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Volumn 360, Issue 1, 1999, Pages 5-13

New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies

Author keywords

G protein; Knockout; Signal transduction; Transgenic animals

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 0032839890     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900030     Document Type: Review
Times cited : (29)

References (79)
  • 3
    • 0032499260 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392: 565-568
    • (1998) Nature , vol.392 , pp. 565-568
    • Baggiolini, M.1
  • 9
    • 0029620817 scopus 로고
    • Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice
    • Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, Hashimoto K, Thompson RF, Tonegawa S (1995) Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell 83:1233-1242
    • (1995) Cell , vol.83 , pp. 1233-1242
    • Chen, C.1    Kano, M.2    Abeliovich, A.3    Chen, L.4    Bao, S.5    Kim, J.J.6    Hashimoto, K.7    Thompson, R.F.8    Tonegawa, S.9
  • 13
    • 0031058676 scopus 로고    scopus 로고
    • Basic determinants of myocardial hypertrophy: A review of molecular mechanisms
    • Cooper G ( 1997) Basic determinants of myocardial hypertrophy: a review of molecular mechanisms. Annu Rev Med 48:13-23
    • (1997) Annu Rev Med , vol.48 , pp. 13-23
    • Cooper, G.1
  • 14
    • 0000031322 scopus 로고
    • Regression of functional synapses in the immature mammalian cerebellum
    • Crépel F (1982) Regression of functional synapses in the immature mammalian cerebellum. Trends Neurosci 5:266-269
    • (1982) Trends Neurosci , vol.5 , pp. 266-269
    • Crépel, F.1
  • 17
    • 0027399429 scopus 로고
    • Imprinting in Albright's hereditary osteodystrophy
    • Davies SJ, Hughes HE (1993) Imprinting in Albright's hereditary osteodystrophy. J Med Genet 30:101-103
    • (1993) J Med Genet , vol.30 , pp. 101-103
    • Davies, S.J.1    Hughes, H.E.2
  • 19
    • 0031963368 scopus 로고    scopus 로고
    • Mechanisms of modulation of voltage-dependent calcium channels by G proteins
    • Dolphin AC (1998) Mechanisms of modulation of voltage-dependent calcium channels by G proteins. J Physiol (Lond) 506:3-11
    • (1998) J Physiol (Lond) , vol.506 , pp. 3-11
    • Dolphin, A.C.1
  • 20
    • 0029936331 scopus 로고    scopus 로고
    • Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins
    • Exton JH (1996) Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36:481-509
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 481-509
    • Exton, J.H.1
  • 24
    • 0027339528 scopus 로고
    • G(olf) and Gs in rat basal ganglia: Possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase
    • Herve D, Levi-Strauss M, Marey-Semper I, Verney C, Tassin JP, Glowinski J, Girault JA (1993) G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase. J Neurosci 13:2237-2248
    • (1993) J Neurosci , vol.13 , pp. 2237-2248
    • Herve, D.1    Levi-Strauss, M.2    Marey-Semper, I.3    Verney, C.4    Tassin, J.P.5    Glowinski, J.6    Girault, J.A.7
  • 25
    • 0029908546 scopus 로고    scopus 로고
    • Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin
    • Höfer D, Puschel B, Drenckhahn D (1996) Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA 93:6631-6634
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6631-6634
    • Höfer, D.1    Puschel, B.2    Drenckhahn, D.3
  • 26
    • 0000201075 scopus 로고    scopus 로고
    • + exchange through distinct Cdc42-dependent and RhoA-dependent pathways
    • + exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J Biol Chem 271:6152-6158
    • (1996) J Biol Chem , vol.271 , pp. 6152-6158
    • Hooley, R.1    Yu, C.Y.2    Symons, M.3    Barber, D.L.4
  • 27
    • 0031066597 scopus 로고    scopus 로고
    • Gαi2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines
    • Hornquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR (1997) Gαi2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 158:1068-1077
    • (1997) J Immunol , vol.158 , pp. 1068-1077
    • Hornquist, C.E.1    Lu, X.2    Rogers-Fani, P.M.3    Rudolph, U.4    Shappell, S.5    Birnbaumer, L.6    Harriman, G.R.7
  • 28
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoitiositide hydrolysis and inhibit adenylyl cyclase
    • Hung DT, Wong YH, Vu TKH, Coughlin SR (1992) The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoitiositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem 267:20831-20834
    • (1992) J Biol Chem , vol.267 , pp. 20831-20834
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.K.H.3    Coughlin, S.R.4
  • 31
    • 0031035031 scopus 로고    scopus 로고
    • Persistent multiple climbing fiber innervation of cercbellar Purkinje cells in mice lacking mGIuR 1
    • Kano M, Hashimoto K, Kurihara H, Watanabe M, Inoue Y, Aiba A, Tonegawa S (1997) Persistent multiple climbing fiber innervation of cercbellar Purkinje cells in mice lacking mGIuR 1. Neuron 18:71-79
    • (1997) Neuron , vol.18 , pp. 71-79
    • Kano, M.1    Hashimoto, K.2    Kurihara, H.3    Watanabe, M.4    Inoue, Y.5    Aiba, A.6    Tonegawa, S.7
  • 34
    • 0033593667 scopus 로고    scopus 로고
    • 13 results in shape change and Rho/Rho-kinase-medialed myosin light chain phosphorylation in mouse platelets
    • 13 results in shape change and Rho/Rho-kinase-medialed myosin light chain phosphorylation in mouse platelets. J Cell Biol 144:745-754
    • (1999) J Cell Biol , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 38
    • 0030266428 scopus 로고    scopus 로고
    • Chemoreception: Tasting the sweet and the bitter
    • Lindemann B (1996) Chemoreception: tasting the sweet and the bitter. Curr Biol 6:1234-1237
    • (1996) Curr Biol , vol.6 , pp. 1234-1237
    • Lindemann, B.1
  • 40
    • 0032524525 scopus 로고    scopus 로고
    • Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene
    • Mattera R, Hayek S, Summers BA, Grove DL (1998) Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene. Biochem J 332:263-271
    • (1998) Biochem J , vol.332 , pp. 263-271
    • Mattera, R.1    Hayek, S.2    Summers, B.A.3    Grove, D.L.4
  • 41
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin SK, McKinnon PJ, Margolskee RF (1992) Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357:563-569
    • (1992) Nature , vol.357 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 42
    • 0032506233 scopus 로고    scopus 로고
    • Transient cardiac expression of constitutively active Galphaq lends to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
    • Mende U, Kagen A, Cohen A, Aramburu J, Schoen FJ, Neer EJ (1998) Transient cardiac expression of constitutively active Galphaq lends to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci USA 95:13893-13898
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13893-13898
    • Mende, U.1    Kagen, A.2    Cohen, A.3    Aramburu, J.4    Schoen, F.J.5    Neer, E.J.6
  • 45
    • 0030025047 scopus 로고    scopus 로고
    • Insulin action impaired by deficiency of the G-protein subunit Gi alpha2
    • Moxham CM, Malbon CC (1996) Insulin action impaired by deficiency of the G-protein subunit Gi alpha2. Nature 379:840-844
    • (1996) Nature , vol.379 , pp. 840-844
    • Moxham, C.M.1    Malbon, C.C.2
  • 46
    • 0027249144 scopus 로고
    • Induction of G alpha 12-specific antisense RNA in vivo inhibits neonatal growth
    • Moxham CM, Hod Y, Malbon CC ( 1993a) Induction of G alpha 12-specific antisense RNA in vivo inhibits neonatal growth. Science 260:991-995
    • (1993) Science , vol.260 , pp. 991-995
    • Moxham, C.M.1    Hod, Y.2    Malbon, C.C.3
  • 47
    • 0027340250 scopus 로고
    • Gi alpha 2 mediates the inhibitory regulation of adenylylcyclase in vivo: Analysis in transgenic mice with Gi alpha 2 suppressed by inducible antisense RNA
    • Moxham CM, Hod Y, Malbon CC (1993b) Gi alpha 2 mediates the inhibitory regulation of adenylylcyclase in vivo: analysis in transgenic mice with Gi alpha 2 suppressed by inducible antisense RNA. Dev Genet 14:266-273
    • (1993) Dev Genet , vol.14 , pp. 266-273
    • Moxham, C.M.1    Hod, Y.2    Malbon, C.C.3
  • 48
    • 0032557723 scopus 로고    scopus 로고
    • Pseudohypoparathyroidism type Ia from maternal but not paternal transmission of a Gsalpha gene mutation
    • Nakamoto JM, Sandstrom AT, Briekman AS, Christenson RA, Van Dop C (1998) Pseudohypoparathyroidism type Ia from maternal but not paternal transmission of a Gsalpha gene mutation. Am J Med Genet 77:261-267
    • (1998) Am J Med Genet , vol.77 , pp. 261-267
    • Nakamoto, J.M.1    Sandstrom, A.T.2    Briekman, A.S.3    Christenson, R.A.4    Van Dop, C.5
  • 49
  • 55
    • 0032570827 scopus 로고    scopus 로고
    • 13 activates a phospholipase D isozyme by a pathway requiring Rho family GTPases
    • 13 activates a phospholipase D isozyme by a pathway requiring Rho family GTPases. J Biol Chem 273: 4823-4826
    • (1998) J Biol Chem , vol.273 , pp. 4823-4826
    • Plonk, S.G.1    Park, S.K.2    Exton, J.H.3
  • 56
    • 0029143947 scopus 로고
    • Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13
    • Prasad MV, Dermott JM, Heasley LE, Johnson GL, Dhanasekuran N (1995) Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13. J Biol Chem 270:18655-18659
    • (1995) J Biol Chem , vol.270 , pp. 18655-18659
    • Prasad, M.V.1    Dermott, J.M.2    Heasley, L.E.3    Johnson, G.L.4    Dhanasekuran, N.5
  • 58
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W (1997) Mechanisms of angiogenesis. Nature 386:671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 62
    • 0031918820 scopus 로고    scopus 로고
    • Transduction mechanisms in vertebrate olfactory receptor cells
    • Schild D, Restrepo D (1998) Transduction mechanisms in vertebrate olfactory receptor cells. Physiol Rev 78:429-466
    • (1998) Physiol Rev , vol.78 , pp. 429-466
    • Schild, D.1    Restrepo, D.2
  • 63
    • 0025880172 scopus 로고
    • 2 receptor in human platelets is a member of the novel Gq family
    • Shenker A, Goldsmith P, Unson CG, Spiegel AM (1991) The G protein coupled to the thromboxane A, receptor in human platelets is a member of the novel Gq family. J Biol Chem 266:9309-9313
    • (1991) J Biol Chem , vol.266 , pp. 9309-9313
    • Shenker, A.1    Goldsmith, P.2    Unson, C.G.3    Spiegel, A.M.4
  • 64
    • 0025834532 scopus 로고
    • Diversity of G proteins in signal transduction
    • Simon MI, Strathmann MP, Gautam N (1991) Diversity of G proteins in signal transduction. Science 252:802-808
    • (1991) Science , vol.252 , pp. 802-808
    • Simon, M.I.1    Strathmann, M.P.2    Gautam, N.3
  • 66
    • 0025695580 scopus 로고
    • G protein diversity: A distinct class of alpha subunits is present in vertebrates and invertebrates
    • Strathmann M, Simon MI (1990) G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci USA 87:9113-9117
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9113-9117
    • Strathmann, M.1    Simon, M.I.2
  • 67
    • 0026003089 scopus 로고
    • G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits
    • Strathmann MP, Simon MI (1991) G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits. Proc Natl Acad Sci USA 88:5582-5586
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5582-5586
    • Strathmann, M.P.1    Simon, M.I.2
  • 69
    • 0028853240 scopus 로고
    • Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43
    • Strittmatter SM, Funkhauser C, Huang PL, Mashimo H, Fishman MC (1995) Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell 80:445-452
    • (1995) Cell , vol.80 , pp. 445-452
    • Strittmatter, S.M.1    Funkhauser, C.2    Huang, P.L.3    Mashimo, H.4    Fishman, M.C.5
  • 73
    • 0027489301 scopus 로고
    • G protein mutations in human disease
    • Weinstein LS, Shenker A (1993) G protein mutations in human disease. Clin Biochem 26:333-338
    • (1993) Clin Biochem , vol.26 , pp. 333-338
    • Weinstein, L.S.1    Shenker, A.2
  • 74
    • 0032818573 scopus 로고    scopus 로고
    • Regulators of G-protein signalling: A novel protein family involved in timely deactivation and desensitization of signalling via heterotrimeric G proteins
    • Wieland T, Chen C-K (1999) Regulators of G-protein signalling: a novel protein family involved in timely deactivation and desensitization of signalling via heterotrimeric G proteins. Naunyn-Schmiedeberg's Arch Pharmacol 360:14-26
    • (1999) Naunyn-Schmiedeberg's Arch Pharmacol , vol.360 , pp. 14-26
    • Wieland, T.1    Chen, C.-K.2
  • 76
    • 0029957779 scopus 로고    scopus 로고
    • Transduction of bitter and sweet taste by gustducin
    • Wong GT, Cannon KS, Margolskee RF (1996) Transduction of bitter and sweet taste by gustducin. Nature 381:796-800
    • (1996) Nature , vol.381 , pp. 796-800
    • Wong, G.T.1    Cannon, K.S.2    Margolskee, R.F.3
  • 77
    • 0027050601 scopus 로고
    • Activation of phospholipase C by alpha I-adrenergic receptors is mediated by the alpha subunits of Gq family
    • Wu D, Katz A, Lee CH, Simon MI (1992) Activation of phospholipase C by alpha I-adrenergic receptors is mediated by the alpha subunits of Gq family. J Biol Chem 267:25798-25802
    • (1992) J Biol Chem , vol.267 , pp. 25798-25802
    • Wu, D.1    Katz, A.2    Lee, C.H.3    Simon, M.I.4
  • 78
    • 0028332848 scopus 로고
    • Transduction mechanisms of vertebrate and invertebrate photoreceptors
    • Yarfitz S, Hurley JB (1994) Transduction mechanisms of vertebrate and invertebrate photoreceptors. J Biol Chem 269:14329-14332
    • (1994) J Biol Chem , vol.269 , pp. 14329-14332
    • Yarfitz, S.1    Hurley, J.B.2
  • 79
    • 0032555241 scopus 로고    scopus 로고
    • Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene
    • Yu S, Yu D, Lee E, Eckhaus M, Lee R, Corria Z, Accili D, Westphal H, Weinstein LS (1998) Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene. Proc Natl Acad Sci USA 95:8715-8720
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8715-8720
    • Yu, S.1    Yu, D.2    Lee, E.3    Eckhaus, M.4    Lee, R.5    Corria, Z.6    Accili, D.7    Westphal, H.8    Weinstein, L.S.9


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