Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin: Retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration

Carcinogenesis

Volumn 33, Issue 2, 2012, Pages 268-274

  Shirakami, Yohei ^a   Gottesman, Max E ^a,b   Blaner, William S ^a  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CYCLIN D1; CYTOCHROME P450; DIETHYLNITROSAMINE; FAT DROPLET; LECITHIN RETINOL ACYLTRANSFERASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P21; RETINOIC ACID; RETINOID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CELL ACTIVATION; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER TUMOR; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; TUMOR GROWTH; TUMOR VOLUME;

EID: 84856583657     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr275     Document Type: Article

References (50)

1. Jemal, A. et al. (2011) Global cancer statistics. CA Cancer J. Clin., 61, 69-90.
2. Perz, J.F. et al. (2006) The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J. Hepatol., 45, 529-538.
3. El-Serag, H.B. et al. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-2576.
4. Altekruse, S.F. et al. (2009) Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J. Clin. Oncol., 27, 1485-1491.
5. Bosetti, C. et al. (2008) Trends in mortality from hepatocellular carcinoma in Europe, 1980-2004. Hepatology, 48, 137-145.
6. El-Serag, H.B. et al. (2003) The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann. Intern. Med., 139, 817-823.
7. Naugler, W.E. et al. (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science, 317, 121-124.
8. Fan, Y. et al. (2010) The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res., 70, 212-220.
9. Verna, L. et al. (1996) N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol. Ther., 71, 57-81.
10. Jacinto, F.V. et al. (2007) MGMT hypermethylation: a prognostic foe, a predictive friend. DNA Repair (Amst.), 6, 1155-1160.
11. Kang, J.S. et al. (2007) Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Res., 67, 11141-11146.
12. Altucci, L. et al. (2001) The promise of retinoids to fight against cancer. Nat. Rev. Cancer, 1, 181-193.
13. Fields, A.L. et al. (2007) Retinoids in biological control and cancer. J. Cell. Biochem., 102, 886-898.
14. Goodman, D.S. (1984) Vitamin A and retinoids in health and disease. N. Engl. J. Med., 310, 1023-1031.
15. Chambon, P. (1996) A decade of molecular biology of retinoic acid receptors. FASEB J., 10, 940-954.
16. Blaner, W.S. et al. (2009) Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim. Biophys. Acta, 1791, 467-473.
17. O'Byrne, S.M. et al. (2005) Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J. Biol. Chem., 280, 35647-35657.
18. Liu, L. et al. (2005) Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency. J. Biol. Chem., 280, 40226-40234.
19. Batten, M.L. et al. (2004) Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J. Biol. Chem., 279, 10422-10432.
20. Boorjian, S. et al. (2004) Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. Clin. Cancer Res., 10, 3429-3437.
21. Guo, X. et al. (2002) Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Cancer Res., 62, 1654-1661.
22. Zhan, H.C. et al. (2003) Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. Clin. Cancer Res., 9, 4897-4905.
23. Tang, X.H. et al. (2009) Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol. Ther., 8, 1212-1213.
24. Leo, M.A. et al. (1982) Hepatic vitamin A depletion in alcoholic liver injury. N. Engl. J. Med., 307, 597-601.
25. Karin, M. (2009) NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb. Perspect. Biol., 1, a000141.
26. Hongeng, S. et al. (1997) O6-methylguanine-DNA methyltransferase protein levels in pediatric brain tumors. Clin. Cancer Res., 3, 2459-2463.
27. Niles, R.M. (2007) Biomarker and animal models for assessment of retinoid efficacy in cancer chemoprevention. Acta Pharmacol. Sin., 28, 1383-1391.
28. Fenaux, P. et al. (2001) All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia. Semin. Hematol., 38, 13-25.
29. Muto, Y. et al. (1996) Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N. Engl. J. Med., 334, 1561-1567.
30. Takai, K. et al. (2005) Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. Updated analysis of the long-term follow-up data. Intervirology, 48, 39-45.
31. Kluwe, J. et al. (2011) Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis. Gut., 60, 1260-1268.
32. Maeda, S. et al. (2005) IKKbeta couples hepatocyte death to cytokinedriven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell, 121, 977-990.
33. Liu, C. et al. (2001) Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1. Gastroenterology, 120, 179-189.
34. Balmer, J.E. et al. (2002) Gene expression regulation by retinoic acid. J. Lipid Res., 43, 1773-1808.
35. Wang, L. et al. (2005) Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells. Dev. Growth Differ., 47, 119-130.
36. Zhang, D. et al. (2001) Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression. Oncogene, 20, 7935-7944.
37. Abbas, T. et al. (2009) p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer, 9, 400-414.
38. Altucci, L. et al. (2007) RAR and RXR modulation in cancer and metabolic disease. Nat. Rev. Drug Discov., 6, 793-810.
39. Faria, T.N. et al. (1999) The targeted disruption of both alleles of RARbeta(2) in F9 cells results in the loss of retinoic acid-associated growth arrest. J. Biol. Chem., 274, 26783-26788.
40. Guengerich, F.P. (2003) Cytochromes P450, drugs, and diseases. Mol. Interv., 3, 194-204.
41. Lim, I.K. et al. (1999) Differential expression of O6-methylguanine-DNA methyltransferase during diethylnitrosamine-induced carcinogenesis and liver regeneration in Sprague-Dawley male rats. J. Cancer Res. Clin. Oncol., 125, 493-499.
42. Nakatsuru, Y. et al. (1993) O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc. Natl Acad. Sci. USA, 90, 6468-6472.
43. Niture, S.K. et al. (2007) Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis, 28, 378-389.
44. Juillerat, A. et al. (2007) S-alkylthiolation of O6-methylguanine-DNAmethyltransferase (MGMT) to sensitize cancer cells to anticancer therapy. Expert Opin. Ther. Targets, 11, 349-361.
45. Zhang, Y.J. et al. (2003) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma. Int. J. Cancer, 103, 440-444.
46. Cortellino, S. et al. (2011) Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell, 146, 67-79.
47. Tang, X.H. et al. (2009) A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Cancer Prev. Res. (Phila.), 2, 1100-1110.
48. Ross, A.C. et al. (2004) Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. J. Nutr., 134, 269S-275S.
49. Matsushima-Nishiwaki, R. et al. (2001) Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res., 61, 7675-7682.
50. Yanagitani, A. et al. (2004) Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice. Hepatology, 40, 366-375.