Expression of functional ciliary neurotrophic factor receptors in immortalized gonadotrophin-releasing hormone-secreting neurones

Journal of Neuroendocrinology

Volumn 17, Issue 5, 2005, Pages 286-291

  Dozio, E ^a   Watanobe, H ^b   Ruscica, M ^a   Maggi, R ^a   Motta, M ^a   Magni, Paolo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Ciliary neurotrophic factor; Gonadotrophin releasing hormone; Immortalized neurones; JAK STAT pathway

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR; GLYCOPROTEIN GP 130; GONADORELIN; JANUS KINASE 2; LEUKEMIA INHIBITORY FACTOR RECEPTOR; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL IMMORTALIZATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; GONADORELIN RELEASE; HUMAN; HUMAN CELL; HYPOTHALAMUS; HYPOTHESIS; IMMUNOFLUORESCENCE TEST; INTERNEURON; MOUSE; NERVE CELL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD; CELL LINE; CYTOKINE RECEPTOR GP130; DNA-BINDING PROTEINS; GONADOTROPIN-RELEASING HORMONE; HUMANS; HYPOTHALAMUS; JANUS KINASE 2; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MEMBRANE GLYCOPROTEINS; MICE; NEURONS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTORS, CYTOKINE; RECEPTORS, OSM-LIF; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 19044367486     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01309.x     Document Type: Article

References (38)

1. Xu B, Dube MG, Kalra PS, Farmerie WG, Kaibara A, Moldawer LL, Martin D, Kalra SP. Anorectic effects of the cytokine, ciliary neurotropic factor (CNTF), are mediated by hypothalamic neuropeptide Y (NPY): comparison with leptin. Endocrinology 1998; 139: 466-473.
2. Watanobe H, Hahn S. Ciliary neurotrophic factor, a gp 130 cytokine, regulates preovulatory surges of luteinizing hormone and prolactin in the rat. Neuroendocrinology 2001; 74: 281-287.
3. Dobrea GM, Unnerstall JR, Rao MS. The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat. Brain Res Dev Brain Res 1992; 66: 209-219.
4. Richardson PM. Ciliary neurotrophic factor: a review. Pharmacol Ther 1994; 63: 187-198.
5. Ip NY, Wiegand SJ, Morse J, Rudge JS. Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur J Neurosci 1993; 5: 25-33.
6. Massaro AR, Soranzo C, Carnevale A. Cerebrospinal-fluid ciliary neurotrophic factor in neurological patients. Eur Neurol 1997; 37: 243-246.
7. Hu J, Saito T, Abe K, Deguchi T. Increase of ciliary neurotrophic factor (CNTF) in the ischemic rat brain as determined by a sensitive enzyme-linked immunoassay. Neurol Res 1997; 19: 593-598.
8. Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD. The receptor for ciliary neurotrophic factor. Science 1991; 253: 59-63.
9. Gloaguen I, Costa P, Demartis A, Lazzaro D, Marco AD, Graziani R, Paonessa G, Chen F, Rosenblum CI, Ploeg LHVD, Cortese R, Ciliberto G, Laufer R. Ciliary neurotropic factor corrects obesity and diabetes associated with leptin deficiency and resistence. Proc Natl Acad Sci USA 1997; 94: 6456-6461.
10. Stanley SA, Todd JF, Small CJ, Kim MS, Heath MM, Anand P, Ghatei MA, Bloom SR. The effects of ciliary neurotrophic factor on the hypothalamo-pituitary gonadal axis in vitro in female rats. J Neuroendocrinol 2000; 12: 1009-1013.
11. De Serio A, Graziani R, Laufer R, Ciliberto G, Paonessa G. In vitro binding of ciliary neurotrophic factor to its receptors. Evidence for the formation of an IL-6-type hexameric complex. J Mol Biol 1995; 254: 795-800.
12. MacLennan AJ, Vinson EN, Marks L, McLaurin DL, Pfeifer M, Lee N. Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system. J Neurosci 1996; 16: 621-630.
13. Ip NY, Nye SH, Boulton TG, Davis S, Taga T, Li Y, Birren SJ, Yasukawa K, Kishimoto T, Anderson DJ, Stahl N, Yancopoulos GD. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 1992; 67: 1121-1132.
14. Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genet 1996; 14: 95-97.
15. Kalra SP, Xu B, Dube MG, Moldawer LL, Martin D, Kalra PS. Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y. Neurosci Lett 1998; 240: 45-49.
16. Kohsaka A, Watanobe H, Kakizaki Y, Habu S, Suda T. A significant role of leptin in the generation of steroid-induced luteinizing hormone and prolactin surges in female rats. Biochem Biophys Res Commun 1999; 254: 578-581.
17. Magni P, Vettor R, Pagano C, Calcagno A, Beretta E, Messi E, Zanisi M, Martini L, Motta M. Expression of a leptin receptor in immortalized GnRH-secreting neurons. Endocrinology 1999; 140: 1581-1585.
18. Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997; 94: 1023-1028.
19. Mellon P, Windle J, Goldsmith P, Padula C, Roberts J, Weiner R. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 1990; 5: 1-10.
20. Liposits Z, Merchenthaler I, Wetsel WC, Reid JJ, Mellon PL, Weiner RI, Negro-Vilar A. Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. Endocrinology 1991; 129: 1575-1583.
21. Weiner RI, Wetsel W, Goldsmith P, Martinez de la Escalera G, Windle J, Padula C, Choi A, Negro-Vilar A, Mellon P. Gonadotropin-releasing hormone neuronal cell lines. Front Neuroendocrinol 1992; 13: 95-119.
22. Wetsel WC. Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons. a new tool for dissecting the molecular and cellular basis of LHRH physiology. Cell Mol Neurobiol 1995; 15: 43-78.
23. Gore AC, Roberts JL. Regulation of gonadotropin-releasing hormone gene expression in vivo and in vitro. Front Neuroendocrinol 1997; 18: 209-245.
24. Bjorbaek C, Elmquist JK, El-Haschimi K, Kelly J, Ahima RS, Hileman S, Flier JS. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology 1999; 140: 2035-2043.
25. Malek RL, Halvorsen SW. Opposing regulation of ciliary neurotrophic factor receptors on neuroblastoma cells by distinct differentiating agents. J Neurobiol 1997; 32: 81-94.
26. Hanisch A, Dieterich KD, Dietzmann K, Ludecke K, Buchfelder M, Fahlbusch R, Lehnert H. Expression of members of the interleukin-6 family of cytokines and their receptors in human pituitary and pituitary adenomas. J Clin Endocrinol Metab 2000; 85: 4411-4414.
27. Tomida M, Yamamoto-Yamaguchi Y, Hozumi M. Pregnancy associated increase in mRNA for soluble D-factor/LIF receptor in mouse liver. FEBS Lett 1993; 334: 193-197.
28. Lin SC, Yamate T, Taguchi Y, Borba VZ, Girasole G, O'Brien CA, Bellido T, Abe E, Manolagas SC. Regulation of the gp8O and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. J Clin Invest 1997; 100: 1980-1990.
29. Shisheva A, Buxton J, Czech MP. Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes. J Biol Chem 1994; 269: 23865-23868.
30. Mellott T, Lopez-Coviella I, Blusztajn JK, Berse B. Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression. Eur J Biochem 2002; 269: 850-858.
31. Maggi R, Pimpinelli F, Martini L, Piva F. Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells. Endocrinology 1995; 136: 5177-5181.
32. Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ. The ciliary neurotrophic factor and its receptor, CNTFRalpha. Pharma Acta Helv 2000; 74: 265-272.
33. Blanchard F, Duplomb L, Wang Y, Robledo O, Kinzie E, Pitard V, Godard A, Jacques Y, Baumann H. Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase. J Biol Chem 2000; 275: 28793-28801.
34. Vermes C, Jacobs JJ, Zhang J, Firneisz G, Roebuck KA, Glant TT. Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. J Biol Chem 2002; 277: 16879-16887.
35. Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A. Leptin in reproduction. Trends Endocrinol Metab 2001; 12: 65-72.
36. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 1998; 334: 297-314.
37. Taga T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997; 15: 797-819.
38. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93: 8374-8378.