Differential expression of O6-methylguanine-DNA methyltransferase during diethylnitrosamine-induced carcinogenesis and liver regeneration in Sprague-Dawley male rats

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 8-9, 1999, Pages 493-499

  Lim, In Kyoung ^a   Park, Tae Jun ^a   Jee, Jae Woong ^a   Lee, Myung Soog ^a   Paik, Woon Ki ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

DEN carcinogenesis; Liver regeneration; MGMT modification

Indexed keywords

DIETHYLNITROSAMINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DRUG INDUCED DISEASE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CELL; LIVER REGENERATION; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROCESSING; RAT; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LIVER; LIVER RESECTION; LIVER TUMOR; METABOLISM; NORTHERN BLOTTING; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; DIETHYLNITROSAMINE; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATECTOMY; LIVER; LIVER NEOPLASMS; LIVER REGENERATION; MALE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0032587737     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050307     Document Type: Article

References (44)

1. 6-mothylguanine lesions in methylated DNA. Nucleic Acids Res 9:3089-3103
2. 6mG in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1. Br J Cancer 43:850-855
3. Cooper DP, O'Connor PJ, Margison GP (1982) Effect of acute doses of 2-acetylaminofluorene on the capacity of rat liver to repair methylated purines in DNA in vivo and in vitro. Cancer Res 42:4203-4209
4. Dolan ME (1997) Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents. Adv Drug Delivery Rev 26:105-118
5. 6-alkylguanine-DNA alkyltransferase. Cancer Res 49:6044-6051
6. 6-methyl guanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. Biochem Biophy Res Commun 97:654-659
7. 6-methylguanine-DNA methyltransferase activity of rat hepatoma cells is increased after a single exposure to alkylating agents. Carcinogenesis 8:91-95
8. 6-alkylguanine DNA alkyltransferase. Proc Am Assoc Cancer Res 35:699-700
9. Habraken Y, Laval F (1991) Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea resistance by γ-irradiation of drug pretreatment in rat hepatoma cells. Cancer Res 51:1217-1220
10. 6-methylguanine-DNA methyltransferase in rat and hamster liver after treatment with dimethylnitrosamine. Cancer Res 50:5426-5430
11. 6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells. Cancer Res 43:3247-3252
12. 6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts. Carcinogenesis 17:219-224
13. 6methylguanine in DNA. J Mol Biol 213:739-747
14. Laval F (1990) Induction of proteins involved in the repair of alkylated bases in mammalian cells by DNA-damaging agents. Mutat Res 233:211-218
15. 6methylguanine-DNA methyltransferase activity induced by various treatments in mammalian cells. Cancer Res 46:5701-5705
16. 6methylguanine-DNA methyltransferase and N-methyladine-DNA-glycosylase in human cells exposed to DNA-damaging agents. DNA Cell Biol 12:233-241
17. 6-alkylguanine-DNA alkyltransferase gene into NRK cells. Carcinogenesis 11:737-743
18. 6-alkylguanine-DNA alkyltransferase (ada) gene in transgenic mice. Cancer Rec 50:1701-1708
19. Lim IK, Kim NK, Lee MS, Lee SH (1994a) Expression of TIS-21 gene during the development of BALB/c mice and the liver regeneration. Korean J Biochem 26:169-175
20. Lim IK, Vician L, Herschman HR (1994b) Subtraction library specific for PC12 cells. Korean J Biochem 26:21-28
21. Lim IK, Lee MS, Kim NK, Lee SH, Jou IL, Seo J-S, Park SC (1995) Differential expression of TIS21 and TIS1 genes in the various organs of BALB/c mice, thymic carcinoma tissues and human cancer cell lines. J Cancer Res Clin Oncol 1:279-284
22. 6-methylguanine-DNA methyltransferase. Anal Biochem 236:284-289
23. Margison GP, O'Connor PJ (1981) Nucleic acid modification by N-nitroso compounds. In: Gover PL (ed) Chemical carcinogens and DNA, vol 1. CRC, Boca Raton, Fla, pp 111-159
24. Montesano R (1981) Alkylation of DNA and tissue specificity in nitrosamine carcinogenesis. J Supramol Struct Cell Biochem 17:259-273
25. 6-methylguanine DNA methyltransferase substrate specificity and temperature sensitivity. J Biol Chem 26:19 802-19 809
26. 6-Methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc Natl Acad Sci USA 90:6468-6472
27. 6-methylguanine to a protein cysteine residue. J Biol Chem 255:10 569-10 571
28. Pegg AE (1977) Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents. Adv Cancer Res 25:195-267
29. Pegg AE (1983) Alkylation and subsequent repair of DNA after exposure to dimethylnitrosamine and related carcinogens. In: Hodgson E, Bend JR, Philpot RM (eds) Reviews in biochemical toxicology, vol 5. Elsevier/North-Holland, Amsterdam, pp 83-133
30. 6-methylguanine-DNA repair system of mammalian cells. IARC Sci Publ 57:575-580
31. 6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins. Carcinogenesis 2:1195 1200
32. 6-methylguanine-DNA methyltransferase levels in rat liver and kidney. Cancer Res 43:972-975
33. 6-alkylguanine DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol 51:167-223
34. 6-methylguanine-DNA methyltransferase expression. Pharmacol Ther 74:285-297
35. 6-methylguanine DNA methyltransferase. Biochem Biophy Res Commun 177:597-602
36. 6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. J Biol Chem 265:9563-9569
37. 6-methylguanineDNA methyltransferase. Nucleic Acids Res 19:5597-5601
38. Sakumi K, Shiraishi A, Shimizu S, Tsuzuki T, Ishikawa T, Sekiguchi M (1997) Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. Cancer Res 57:2415-2418
39. 6-alkylguanine-DNA alkyltransferase by bleomycin. Chem Biol Interact 60:297-304
40. 6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli. Biochemistry 31:1897-1903
41. 6-methylguanine-DNA methyltransferase. Carcinogenesis 13:289-296
42. 6-Methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. Cancer Res 58:1068-1073
43. 6-alkylguanine. Proc Natl Acad Sci USA 87:686-690
44. 6-methylguanine. Proc Natl Acad Sci USA 79:4786-4790