sen U, Vacek TP, Hughes WM et al. Cardioprotective role of sodium thiosulfate on chronic heart failure by modulating endogenous H2S generation. Pharmacology 2008; 82: 201-213
32. Yan H, Du J, Tang C. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun 2004; 313: 22-27
33. Zhao W, Zhang J, Lu Y et al. The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener. EMBO J 2001; 20: 6008-6016
34. Zhoung G. Hydrogen sulfide-a potent multichannel anti-arrythmic drug. J Cardiovasc Dis Res 2010; 1: 37-39
35. Jackson-Weaver O, Paredes DA, Gonzales Bosc LV et al. Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca(21)-activated potassium channels. Circ Res 2011; 108: 1439-1447
36. Jiang HL, Wu HC, Li ZL et al. Changes of the new gaseous transmitter H2S in patients with coronary heart disease. Di Yi Jun Yi Da Xue Bao 2005; 25: 951-954
37. Li C, Sumou I, Ya-guang D et al. Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children. Chin Med J (Engl) 2007; 120: 389-393
38. Kriebitzsch C, Verlinden L, Eelen G et al. 1,25-dihydroxyvitamin D(3) influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine b-synthase. J Bone Miner Res 2011; doi: 10.1002/jbmr.493
39. Perna AF, Luciano MG, Ingrosso D et al. Hydrogen sulfide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes. Nephrol Dial Transplant 2009; 24: 3756-3763
40. Aminzadeh M, Vaziri N. Down-regulation of the renal and hepatic hydrogen sulfide (H2S) producing enzymes and capacity in chronic kidney disease. Nephrol Dial Transplant 2012; 27: 498-504
41. Xia M, Chen L, Muh RW et al. Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys. J Exp Pharmacol Exp Ther 2009; 329: 1056-1062
42. Roy A, Khan AH, Islam MT et al. Interdependency of cystathionine c-lyase and cystathionine b-synthase in hydrogen sulfide-induced blood pressure regulation in rats. Am J Hypertens 2011; doi:10.1038/ajh.2011.149
43. Beltowski J. Hypoxia in the renal medulla: Implications for hydrogen sulfide signaling. J Pharmacol Exp Ther 2010; 334: 358-363
44. Lu M, Liu Y, Goh HS et al. Hydrogen sulfide inhibits plasma renin activity. J Am Soc Nephrol 2010; 21: 993-1002
45. Zavaczki E, Jeney V, Agarwal A et al. Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells. Kidney Int 2011; doi:10.1038/ki.2011.212
46. Sen U, Basu P, Abe OA et al. Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure. Am J Physiol Renal Physiol 2009; 297: F410-F419
47. Sen U, Munjal C, Qipshidze N et al. Hydrogen sulfide regulates homocysteine-mediated glomerulosclerosis. Am J Nephrol 2010; 31: 442-455
48. Sen U, Givvimani S, Abe OA et al. Cystathionine b-synthase and cystathionine-c-lyase double gene transfer ameliorate homocysteinemediated mesangial inflammation through hydrogen sulfide generation. Am J Physiol Cell Physiol 2011; 300: C155-C163
49. Ingrosso D, Cimmino A, Perna AF et al. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet 2003; 361: 1693-1699
50. Perna AF, Ingrosso D, De Santo NG et al. Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia. Kidney Int 1995; 47: 247-253
51. Perna AF, Ingrosso D, Violetti E et al. Hyperhomocysteinemia in uremia-a red flag in a disrupted circuit. Semin Dial 2009; 22: 351-356
52. Hasuike Y, Nakanishi T, Moriguchi R et al. Accumulation of cyanide and thiocyanate in hemodialysis patients. Nephrol Dial Transplant 2004; 19: 1474-1479
53. Chang L, Geng B, Yu F et al. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 2008; 34: 573-585
54. Singh S, Padovani D, Leslie RA et al. The relative contributions of cystathionine b-synthase and c-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. J Biol Chem 2009; 284: 22457-22466
55. Della Coletta Francescato H, Cunha FQ, Costa RS et al. Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage. Nephrol Dial Transplant 2011; 26: 479-488
56. Francescato HD, Marin EC, da Queiroz Cunha F et al. Role of endogenous hydrogen sulfide on renal damage induced by adriamycin injection. Arch Toxicol 2011; doi:10.1007/s00204-011-0717-y
57. Wu N, Siow YL, Karmin O. Ischemia/reperfusion reduces transcription factor SP1 mediated cystathionine b-synthase expression in the kidney. J Biol Chem 2010; 285: 18225-18233
58. Tripatara P, Patel NSA, Collino M et al. Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction. Lab Invest 2008; 88: 1038-1048
59. Tripatara P, Patel NS, Brancaleone V et al. Characterization of cystathionine gamma-lyase/hydrogen sulfide pathway in ischemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol 2009; 606: 205-209
60. Bos EM, Leuvenink HGD, Snijder PM et al. Hydrogen sulfideinduced hypometabolism prevents renal ischemia/reprfusion injury. J Am Soc Nephrol 2009; 20: 1901-1905
61. Perna AF, Sepe I, Lanza D et al. Hydrogen sulfide increases after a single hemodialysis session. Kidney Int 2011; 80: 1108-1109