Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 4041-4052

  Mayati, Abdullah ^a   Levoin, Nicolas ^b   Paris, Hervé ^c   N'Diaye, Monique ^a   Courtois, Arnaud ^d   Uriac, Philippe ^e   Lagadic Gossmann, Dominique ^a   Fardel, Olivier ^a,f   Le Ferrec, Eric ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b Bioprojet Biotech   (France)

^c INSERM   (France)

^d CENTRE DE RECHERCHE CARDIO THORACIQUE DE BORDEAUX   (France)

^e INSTITUT DES SCIENCES CHIMIQUES DE RENNES   (France)

^f PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLYL CYCLASE; ARYL HYDROCARBON RECEPTOR; BENZO(A)PYRENE; CALCIUM MOBILIZATION; CYCLASES; CYTOCHROME P450; ENVIRONMENTAL CONTAMINANT; ENVIRONMENTAL POLLUTANTS; G PROTEIN; HEK293 CELLS; HUMAN KIDNEY; IN-VITRO; INTRACELLULAR CALCIUM CONCENTRATION; OVER-EXPRESSION; PHARMACOLOGICAL INHIBITION; SIGNALING PATHWAYS; TARGET GENES; UP-REGULATION;

ALCOHOLS; ENDOTHELIAL CELLS; GENES; MACHINERY; PYRENE; SUGARS;

CALCIUM;

2',5' DIDEOXYADENOSINE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ADENYLATE CYCLASE; BENZO[A]PYRENE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR ANTIBODY; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BINDING PROTEIN; BREFELDIN A; CALCIUM ION; CARAZOLOL; CYTOCHROME P450 1B1; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PROPRANOLOL; PROTEIN EPAC 1; SMALL INTERFERING RNA; SURAMIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENDOTHELIUM CELL; ENZYME INDUCTION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING;

ADENYLATE CYCLASE; AIR POLLUTANTS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CALCIUM; CALCIUM SIGNALING; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ARYL HYDROCARBON;

EID: 84856755960     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.319970     Document Type: Article

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