Endoplasmic reticulum dysfunction - A common denominator for cell injury in acute and degenerative diseases of the brain?

Journal of Neurochemistry

Volumn 79, Issue 4, 2001, Pages 719-725

  Paschen, Wulf ^a   Frandsen, Aase ^b  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Alzheimer's disease; Endoplasmic reticulum; Ischemia; Neuronal cell injury; Parkinson's disease; Unfolded protein response

Indexed keywords

CALCIUM; GLUTAMATE RECEPTOR;

AGE; ALZHEIMER DISEASE; BRAIN DEGENERATION; CALCIUM HOMEOSTASIS; CELL FUNCTION; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; HUMAN; MOLECULAR BIOLOGY; NERVE CELL LESION; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SHORT SURVEY;

ACUTE DISEASE; AGE FACTORS; ANIMALS; BRAIN; BRAIN DISEASES; CALCIUM; ENDOPLASMIC RETICULUM; HUMANS; NEURODEGENERATIVE DISEASES; NEUROTOXINS;

EID: 0035190132     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00623.x     Document Type: Short Survey

References (62)

1. Possible mechanism of the potent vasoconstrictor responses to ryanodine in dog cerebral arteries
2. Penumbral tissue alkalosis in focal cerebral ischemia: Relationship to energy metabolism, blood flow, and steady potential
3. Kainic acidinduced seizures and brain damage in the rat - Role of calcium homeostasis
4. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons
5. Role of the proteasome in Alzheimer's disease
6. Nutritional factors in cerebral aging and dementia: Epidemiological arguments for a role of oxidative stress
7. Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: Implications for a role of disturbances of endoplasmic reticulum calcium homeostasis
8. Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism
9. Mobilization of dantrolenesensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionate and kainate in cultured cerebral cortical neurons
10. Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons
11. A regulatory link between ER-associated protein degradation and the unfolded-protein response
12. Effects of hypoxia/reoxygenation on aortic vasoconstrictor responsiveness
13. In vivo 2-deoxyglucose administration preserves glucose and glutamate transport and mitochondrial function in cortical synaptic terminals after exposure to amyloid β-peptide and iron: Evidence for a stress response
14. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
15. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
16. Reperfusion of the brain after global ischemia: Hemodynamic disturbances
17. Protein aggregation after transient cerebral ischemia
18. 3 receptor, and cellular senescence
19. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: Effect on volume of ischemic injury
20. Parkin suppress unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
21. Presenilin and the UPR
22. 2+ signaling in rat hippocampus astrocytes
23. Presenilin-1 mutations downregulate the signalling pathway of the unfolded protein response
24. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
25. 2+ mobilization in brain microvascular endothelial cells
26. Calcium homeostasis in aged neurons
27. Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil
28. 2+ determine nerve growth factor dependence of sympathetic ganglion cells
29. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK
30. Inhibition of the ubiquitinproteasome system in Alheimer's disease
31. Frameshift mutants of β amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
32. 2+ stores and contractility: Changes with development
33. Neuroprotective signaling and the aging brain: Take away my food and let me run
34. Neurodegenerative disorders and ischemic brain disease
35. A receptor associated mechanisms
36. Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex
37. Characterization of mouse Irelot: Cloning, mRNA localozation in the brain and functional analysis in a neural cell line
38. 2+ relase
39. Neuroprotective effects of early vs. late administartion of dantrolene in experimental status epilepticus
40. A role of presenilin-1 in nuclear accumulation of Irel fragments and induction of the mammalian unfolded protein response
41. 2+ ATPase
42. 2+ uptake
43. Disturbances in calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic cell damage
44. Disturbances of the functioning of endoplasmic reticulum: A key mechanism underlying neuronal cell injury?
45. Peroxidative stress selectively down-regulates the neuronal stress response activated under conditions of endoplasmic reticulum dysfunction
46. Mechanisms of calcium buffering in adrenergic neurons and effects of ageing: Testing the limits of homeostasis
47. Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores
48. 2+ release: An intimate connection
49. A novel presenilin-2 splice variant in human Alzheimer's disease brain Tissue
50. Upregulation of BIP and CHOP by the unfolded-protein response is independent of presenilin expression
51. Increased production of β-amyloid and vulnerability to endoplasmic reticulum stress by an abbarant spliced form of presenilin 2
52. Molecular mechanisms of calcium-dependent excitotoxicity
53. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
54. Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and fascilitating longterm potentiation
55. Cell damage in the brain: A speculative synthesis
56. ORP150 protects against hypoxia/ischemiainduced neuronal death
57. The effects of intracellular pH changes on resting cytosolic calcium in voltageclamped snail neurones
58. 2+ concentration and subsequent loss of neuronal function in individual neocortical neurons in culture
59. Stress-associated endoplasmic reticulum protein 1 (SERP1) /ribosome-associated membrane protein 4 (RAMP4) stabolizes membrane proteins during stress and fascilitates subsequent glycosylation
60. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: Suppression of oxidative stress and stabolization of calcium homeostasis