Unique Expression Patterns of 5-HT2A and 5-HT2C Receptors in the Rat Brain during Postnatal Development: Western Blot and Immunohistochemical Analyses

Journal of Comparative Neurology

Volumn 469, Issue 1, 2004, Pages 128-140

  Li, Qing Hua ^a,b   Nakadate, Kazuhiko ^b   Tanaka Nakadate, Sawako ^b   Nakatsuka, Daisaku ^a,b   Cui, Yilong ^b   Watanabe, Yasuyoshi ^a,b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

Developmental change; Layer IV of cerebral cortex; Plasticity; Serotonin receptors

Indexed keywords

RECEPTOR SUBTYPE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; AUDITORY CORTEX; BIOSYNTHESIS; BRAIN; BRAIN DEVELOPMENT; BRAIN LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PERINATAL PERIOD; PHYSIOLOGY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; SOMATOSENSORY CORTEX; THALAMUS; THALAMUS VENTRAL NUCLEUS; VISUAL CORTEX; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C;

EID: 0347417014     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.11004     Document Type: Article

References (59)

1. 2C receptors: a behavioral analysis. Exp Neurol 154:522-530.
2. Bear MF, Singer W. 1986. Modulation of visual cortical plasticity by acetylcholine and noradrenaline. Nature 320:172-176.
3. Bennett-Clarke CA, Leslie MJ, Chiaia NL, Rhoades RW. 1993. Serotonin 1B receptors in the developing somatosensory and visual cortices are located on thalamocortical axons. Proc Natl Acad Sci U S A 90:153-157.
4. Bennett-Clarke CA, Leslie MJ, Lane RD, Rhoades RW. 1994. Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat's somatosensory cortex. J Neurosci 14:7594-7607.
5. Bernardo KL, Woolsey TA. 1987. Axonal trajectories between mouse somatosensory thalamus and cortex. J Comp Neurol 258:542-564.
6. Bina KG, Guzman P, Broide RS, Leslie FM, Smith MA, O'Dowd DK. 1995. Localization of alpha 7 nicotinic receptor subunit mRNA and alpha-bungarotoxin binding sites in developing mouse somatosensory thalamocortical system. J Comp Neurol 363:321-332.
7. Blue ME, Parnavelas JG. 1983a. The formation and maturation of synapses in the visual cortex of the rat. I. Qualitative analysis. J Neurocytol 12:599-616.
8. Blue ME, Parnavelas JG. 1983b. The formation and maturation of synapses in the visual cortex of the rat. II. Quantitative analysis. J Neurocytol 12:697-712.
9. Cases O, Vitalis T, Seif I, De Maeyer E, Sotelo C, Gaspar P. 1996. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 16:297-307.
10. Chen L, Hamaguchi K, Ogawa M, Hamada S, Okado N. 1994. PCPA reduces both monoaminergic afferents and nonmonoaminergic synapses in the cerebral cortex. Neurosci Res 191:111-115.
11. Chubakov AR, Gromova EA, Konovalov GV, Sarkisova EF, Chumasov EI. 1986. The effects of serotonin on the morpho-functional development of rat cerebral neocortex in tissue culture. Brain Res 369:285-297.
12. 2C receptor protein in the rat CNS. Neuropharmacology 39:123-132.
13. 2A receptor in the central nervous system of adult rat. J Comp Neurol 409:187-209.
14. D'Amato RJ, Blue ME, Largent BL, Lynch DR, Ledbetter DJ, Molliver ME, Snyder SH. 1987. Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas. Proc Natl Acad Sci U S A 84:4322-4326.
15. Dyck RH, Cynader MS. 1993. Autoradiographic localization of serotonin receptor subtypes in cat visual cortex: transient regional, laminar, and columnar distributions during postnatal development. J Neurosci 13:4316-4338.
16. Edagawa Y, Saito H, Abe K. 2000. The serotonin 5-HT2 receptor-phospholipase C system inhibits the induction of long-term potentiation in the rat visual cortex. Eur J Neurosci 12:1391-1396.
17. Flanigan TP, Reavley AC, Carey JE, Leslie RA. 1995. Evidence for expression of the 5-HT2B receptor mRNA in rat brain. Br J Pharmacol 114:369P.
18. Flint AC, Maisch US, Weishaupt JH, Kriegstein AR, Monyer H. 1997. NR2 A subunit expression shortens NMDA receptor synaptic currents in developing neocortex. J Neurosci 17:2469-2476.
19. Fox K, Zahs K. 1994. Critical period control in sensory cortex. Curr Opin Neurobiol 4:112-119.
20. Goldberg JI. 1998. Serotonin regulation of neurite outgrowth in identified neurons from mature and embryonic Helisoma trivolvis. Perspect Dev Neurobiol 5:373-387.
21. Gu Q, Singer W. 1995. Involvement of serotonin in developmental plasticity of visual cortex. Eur J Neurosci 7:1146-1153.
22. 2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Brain Res Mol Brain Res 54:199-211.
23. Haring JH, Yan W. 1999. Dentate granule cell function after neonatal treatment with parachloroamphetamine or 5,7-dihydroxytryptamine. Brain Res Dev Brain Res 114:269-272.
24. Haydon PG, McCobb DP, Kater SB. 1984. Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons. Science 226:561-564.
25. 2C receptor mutant mice. Ann N Y Acad Sci 861:74-78.
26. Jensen KF, Killackey HP. 1987. Terminal arbors of axons projecting to the somatosensory cortex of the adult rat. I. The normal morphology of specific thalamocortical afferents. J Neurosci 7:3529-3543.
27. Julius D. 1991. Molecular biology of serotonin receptors. Annu Rev Neurosci 14:335-360.
28. Kalsbeek A, Matthijssen MA, Uylings HB. 1989. Morphometric analysis of prefrontal cortical development following neonatal lesioning of the dopaminergic mesocortical projection. Exp Brain Res 78:279-289.
29. Kasamatsu T, Pettigrew JD, Ary M. 1979. Restoration of visual cortical plasticity by local microperfusion of norepinephrine. J Comp Neurol 185:163-181.
30. Kojic L, Dyck RH, Gu Q, Douglas RM, Matsubara J, Cynader MS. 2000. Columnar distribution of serotonin-dependent plasticity within kitten striate cortex. Proc Natl Acad Sci U S A 97:1841-1844.
31. Lauder JM, Wallace JA, Krebs H. 1981. Roles for serotonin in neuroembryogenesis. Adv Exp Med Biol 133:477-506.
32. Lauder JM, Wilkie MB, Wu C, Singh S. 2000. Expression of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in the mouse embryo. Int J Dev Neurosci 18:653-662.
33. Lebrand C, Cases O, Adelbrecht C, Doye A, Alvarez C, El Mestikawy S, Seif I, Gaspar P. 1996. Transient uptake and storage of serotonin in developing thalamic neurons. Neuron 17:823-835.
34. Leslie MJ, Bennett-Clarke CA, Rhoades RW. 1992. Serotonin 1B receptors form a transient vibrissa-related pattern in the primary somatosensory cortex of the developing rat. Brain Res Dev Brain Res 69:143-148.
35. Levitt P, Harvey JA, Friedman E, Simansky K, Murphy EH. 1997. New evidence for neurotransmitter influences on brain development. Trends Neurosci 20:269-274.
36. 2C receptors in serotonin transporter knockout mice. J Neurochem 84:1256-1265.
37. Lidov HG, Molliver ME. 1982. An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res Bull 8:389-430.
38. Lieske V, Bennett-Clarke CA, Rhoades RW. 1999. Effects of serotonin on neurite outgrowth from thalamic neurons in vitro. Neurosci 90:967-974.
39. Lotto B, Upton L, Price DJ, Gaspar P. 1999. Serotonin receptor activation enhances neurite outgrowth of thalamic neurones in rodents. Neurosci Lett 269:87-90.
40. Mansour-Robaey S, Mechawar N, Radia F, Beaulieu C, Descarries L. 1998. Quantified distribution of serotonin transporter and receptors during the postnatal development of the rat barrel field cortex. Brain Res Dev Brain Res 107:159-163.
41. Mazer C, Muneyyirci J, Taheny K, Raio N, Borella A, Whitaker-Azmitia P. 1997. Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits. Brain Res 760:68-73.
42. Mercer AR, Kirchhof BS, Hildebrand JG. 1996. Enhancement by serotonin of the growth in vitro of antennal lobe neurons of the sphinx moth Manduca sexta. J Neurobiol 29:49-64.
43. Miller M, Peters A. 1981. Maturation of rat visual cortex. II. A combined Golgi-electron microscope study of pyramidal neurons. J Comp Neurol 203:555-573.
44. 2A receptor agonist and antagonist in the spinal cord of chicken embryo. Neurosci Lett 195:159-162.
45. Osterheld-Haas MC, Hornung JP. 1994. Monoaminergic afferents to cortex modulate structural plasticity in the barrel field of the mouse. Dev Brain Res 77:189-202.
46. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. London: Academic Press.
47. Rhoades RW, Bennett-Clarke CA, Lane RD, Leslie MJ, Mooney RD. 1993. Increased serotoninergic innervation of the hamster's superior colliculus alters retinotectal projections. J Comp Neurol 334:397-409.
48. Roth BL, Hamblin MW, Ciaranello RD. 1991. Developmental regulation of 5-HT2 and 5-HT1c mRNA and receptor levels. Brain Res Dev Brain Res 58:51-58.
49. Roth BL, Willins DL, Kristiansen K, Kroeze WK. 1998. 5-Hydroxytryptamine 2-family receptors (5-hydroxytryptamine 2A, 5-hydroxytryptamine 2B, 5-hydroxytryptamine 2C): where structure meets function. Pharmacol Ther 79:231-257.
50. Salichon N, Gaspar P, Upton AL, Picaud S, Hanoun N, Hamon M, De Maeyer E, Murphy DL, Mossner R, Lesch KP, Hen R, Seif I. 2001. Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase A and 5-HT transporter knock-out mice. J Neurosci 21:884-896.
51. Schlaggar BL, Fox K, O'Leary DD. 1993. Postsynaptic control of plasticity in developing somatosensory cortex. Nature 364:623-626.
52. Sherwood NM, Timiras PS. 1970. A stereotaxic atlas of the developing rat brain. London: University of California Press.
53. Swanson LM. 1992. Brain Maps: structure of the rat brain. Amsterdam: Elsevier.
54. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. 1995. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374:542-546.
55. Uylings HBM, Verwer RWH, Van Plet J, Parnavelas JG. 1983. Topological analysis of dendritic growth at various stages of cerebral development. Acta Stereol 2:55-60.
56. Whitaker-Azmitia PM, Druse M, Walker P, Lauder JM. 1996. Serotonin as a developmental signal. Behav Brain Res 73:19-29.
57. Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L. 1995. Comparative localization of serotonin 1A, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351:357-373.
58. 2A receptor. J Histochem Cytochem 46:811-824.
59. Yan W, Wilson CC, Haring JH. 1997. Effects of neonatal serotonin depletion on the development of rat dentate granule cells. Brain Res Dev Brain Res 98:177-184.