Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1

Gastroenterology

Volumn 120, Issue 1, 2001, Pages 179-189

  Liu, Chun ^a   Russell, Robert M ^a   Seitz, Helmut K ^b   Wang, Xiang Dong ^a,c  

^a TUFTS UNIVERSITY   (United States)

^b Krankenhaus Salem   (Germany)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

18 HYDROXYRETINOIC ACID; 4 OXORETINOIC ACID; ALCOHOL; ALLYL SULFIDE; CLOMETHIAZOLE; CYTOCHROME P450; CYTOCHROME P450 2E1; DISULFIRAM; DRUG METABOLITE; ENZYME INHIBITOR; LIAROZOLE; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOL; UNCLASSIFIED DRUG;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INDUCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CARCINOGENESIS; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTROSCOPY; VITAMIN METABOLISM;

EID: 0035162101     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.20877     Document Type: Article

References (52)

1. Alcohol and cancer
2. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver
3. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation
4. Risk of liver and other types of cancer in patients with cirrhosis: A nationwide cohort study in Denmark
5. Alcohol: Medical and nutritional effects
6. Free radical formation in livers of rats treated acutely and chronically with alcohol
7. DNA cleavage during ethanol metabolism: Role of superoxide radicals and catalytic iron
8. Effect of ethanol on nitrosamine metabolism and distribution. Implications for the role of nitrosamines in human cancer and for the influence of alcohol consumption on cancer incidence
9. Retinoids in cancer prevention
10. Regulation of metabolism by retinoic acid and its nuclear receptor
11. Chronic alcohol intake interferes with retinoid metabolism and signaling
12. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver
13. Vitamin A and zinc metabolism in alcoholism
14. Hepatic vitamin A depletion in alcoholic liver injury
15. Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanol consumption in the rat
16. Age-related effects of chronic ethanol intake on vitamin A status in Fisher 344 rats
17. The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina
18. Catalytic efficiency of human alcohol dehydrogenase for retinol oxidation and retinal reduction
19. Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome
20. Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in the human alcohol dehydrogenase family
21. Increased metabolism of retinoic acid after chronic ethanol consumption in rat liver microsomes
22. Cytochrome P-4502E1: Its physiological and pathological role
23. Hydroxyl-radical production and ethanol oxidation by liver microsomes isolated from ethanol-treated rats
24. Ligand-dependent maintenance of ethanol-inducible cytochrome P450 in primary rat hepatocyte cell cultures
25. The intralobular distribution of ethanol-inducible P4502E1 in rat and human liver
26. Induction of cytochrome P4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA
27. Retinoic acid regulates retinol metabolism via feedback inhibition of retinol oxidation and stimulation of retinol esterification in ferret liver
28. β-Oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from β-apo-carotenoic acids
29. Isolation and identification of 4-hydroxy- and 4-Oxo-retinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver
30. Participation of P4503A enzymes in rat hepatic microsomal retinoic acid 4-hydroxylation
31. Chlormethiazole as an efficient inhibitor of cytochrome P4502E1 expression in rat liver
32. Chlormethiazole inhibition of cytochrome P4502E1 as assessed by chlorzoxazone hydroxylation in humans
33. Modulation of rat hepatic microsomal monooxygenase activities and cytotoxicity by diallyl sulfide
34. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol
35. Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system
36. Effects of liarozole, a new antitumoral compound, on retinoic acid inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells
37. Effects of disulfiram on hepatic P45011E1, other microsomal enzymes and hepatotoxicity in rats
38. Ethanol-inducible cytochrome P4502E1 genetic polymorphism, regulation, and possible role: The etiology of alcohol-induced liver disease
39. Modulation of alcoholic liver disease by cytochrome P4502E1 inhibitors
40. Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: Regulation and characteristics of enzymes belonging to the IIb and IIE gene subfamilies
41. Immunohistochemical localization of ethanol-inducible P45011E1 in the rat alimentary tract
42. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver
43. Cellular retinol-binding protein-supported retinoic acid synthesis: Relative roles of microsomes and cytosol
44. Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid
45. Role of isozymes of rabbit microsomal cytochrome P450 in the metabolism of retinoic acid, retinol, and retinal
46. In vitro metabolism of retinoic acid in hamster intestine and liver
47. Identification of a microsomal retinoic acid synthase as a microsomal cytochrome P450-linked monooxygenase system
48. Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes
49. CYP2C7 expression in rat liver and hepatocytes: Regulation by retinoids
50. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
51. Retinoic acid metabolism by a system reconstituted with cytochrome P-450
52. Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8