A xenograft mouse model coupled with in-depth plasma proteome analysis facilitates identification of novel serum biomarkers for human ovarian cancer

Journal of Proteome Research

Volumn 11, Issue 2, 2012, Pages 678-691

  Tang, Hsin Yao ^a   Beer, Lynn A ^a   Chang Wong, Tony ^a   Hammond, Rachel ^b   Gimotty, Phyllis ^b   Coukos, George ^b   Speicher, David W ^a  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

biomarker discovery; cancer biomarkers; multidimensional protein profiling; ovarian cancer; proteomics; xenograft mouse model

Indexed keywords

ALDEHYDE REDUCTASE; BIOLOGICAL MARKER; CA 125 ANTIGEN; CATHEPSIN D; CHLORIDE CHANNEL; CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1; CLUSTERIN; HOMEODOMAIN PROTEIN; HOMEODOMAIN PROTEIN HMX1; PEROXIREDOXIN 6; PROTEIN CUTA; PROTEIN SERPINB12; PROTEOME; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VOLUME; CANCER CELL CULTURE; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIOID CARCINOMA; FEMALE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; OVARY CANCER; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; TUMOR XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; BLOOD PROTEINS; CASE-CONTROL STUDIES; CATHEPSIN D; CELL LINE, TUMOR; CHLORIDE CHANNELS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; PEROXIREDOXIN VI; PROTEOME; PROTEOMICS; REPRODUCIBILITY OF RESULTS; ROC CURVE; SEQUENCE ALIGNMENT; SPECIES SPECIFICITY; TRANSPLANTATION, HETEROLOGOUS; TUMOR MARKERS, BIOLOGICAL;

EID: 84856666193     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200603h     Document Type: Article

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