Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma: Updated analysis of the long-term follow-up data

Intervirology

Volumn 48, Issue 1, 2005, Pages 39-45

  Takai, Koji ^a   Okuno, Masataka ^a   Yasuda, Ichiro ^a   Matsushima Nishiwaki, Rie ^a   Uematsu, Takahiro ^a   Tsurumi, Hisashi ^a   Shiratori, Yoshimune ^a   Muto, Yasutoshi ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemoprevention; Clonal deletion; Lectin reactive alpha fetoprotein; Protein induced by vitamin K absence or antagonist II; Retinoid

Indexed keywords

ACYCLIC RETINOID; ALPHA FETOPROTEIN; AMINOTRANSFERASE; DECARBOXYPROTHROMBIN; INTERFERON; LECTIN; PLACEBO; PROTEIN; RETINOL DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD CHEMISTRY; CANCER PREVENTION; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FOLLOW UP; HUMAN; LIVER CELL CARCINOMA; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SECOND CANCER;

ALPHA-FETOPROTEINS; ANTINEOPLASTIC AGENTS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; HUMANS; JAPAN; LIVER NEOPLASMS; NEOPLASMS, SECOND PRIMARY; PROTEIN PRECURSORS; PROTHROMBIN; SURVIVAL ANALYSIS; TRETINOIN;

EID: 17244370381     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000082093     Document Type: Article

References (21)

1. Hong WK, Lippman SM, Hittelman WN, Lotan R: Retinoid chemoprevention of aerodigestive cancer: From basic research to the clinic. Clin Cancer Res 1995;1:677-686.
2. Shiratori Y, Shiina S, Imamura M, Kato N, Kanai F, Okudaira T, Teratani T, Tohgo G, Toda N, Ohashi M, Omata M: Characteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in Japan. Hepatology 1995;22:1027-1033.
3. Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Takayama T, Kawasaki S, Makuuchi M: Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003;38:200-207.
4. Yamada Y, Shidoji Y, Fukutomi Y, Ishikawa T, Kameko T, Nakagama H, Imawari M, Moriwaki H, Muto Y: Positive and negative regulations of albumin gene expression by retinoids in human hepatoma cell lines. Mol Carcinog 1994;10:151-158.
5. Araki H, Shidoji Y, Yamada Y, Moriwaki H, Muto Y: Retinoid agonist activities of synthetic geranyl geranoic acid derivatives. Biochem Biophys Res Commun 1995;209:66-72.
6. Yasuda I, Shiratori Y, Adachi S, Obora A, Takemura M, Okuno M, Shidoji Y, Seishima M, Muto Y, Moriwaki H: Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines. J Hepatol 2002;36:660-671.
7. Muto Y, Moriwaki H, Ninomiya M, Adachi S, Saito A, Takasaki KT, Tanaka T, Tsurumi K, Okuno M, Tomita E, Nakamura T, Kojima T: Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. N Engl J Med 1996;334:1561-1567.
8. Muto Y, Moriwaki H, Saito A: Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. N Engl J Med 1999;340:1046-1047.
9. Aoyagi Y, Suzuki Y, Isemura M, Nomoto M, Sekiya C, Igarashi K, Ichida F: The fucosylation index of alpha-fetoprotein and its usefulness in the early diagnosis of hepatocellular carcinoma. Cancer 1988;61:769-774.
10. Sato Y, Nakata K, Kato Y, Shima M, Ishii N, Koji T, Taketa K, Nagataki S: Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Engl J Med 1993;328:1802-1806.
11. Shiraki K, Takase K, Tameda Y, Hamada M, Kosaka Y, Nakano T: A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients. Hepatology 1995;22:802-807.
12. Ikoma J, Kaito M, Ishihara T, Nakagawa M, Kamei A, Fujita N, Iwasa M, Tamaki S, Watanabe S, Adachi Y: Early diagnosis of hepatocellular carcinoma using a sensitive assay for serum des-gamma-carboxy prothrombin: A prospective study. Hepatogastroenterology 2002;49:235-238.
13. Moriwaki H, Yasuda I, Shiratori Y, Uematsu T, Okuno M, Muto Y: Deletion of serum lectin-reactive alpha-fetoprotein by acyclic retinoid: A potent biomarker in the chemoprevention of second primary hepatoma. Clin Cancer Res 1997;3:727-731.
14. Yoshida H, Shiratori Y, Moriyama M, Arakawa Y, Ide T, Sata M, Inoue O, Yano Y, Tanaka M, Fujiyama S, Nishiguchi S, Kuroki T, Imazeki F, Yokosuka O, Kinoyama S, Yamada G, Omata M: Interferon therapy reduces the risk for hepatocellular carcinoma: National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT study group. Ann Intern Med 1999;131:174-181.
15. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, Urushihara A, Kiyosawa K, Okuda M, Hino K, Okita K, Osaka liver disease study group: Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Hepatology 1998;27:1394-1402.
16. Kojima S, Okuno M, Matsushima-Nishiwaki R, Friedman SL, Moriwaki H: Acyclic retinoid in the chemoprevention of hepatocellular carcinoma. Int J Oncol 2004;24:797-805.
17. Matsushima-Nishiwaki R, Okuno M, Adachi S, Sano T, Akita K, Moriwaki H, Friedman SL, Kojima S: Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res 2001;61:7675-7682.
18. Adachi S, Okuno M, Matsushima-Nishiwaki R, Takano Y, Kojima S, Friedman SL, Moriwaki H, Okano Y: Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma. Hepatology 2002;35:332-340.
19. CIP1 and inhibition of expression of cyclin D1. Cancer Res 2002;62:3997-4006.
20. Obora A, Shiratori Y, Okuno M, Adachi S, Takano Y, Matsushima-Nishiwaki R, Yasuda I, Yamada Y, Akita K, Sano T, Shimada J, Kojima S, Okano Y, Friedman SL, Moriwaki H: Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells. Hepatology 2002;36:1115-1124
21. Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H: Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid. Carcinogenesis 2003;24:1353-1359.