Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 4165-4176

  Zhuang, Xiaolei ^a,b   Northup, John K ^a   Ray, Kausik ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; AUTOSOMAL DOMINANT HYPOCALCEMIA; CARBOXYL TERMINUS; CELL IMAGING; CELL SURFACE EXPRESSION; CELL SURFACE RECEPTORS; CELL SURFACES; DELETION MAPPING; G PROTEIN COUPLED RECEPTORS; HEK293 CELLS; LAGARDE; LYSOSOMAL DEGRADATION; SEQUENCE MOTIFS; SIGNALING ACTIVITY; UNDERLYING MECHANISM;

AMINO ACIDS; DEGRADATION; RECYCLING; SORTING;

CELL MEMBRANES;

CALCIUM RECEPTOR; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; DEGRADATION; DOWN REGULATION; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOMAL DEGRADATION; MUTANT; PEST LIKE SEQUENCE MOTIF; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; HEK293 CELLS; HELA CELLS; HUMANS; HYPOCALCEMIA; LYSOSOMES; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECEPTORS, CALCIUM-SENSING; SEQUENCE DELETION;

EID: 84856710439     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.271528     Document Type: Article

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