Signaling of cytokines is important in regulation of GnRH neurons

Molecular Neurobiology

Volumn 45, Issue 1, 2012, Pages 119-125

  Wu, Sheng ^a   Wolfe, Andrew ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Fertility; GnRH; Jak2; Signaling

Indexed keywords

CYTOKINE; GONADORELIN; JANUS KINASE 2;

ENZYME ACTIVATION; ENZYME ACTIVITY; GONADORELIN RELEASE; HUMAN; INFECTION; INFLAMMATION; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; OBESITY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 84856707980     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-011-8224-y     Document Type: Review

References (56)

1. D Tomaszewska-Zaremba A Herman 2009 The role of immunological system in the regulation of gonadoliberin and gonadotropin secretion Reprod Biol 9 11 23 19352414
2. KI Arai F Lee A Miyajima S Miyatake N Arai T Yokota 1990 Cytokines: coordinators of immune and inflammatory responses Annu Rev Biochem 59 783 836 1695833 10.1146/annurev.bi.59.070190.004031 1:CAS:528:DyaK3cXls12rsbY%3D
3. S Rivest C Rivier 1993 Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity Ann N Y Acad Sci 697 117 141 8257006 10.1111/j.1749-6632.1993.tb49928.x 1:CAS:528:DyaK2cXpsFyrtw%3D%3D (Pubitemid 24028960)
4. C Rivier W Vale 1990 Cytokines act within the brain to inhibit luteinizing hormone secretion and ovulation in the rat Endocrinology 127 849 856 2115435 10.1210/endo-127-2-849 1:CAS:528:DyaK3cXltFemtLo%3D (Pubitemid 20248131)
5. T Porkka-Heiskanen JH Urban FW Turek JE Levine 1994 Gene expression in a subpopulation of luteinizing hormone-releasing hormone (LHRH) neurons prior to the preovulatory gonadotropin surge J Neurosci 14 9 5548 5558 8083753 1:CAS:528:DyaK2cXmt1ans70%3D (Pubitemid 24279071)
6. S Nagatani DC Bucholtz K Murahashi MA Estacio H Tsukamura DL Foster KI Maeda 1996 Reduction of glucose availability suppresses pulsatile luteinizing hormone release in female and male rats Endocrinology 137 1166 1170 8625885 10.1210/en.137.4.1166 1:CAS:528:DyaK28XhvVegsLc%3D (Pubitemid 26095227)
7. DC Bucholtz A Chiesa WN Pappano S Nagatani H Tsukamura KI Maeda DL Foster 2000 Regulation of pulsatile luteinizing hormone secretion by insulin in the diabetic male lamb Biol Reprod 62 1248 1255 10775173 10.1095/biolreprod62.5.1248 1:CAS:528:DC%2BD3cXisl2ht7c%3D (Pubitemid 30238476)
8. MS Smith KL Grove 2002 Integration of the regulation of reproductive function and energy balance: lactation as a model Front Neuroendocrinol 23 225 256 12127305 10.1016/S0091-3022(02)00002-X 1:CAS:528:DC%2BD38XltlKhu70%3D (Pubitemid 34856514)
9. N Pitteloud R Quinton S Pearce T Raivio J Acierno A Dwyer L Plummer V Hughes S Seminara YZ Cheng WP Li G Maccoll AV Eliseenkova SK Olsen OA Ibrahimi FJ Hayes P Boepple JE Hall P Bouloux M Mohammadi W Crowley 2007 Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism J Clin Invest 117 457 463 17235395 10.1172/JCI29884 1:CAS:528:DC%2BD2sXhs1OqtrY%3D (Pubitemid 46203974)
10. JN Ihle 1995 Cytokine receptor signalling Nature 377 591 594 7566171 10.1038/377591a0 1:CAS:528:DyaK2MXovVGmsbo%3D
11. E Parganas D Wang D Stravopodis DJ Topham JC Marine S Teglund EF Vanin S Bodner OR Colamonici JM van Deursen G Grosveld JN Ihle 1998 Jak2 is essential for signaling through a variety of cytokine receptors Cell 93 385 395 9590173 10.1016/S0092-8674(00)81167-8 1:STN:280:DyaK1c3ltVSmtw%3D%3D (Pubitemid 28232083)
12. S Pellegrini I Dusanter-Fourt 1997 The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs) Eur J Biochem 248 615 633 9342212 10.1111/j.1432-1033. 1997.00615.x 1:CAS:528:DyaK2sXmvFKhtr8%3D (Pubitemid 27400015)
13. S Wu S Divall GE Hoffman WW Le KU Wagner A Wolfe 2011 Jak2 is necessary for neuroendocrine control of female reproduction J Neurosci 31 184 192 21209203 10.1523/JNEUROSCI.2974-10.2011 1:CAS:528:DC%2BC3MXls1ygsw%3D%3D
14. SA Divall TR Williams SE Carver L Koch JC Bruning CR Kahn F Wondisford S Radovick A Wolfe 2010 Divergent roles of growth factors in the GnRH regulation of puberty in mice J Clin Invest 120 2900 2909 20628204 10.1172/JCI41069 1:CAS:528:DC%2BC3cXhtVaiur%2FJ
15. YM Wang DA Bayliss DE Millhorn P Petrusz DR Joseph 1990 The androgen-binding protein gene is expressed in male and female rat brain Endocrinology 127 3124 3130 1701136 10.1210/endo-127-6-3124 1:CAS:528: DyaK3MXjvFygsg%3D%3D
16. CA Dinarello 1996 Biologic basis for interleukin-1 in disease Blood 87 2095 2147 8630372 1:CAS:528:DyaK28Xhs1CktLc%3D (Pubitemid 26086851)
17. SM Allan PJ Tyrrell NJ Rothwell 2005 Interleukin-1 and neuronal injury Nat Rev Immunol 5 629 640 16034365 10.1038/nri1664 1:CAS:528: DC%2BD2MXmvVClsLs%3D (Pubitemid 41113194)
18. H Lim HP Kim 2011 Matrix metalloproteinase-13 expression in IL-1beta-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways Arch Pharm Res 34 109 117 21468922 10.1007/s12272-011-0113-4 1:CAS:528:DC%2BC3MXktlSjtbs%3D
19. CD Breder CA Dinarello CB Saper 1988 Interleukin-1 immunoreactive innervation of the human hypothalamus Science 240 321 324 3258444 10.1126/science.3258444 1:CAS:528:DyaL1cXitVaqu7s%3D
20. RM Lechan R Toni BD Clark JG Cannon AR Shaw CA Dinarello S Reichlin 1990 Immunoreactive interleukin-1 beta localization in the rat forebrain Brain Res 514 135 140 2357520 10.1016/0006-8993(90)90445-H 1:CAS:528:DyaK3cXkt1Wquro%3D (Pubitemid 20147597)
21. PS Kalra TG Edwards B Xu M Jain SP Kalra 1998 The anti-gonadotropic effects of cytokines: the role of neuropeptides Domest Anim Endocrinol 15 321 332 9785036 10.1016/S0739-7240(98)00030-7 1:CAS:528:DyaK1cXmvVKjtrw%3D (Pubitemid 29305014)
22. PS Kalra A Sahu SP Kalra 1990 Interleukin-1 inhibits the ovarian steroid-induced luteinizing hormone surge and release of hypothalamic luteinizing hormone-releasing hormone in rats Endocrinology 126 2145 2152 2180683 10.1210/endo-126-4-2145 1:CAS:528:DyaK3cXitlekt74%3D (Pubitemid 20139765)
23. H Watanobe Y Hayakawa 2003 Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats Endocrinology 144 4868 4875 12960020 10.1210/en.2003-0644 1:CAS:528:DC%2BD3sXoslertbg%3D (Pubitemid 37378401)
24. D Dondi P Limonta MM Montagnani F Piva 1998 Mechanism of action of interleukin-1 in modulating gonadotropin secretion. In vivo and in vitro studies Biol Signals Recept 7 55 60 9641798 10.1159/000014528 1:CAS:528: DyaK1cXjtVeksLo%3D (Pubitemid 28266312)
25. M Yamaguchi Y Yoshimoto H Komura K Koike N Matsuzaki K Hirota A Miyake O Tanizawa 1990 Interleukin 1 beta and tumour necrosis factor alpha stimulate the release of gonadotropin-releasing hormone and interleukin 6 by primary cultured rat hypothalamic cells Acta Endocrinol (Copenh) 123 476 480 1:CAS:528: DyaK3MXit1Wltr0%3D (Pubitemid 20377201)
26. S Rivest G Torres C Rivier 1992 Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions Brain Res 587 13 23 1326374 10.1016/0006-8993(92)91424- D 1:CAS:528:DyaK38Xls12ht7w%3D
27. SS Kang SR Kim S Leonhardt H Jarry W Wuttke K Kim 2000 Effect of interleukin-1beta on gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in castrated male rats J Neuroendocrinol 12 421 429 10792581 10.1046/j.1365-2826.2000.00466.x 1:CAS:528:DC%2BD3cXjsVKjtbo%3D (Pubitemid 30223989)
28. AC Gore TT Yeo A Ho JL Roberts 1997 Post-transcriptional regulation of the gonadotropin-releasing hormone gene in GT1-7 cells J Neuroendocrinol 9 271 277 9147290 10.1046/j.1365-2826.1997.00579.x 1:CAS:528:DyaK2sXivVOnsbg%3D (Pubitemid 27168433)
29. P Igaz R Salvi JP Rey M Glauser FP Pralong RC Gaillard 2006 Effects of cytokines on gonadotropin-releasing hormone (GnRH) gene expression in primary hypothalamic neurons and in GnRH neurons immortalized conditionally Endocrinology 147 1037 1043 16282355 10.1210/en.2005-0729 1:CAS:528: DC%2BD28XpvVeiug%3D%3D (Pubitemid 43113024)
30. RA Gadient U Otten 1993 Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus Neurosci Lett 153 13 16 8510817 10.1016/0304-3940(93)90065-S 1:CAS:528:DyaK3sXktVKqtrY%3D (Pubitemid 23147025)
31. E Dozio M Ruscica E Galliera MM Corsi P Magni 2009 Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function Curr Protein Pept Sci 10 577 584 19751193 10.2174/138920309789630561 1:CAS:528:DC%2BD1MXhsFGqtLzF
32. PC Heinrich I Behrmann G Muller-Newen F Schaper L Graeve 1998 Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Biochem J 334 Pt 2 297 314 9716487 1:CAS:528:DyaK1cXmtFOls7c%3D (Pubitemid 28448572)
33. K Lyson SM McCann 1991 The effect of interleukin-6 on pituitary hormone release in vivo and in vitro Neuroendocrinology 54 262 266 1658674 10.1159/000125884 1:CAS:528:DyaK3MXltFanurg%3D
34. SH Russell CJ Small SA Stanley S Franks MA Ghatei SR Bloom 2001 The in vitro role of tumour necrosis factor-alpha and interleukin-6 in the hypothalamic-pituitary gonadal axis J Neuroendocrinol 13 296 301 11207945 10.1046/j.1365-2826.2001.00632.x 1:CAS:528:DC%2BD3MXhsFeitL8%3D (Pubitemid 32170995)
35. M Yamaguchi K Koike Y Yoshimoto N Matsuzaki A Miyake O Tanizawa 1991 Interleukin-6 stimulates gonadotropin-releasing hormone secretion from rat hypothalamic cells Horm Res 35 252 256 1819551 10.1159/000181915 1:STN:280:DyaK38zgslKhsw%3D%3D
36. C Perez I Albert K DeFay N Zachariades L Gooding M Kriegler 1990 A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact Cell 63 251 258 2208285 10.1016/0092-8674(90)90158-B 1:CAS:528:DyaK3cXmtV2kt7s%3D (Pubitemid 20355446)
37. GS Hotamisligil NS Shargill BM Spiegelman 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 87 91 7678183 10.1126/science.7678183 1:CAS:528:DyaK3sXnvFaitw%3D%3D (Pubitemid 23036092)
38. BB Aggarwal 2003 Signalling pathways of the TNF superfamily: a double-edged sword Nat Rev Immunol 3 745 756 12949498 10.1038/nri1184 1:CAS:528:DC%2BD3sXmvVWmtb0%3D (Pubitemid 41070815)
39. R Pincheira AF Castro ON Ozes PS Idumalla DB Donner 2008 Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity J Immunol 181 1288 1298 18606683 1:CAS:528:DC%2BD1cXotF2rtr0%3D
40. S Nadeau S Rivest 1999 Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier Neuroscience 93 1449 1464 10501470 10.1016/S0306-4522(99)00225-0 1:CAS:528:DyaK1MXls1Wju7Y%3D (Pubitemid 29397574)
41. MJ Yoo M Nishihara M Takahashi 1997 Tumor necrosis factor-alpha mediates endotoxin induced suppression of gonadotropin-releasing hormone pulse generator activity in the rat Endocr J 44 141 148 9152627 10.1507/endocrj.44.141 1:CAS:528:DyaK2sXjvFegtL0%3D (Pubitemid 27150173)
42. PH Patterson MJ Fann 1992 Further studies of the distribution of CDF/LIF mRNA CIBA Found Symp 167 125 135 1425009 1:CAS:528:DyaK3sXit1Kms78%3D discussion 135-40
43. DP Gearing T VandenBos MP Beckmann CJ Thut MR Comeau B Mosley SF Ziegler 1992 Reconstitution of high affinity leukaemia inhibitory factor (LIF) receptors in haemopoietic cells transfected with the cloned human LIF receptor CIBA Found Symp 167 245 255 1425017 1:CAS:528:DyaK3sXktVWjs7c%3D discussion 255-9
44. TG Boulton N Stahl GD Yancopoulos 1994 Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors J Biol Chem 269 11648 11655 7512571 1:CAS:528:DyaK2cXivFSksrY%3D
45. P Magni E Dozio M Ruscica H Watanobe A Cariboni R Zaninetti M Motta R Maggi 2007 Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways Mol Endocrinol 21 1163 1174 17299136 10.1210/me.2006-0270 1:CAS:528:DC%2BD2sXltF2jsbk%3D (Pubitemid 46984766)
46. GM Dobrea JR Unnerstall MS Rao 1992 The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat Brain Res Dev Brain Res 66 209 219 1606686 10.1016/0165-3806(92)90082-8 1:CAS:528:DyaK38XktVWkt7w%3D
47. JT Henderson NA Seniuk JC Roder 1994 Localization of CNTF immunoreactivity to neurons and astroglia in the CNS Brain Res Mol Brain Res 22 151 165 8015376 10.1016/0169-328X(94)90043-4 1:CAS:528:DyaK2cXhvVeqsro%3D (Pubitemid 24063636)
48. TM DeChiara R Vejsada WT Poueymirou A Acheson C Suri JC Conover B Friedman J McClain L Pan N Stahl NY Ip GD Yancopoulos 1995 Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth Cell 83 313 322 7585948 10.1016/0092-8674(95)90172-8 1:CAS:528: DyaK2MXovVGrurg%3D
49. A De Serio R Graziani R Laufer G Ciliberto G Paonessa 1995 In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex J Mol Biol 254 795 800 7500350 10.1006/jmbi.1995.0655 (Pubitemid 26006851)
50. S Davis TH Aldrich DM Valenzuela VV Wong ME Furth SP Squinto GD Yancopoulos 1991 The receptor for ciliary neurotrophic factor Science 253 59 63 1648265 10.1126/science.1648265 1:CAS:528:DyaK38XhvV2kt7Y%3D (Pubitemid 21917117)
51. Y Masu E Wolf B Holtmann M Sendtner G Brem H Thoenen 1993 Disruption of the CNTF gene results in motor neuron degeneration Nature 365 27 32 8361533 10.1038/365027a0 1:CAS:528:DyaK3sXlvFKmtL8%3D (Pubitemid 23305564)
52. SA Stanley JF Todd CJ Small MS Kim MM Heath P Anand MA Ghatei SR Bloom 2000 The effects of ciliary neurotrophic factor on the hypothalamo-pituitary gonadal axis in vitro in female rats J Neuroendocrinol 12 1009 1013 11012842 10.1046/j.1365-2826.2000.00550.x 1:CAS:528:DC%2BD3cXnt12nsLY%3D
53. H Watanobe S Habu 2001 Ciliary neurotrophic factor, a gp130 cytokine, regulates preovulatory surges of luteinizing hormone and prolactin in the rat Neuroendocrinology 74 281 287 11694760 10.1159/000054695 1:CAS:528: DC%2BD3MXovFWjs7s%3D (Pubitemid 33033396)
54. E Dozio H Watanobe M Ruscica R Maggi M Motta P Magni 2005 Expression of functional ciliary neurotrophic factor receptors in immortalized gonadotrophin-releasing hormone-secreting neurones J Neuroendocrinol 17 286 291 15869563 10.1111/j.1365-2826.2005.01309.x 1:CAS:528:DC%2BD2MXksFGqur0%3D (Pubitemid 40711623)
55. T Kisseleva S Bhattacharya J Braunstein CW Schindler 2002 Signaling through the JAK/STAT pathway, recent advances and future challenges Gene 285 1 24 12039028 10.1016/S0378-1119(02)00398-0 1:CAS:528:DC%2BD38XitlWmsbg%3D (Pubitemid 34246317)
56. CC Korenbrot IT Huhtaniemi RI Weiner 1977 Preputial separation as an external sign of pubertal development in the male rat Biol Reprod 17 298 303 889997 10.1095/biolreprod17.2.298 1:CAS:528:DyaE2sXlsV2gtbY%3D (Pubitemid 8171796)