Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells

International Journal of Cancer

Volumn 124, Issue 5, 2009, Pages 1037-1044

  Dafou, Dimitra ^a,b   Ramus, Susan J ^a   Choi, Ken ^a   Grun, Barbara ^a   Trott, Deborah A ^b   Newbold, Robert F ^b   Jacobs, Ian J ^a   Jones, Christopher ^a   Gayther, Simon A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Array comparative genomic hybridisation; Microcell mediated chromosome transfer; Ovarian cancer; Tumour suppressor genes

Indexed keywords

ARTICLE; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME 4; CHROMOSOME 6; CONTROLLED STUDY; GENE FREQUENCY; GENE MAPPING; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL; CHROMOSOME MAP; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; GENETICS; NEOPLASM; OVARY TUMOR; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

CELL LINE, TUMOR; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 6; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS;

EID: 58749110697     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24058     Document Type: Article

References (37)

1. Boente MP, Hurteau J, Rodriguez GC, Bast RC, Jr. Berchuck A. The biology of ovarian cancer. Curr Opin Oncol 1993;5:900-7.
2. Manderson EN, Presneau N, Provencher D, Mes-Masson AM, Tonin PN. Comparative analysis of loss of heterozygosity of specific chromosome 3, 13, 17, and X loci and TP53 mutations in human epithelial ovarian cancer. Mol Carcinog 2002;34:78-90.
3. Ramus SJ, Pfiaroah PD, Harrington P, Pye C, Wetness B, Bobrow L, Ayhan A, Wells D, Fishman A, Gore M, DiCioccio RA, Piver MS, et al. BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases. Cancer Res 2003;63:417-23.
4. Helou K, Padilla-Nash H, Wangsa D, Karlsson E, Osterberg L, Karls-son P, Ried T, Knutsen T. Comparative genome hybridization reveals specific genomic imbalances during the genesis from benign through borderline to malignant ovarian tumors. Cancer Genet Cytogenet 2006;170:1-8.
5. Bandera CA, Takahashi H, Behbakht K, Liu PC, LiVolsi VA, Benjamin T, Morgan MA, King SA, Rubin SC, Boyd J. Deletion mapping of two potential chromosome 14 tumor suppressor gene loci in ovarian carcinoma. Cancer Res 1997;57:513-15.
6. Kerr J, Leary JA, Hurst T, Shih YC, Antalis TM, Friedlander M, Crawford E, Khoo SK, Ward B, Chenevix-Trench G. Allelic loss on chromosome 7q in ovarian adenocarcinomas: two critical regions and a rearrangement of the PLANH1 locus. Oncogene 1996; 13:1815-18.
7. Cuthbert AP, Trott DA, Ekong RM, Jezzard S, England NL, Themis M, Todd CM, Newbold RF. Construction and characterization of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies. Cytogenet Cell Genet 1995;71:68-76.
8. Rimessi P, Gualandi F, Morelli C, Trabanelli C, Wu Q, Possati L, Montesi M, Barrett JC, Barbanti-Brodano G. Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer. Oncogene 1994;9:3467-74.
9. Stronach EA, Sellar GC, Blenkiron C, Rabiasz GJ, Taylor KJ, Miller EP, Massie CE, Al-Nafussi A, Smyth JF, Porteous DJ, Gabra H. Identification of clinically relevant genes on chromosome 11 in a functional model of ovarian cancer tumor suppression. Cancer Res 2003;63:8648-55.
10. Abeysinghe HR, Cao Q, Xu J, Pollock S, Veyberman Y, Guckert NL, Keng P, Wang N. THY1 expression is associated with tumor suppres-sion of human ovarian cancer. Cancer Genet Cytogenet 2003;143: 125-32.
11. Wan M, Sun T, Vyas R, Zheng J, Granada E, Dubeau L. Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25. Oncogene 1999;18:1545-51.
12. Acquati F, Possati L, Ferrante L, Campomenosi P, Talevi S, Bardelli S, Margiotta C, Russo A, Bortoletto E, Rocchetti R, Calza R, Cin-quetti R. et al. Tumor and metastasis suppression by the human RNA-SET2 gene. Int J Oncol 2005;26:1159-68.
13. Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A. Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. Gynecol Oncol 2004;95:449-55.
14. Padalecki SS, Weldon KS, Reveles XT, Buller CL, Grubbs B, Cui Y, Yin JJ, Hall DC, Hummer BT, Weissman BE, Dallas M, Guise TA, et al. Chromosome 18 suppresses prostate cancer metastases. Urol Oncol 2003;5:366-73.
15. Provencher DM, Lounis H, Champoux L, Tétrault M, Manderson EN, Wang JC, Eydoux P, Savoie R, Tonin PN, Mes-Masson AM. Characterization of four novel epithelial ovarian cancer cell lines. In Vitro Cell Dev Biol Anim 2000;36:357-61.
16. Neuvial P, Hupe P, Brito I, Liva S, Manie E, Brennetot C, Radvanyi F, Aurias A, Barillot E. Spatial normalization of array-CGH data. Bio-informatics 2006;22:264-8.
17. Padalecki SS, Johnson-Pais TL, Killary AM, Leach RJ. Chromosome 18 suppresses the tumorigenicity of prostate cancer cells. Genes Chromosomes Cancer 2001;3:221-9.
18. Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S. Functional analysis of chromosome 18 in pancreatic cancer: strong evidence for new tumour suppressor genes. Asian J Surg 2004;27:85-92.
19. Gagnon A, Ripeau JS, Zvieriev V, Chevrette M. Chromosome 18 suppresses tumorigenic properties of human prostate cancer cells. Genes Chromosomes Cancer 2006;3:220-30.
20. Lefter LP, Sunamura M, Furukawa T, Takeda K, Kotobuki N, Oshi-inura M, Matsuno S, Horii A. Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. Clin Cancer Res 2003;9:5044-52.
21. Bignone PA, Lee KY, Liu Y, Emilion G, Finch J, Soosay AE, Char-nock FM, Beck S, Dunham T, Mungall AJ, Ganesan TS. RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. Oncogene 20 07:26:683-700.
22. Whitcomb BP, Mutch DG, Herzog TJ, Rader JS, Gibb RK, Goodfel-low PJ. Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma. Clin Cancer Res 2003;9:2277-87.
23. Yang S, Shin J, Park KH, Jeung HC, Rha SY, Noh SH, Yang WI, Chung HC. Molecular basis of the differences between nomial and tumor tissues of gastric cancer. Biochim Biophys Acta 2007; 1772;1033-40.
24. Zhang P, Yang Y, Zweidler-McKay PA, Hughes DP. Critical role of notch signaling in osteosarcoma invasion and metastasis. Clin Cancer Res 2008;14:2962-9.
25. Saha V, Lillington DM, Shelling AN, Chaplin T, Yaspo ML, Ganesan TS, Young BD. AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer. Genes Chromosomes Cancer 1995;14:220-2.
26. L'Espérance S, Popa I, Bachvarova M, Plante M, Patten N, Wu L, Têtu B, Bachvarov D. Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. Int J Oncol 2006;29:5-24.
27. Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS. The human homologue of unc-93 maps to chromosome 6q27-characterisation and analysis in sporadic epithelial ovarian cancer. BMC Genet 2002;3:20.
28. Steinemann D, Gesk S, Zhang Y, Harder L, Pilarsky C, Hinzmann B, Martin-Subero JT, Calasanz MJ, Mungall A, Rosenthal A, Siebert R, Schlegelberger B. Identification of candidate tumor-suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasms. Genes Chromosomes Cancer 2003;37:421-6.
29. Minaguchi T, Matsushima M, Saito S, Kanamori Y, Shirahama S, Okamoto S, Minami M, Taketani Y, Nakamura Y. Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer. DNA Res 1999;6:131-6.
30. Haveri H, Westerhoim-Ormio M, Lindfors K, Maki M, Savilahti E, Andersson LC, Heikinheirao M. Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. BMC Gastroenterol 2008;8:9.
31. Zukerberg LR, DeBernardo RL, Kirley SD, D'Apuzzo M, Lynch MP, Littell RD, Duska LR, Boring L, Rueda BR. Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res 2004;64:202-8.
32. Sathyanarayana UG, Padar A, Huang CX, Suzuki M, Shigeraatsu H, Bekele BN, Gazdar AF. Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma. Clin Cancer Res 2003;9:6389-94.
33. Xu XL, Yu J, Zhang HY, Sun MH, Gu J, Du X, Shi DR, Wang P, Yang ZH, Zhu JD. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 2004;10:3441-54.
34. Nebral K, König M, Harder L, Siebert R, Haas OA, Strehl S. Identification of PML as novel PAX5 fusion partner in childhood acute lymphoblastic leukaemia. Br J Haematol 2007;139:269-74.
35. Törnkvist M, Natalishvili N, Xie Y, Girnita A, D'Arcy P, Brodin B, Axelson M, Girnita L. Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth. Biochem Biophys Res Commun 2008;368:793-800.
36. Münstedt K, von Georgi R, Franke FE. Correlation between MIB1-determined tumor growth fraction and incidence of tumor recurrence in early ovarian carcinomas. Cancer Invest 2004;22:185-94.
37. Mullighan CG. Goorha S. Radtke I. Miller CB, Coustan-Smith E, Dai-ton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007;446:758-64.