Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults

Journal of Geriatric Psychiatry and Neurology

Volumn 21, Issue 3, 2008, Pages 166-170

  Gunstad, John ^a,b   Benitez, Andreana ^a   Smith, Joseph ^a   Glickman, Ellen ^a   Spitznagel, Mary B ^a,b   Alexander, Thomas ^b   Juvancic Heltzel, Judi ^a   Murray, Leigh ^c  

^a KENT STATE UNIVERSITY   (United States)

^b SUMMA HEALTH SYSTEM   (United States)

^c WALSH UNIVERSITY   (United States)

Author keywords

Brain derived neurotrophic factor; Cognition; Elderly

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

AGED; ARTICLE; BLOOD SAMPLING; COGNITION; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL HEALTH; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL; COGNITION DISORDERS; FEMALE; HUMANS; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PSYCHOMETRICS;

EID: 49749131573     PISSN: 08919887     EISSN: 15525708     Source Type: Journal    
DOI: 10.1177/0891988708316860     Document Type: Article

References (37)

1. Ritchie K., Ledesert B., Touchon J. Subclinical cognitive impairment: epidemiology and clinical characteristics. Compr Psychiatry. 2000 ; 41: 61-65.
2. Cargin JR, Maruff P., Collie A., Masters C. Mild memory impairment in healthy older adults is distinct from normal aging. Brain Cogn. 2006 ; 60: 146-155.
3. De Jager C., Blackwell AD, Budge MM, Sahakian BJ Predicting cognitive decline in healthy older adults. Am J Geriatr Psychiatry. 2005 ; 13: 735-740.
4. Chapman DP, Williams SM, Strine TW, Anda RF, Moore MJ Dementia and its implications for public health [serial online]. Prev Chronic Dis. 2006. http://www.cdc.gov/pcd/issues/2006/apr/05_0167.htm. Accessed March 18, 2007.
5. Bartzokis G. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. Neurobiol Aging. 2004 ; 25: 5-18.
6. Blank T., Nijholt I., Spiess J. Treatment strategies of age-related memory dysfunction by modulation of neuronal plasticity. Mini Rev Med Chem. 2007 ; 7: 55-64.
7. Pfefferbaum A., Adalsteinsson E., Sullivan EV Frontal circuitry degradation marks healthy adult aging: evidence from diffusion tensor imaging. Neuroimage. 2005 ; 26: 891-899.
8. Huang EJ, Reichardt LF Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001 ; 24: 677-736.
9. Egan M., Kojima M., Callilcott J., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003 ; 112: 257-269.
10. Gorski J., Balogh S., Wehner J., Jones K. Learning deficits in forebrain-restricted brain derived-neurotrophic factor mutant mice. Neurosci. 2003 ; 121: 341-354.
11. Harris S., Fox H., Wright A., et al. The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. Mol Psychiatry. 2006 ; 11: 505-513.
12. Monteggia LM, Barrot M., Powell CM, et al. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A. 2004 ; 101: 10827-10832.
13. Laske C., Stransky E., Leyhe T., et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm. 2006 ; 113: 1217-1224.
14. Peng S., Wuu J., Mufson E., Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem. 2005 ; 93: 1412-1421.
15. Yasutake C., Kuroda K., Yanagawa T., et al. Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. Eur Arch Psychiatry Clin Neurosci. 2006 ; 256: 402-406.
16. Folstein MF, Folstein SE, McHugh PR Mini-mental state. J Psychiatr Res. 1975 ; 12: 189-198.
17. Lacritz LH, Cullum CM The Hopkins verbal learning test and the CVLT: a preliminary comparison. Arch Clin Neuropsychol. 1998 ; 13: 623-628.
18. Shapiro AM, Benedict RH, Schretlen D., Brandt J. Construct and concurrent validity of the Hopkins verbal learning test- revised. Clin Neuropsychol. 1999 ; 13: 348-358.
19. Reitan R. Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills. 1958 ; 8: 271-276.
20. Wechsler D. Manual for the Wechsler Adult Intelligence Scale. San Antonio, TX: The psychological corporation ; 1997.
21. DuBois B., Slachevsky A., Litvan I., Pillon B. The FAB: a frontal assessment battery at bedside. Neurology. 2000 ; 55: 1621-1626.
22. Kaplan E., Goodglass H., Weintraub S., et al. Boston Naming Test. Philadelphia, PA: Lea & Febiger ; 1983.
23. Eslinger P., Damasio A., Benton A. The Iowa Screening Battery for Mental Decline. Iowa City, IA: University of Iowa ; 1984.
24. Glasgow RE, Ory MG, Klesges LM, Cifuentes M., Fernald DH, Green LA Practical and relevant self-report measures of patient health behaviors for primary care research. Ann Fam Med. 2005 ; 3: 73-81.
25. University of Washington Health Promotion Reseach Center. Rapid assessment of physical activity (RAPA). http://hmcrc.srph.tau.edu. Accessed March 1, 2007.
26. Elliott E., Ginzburg I. The role of neurotrophins and insulin on tau pathology in Alzheimer's disease. Rev Neurosci. 2006 ; 17: 635-642.
27. Kuipers SD, Bramham CR Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Curr Opin Drug Discov Devel. 2006 ; 9: 580-586.
28. Blasko I., Grubeck-Loebenstein B. Role of the immune system in the pathogenesis, prevention and treatment of Alzheimer's disease. Drugs Aging. 2003 ; 20: 101-113.
29. Kimura N., Takahashi M., Tashiro T., Terao K. Amyloid beta up-regulates brain-derived neurotrophic factor production from astrocytes: rescue from amyloid beta-related neuritic degeneration. J Neurosci Res. 2006 ; 84: 782-789.
30. Lindvall O., Ernfors P., Bengzon J., et al. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci U S A. 1992 ; 89: 648-652.
31. Tong L., Balazs R., Thornton PL, Cotman CW Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci. 2004 ; 24: 6799-6809.
32. Tsai SJ Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression [published online ahead of print]. Med Hypotheses. 2007 ; 68: 1296-1299.
33. Manni L., Nikolova V., Vyagova D., et al. Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes. Int J Cardiol. 2005 ; 102: 169-171.
34. Bueller JA, Aftab M., Sen S., et al. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry. 2006 ; 59: 812-815.
35. Nemoto K., Ohnishi T., Mori T., et al. The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology. Neurosci Lett. 2006 ; 397: 25-29.
36. Colcombe SJ, Kramer AF, McAuley E., et al. Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci. 2004 ; 24: 9-14.
37. Winter B., Breitenstein C., Mooren FC, et al. High impact running improves learning [published online ahead of print]. Neurobiol Learn Mem. 2007 ; 87: 597-609.