Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-X(L), regulate the survival of murine pro-B lymphocytes

Molecular and Cellular Biology

Volumn 19, Issue 4, 1999, Pages 2754-2762

  Kuribara, Ryoko ^a   Kinoshita, Taisei ^b   Miyajima, Atsushi ^b   Shinjyo, Tetsuharu ^a   Yoshihara, Takao ^c   Inukai, Takeshi ^c   Ozawa, Keiya ^a   Look, A Thomas ^c   Inaba, Toshiya ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL X; RAS PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CELL SURVIVAL; HEMATOPOIETIC CELL; IMMUNOREGULATION; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 0032913694     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.4.2754     Document Type: Article

References (40)

1. Ahmed, N. N., H. L. Grimes, A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94:3627-3632.
2. Akasaka, K., M. Tamada, F. Wang, K. Kariya, F. Shima, A. Kikuchi, M. Yamamoto, M. Shirouzu, S. Yokoyama, and T. Kataoka. 1996. Differential structural requirements for interaction of Ras protein with its distinct downstream effectors. J. Biol. Chem. 271:5353-5360.
3. Askew, D. S., R. A. Ashmun, B. C. Simmons, and J. L. Cleveland. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915-1922.
4. Bollag, G., D. W. Clapp, S. Shih, F. Adler, Y. Y. Zhang, P. Thompson, B. J. Lange, M. H. Freedman, F. McCormick, T. Jacks, and K. Shannon. 1996. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat. Genet. 12:144-148.
5. Chen, W.-J., K. S. Lewis, G. Chandra, J. P. Cogswell, S. W. Stinnett, S. H. Kadwell, and J. G. Gray. 1995. Characterization of human E4BP4, a phosphorylated bZIP factor. Biochim. Biophys. Acta 1264:388-396.
6. Conradt, B., and H. R. Horvitz. 1998. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93:519-529.
7. Cortez, D., L. Kadlec, and A. M. Pendergast. 1995. Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. Mol. Cell. Biol. 15:5531-5541.
8. Cortez, D., G. Stoica, J. H. Pierce, and A. M. Pendergast. 1996. The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene 13:2589-2594.
9. Cowell, I. G., A. Skinner, and H. C. Hurst. 1992. Transcriptional repression by a novel member of the bZIP family of transcription factors. Mol. Cell. Biol. 12:3070-3077.
10. Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
11. del Peso, L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689.
12. Ellis, R. E., and H. R. Horvitz. 1991. Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development 112:591-603.
13. Ellis, R. E., J. Y. Yuan, and H. R. Horvitz. 1991. Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7:663-698.
14. Hunger, S. P., K. Ohyashiki, K. Toyama, and M. L. Cleary. 1992. HLF, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6:1608-1620.
15. Hunger, S. P., R. Brown, and M. L. Cleary. 1994. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17:19) acute lymphoblastic leukemia chimera E2A-HLF. Mol. Cell. Biol. 14:5986-5996.
16. Ikushima, S., T. Inukai, T. Inaba, S. D. Nimer, J. L. Cleveland, and A. T. Look. 1997. Pivotal role for the NFIL3/E4BP4 transcription factor in IL-3-mediated survival of pro-B lymphocytes. Proc. Natl. Acad. Sci. USA 94: 2609-2614.
17. Inaba, T., W. M. Roberts, L. H. Shapiro, K. W. Jolly, S. C. Raimondi, S. D. Smith, and A. T. Look. 1992. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 257:531-534.
18. Inaba, T., L. H. Shapiro, T. Funabiki, A. E. Sinclair, B. G. Jones, R. A. Ashmun, and A. T. Look. 1994. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. Mol. Cell. Biol. 14:3403-3413.
19. Inaba, T., T. Inukai, T. Yoshihara, H. Seyschab, R. A. Ashmun, C. E. Canman, S. J. Laken, M. B. Kastan, and A. T. Look. 1996. Reversal of apoptosis by the leukemia-associated E2A-HLF chimeric transcription factor. Nature 382:541-544.
20. Inukai, T., T. Inaba, T. Yoshihara, and A. T. Look. 1997. Cell transformation mediated by homodimeric E2A-HLF transcription factors. Mol. Cell. Biol. 17:1417-1424.
21. Inukai, T., T. Inaba, S. Ikushima, and A. T. Look. 1998. The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the E2A-HLF chimeric oncoprotein. Mol. Cell. Biol. 18:6035-6043.
22. Joneson, T., and D. Bar Sagi. 1997. Ras effectors and their role in mitogenesis and oncogenesis. J. Mol. Med. 75:587-593.
23. Kinoshita, T., T. Yokota, K. Arai, and A. Miyajima. 1995. Suppression of apoptotic death in hematopoietic cells by signaling through the IL-3/GM-CSF receptors. EMBO J. 14:266-275.
24. Kinoshita, T., M. Shirouzu, A. Kamiya, K. Hashimoto, S. Yokoyama, and A. Miyajima. 1997. Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells. Oncogene 15:619-627.
25. Kroemer, G. 1997. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3:614-620.
26. Kuo, C. J., J. Chung, D. F. Florentino, W. M. Flanagan, J. Blenis, and G. R. Crabtree. 1992. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358:70-73.
27. Leverrier, Y., J. Thomas, G. R. Perkins, M. Mangeney, M. K. L. Collins, and J. Marvel. 1997. In bone marrow derived Baf-3 cells, inhibition of apoptosis by IL-3 is mediated by two independent pathways. Oncogene 14:425-430.
28. Metzstein, M. M., M. O. Hengartner, N. Tsung, R. E. Ellis, and H. R. Horvitz. 1996. Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2. Nature 382:545-547.
29. Nicholson, D. W., and N. A. Thornberry. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22:299-306.
30. Ohta, T., T. Kinoshita, M. Naito, T. Nozaki, M. Masutani, T. Tsuruo, and A. Miyajima. 1997. Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells. J. Biol. Chem. 272:23111-23116.
31. Onishi, M., S. Kinoshita, Y. Morikawa, A. Shibuya, J. Phillips, L. L. Lanier, D. M. Gorman, G. P. Nolan, A. Miyajima, and T. Kitamura. 1996. Application of retrovirus-mediated expression cloning. Exp. Hematol. 24:324-329.
32. Packham, G., E. L. White, C. M. Eischen, H. Yang, E. Parganas, J. N. Ihle, D. A. Grillot, G. P. Zambetti, G. Nunez, and J. L. Cleveland. 1998. Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. Genes Dev. 12:2475-2487.
33. Sato, N., K. Sakamaki, N. Terada, K. Arai, and A. Miyajima. 1993. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for different signaling. EMBO J. 12:4181-4189.
34. Shirouzu, M., H. Koide, Y.-J. Fujita, H. Oshio, Y. Toyama, K. Yamasaki, S. A. Fuhrman, E. Villafranca, Y. Kaziro, and S. Yokoyama. 1994. Mutations that abolish the ability of Ha-Ras to associate with Raf-1. Oncogene 9:2153-2157.
35. Songyang, Z., D. Baltimore, L. C. Cantley, D. R. Kaplan, and T. F. Franke. 1997. Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl. Acad. Sci. USA 94:11345-11350.
36. Terada, N., J. J. Lucas, A. Szepesi, R. A. Franklin, K. Takase, and E. W. Gelfand. 1992. Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells. Biochem. Biophys. Res. Commun. 186:1315-1321.
37. Yoshihara, T., T. Inaba, L. H. Shapiro, J. Kato, and A. T. Look. 1995. E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF. Mol. Cell. Biol. 15:3247-3255.
38. L. Cell 87:619-628.
39. Zhang, W., J. Zhang, M. Kornuc, K. Kwan, R. Frank, and S. D. Nimer. 1995. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. Mol. Cell. Biol. 15:6055-6063.
40. Zou, H., W. J. Henzel, X. Liu, A. Lutschg, and X. Wang. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405-413.