Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2 C95S)

Diabetologia

Volumn 55, Issue 2, 2012, Pages 382-391

  Kautz, S ^a   Van Burck L ^a,b   Schuster, M ^a   Wolf, E ^a   Wanke, R ^a   Herbach, N ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

ER stress; Insulin secretion in vivo; Insulin sensitivity and resistance; Insulin therapy; Islet degeneration and damage; Mouse; Oxidative stress

Indexed keywords

AVE 2268; C PEPTIDE; IMMUNOGLOBULIN BINDING FACTOR; INITIATION FACTOR 2ALPHA; INSULIN; PLACEBO; PROTEIN INHIBITOR; SODIUM GLUCOSE COTRANSPORTER 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LOSS; CELL VOLUME; DIABETES MELLITUS; DRUG PELLET; EARLY INTERVENTION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; MALE; MOUSE; NEWBORN; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL; PROTEIN CONTENT;

ANIMALS; ANIMALS, NEWBORN; C-PEPTIDE; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; GLUCOSE; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; OXIDATIVE STRESS; PANCREAS; PHENOTYPE; PLACEBOS; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 84856735931     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2362-7     Document Type: Article

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