BDNF val 66met affects hippocampal volume and emotion-related hippocampal memory activity

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Molendijk, M L ^a,b   Van Tol, M J ^b,c   Penninx, B W J H ^b,c,d   Van Der Wee, N J A ^b   Aleman, A ^c,e   Veltman, D J ^d   Spinhoven, P ^a,b   Elzinga, B M ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

BDNF; childhood abuse; fMRI; hippocampus; human memory; val 66met

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ANXIETY DISORDER; ARTICLE; BRAIN SIZE; CHILD ABUSE; CONTROLLED STUDY; DEPRESSION; EFFECT SIZE; EMOTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; TASK PERFORMANCE; AROUSAL; CHILD; COMPUTER ASSISTED DIAGNOSIS; ECHO PLANAR IMAGING; GENETIC POLYMORPHISM; GENETICS; HETEROZYGOTE DETECTION; INDIVIDUALITY; LEARNING; LIFE EVENT; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RECALL; REFERENCE VALUE;

ADULT; ANXIETY DISORDERS; AROUSAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD ABUSE; DEPRESSIVE DISORDER; ECHO-PLANAR IMAGING; EMOTIONS; FEMALE; HETEROZYGOTE DETECTION; HIPPOCAMPUS; HOMOZYGOTE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INDIVIDUALITY; LIFE CHANGE EVENTS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL RECALL; MIDDLE AGED; ORGAN SIZE; POLYMORPHISM, GENETIC; REFERENCE VALUES; VERBAL LEARNING;

EID: 84856529144     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.72     Document Type: Article

References (59)

1. Murer MG, Yan Q, Raisman-Vosari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 2001; 63: 71-124.
2. Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 2005; 76: 99-125. (Pubitemid 41242884)
3. Komulainen P, Pedersen M, Hanninen T, Bruunsgaard H, Lakka TA, Kivipelto M et al. BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA study. Neurobiol Learning Mem 2008; 4: 596-603.
4. MacQueen G, Frodl T. The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry 2011; 16: 252-264.
5. Taliaz D, Stall N, Dar DE, Zangen A. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 2010; 15: 80-92.
6. Lu B, Gottschalk W. Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. Prog Brain Res 2000; 128: 231-241. (Pubitemid 35461239)
7. Poo MM. Neurotrophins as synaptic modulators. Nat Rev Neurosci 2001; 2: 24-32.
8. Choi DC, Maguschak KA, Ye K, Jang S-W, Myers KM, Ressler KJ. Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci USA 2010; 107: 2675-2680.
9. Gunstad J, Benitez A, Smith J, Glickman E, Spitznagel MB, Alexander T et al. Serum brainderived neurotrophic factor is associated with cognitive function in healthy older adults. J Geriatr Psychiatry Neurol 2008; 21: 166-170.
10. Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, McLaren M. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci 2010; 30: 5368-5375.
11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A et al. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-269. (Pubitemid 36144114)
12. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL et al. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activitydependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004; 24: 4401-4411. (Pubitemid 38608151)
13. 66met polymorphism on levels of N-Acetyl-Aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla. Biol Psychiatry 2008; 64: 856-862.
14. Rybakowski A, Czerski PM, Skibinska M, Hauser J. Polymorphisms on the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 2003; 5: 468-472. (Pubitemid 38072252)
15. Erickson KI, Kim JS, Suever BL, Voss MW, Francis BM, Kramer AF. Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms. Front Hum Neurosci 2008; 2: 1-9.
16. 66met polymorphism and variation in human cortical morphology. J Neurosci 2004; 24: 10099-10102. (Pubitemid 39492034)
17. 66met polymorphism and volume of hippocampal formation. Mol Psychiatry 2005; 10: 631-636. (Pubitemid 40961733)
18. 66met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 2006; 59: 812-815.
19. 66met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 2007; 64: 410-416. (Pubitemid 46556460)
20. 66met polymorphism affects human-memory related hippocampal activity and predicts memory performance. J Neurosci 2003; 23: 6690-6694. (Pubitemid 36951196)
21. 66met polymorphism, hippocampal volume, and cognitive function in geriatric depression. Am J Ger Psychiatry 2010; 18: 323-331.
22. Karnik MS, Wang L, Barch DM, Morris JC, Csernansky JG. BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects. Psychiatry Res 2010; 178: 425-429.
23. 66met Polymorphism: evidence from cognition, the P300 and fronto-hippocampal systems. Biol Psychology 2009; 80: 176-188.
24. 66met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage 2010; 53: 952-961.
25. 66met polymorphism and hippocampal activation during episodic memory encoding and retrieval tasks. Hippocampus 2010; e-pub ahead of print, 20 May; doi: 10:1002/hipo.20809.
26. 66met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. Mol Psychiatry 2011; e-pub ahead of print, 17 May; doi: 10:10.1038/mp.2011.51.
27. Bremner JD, Elzinga BM, Schmahl C, Vermetten E. Structural and functional plasticity of the human brain in post-traumatic stress disorder. Prog Brain Res 2007; 167: 171-186. (Pubitemid 350123232)
28. Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RH, Schofield R et al. Interactions between BDNF Val66Met polymorphism predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry 2009; 14: 681-695.
29. Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D et al. The CREB1-BDNFNTRK2 pathway in depression: Multiple gene-cognition-environment interactions. Biol Psychiatry 2010; 69: 762-771; e-pub ahead of print, 18 November; doi:10.1016/j.biopsych. 2010.11.019.
30. Penninx BJW, Beekman ATH, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al. For the NESDA Research Consortium. The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int J Methods Psychiatr Res 2008; 17: 121-140.
31. Van Tol MJ, van der Wee NJ, van den Heuvel OA, Demenescu LR, Nielen MM, Renken R et al. Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 2010; 67: 1002-1011, e-pub ahead of print October 2010; doi: 10.1001/archgen psychiatry. 2010.121.e.
32. American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn American Psychiatric Association: Washington, DC.
33. World Health Organization (WHO) Collaborating Centre for Drug Statistics Methodology. Anatomical Therapeutic Chemical (ATC) Classification, 2008. http://www.whocc.no/ atcddd/ (accessed January 2011).
34. Wittchen HU, Robins LN, Cottler LB, Sartorius N, Burke JD, Regier D. Feasibility, reliability and sources of variance of the Composite International Diagnostic Interview (CIDI). The multicentre WHO/ADAMHA field trials. Br J Psychiatry 1991; 159: 645-653.
35. Wacker HR, Battegay R, Mullejans R, Schlosser C (2006) Using the CIDI-C in the general population. In: Stefanis CN, Rabavilas AD, Soldatos CR (eds). Psychiatry: A World Perspective. Elsevier Science Publishers: Amsterdam.
36. Montgomery SA, Asberg MA. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382-389. (Pubitemid 9136500)
37. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 1988; 56: 893-897. (Pubitemid 19008360)
38. Davidson J, Turnbull CD, Strickland R, Miller R, Graves K. The Montgomery-Asberg depression scale: reliability and validity. Acta Psychiatr Scand 1986; 73: 544-548. (Pubitemid 16091046)
39. Kabacoff RI, Segal DL, Hersen M, van Hasselt VB. Psychometric properties and diagnostic utility of the Beck anxiety inventory and the state-trait anxiety inventory with older adult psychiatric outpatients. J Anx Dis 1997; 11: 33-47. (Pubitemid 27199171)
40. de Graaf R, Bijl RV, ten Have M, Beekman ATF, Vollebergh WAM. Pathways to comorbidity: the transition of pure mood, anxiety and substance abuse disorder into comorbid conditions in a longitudinal population based study. J Affect Dis 2004a; 82: 461-467. (Pubitemid 39536180)
41. de Graaf R, Bijl RV, ten Have M, Beekman ATF, Vollebergh WAM. Rapid onset of comorbidity of common mental disorders: findings from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Acta Psychiatr Scand 2004b; 109: 55-63. (Pubitemid 38161101)
42. Wiersma JE, Hovens JGFM, van Oppen P, Giltay EJ, van Schaik JF, Beekman ATF et al. The importance of childhood trauma and childhood life events for chronicity of depression in adults. J Clin Psychiatry 2009; 70: 983-989.
43. Boomsma DI, Willemsen G, Sullivan PF, Heutink P, Meijer P, Sondervan D. Genome-wide association of major depression: description of samples for the GAIN major depressive disorder study: NTR and NESDA biobank projects. Eur J Hum Genet 2008; 16: 335-342. (Pubitemid 351292233)
44. Daselaar SM, Veltman DJ, Rombouts SA, Raaijmakers JG, Jonker C. Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain 2003; 126: 43-56. (Pubitemid 36068559)
45. van Tol M-J, Demenescu LR, van der Wee NJA, Kortekaas R, Nielen MMA, Den Boer JA et al. Emotional word encoding and recognition in depression and anxiety disorders. Biol Psychiatry 2011; e-pub ahead of print, 28 December; doi:10.1016/j.biopsych.2011.11.016.
46. Brett M, Anton J-L, Valabregue R, Poline JB. Region of interest analysis using an SPM toolbox [abstract]. Presented at the 8th International Conference on Functional Mapping of the Human Brain; 2-6 June 2002; Sendai, Japan. Available on CD-ROM in NeuroImage 2002; 16.
47. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003; 19: 1233-1239. (Pubitemid 36918259)
48. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007; 38: 95-113. (Pubitemid 47440133)
49. Cohen J 1988. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates: Hillsdale, NJ.
50. 66met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increase use of caudate nucleus-dependent strategies in a human virtual navigation task. Eur J Neurosci 2011; 33: 968-977.
51. 66met polymorphism. J Ab Psychology 2008; 117: 699-704.
52. Werner NS, Meindl T, Engel RR, Rosner R, Riedel M, Reiser M et al. Hippocampal function during associative learning in patients with posttraumatic stress disorder. J Psychiatric Res 2009; 43: 309-318.
53. Thomaes K, Dorrepaal E, Draijer NPJ, de Ruiter MB, Elzinga BM, van Balkom AJ et al. Increased activation of the left hippocampus region in complex PTSD during encoding and recognition of emotional words: a pilot study. Psychiatric Res: Neuroimaging 2009; 171: 44-53.
54. Heim C, Shugart M, Craighead WE, Nemeroff CB. Neurobiological and psychiatric consequences of childhood abuse and neglect. Dev Psychobiology 2010; 52: 671-690.
55. 66met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 2010; 15: 260-271.
56. Eyler LT, Sherzai A, Kaup AR, Jeste DV. A review of functional brain imaging correlates of successful cognitive aging. Biol Psychiatry 2011; 70: 115-122, e-pub ahead of print, 13 December 2010; doi: 10.1016/j.biopsych.2010. 12.032.
57. Cardon LR, Palmer LJ. Population stratification and spurious allelic association. Lancet 2003; 361: 598-604. (Pubitemid 36207482)
58. Campbell S, Marriott M, Nahmias C, Macqueen GM. Lower hippocampal volumes in patients suffering from depression: a meta-analysis. Am J Psychiatry 2004; 161: 598-607. (Pubitemid 38445502)
59. Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004; 161: 1957-1966. (Pubitemid 39441394)