Activity modes in thalamocortical relay neurons are modulated by G q/G 11 family G-proteins - serotonergic and glutamatergic signaling

Frontiers in Cellular Neuroscience

Volumn 4, Issue , 2010, Pages 1-10

  Coulon, Philippe ^a,d   Kanyshkova, Tatyana ^a,d   Broicher, Tilman ^a,d   Munsch, Thomas ^b   Wettschureck, Nina ^b   Seidenbecher, Thomas ^a   Meuth, Sven G ^a   Offermanns, Stefan ^c   Pape, Hans Christian ^a   Budde, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^d University of Utah   (United States)

Author keywords

G protein; Gene knockout; Metabotropic glutamate receptor; Muscarinic receptor; Serotonin receptor; Thalamic function

Indexed keywords

ACETYLCHOLINE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 1 ALPHA; MUSCARINIC RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN STEM; CONTROLLED STUDY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LATERAL GENICULATE BODY; MEMBRANE POTENTIAL; MOUSE; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; SEROTONIN METABOLISM; SEROTONINERGIC SYSTEM; THALAMOCORTICAL TRACT;

EID: 84856696369     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2010.00132     Document Type: Article

References (44)

1. 2+ spike in the thalamus of a rat model of absence epilepsy. Mol. Cell. Neurosci. 39, 384-399.
2. Broicher, T., Wettschureck, N., Munsch, T., Coulon, P., Meuth, S. G., Kanyshkova, T., Seidenbecher, T., Offermanns, S., Pape, H. C., and Budde, T. (2008b). Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/ G(11)-family G-proteins. Pflugers Arch. 456, 1049-1060.
3. + channels. EMBO J. 22, 5403-5411.
4. Chen, X., Talley, E. M., Patel, N., Gomis, A., McIntire, W. E., Dong, B., Viana, F., Garrison, J. C., and Bayliss, D. A. (2006). Inhibition of a background potassium channel by Gq protein {alpha}-subunits. Proc. Natl. Acad. Sci. U. S.A.103, 3422-3427.
5. Exton, J. H. (1996). Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36, 481-509.
6. Godwin, D. W., Vaughan, J. W., and Sherman, S. M. (1996a). Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic. J. Neurophysiol. 76, 1800-1816.
7. Godwin, D. W., Van Horn, S. C., Eriir, A., Sesma, M., Romano, C., and Sherman, S. M. (1996b). Ultrastructural localization suggests that retinal and cortical inputs access different metabotropic glutamate receptors in the lateral geniculate nucleus. J. Neurosci. 16, 8181-8192.
8. Greif, G. J., Sodickson, D. L., Bean, B. P., Neer, E. J., and Mende, U. (2000). Altered regulation of potassium and calcium channels by GABAB and adenosine receptors in hippocampal neurons from mice lacking galpha o. J. Neurophysiol. 83, 1010-1018.
9. Hirsch, J. C., Fourment, A., and Marc, M. E. (1983). Sleep-related variations of membrane potential in the lateral geniculate body relay neurons of the cat. Brain Res. 259, 308-312.
10. Ito, I., Kohda, A., Tanabe, S., Hirose, E., Hayashi, M., Mitsunaga, S., and Sugiyama, H. (1992). 3,5-Dihydroxyphenyl- glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport 3, 1013-1016.
11. Lee, K. H., and McCormick, D. A. (1996). Abolition of spindle oscillations by serotonin and norepinephrine in the ferret lateral geniculate and perigeniculate nuclei in vitro. Neuron 17, 309-321.
12. Li, Q. H., Nakadate, K., Tanaka-Nakadate, S., Nakatsuka, D., Cui, Y., and Watanabe, Y. (2004). Unique expression patterns of 5-HT2A and 5-HT2C receptors in the rat brain during postnatal development: western blot and immunohistochemical analyses. J. Comp. Neurol. 469, 128-140.
13. Liu, X. B., Munoz, A., and Jones, E. G. (1998). Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus. J. Comp. Neurol. 395, 450-465.
14. + channels. J. Physiol. (Lond.) 564, 117-129.
15. Lourenco Neto, F., Schadrack, J., Berthele, A., Zieglgansberger, W., Tolle, T. R., and Castro-Lopes, J. M. (2000). Differential distribution of metabotropic glutamate receptor subtype mRNAs in the thalamus of the rat. Brain Res. 854, 93-105.
16. Ludwig, A., Budde, T., Stieber, J., Moosmang, S., Wahl, C., Holthoff, K., Langebartels, A., Wotjak, C., Munsch, T., Zong, X., Feil, S., Feil, R., Lancel, M., Chien, K. R., Konnerth, A., Pape, H. C., Biel, M., and Hofmann, F. (2003). Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 22, 216-224.
17. 2+- mediated upregulation of Ih. Neuron 20, 553-563.
18. Mantamadiotis, T., Lemberger, T., Bleckmann, S. C., Kern, H., Kretz, O., Villalba, A. M., Tronche, F., Kellendonk, C., Gau, D., Kapfhammer, J., Otto, C., Schmid, W., and Schutz, G. (2002). Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31, 47-54.
19. Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Gutierrez, S. O., van der Stelt, M., Lopez-Rodriguez, M. L., Casanova, E., Schutz, G., Zieglgansberger, W., Di Marzo, V., Behl, C., and Lutz, B. (2003). CB1 cannabinoid receptors and ondemand defense against excitotoxicity. Science 302, 84-88.
20. Marty, C., and Ye, R. D. (2010). Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors. Mol. Pharmacol. 78, 12-18.
21. McCormick, D. A. (1992a). Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Prog. Neurobiol. 39, 337-388.
22. McCormick, D. A. (1992b). Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. J. Neurosci. 12, 278-289.
23. McCormick, D. A., and Pape, H.-C. (1990). Noradrenergic and serotonergic modulation of a hyperpolarizationactivated cation current in thalamic relay neurones. J. Physiol. (Lond.) 431, 319-342.
24. McCormick, D. A., and von Krosigk, M. (1992). Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proc. Natl. Acad. Sci. U.S.A. 89, 2774-2778.
25. Meuth, S. G., Aller, M. I., Munsch, T., Schuhmacher, T., Seidenbecher, T., Kleinschnitz, C., Pape, H. C., Wiendl, H., Wisden, W., and Budde, T. (2006). The contribution of TASK-1- containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. Mol. Pharmacol. 69, 1468-1476.
26. + channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons. J. Neurosci. 23, 6460-6469.
27. Munsch, T., Yanagawa, Y., Obata, K., and Pape, H. C. (2005). Dopaminergic control of local interneuron activity in the thalamus. Eur. J. Neurosci. 21, 290-294.
28. Offermanns, S. (1999). New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies. Naunyn Schmiedebergs Arch. Pharmacol. 360, 5-13.
29. Offermanns, S., and Simon, M. I. (1995). G and G couple a wide variety of receptors to phospholipase C. J. Biol. Chem. 270, 15175-15180.
30. Offermanns, S., Zhao, L. P., Gohla, A., Sarosi, I., Simon, M. I., and Wilkie, T. M. (1998). Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J. 17, 4304-4312.
31. Roth, B. L., Willins, D. L., Kristiansen, K., and Kroeze, W. K. (1998). 5-Hydroxytryptamine2- family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacol. Ther. 79, 231-257.
32. Salt, T. E. (2002). Glutamate receptor functions in sensory relay in the thalamus. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 357, 1759-1766.
33. Sato, M., and Ishikawa, Y. (2010). Accessory proteins for heterotrimeric G-protein: implication in the cardiovascular system. Pathophysiology 17, 89-99.
34. Sherman, S. M. (1996). Dual reponse modes in lateral geniculate neurons: mechanisms and functions. Vis. Neurosci. 13, 205-213.
35. Sherman, S. M. (2004). Interneurons and triadic circuitry of the thalamus. Trends Neurosci. 27, 670-675.
36. Siuciak, J. A., McCarthy, S. A., Chapin, D. S., Reed, T. M., Vorhees, C. V., and Repaske, D. R. (2007). Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase- 1B (PDE1B) enzyme. Neuropharmacology 53, 113-124.
37. Steriade, M. (1991). Alertness, quiet sleep, dreaming. Cereb. Cortex 9, 279-357.
38. Steriade, M., Jones, E. G., and McCormick, D. A. (1997). Thalamus 1st Edn. Amsterdam: Elsevier,.
39. Sun, Y., McGarrigle, D., and Huang, X.-Y. (2007). When a G protein-coupled receptor does not couple to a G protein. Mol. Biosyst. 3, 849-854.
40. Turner, J. P., and Salt, T. E. (2000). Synaptic activation of the group I metabotropic glutamate receptor mGlu1 on the thalamocortical neurons of the rat dorsal lateral geniculate nucleus in vitro. Neuroscience 100, 493-505.
41. Wettschureck, N., Moers, A., and Offermanns, S. (2004a). Mouse models to study G-protein-mediated signaling. Pharmacol. Ther. 101, 75-89.
42. Wettschureck, N., Moers, A., Hamalainen, T., Lemberger, T., Schutz, G., and Offermanns, S. (2004b). Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice. Mol. Cell. Biol. 24, 8048-8054.
43. Wettschureck, N., Rutten, H., Zywietz, A., Gehring, D., Wilkie, T. M., Chen, J., Chien, K. R., and Offermanns, S. (2001). Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat. Med. 7, 1236-1240.
44. Wettschureck, N., van der Stelt, M., Tsubokawa, H., Krestel, H., Moers, A., Petrosino, S., Schutz, G., Di Marzo, V., and Offermanns, S. (2006). Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol. Cell. Biol. 26, 5888-5894.