Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression

Diseases of the Colon and Rectum

Volumn 51, Issue 3, 2008, Pages 342-347

  Leung, Edmund ^a   McArthur, David ^a   Morris, Alan ^b   Williams, Nigel ^a  

^a UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Cyclooxgenase 2; Extracellular matrix; Matrix metalloproteinase 2

Indexed keywords

CYCLOOXYGENASE 2; GELATINASE A; MATRIGEL; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL MIGRATION; CELL STRAIN CACO 2; CELL STRAIN HT29; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HUMANS; MATRIX METALLOPROTEINASE 2; NITROBENZENES; SULFONAMIDES; TUMOR CELLS, CULTURED;

EID: 39749111797     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/s10350-007-9120-4     Document Type: Article

References (24)

1. Sheng H, Shao J, Kirkland SC, et al. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 1997;97:2254-9.
2. Thun MJ, Namboodiri MM, Calle EE, Flanders WD, Heath CW Jr. Aspirin use and risk of fatal cancer. Cancer Res 1993;53:1322-7.
3. Reddy BS, Rao CV, Rivenson A, Kelloff G. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 1993;14:1493-7.
4. Eberhart CE, Dubois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology 1995;109:285-301.
5. Ristimäki A, Garfinkel S, Wessendorf J, Maciag T, Hla T. Induction of cyclooxgenase-2 by Interleukin-1-alpha. J Biol Chem 1994;269:11769-75.
6. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Up-regulation of cyclooxgenase-2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994;107:1183-8.
7. Sano H, Kawahito Y, Wilder RL, et al. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human colorectal cancer. Cancer Res 1995;55:3785-9.
8. Chen WS, Wei SJ, Liu JM, Hsiao M, Kou-Lin J, Yang WK. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 expression. Int J Cancer 2001;91:894-9.
9. Liotta LA, Rao CN. Tumour invasion and metastasis. Cancer Res 1986;46:1-7.
10. Martisian LM. The matrix degrading metalloproteinases. Bio Assays 1992;14:455-63.
11. Tryggvason K, Höyhtyä M, Salo T. Proteolytic degradation of extra-cellular matrix in tumor invasion. Biochem Biophy Acta 1987;907:191-217.
12. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003;92:827-39.
13. Fux R, Schwab M, Thon KP, Gleiter CH, Fritz P. Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. Clin Cancer Res 2005;11:4754-60.
14. Honn KV, Bockman RS, Marnett LJ. Prostaglandins and cancer. Prostaglandins 1981;21:833-64.
15. Tsujii M, Kawano S, Tsujii S, Sawaoka H, Hori M, DuBois RN. Cyclooxgenase regulates angiogenesis induced by colon cancer. Cell 1998;93:705-16.
16. Hwang D, Scollard D, Bryne J, Levine E. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst 1998;90:455-60.
17. Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A 1997;94:3336-40.
18. Yao M, Lam EC, Kelly CR, Zhou W, Wolfe MM. Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. Br J Cancer 2004;90:712-9.
19. Nagatsuka I, Yamada N, Shimizu S, et al. Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. Int J Cancer 2002;100:515-9.
20. Larkins TL, Nowell M, Singh S, Sandford GL. Inhibition of cyclooxygenase-2 decreases breast cancer motility and MMP expression. BMC Cancer 2006;6:181.
21. Attiga FA, Fernandez PM, Weeraratna AT, Manyak MJ, Patierno SR. Inhibitors of prostaglandins synthesis inhibit human prostate tumor cell invasiveness and the release of matrix metalloproteinases. Cancer Res 2000;60:4629-37.
22. Xiong B, Sun TJ, Hu WD, Cheng FL, Mao M, Zhou YF. Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. World J Gastroenterol 2005;11:1105-8.
23. Fournier DB, Gordon GB. COX2 and colon cancer: potential targets for chemoprevention. J Cell Biochem 2000;34:97-102.
24. Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclooxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ 2006;332:1302-8.