메뉴 건너뛰기




Volumn 5, Issue 10, 2011, Pages 155-158

High-performance liquid chromatography analysis of plant saponins: An update 2005-2010

Author keywords

Charged aerosol; diode array detector; ESI; evaporative light scattering detection; high performance liquid chromatography; mass spectrometry; mobile phase; potodiode array detectors; sapogenins; saponins; ultraviolet

Indexed keywords

ACETIC ACID; ACETONITRILE; DIGITALIS; METHANOL; PLANT EXTRACT; SAPONIN; SARSASAPOGENIN; TRIETHYLAMINE; TRITERPENOID; WATER;

EID: 84856606372     PISSN: 09737847     EISSN: 09762787     Source Type: Journal    
DOI: 10.4103/0973-7847.91109     Document Type: Review
Times cited : (23)

References (45)
  • 1
    • 0345666397 scopus 로고
    • Chemistry of Ayurvedic crude drugs: Part VIa-(Shatavari-l): Structure of Shatavarin-IV
    • Ravikumar PR, Soman R, Chetty GL, Pandey RC, Sukhdev. Chemistry of Ayurvedic crude drugs: Part VIa-(Shatavari-l): Structure of Shatavarin-IV. Ind J Chem 1987;26:1012-7.
    • (1987) Ind J Chem , vol.26 , pp. 1012-7
    • Ravikumar, P.R.1    Soman, R.2    Chetty, G.L.3    Pandey, R.C.4    Sukhdev5
  • 2
    • 0032879573 scopus 로고    scopus 로고
    • Industrial uses and sustainable supply of Quillaja saponaria (Rosaceae) saponins
    • San Martin R, Briones R. Industrial uses and sustainable supply of Quillaja saponaria (Roseaceae). Econ Bot 1999;53:302-11. (Pubitemid 29452289)
    • (1999) Economic Botany , vol.53 , Issue.3 , pp. 302-311
    • San Martin, R.1    Briones, R.2
  • 3
    • 0022523219 scopus 로고
    • A mechanism for the hypocholesterolaemic activity of saponins
    • Sidhu GS, Oekenfull DG. A mechanism for the hypocholesterolaemic activity of saponins. Br J Nutr 1986;55:643-9. (Pubitemid 16086371)
    • (1986) British Journal of Nutrition , vol.55 , Issue.3 , pp. 643-649
    • Sidhu, G.S.1    Oakenfull, D.G.2
  • 4
    • 0001030152 scopus 로고    scopus 로고
    • Micellar Properties of Quillaja Saponin. 1. Effects of Temperature, Salt, and pH on Solution Properties
    • Mitra S, Dungan SR. Micellar Properties of Quillaja Saponin. Effects of Temperature, Salt, and pH on Solution Properties. J Agric Food Chem 1997;45:1587-95. (Pubitemid 127485586)
    • (1997) Journal of Agricultural and Food Chemistry , vol.45 , Issue.5 , pp. 1587-1595
    • Mitra, S.1    Dungan, S.R.2
  • 5
    • 0034521898 scopus 로고    scopus 로고
    • The bioactivity of saponins: Triterpenoid and steroidal glycosides
    • Rao AV, Gurfinkel DM. The bioactivity of saponins: Triterpenoid and steroidal glycosides. Drug Metabol Drug Interact 2000;17:211-35. (Pubitemid 32047536)
    • (2000) Drug Metabolism and Drug Interactions , vol.17 , Issue.1-4 , pp. 211-235
    • Rao, A.V.1    Gurfinkel, D.M.2
  • 7
    • 0023376317 scopus 로고
    • Effect of feeding sarsaponin in cattle and swine diets
    • Mader TL, Brumm MC. Effect of feeding sarsaponin in cattle and swine diets. J Anim Sci 1987;65:9-15.
    • (1987) J Anim Sci , vol.65 , pp. 9-15
    • Mader, T.L.1    Brumm, M.C.2
  • 8
    • 0022251437 scopus 로고
    • Interaction of saponin of Bupleuri radix with Ginseng saponin: Solubilization of saikosaponin-a with Chikusetsu-saponin V (=ginsenoside-Ro)
    • Kimata H, Sumida N, Matsufuji N, Orita T, Ito K, Yata N, et al. Interaction of saponin of Bupleuri radix with ginseng saponin: Solubilization of saikosaponin-a with chikusetsu saponin V (=ginsenoside-Ro). Chem Pharm Bull 1985;33:2849-53. (Pubitemid 16251189)
    • (1985) Chemical and Pharmaceutical Bulletin , vol.33 , Issue.7 , pp. 2849-2853
    • Kimata, H.1    Sumida, N.2    Matsufuji, N.3
  • 9
    • 33750375026 scopus 로고    scopus 로고
    • Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry
    • DOI 10.1016/j.chroma.2006.09.015, PII S0021967306017547
    • Ha YW, Na YC, Seo JJ, Kim SN, Linhardt RJ, Kim YS. Qualitative and Quantitative determination of ten major saponins in Platycodi radix by High performance liquid chromatography with evaporative light scattering detection and mass spectrometry. J Chromatogr A 2006;1335:27-35. (Pubitemid 44635538)
    • (2006) Journal of Chromatography A , vol.1135 , Issue.1 , pp. 27-35
    • Ha, Y.W.1    Na, Y.-C.2    Seo, J.-J.3    Kim, S.-N.4    Linhardt, R.J.5    Kim, Y.S.6
  • 10
    • 33645830693 scopus 로고    scopus 로고
    • Chromatographic determination of plant saponins - An update (2002-2005)
    • Oleszek W, Bialy Z. Chromatographic determination of plant saponins - an update (2002-2005). J Chromatogr A 2006;1112:78-91.
    • (2006) J Chromatogr A , vol.1112 , pp. 78-91
    • Oleszek, W.1    Bialy, Z.2
  • 11
    • 34147180057 scopus 로고    scopus 로고
    • Chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry
    • DOI 10.1016/j.chroma.2007.03.012, PII S0021967307004761
    • Kite GC, Porter EA, Simmonds MS. Chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry. J Chromatogr A 2007;1148:177-83. (Pubitemid 46566360)
    • (2007) Journal of Chromatography A , vol.1148 , Issue.2 , pp. 177-183
    • Kite, G.C.1    Porter, E.A.2    Simmonds, M.S.J.3
  • 13
    • 0027476897 scopus 로고
    • Determination of acidic saponins in crude drugs by high-performance liquid chromatography on octadecylsilyl porous glass
    • DOI 10.1016/0021-9673(93)80479-R
    • Kanazawa H, Nagata Y, Matsushima Y, Tomota M, Takai N. Determination of acidic saponins in crude drugs by high-performance liquid chromatography on octadecylsilyl porous glass. J Chromatogr 1993;630:408-14. (Pubitemid 23045936)
    • (1993) Journal of Chromatography , vol.630 , Issue.1-2 , pp. 408-414
    • Kanazawa, H.1    Nagata, Y.2    Matsushima, Y.3    Tomoda, M.4    Takai, N.5
  • 14
    • 15744369749 scopus 로고    scopus 로고
    • Quality evaluation of Flos Lonicerae through a simultaneous determination of seven saponins by HPLC with ELSD
    • DOI 10.1016/j.chroma.2005.02.031, PII S0021967305002748
    • Chai XY, Li SL, Li P. Quality evaluation of Flos Lonicerae through a simultaneous determination of seven saponins by HPLC with ELSD. J Chromatogr A 2005;1070:43-8. (Pubitemid 40417765)
    • (2005) Journal of Chromatography A , vol.1070 , Issue.1-2 , pp. 43-48
    • Chai, X.-Y.1    Li, S.-L.2    Li, P.3
  • 15
    • 80051850920 scopus 로고    scopus 로고
    • Determination of sarsasapogenin in Rhizoma Anemarrhenae with precolumn derivatization by HPLC
    • Peng Y, Luo F, Wang S, LI L, Sun Y, Pan W. Determination of sarsasapogenin in Rhizoma Anemarrhenae with precolumn derivatization by HPLC. J Shenyng Pharm University 2008;25:372-5.
    • (2008) J Shenyng Pharm University , vol.25 , pp. 372-5
    • Peng, Y.1    Luo, F.2    Wang, S.3    I, L.L.4    Sun, Y.5    Pan, W.6
  • 17
    • 33747764917 scopus 로고    scopus 로고
    • Structural revision of shatavarins i and IV, the major components from the roots of Asparagus racemosus
    • Patricia YH, Aisyah HJ, Reg L, Kerry P, William K, James JD. Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus. Tetrahedron Lett 2006;47:6965-9.
    • (2006) Tetrahedron Lett , vol.47 , pp. 6965-9
    • Patricia, Y.H.1    Aisyah, H.J.2    Reg, L.3    Kerry, P.4    William, K.5    James, J.D.6
  • 18
    • 33750446696 scopus 로고    scopus 로고
    • Asparinins, asparosides, curillins, curillosides and shavatarins: Structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus
    • Patricia YH, Aisyah HJ, Reg L, Kerry P, William K, James JD. Asparinins, asparosides, curillins, curillosides and shavatarins: Structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus. Tetrahedron Lett 2006;47:8683-7.
    • (2006) Tetrahedron Lett , vol.47 , pp. 8683-7
    • Patricia, Y.H.1    Aisyah, H.J.2    Reg, L.3    Kerry, P.4    William, K.5    James, J.D.6
  • 19
    • 33750375026 scopus 로고    scopus 로고
    • Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry
    • DOI 10.1016/j.chroma.2006.09.015, PII S0021967306017547
    • Ha YW, Na YC, Seo JJ, Kim SN, Linhardt RJ, Kim YS. Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry. J Chromatogr A 2006;1135:27-35. (Pubitemid 44635538)
    • (2006) Journal of Chromatography A , vol.1135 , Issue.1 , pp. 27-35
    • Ha, Y.W.1    Na, Y.-C.2    Seo, J.-J.3    Kim, S.-N.4    Linhardt, R.J.5    Kim, Y.S.6
  • 20
    • 15444367665 scopus 로고    scopus 로고
    • Quantification of saponins in aerial and subterranean tissues of Medicago truncatula
    • DOI 10.1021/jf0482663
    • Huhman DV, Berhow MA, Sumner LW. Quantification of Saponins in aerial and subterranean tissues of Medicago truncatula. J Agric Food Chem 2005;53:1914-20. (Pubitemid 40395754)
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.6 , pp. 1914-1920
    • Huhman, D.V.1    Berhow, M.A.2    Sumner, L.W.3
  • 22
    • 4143146406 scopus 로고    scopus 로고
    • An analytical method for soy saponins by HPLC/ELSD
    • Lin J, Wang C. An analytical method for soy saponins by HPLC/ELSD. J Food Sci 2006;69 : C456-62.
    • (2006) J Food Sci , vol.69
    • Lin, J.1    Wang, C.2
  • 24
    • 15744369749 scopus 로고    scopus 로고
    • Quality evaluation of Flos Lonicerae through a simultaneous determination of seven saponins by HPLC with ELSD
    • DOI 10.1016/j.chroma.2005.02.031, PII S0021967305002748
    • Chai XY, Li SL, Li P. Quality evaluation of Flos Lonicerae through a simultaneous determination of seven saponins by HPLC with ELSD. J Chromatogr A 2005;1070:43-8. (Pubitemid 40417765)
    • (2005) Journal of Chromatography A , vol.1070 , Issue.1-2 , pp. 43-48
    • Chai, X.-Y.1    Li, S.-L.2    Li, P.3
  • 25
    • 33845731721 scopus 로고    scopus 로고
    • Development and validation of an HPLC method for the characterization and assay of the saponins from Ilex paraguariensis A. St.-Hil (mate) fruits
    • DOI 10.1080/10826070601034311, PII L1624V8544812051
    • Cabral P, Paula G, Petrovick PR, Gosmann G, Ortega G, George. Development and validation of an HPLC method for the characterization and assay of the saponins from Ilex paraguariensis Fruits. J Liq Chromatogr Relat Technol 2007;30:87-95. (Pubitemid 46005186)
    • (2007) Journal of Liquid Chromatography and Related Technologies , vol.30 , Issue.1 , pp. 87-95
    • Pavei, C.1    Guzatto, P.2    Ros Petrovick, P.3    Gosmann, G.4    Gonzalez-Ortega, G.5
  • 26
    • 73249118435 scopus 로고    scopus 로고
    • O-glycoside sequence of pentacyclic triterpene saponins from Phytolacca bogotensis using HPLC-ESI/multi-stage tandem mass spectrometry
    • Montoya G, Arango GJ, Unger M, Holzgrabe U. O-glycoside sequence of pentacyclic triterpene saponins from Phytolacca bogotensis using HPLC-ESI/multi-stage tandem mass spectrometry. Phytochem Anal 2009;20:465-74.
    • (2009) Phytochem Anal , vol.20 , pp. 465-74
    • Montoya, G.1    Arango, G.J.2    Unger, M.3    Holzgrabe, U.4
  • 27
    • 70349306234 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry
    • Zhang T, Liu H, Liu XT, Xu DR, Chen XQ, Wang Q. Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry. J Pharm Biomed Anal 2010;51:114-24.
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 114-24
    • Zhang, T.1    Liu, H.2    Liu, X.T.3    Xu, D.R.4    Chen, X.Q.5    Wang, Q.6
  • 28
    • 50049088189 scopus 로고    scopus 로고
    • Identification of major alkaloids and steroidal saponins in rat serum by HPLC-diode array detection-MS/MS following oral administration of Huangbai-Zhimu herb-pair Extract
    • Ma C, Fan M, Tang Y, Li Z, Sun Z, Ye G, et al. Identification of major alkaloids and steroidal saponins in rat serum by HPLC-diode array detection-MS/MS following oral administration of Huangbai-Zhimu herb-pair Extract. Biomed Chromatogr 2008;22:835-50.
    • (2008) Biomed Chromatogr , vol.22 , pp. 835-50
    • Ma, C.1    Fan, M.2    Tang, Y.3    Li, Z.4    Sun, Z.5    Ye, G.6
  • 29
    • 32044452454 scopus 로고    scopus 로고
    • Rapid quantification and characterization of soyasaponins by high-performance liquid chromatography coupled with electrospray mass spectrometry
    • DOI 10.1016/j.chroma.2005.12.099, PII S0021967306000975
    • Jin M, Yang Y, Su B, Ren Q. Rapid quantification and characterization of soyasaponins by high-performance liquid chromatography coupled with electrospray mass spectrometry. J Chromatogr A 2006;1108:31-7. (Pubitemid 43202628)
    • (2006) Journal of Chromatography A , vol.1108 , Issue.1 , pp. 31-37
    • Jin, M.1    Yang, Y.2    Su, B.3    Ren, Q.4
  • 30
    • 27144450183 scopus 로고    scopus 로고
    • Determination of saponins in aerial parts of barrel medic (Medicago truncatula) by liquid chromatography-electrospray ionization/mass spectrometry
    • DOI 10.1021/jf051256x
    • Kapusta I, Janda B, Stochmal A, Oleszek W. Determination of saponins in aerial parts of Barrel Medic (Medicago truncatula) by Liquid Chromatography-Electrospray Ionization/Mass Spectrometry. J Agric Food Chem 2005;53:7654-60. (Pubitemid 41499604)
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.20 , pp. 7654-7660
    • Kapusta, I.1    Janda, B.2    Stochmal, A.3    Oleszek, W.4
  • 31
    • 32944459339 scopus 로고    scopus 로고
    • Simultaneous determination of saponins and fatty acids in Ziziphus jujuba (Suanzaoren) by high performance liquid chromatography-evaporative light scattering detection and pressurized liquid extraction
    • DOI 10.1016/j.chroma.2005.12.104, PII S0021967306000501
    • Zhao J, Li SP, Yang FQ, Li P, Wang YT. Simultaneous determination of saponins and fatty acids in Ziziphus jujuba (Suanzaoren) by high performance liquid chromatography-evaporative light scattering detection and pressurized liquid extraction. J Chromatogr A 2006;1108:188-94. (Pubitemid 43256731)
    • (2006) Journal of Chromatography A , vol.1108 , Issue.2 , pp. 188-194
    • Zhao, J.1    Li, S.P.2    Yang, F.Q.3    Li, P.4    Wang, Y.T.5
  • 33
    • 41549156517 scopus 로고    scopus 로고
    • Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography
    • DOI 10.1002/bmc.915
    • Gao X, Dan M, Zhao A, Xie G, Jia W. Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography. Biomed Chromatogr 2008;22:244-9. (Pubitemid 351459937)
    • (2008) Biomedical Chromatography , vol.22 , Issue.3 , pp. 244-249
    • Gao, X.1    Dan, M.2    Zhao, A.3    Xie, G.4    Jia, W.5
  • 34
    • 58149085680 scopus 로고    scopus 로고
    • Sensitive Determination of saponins in Radix et Rhizoma Notoginseng by charged aerosol detector coupled with HPLC
    • Bai C, Han S, Chai X, Jiang Y, Li P, Tu P. Sensitive Determination of saponins in Radix et Rhizoma Notoginseng by charged aerosol detector coupled with HPLC. J Liq Chromatogr Relat Technol 2009;32:242-60.
    • (2009) J Liq Chromatogr Relat Technol , vol.32 , pp. 242-60
    • Bai, C.1    Han, S.2    Chai, X.3    Jiang, Y.4    Li, P.5    Tu, P.6
  • 35
    • 63449095891 scopus 로고    scopus 로고
    • Rapid method for simultaneous determination of flavonoid, saponins and polyacetylenes in Folium Ginseng and Radix Ginseng by pressurized liquid extraction and high-performance liquid chromatography coupled with diode array detection and mass spectrometry
    • Qian ZM, Lu J, Gao QP, Li SP. Rapid method for simultaneous determination of flavonoid, saponins and polyacetylenes in Folium Ginseng and Radix Ginseng by pressurized liquid extraction and high-performance liquid chromatography coupled with diode array detection and mass spectrometry. J Chromatogr A 2009;1216:3825-30.
    • (2009) J Chromatogr A , vol.1216 , pp. 3825-30
    • Qian, Z.M.1    Lu, J.2    Gao, Q.P.3    Li, S.P.4
  • 36
    • 78651260872 scopus 로고    scopus 로고
    • Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study
    • Chen W, Dang Y, Zhu C. Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study. Chin Med 2010;5 : 12.
    • (2010) Chin Med , vol.5 , pp. 12
    • Chen, W.1    Dang, Y.2    Zhu, C.3
  • 37
    • 79953106012 scopus 로고    scopus 로고
    • Determination of saponin content in turkish Tahini halvah by using HPLC
    • Ceyhun Sezgin AE, Artik N. Determination of saponin content in turkish Tahini halvah by using HPLC. Advance J Food Sci Technol 2010;2:109-15.
    • (2010) Advance J Food Sci Technol , vol.2 , pp. 109-15
    • Ceyhun Sezgin, A.E.1    Artik, N.2
  • 38
    • 77953494015 scopus 로고    scopus 로고
    • Quality control of Pulsatilla koreana based on the simultaneous determination of triterpenoidal saponins by HPLC-ELSD and principal component analysis
    • Lee KY, Cho YW, Park J, Lee DY, Kim SH, Kim YC, et al. Quality control of Pulsatilla koreana based on the simultaneous determination of triterpenoidal saponins by HPLC-ELSD and principal component analysis. Phytochemical analysis 2010;314-21.
    • (2010) Phytochemical Analysis , pp. 314-21
    • Lee, K.Y.1    Cho, Y.W.2    Park, J.3    Lee, D.Y.4    Kim, S.H.5    Kim, Y.C.6
  • 40
    • 77953614549 scopus 로고    scopus 로고
    • Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
    • Niiho Y, Nakajima Y, Yamazaki T, Okamoto M, Tsuchihashi R, Kodera M, et al. Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside. J Nat Med 2010;64:313-20.
    • (2010) J Nat Med , vol.64 , pp. 313-20
    • Niiho, Y.1    Nakajima, Y.2    Yamazaki, T.3    Okamoto, M.4    Tsuchihashi, R.5    Kodera, M.6
  • 41
    • 70349306234 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry
    • Zhang T, Liu H, Liu XT, Xu DR, Chen XQ, Wang Q. Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry. J Pharm Biomed Anal 2010;51:114-24.
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 114-24
    • Zhang, T.1    Liu, H.2    Liu, X.T.3    Xu, D.R.4    Chen, X.Q.5    Wang, Q.6
  • 42
    • 77953546134 scopus 로고    scopus 로고
    • Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins
    • Eom HY, Park SY, Kim MK, Suh JH, Yeom H, Min JW, et al. Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins. J Chromatogr A 2010;1217:4347-54.
    • (2010) J Chromatogr A , vol.1217 , pp. 4347-54
    • Eom, H.Y.1    Park, S.Y.2    Kim, M.K.3    Suh, J.H.4    Yeom, H.5    Min, J.W.6
  • 43
    • 76749149603 scopus 로고    scopus 로고
    • Separation and purification of triterpene saponins from roots of Radix phytolaccae by high-speed countercurrent chromatography coupled with evaporative light scattering detection
    • Chen Q, Lai D, Sun W, Zhang T, Ito Y. Separation and purification of triterpene saponins from roots of Radix phytolaccae by high-speed countercurrent chromatography coupled with evaporative light scattering detection. J Liq Chromatogr Relat Technol 2010;33:563-71.
    • (2010) J Liq Chromatogr Relat Technol , vol.33 , pp. 563-71
    • Chen, Q.1    Lai, D.2    Sun, W.3    Zhang, T.4    Ito, Y.5
  • 45
    • 77953614549 scopus 로고    scopus 로고
    • Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
    • Niiho Y, Nakajima Y, Yamazaki T, Okamoto M, Tsuchihashi R, Kodera M, et al. Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside. J Nat Med 2010;64:313-20.
    • (2010) J Nat Med , vol.64 , pp. 313-20
    • Niiho, Y.1    Nakajima, Y.2    Yamazaki, T.3    Okamoto, M.4    Tsuchihashi, R.5    Kodera, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.