A common variant upstream of the PAX6 gene influences islet function in man

Diabetologia

Volumn 55, Issue 1, 2012, Pages 94-104

  Ahlqvist, E ^a   Turrini, F ^a,b   Lang, S T ^a   Taneera, J ^a   Zhou, Y ^a   Almgren, P ^a   Hansson, O ^a   Isomaa, B ^c,d   Tuomi, T ^c,e   Eriksson, K ^f   Eriksson, J G ^c,g,h,i   Lyssenko, V ^a   Groop, L ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF VERONA   (Italy)

^c FOLKHÄLSAN RESEARCH CENTER   (Finland)

^d Department of Social Services and Health Care ^*  (Finland)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^f LUND UNIVERSITY HOSPITAL   (Sweden)

^g UNIVERSITY OF HELSINKI   (Finland)

^h VAASA CENTRAL HOSPITAL   (Finland)

ⁱ NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Genetic association; Incretin; Insulin; Insulin processing; Insulin secretion; Meta analysis; PAX6; PCSK1; Proinsulin; Type 2 diabetes

Indexed keywords

ARGININE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCOSE; MESSENGER RNA; POTASSIUM; PROINSULIN;

ADULT; ALLELE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE METABOLISM; HOMOZYGOTE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; MALE; PAIRED BOX 6 GENE; PANCREAS ISLET CELL FUNCTION; PCSK1 GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; EYE PROTEINS; FEMALE; FINLAND; GENETIC ASSOCIATION STUDIES; HOMEODOMAIN PROTEINS; HUMANS; INSULIN RESISTANCE; ISLETS OF LANGERHANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PAIRED BOX TRANSCRIPTION FACTORS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPROTEIN CONVERTASE 1; REPRESSOR PROTEINS; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES; YOUNG ADULT;

EID: 84856709688     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2300-8     Document Type: Article

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