Host strain influences on supercoiled plasmid DNA production in Escherichia coli: Implications for efficient design of large-scale processes

Biotechnology and Bioengineering

Volumn 101, Issue 3, 2008, Pages 529-544

  Yau, Sin Yee ^a   Keshavarz Moore, Eli ^a   Ward, John ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

E. coli host strain selection; Host vector combination; Plasmid DNA production; Plasmid stability; Runaway plasmid replication; Supercoiling

Indexed keywords

BIOCHEMICAL ENGINEERING; DNA; ESCHERICHIA COLI; GENES; NUCLEIC ACIDS; ORGANIC ACIDS; PLANTS (BOTANY); THEOREM PROVING; WATER POLLUTION;

E. COLI HOST STRAIN SELECTION; HOST-VECTOR COMBINATION; PLASMID DNA PRODUCTION; PLASMID STABILITY; RUNAWAY PLASMID REPLICATION; SUPERCOILING;

STRAIN;

PLASMID DNA;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOREACTOR; DNA SUPERCOILING; DNA SYNTHESIS; ESCHERICHIA COLI; FERMENTATION TECHNIQUE; GENOTYPE; GROWTH RATE; NONHUMAN; PROCESS DESIGN; PROCESS OPTIMIZATION; PRODUCTIVITY;

DNA, BACTERIAL; DNA, SUPERHELICAL; ESCHERICHIA COLI; GENES, BACTERIAL; PLASMIDS;

ESCHERICHIA COLI;

EID: 53549102227     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21915     Document Type: Article

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