Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist

Immunobiology

Volumn 217, Issue 3, 2012, Pages 307-315

  Cappelli, Claudio ^a   López, Ximena ^a   Labra, Yohana ^a   Montoya, Margarita ^a   Fernández, Ricardo ^b   Imarai, Mónica ^a   Rojas, Juan Luis ^d   Miranda, Dante ^c   Escobar, Alejandro ^d   Acuña Castillo, Claudio ^a,d  

^a Laboratorio de Cinética y Fotoquímica   (Chile)

^b UNIVERSIDAD ANDRÉS BELLO   (Chile)

^c UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^d UNIVERSITY OF CHILE   (Chile)

Author keywords

Immune response; P2X7 receptor; Polymyxin B; Purinergic agonist; T regulatory cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; POLYMYXIN B; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; CELL FUNCTION; CELL POPULATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T CELL DEPLETION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; DRUG SYNERGISM; FEMALE; IMMUNOPHENOTYPING; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED C57BL; POLYMYXIN B; PURINERGIC AGONISTS; T-LYMPHOCYTES, REGULATORY;

EID: 84856484977     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.10.006     Document Type: Article

References (35)

1. Acuña-Castillo C., Coddou C., Bull P., Brito J., Huidobro-Toro J.P. Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor. J. Neurochem. 2007, 101:17.
2. Allam R., Darisipudi M.N., Rupanagudi K.V., Lichtnekert J., Tschopp J., Anders H.J. Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1beta secretion by activating the NLRP3 inflammasome. J. Immunol. 2011, 186:2714.
3. Aswad F., Dennert G. P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes. Cell Immunol. 2006, 243:58.
4. Aswad F., Kawamura H., Dennert G. High sensitivity of CD4+ CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors. J. Immunol. 2005, 175:3075.
5. Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., Zhu Y., Wei S., Kryczek I., Daniel B., Gordon A., Myers L., Lackner A., Disis M.L., Knutson K.L., Chen L., Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004, 10:942.
6. Di Virgilio F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol. Sci. 2007, 28:465.
7. Elssner A., Duncan M., Gavrilin M., Wewers M.D. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J. Immunol. 2004, 172:4987.
8. Ferrari D., Pizzirani C., Adinolfi E., Forchap S., Sitta B., Turchet L., Falzoni S., Minelli M., Baricordi R., Di Virgilio F. The antibiotic polymyxin B modulates P2X7 receptor function. J. Immunol. 2004, 173:4652.
9. Ferrari D., Pizzirani C., Adinolfi E., Lemoli R.M., Curti A., Idzko M., Panther E., Di Virgilio F. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 2006, 176:3877.
10. Gavin M., Rudensky A. Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr. Opin. Immunol. 2003, 15:690.
11. Gavin M.A., Rasmussen J.P., Fontenot J.D., Vasta V., Manganiello V.C., Beavo J.A., Rudensky A.Y. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007, 445:771.
12. Haag F., Adriouch S., Brass A., Jung C., Moller S., Scheuplein F., Bannas P., Seman M., Koch-Nolte F. Extracellular NAD and ATP: partners in immune cell modulation. Purinergic Signal. 2007, 3:71.
13. Jones E., Dahm-Vicker M., Simon A.K., Green A., Powrie F., Cerundolo V., Gallimore A. Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun. 2002, 2:1.
14. Kanneganti T.D., Lamkanfi M., Kim Y.G., Chen G., Park J.H., Franchi L., Vandenabeele P., Nunez G. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 2007, 26:433.
15. Kawamura H., Aswad F., Minagawa M., Malone K., Kaslow H., Koch-Nolte F., Schott W.H., Leiter E.H., Dennert G. P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide. J. Immunol. 2005, 174:1971.
16. Labasi J.M., Petrushova N., Donovan C., McCurdy S., Lira P., Payette M.M., Brissette W., Wicks J.R., Audoly L., Gabel C.A. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 2002, 168:6436.
17. Leiva-Salcedo E., Coddou C., Rodriguez F.E., Penna A., Lopez X., Neira T., Fernandez R., Imarai M., Rios M., Escobar J., Montoya M., Huidobro-Toro J.P., Escobar A., Acuña-Castillo C. Lipopolysaccharide inhibits the channel activity of the P2X7 receptor. Mediat. Inflamm. 2011, 2011:152625.
18. Motoyoshi Y., Kaminoda K., Saitoh O., Hamasaki K., Nakao K., Ishii N., Nagayama Y., Eguchi K. Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide. Oncol. Rep. 2006, 16:141.
19. Needham D.J., Lee J.X., Beilharz M.W. Intra-tumoural regulatory T cells: a potential new target in cancer immunotherapy. Biochem. Biophys. Res. Commun. 2006, 343:684.
20. Niemi K., Teirila L., Lappalainen J., Rajamaki K., Baumann M.H., Oorni K., Wolff H., Kovanen P.T., Matikainen S., Eklund K.K. Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway. J. Immunol. 2011, 186:6119.
21. Nishikawa H., Sakaguchi S. Regulatory T cells in tumor immunity. Int. J. Cancer 2010, 127:759.
22. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 82:1013.
23. O'Day S.J., Hamid O., Urba W.J. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer 2007, 110:2614.
24. Ohkura N., Sakaguchi S. Regulatory T cells: roles of T cell receptor for their development and function. Semin. Immunopathol. 2010, 32:95.
25. Pelegrin P., Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 2006, 25:5071.
26. Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775.
27. Sakaguchi S., Wing K., Onishi Y., Prieto-Martin P., Yamaguchi T. Regulatory T cells: how do they suppress immune responses?. Int. Immunol. 2009, 21:1105.
28. Salem D.A., Gado N.M., Abdelaziz N.N., Essa A.E., Abdelhafeez Z.M., Kamel T.H. Phase II trial of metronomic chemotherapy as salvage therapy for patients with metastatic breast cancer. J. Egypt Natl. Cancer Inst. 2008, 20:134.
29. Schabowsky R.H., Madireddi S., Sharma R., Yolcu E.S., Shirwan H. Targeting CD4+ CD25+ FoxP3+ regulatory T-cells for the augmentation of cancer immunotherapy. Curr. Opin. Investig. Drugs 2007, 8:1002.
30. Seman M., Adriouch S., Scheuplein F., Krebs C., Freese D., Glowacki G., Deterre P., Haag F., Koch-Nolte F. NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Immunity 2003, 19:571.
31. Sutmuller R.P., van Duivenvoorde L.M., van Elsas A., Schumacher T.N., Wildenberg M.E., Allison J.P., Toes R.E., Offringa R., Melief C.J. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 2001, 194:823.
32. Verstovsek S., Maccubbin D.L., Ehrke M.J., Mihich E. Polymyxin B-mediated lysis of tumor cells. Int. Arch. Allergy Immunol. 1993, 100:47.
33. Wing K., Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 2010, 11:7.
34. Woo E.Y., Yeh H., Chu C.S., Schlienger K., Carroll R.G., Riley J.L., Kaiser L.R., June C.H. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 2002, 168:4272.
35. Yan Z., Li S., Liang Z., Tomic M., Stojilkovic S.S. The P2X7 receptor channel pore dilates under physiological ion conditions. J. Gen. Physiol. 2008, 132:563.