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Volumn 12, Issue 3, 2012, Pages 210-218

Zinc complexes developed as metallopharmaceutics for treating diabetes mellitus based on the bio-medicinal inorganic chemistry

Author keywords

Anti diabetic zinc complexes; Bio coordination chemistry; Bioinorganic chemistry; Diabetes mellitus; Insulin signaling; Medicinal inorganic chemistry; Metallopharmaceutics

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BIGUANIDE; HEMOGLOBIN A1C; MEGLITINIDE; SULFONYLUREA; ZINC COMPLEX;

EID: 84856458633     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802612799078874     Document Type: Review
Times cited : (75)

References (88)
  • 1
    • 0027218815 scopus 로고
    • Metal compounds in therapy and diagnosis
    • Abrams, M. J.; Murrer, B. A. Metal compounds in therapy and diagnosis. Science, 1993, 261, 725-730.
    • (1993) Science , vol.261 , pp. 725-730
    • Abrams, M.J.1    Murrer, B.A.2
  • 3
    • 0037993828 scopus 로고    scopus 로고
    • Boon and bane of metal ions in medicine
    • Thompson, K. H.; Orvig, C. Boon and bane of metal ions in medicine. Science, 2003, 300, 936-939.
    • (2003) Science , vol.300 , pp. 936-939
    • Thompson, K.H.1    Orvig, C.2
  • 4
    • 0029897509 scopus 로고    scopus 로고
    • Organometallics in medicine
    • Respondek, J.; Engel, J. Organometallics in medicine. Drugs Future, 1996, 21, 391-408.
    • (1996) Drugs Future , vol.21 , pp. 391-408
    • Respondek, J.1    Engel, J.2
  • 7
    • 54449086422 scopus 로고    scopus 로고
    • Current state for the development of metallopharmaceutics and anti-diabetic metal complexes
    • Sakurai, H.; Yoshikawa, Y.; Yasui, H. Current state for the development of metallopharmaceutics and anti-diabetic metal complexes. Chem. Soc. Rev., 2008, 37, 2383-2392.
    • (2008) Chem. Soc. Rev. , vol.37 , pp. 2383-2392
    • Sakurai, H.1    Yoshikawa, Y.2    Yasui, H.3
  • 8
    • 0003414085 scopus 로고
    • Trace Elements in Human and Animal Nutrition
    • 4th ed
    • Underwood, E. J. Trace Elements in Human and Animal Nutrition, 4th ed., Academic Press, 1977, 545pp.
    • (1977) Academic Press , pp. 545
    • Underwood, E.J.1
  • 9
    • 0027394031 scopus 로고
    • The biochemical basis of zinc physiology
    • Vallee, B. L.; Falchuk, K. H. The biochemical basis of zinc physiology. Physiol. Rev., 1993, 73, 79-118.
    • (1993) Physiol. Rev. , vol.73 , pp. 79-118
    • Vallee, B.L.1    Falchuk, K.H.2
  • 10
    • 0035690880 scopus 로고    scopus 로고
    • Zinc coordination sphere in biochemical zinc sites
    • Auld, D. S. Zinc coordination sphere in biochemical zinc sites. BioMetals, 2001, 14, 271-313.
    • (2001) BioMetals , vol.14 , pp. 271-313
    • Auld, D.S.1
  • 11
    • 0021100320 scopus 로고
    • Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene
    • Hanas, J. S.; Hazuda, D.; Bogenhagen, D. F.; Wu, F. Y.-H.; Wu, C.-W. Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene. J. Biol. Chem., 1983, 258, 14120-14125.
    • (1983) J. Biol. Chem. , vol.258 , pp. 14120-14125
    • Hanas, J.S.1    Hazuda, D.2    Bogenhagen, D.F.3    Wu, F.Y.-H.4    Wu, C.-W.5
  • 12
    • 0040215628 scopus 로고
    • Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
    • Miller, J.; McLachlan A. D.; Klug, A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J., 1985, 4, 1609-1614.
    • (1985) EMBO J , vol.4 , pp. 1609-1614
    • Miller, J.1    McLachlan, A.D.2    Klug, A.3
  • 13
    • 0035253047 scopus 로고    scopus 로고
    • Zinc finger proteins: New insights into structural and functional diversity
    • Laity, J. H.; Lee, B. M.; Wright, P. E. Zinc finger proteins: new insights into structural and functional diversity. Curr. Opin. Struct. Biol., 2001, 11, 39-46.
    • (2001) Curr. Opin. Struct. Biol. , vol.11 , pp. 39-46
    • Laity, J.H.1    Lee, B.M.2    Wright, P.E.3
  • 14
    • 0028948696 scopus 로고
    • Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc
    • Palmiter, R. D.; Findley, S. D. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J., 1995, 14, 639-649.
    • (1995) EMBO J , vol.14 , pp. 639-649
    • Palmiter, R.D.1    Findley, S.D.2
  • 15
    • 0032584166 scopus 로고    scopus 로고
    • Thiolate ligands in metallothionein confer redox activity on zinc clusters
    • Maret, W.; Vallee, B. L. Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc. Natl. Acad. Sci. USA, 1998, 95, 3478-3482.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3478-3482
    • Maret, W.1    Vallee, B.L.2
  • 16
    • 0004608219 scopus 로고    scopus 로고
    • Importance of zinc in the central nervous system: The zinc-containing neuron
    • Frederickson, C. J.; Su, S. W.; Silva, D.; Thompson, R. B. Importance of zinc in the central nervous system: the zinc-containing neuron. J. Nutr., 2000, 130, 1471S-1483S.
    • (2000) J. Nutr. , vol.130
    • Frederickson, C.J.1    Su, S.W.2    Silva, D.3    Thompson, R.B.4
  • 17
    • 0036308552 scopus 로고    scopus 로고
    • A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
    • Wang, K.; Zhou, B.; Kuo, Y. M.; Zemansky, J.; Gitschier, J. A. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am. J. Hum. Genet., 2002, 71, 66-73.
    • (2002) Am. J. Hum. Genet , vol.71 , pp. 66-73
    • Wang, K.1    Zhou, B.2    Kuo, Y.M.3    Zemansky, J.4    Gitschier, J.A.5
  • 18
    • 0036648254 scopus 로고    scopus 로고
    • Identification of SLC39A4, a gene involved in acrodermatitis enteropathica
    • Kury, S.; Dreno, B.; Bezieau, S.; Giraudet, S.; Kharfi, M.; Kamoun, R.; et al. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat. Genet., 2002, 31, 239-240.
    • (2002) Nat. Genet. , vol.31 , pp. 239-240
    • Kury, S.1    Dreno, B.2    Bezieau, S.3    Giraudet, S.4    Kharfi, M.5    Kamoun, R.6
  • 19
    • 0016809920 scopus 로고
    • Abnormal development of preimplantation rat eggs after three days of maternal dietary zinc deficiency
    • Hurley, L. S.; Shrader, R. E. Abnormal development of preimplantation rat eggs after three days of maternal dietary zinc deficiency. Nature, 1975, 254, 427-429.
    • (1975) Nature , vol.254 , pp. 427-429
    • Hurley, L.S.1    Shrader, R.E.2
  • 21
    • 0029866646 scopus 로고    scopus 로고
    • The galvanization of biology: A growing appreciation for the roles of zinc
    • Berg, J. M.; Shi, Y. The galvanization of biology: a growing appreciation for the roles of zinc. Science, 1996, 271, 1081-1085.
    • (1996) Science , vol.271 , pp. 1081-1085
    • Berg, J.M.1    Shi, Y.2
  • 24
    • 3142705632 scopus 로고    scopus 로고
    • Reprogramming of the immune system during zinc deficiency
    • Fraker, P. J.; King, L. E. Reprogramming of the immune system during zinc deficiency. Annu. Rev. Nutr., 2004, 24, 277-298.
    • (2004) Annu. Rev. Nutr , vol.24 , pp. 277-298
    • Fraker, P.J.1    King, L.E.2
  • 25
    • 0020626162 scopus 로고
    • Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. I. Impaired acquisition of granule cells
    • Dvergsten, C. L.; Fosmire, G. J.; Ollerich, D. A.; Sandstead, H. H. Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. I. Impaired acquisition of granule cells. Brain Res., 1983, 271, 217-226.
    • (1983) Brain Res , vol.271 , pp. 217-226
    • Dvergsten, C.L.1    Fosmire, G.J.2    Ollerich, D.A.3    Sandstead, H.H.4
  • 26
    • 0021485454 scopus 로고
    • Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. II. Impaired maturation of Purkinje cells
    • Dvergsten, C. L.; Fosmire, G. J.; Ollerich, D. A.; Sandstead, H. H. Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. II. Impaired maturation of Purkinje cells. Brain Res., 1984, 318, 11-20.
    • (1984) Brain Res , vol.318 , pp. 11-20
    • Dvergsten, C.L.1    Fosmire, G.J.2    Ollerich, D.A.3    Sandstead, H.H.4
  • 27
    • 0021489502 scopus 로고
    • Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. III. Impaired dendritic differentiation of basket and stellate cells
    • Dvergsten, C. L.; Johnson, L.K.; Sandstead, H. H. Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. III. Impaired dendritic differentiation of basket and stellate cells. Brain Res., 1984, 318, 21-26.
    • (1984) Brain Res , vol.318 , pp. 21-26
    • Dvergsten, C.L.1    Johnson, L.K.2    Sandstead, H.H.3
  • 28
  • 29
    • 24744470458 scopus 로고    scopus 로고
    • Zinc, the pancreas, and diabetes: Insights from rodent studies and future directions
    • Taylor, C. G. Zinc, the pancreas, and diabetes: Insights from rodent studies and future directions. BioMetals, 2005, 18, 305-312.
    • (2005) BioMetals , vol.18 , pp. 305-312
    • Taylor, C.G.1
  • 30
    • 0019941222 scopus 로고
    • The mechanism of the insulin-like effects of ionic zinc
    • James, M. M.; Charles, S. C. The mechanism of the insulin-like effects of ionic zinc. J. Biol. Chem., 1982, 257, 4362-4368.
    • (1982) J. Biol. Chem. , vol.257 , pp. 4362-4368
    • James, M.M.1    Charles, S.C.2
  • 31
    • 0028089672 scopus 로고
    • Hyperzincuria in individuals with insulin-dependent diabetes mellitus: Concurrent zinc status and the effect of high-dose zinc supplementation
    • Cunningham, J. J.; Fu, A. Z.; Mearkle, P. L.; Brown, R. G. Hyperzincuria in individuals with insulin-dependent diabetes mellitus: concurrent zinc status and the effect of high-dose zinc supplementation. Metab. Clin. Exp., 1994, 43, 1558-1562.
    • (1994) Metab. Clin. Exp , vol.43 , pp. 1558-1562
    • Cunningham, J.J.1    Fu, A.Z.2    Mearkle, P.L.3    Brown, R.G.4
  • 32
    • 0019287147 scopus 로고
    • Insulin-like effect of zinc on adipocytes
    • Coulson, L.; Dandona, P. Insulin-like effect of zinc on adipocytes. Diabetes, 1980, 29, 665-667.
    • (1980) Diabetes , vol.29 , pp. 665-667
    • Coulson, L.1    Dandona, P.2
  • 33
    • 0026777881 scopus 로고
    • Insulinlike effects of zinc ion in vitro and in vivo. Preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats
    • Shisheva, A.; Gefel, D.; Shechter, Y. Insulinlike effects of zinc ion in vitro and in vivo. Preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats. Diabetes, 1992, 41, 982-988.
    • (1992) Diabetes , vol.41 , pp. 982-988
    • Shisheva, A.1    Gefel, D.2    Shechter, Y.3
  • 34
    • 0031953045 scopus 로고    scopus 로고
    • Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice
    • Chen, M. D.; Liou, S. J.; Lin, P. Y.; Yang, V. C.; Alexander, P. S.; Lin, W. H. Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice. Biol. Trace Elem. Res., 1998, 61, 303-311.
    • (1998) Biol. Trace Elem. Res , vol.61 , pp. 303-311
    • Chen, M.D.1    Liou, S.J.2    Lin, P.Y.3    Yang, V.C.4    Alexander, P.S.5    Lin, W.H.6
  • 35
    • 2542465510 scopus 로고    scopus 로고
    • Metallokinetic study of zinc in the blood of normal rats given insulinomimetic zinc(II) complexes and improvement of diabetes mellitus in type 2 diabetic GK rats by their oral administration
    • Fugono, J.; Fujimoto, K.; Yasui, H.; Kawabe, K.; Yoshikawa, Y.; Kojima, Y.; Sakurai, H. Metallokinetic study of zinc in the blood of normal rats given insulinomimetic zinc(II) complexes and improvement of diabetes mellitus in type 2 diabetic GK rats by their oral administration. Drug Metab. Pharmacokinet., 2002, 17, 340-347.
    • (2002) Drug Metab. Pharmacokinet. , vol.17 , pp. 340-347
    • Fugono, J.1    Fujimoto, K.2    Yasui, H.3    Kawabe, K.4    Yoshikawa, Y.5    Kojima, Y.6    Sakurai, H.7
  • 36
    • 0003609171 scopus 로고    scopus 로고
    • World Health Organization. E. C., 221: Zinc, Geneva: World Health Organization
    • World Health Organization. E. C., Environmental Health Criteria 221: Zinc, Geneva: World Health Organization, 2001, p. 360.
    • (2001) Environmental Health Criteria , pp. 360
  • 38
    • 33646036991 scopus 로고    scopus 로고
    • Zinc requirements and the risks and benefits of zinc supplementation
    • Maret, W.; Sandstead, H. H. Zinc requirements and the risks and benefits of zinc supplementation. J. Trace Elem.Med. Biol. 2006, 20, 3-18.
    • (2006) J. Trace Elem.Med. Biol. , vol.20 , pp. 3-18
    • Maret, W.1    Sandstead, H.H.2
  • 39
    • 0028967524 scopus 로고
    • Requirements and toxicity of essential trace elements, illustrated by zinc and copper
    • Sandstead, H. H. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am. J. Clin. Nutr., 1995, 61, 621S-624S.
    • (1995) Am. J. Clin. Nutr , vol.61
    • Sandstead, H.H.1
  • 40
    • 0022361336 scopus 로고
    • Indices of copper status in humans consuming a typical American diet containing either fructose or starch
    • Reiser, S.; Smith Jr., J. C.; Mertz, W.; Holbrook, J. T.; Scholfield, D. J.; Powell, A. S.; et al. Indices of copper status in humans consuming a typical American diet containing either fructose or starch. Am., J. Clin., Nutr., 1985, 42, 242-251.
    • (1985) Am., J. Clin., Nutr. , vol.42 , pp. 242-251
    • Reiser, S.1    Smith, J.C.2    Mertz, W.3    Holbrook, J.T.4    Scholfield, D.J.5    Powell, A.6
  • 41
    • 0034072819 scopus 로고    scopus 로고
    • Zinc-induced anemia and neutropenia in an adolescent
    • Porea, T. J.; Belmont, J. W.; Mahoney, D. H. Zinc-induced anemia and neutropenia in an adolescent. J. Pediatr., 2000, 136, 688-690.
    • (2000) J. Pediatr , vol.136 , pp. 688-690
    • Porea, T.J.1    Belmont, J.W.2    Mahoney, D.H.3
  • 43
    • 3242655603 scopus 로고    scopus 로고
    • Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response
    • Faber, C.; Gabriel, P.; Ibs, K. H.; Rink, L. Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response. Bone Marrow Transplant, 2004, 33, 1241-1246.
    • (2004) Bone Marrow Transplant , vol.33 , pp. 1241-1246
    • Faber, C.1    Gabriel, P.2    Ibs, K.H.3    Rink, L.4
  • 45
    • 2542435343 scopus 로고    scopus 로고
    • Moderately High Zinc Intake Impairs Verbal Memory of Healthy Postmenopausal Women On a Low Copper Diet
    • ed. By Roussel, A. M.; Anderson R. A.; Favier, A. E. Kluwer Academic/ Plenum, Evian
    • Penland, J. G.; Milne, D. B.; Davis, C. W. Moderately high zinc intake impairs verbal memory of healthy postmenopausal women on a low copper diet. Trace Elements in Man and Animals, vol. 10, ed. By Roussel, A. M.; Anderson R. A.; Favier, A. E. Kluwer Academic/ Plenum, Evian, 2000, p. 1025-1030, 1172 pp.
    • (2000) Trace Elements in Man and Animals , vol.10 , pp. 1025-1030
    • Penland, J.G.1    Milne, D.B.2    Davis, C.W.3
  • 46
    • 0033950458 scopus 로고    scopus 로고
    • Essentiality and toxicity of trace elements: Principles and methods for assessment of risk from human exposure to essential trace elements
    • Nordberg, G.; Sandström, B.; Becking, G.; Goyer, R. A. Essentiality and toxicity of trace elements: Principles and methods for assessment of risk from human exposure to essential trace elements. J. Trace Elem. Exp. Med., 2000, 13, 141-153.
    • (2000) J. Trace Elem. Exp. Med , vol.13 , pp. 141-153
    • Nordberg, G.1    Sandström, B.2    Becking, G.3    Goyer, R.A.4
  • 47
    • 0035857020 scopus 로고    scopus 로고
    • New drug targets for type 2 diabetes and the metabolic syndrome
    • Moller, D. E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature, 2001, 414, 821-827.
    • (2001) Nature , vol.414 , pp. 821-827
    • Moller, D.E.1
  • 48
    • 33748039456 scopus 로고    scopus 로고
    • Therapies for the treatment of type 2 diabetes mellitus based on incretin action
    • Gallwitz, B. Therapies for the treatment of type 2 diabetes mellitus based on incretin action. Minerva Endocrinol., 2006, 31, 133-147.
    • (2006) Minerva Endocrinol , vol.31 , pp. 133-147
    • Gallwitz, B.1
  • 49
    • 59249083934 scopus 로고    scopus 로고
    • Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: A nested case-control analysis
    • Bodmer, M.; Meier, C.; Krähenbühl, S.; Jick, S. S.; Meier, C. R. Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. Diabetes Care, 2008, 31, 2086-2091.
    • (2008) Diabetes Care , vol.31 , pp. 2086-2091
    • Bodmer, M.1    Meier, C.2    Krähenbühl, S.3    Jick, S.S.4    Meier, C.R.5
  • 51
    • 34547687778 scopus 로고    scopus 로고
    • Effect of chromium supplementation on glucose metabolism and lipids: A systematic review of randomized controlled trials
    • Balk, E. M.; Tatsioni, A.; Lichtenstein, A. H.; Lau, J.; Pittas, A. G. Effect of chromium supplementation on glucose metabolism and lipids: A systematic review of randomized controlled trials. Diabetes Care, 2007, 30, 2154-2163.
    • (2007) Diabetes Care , vol.30 , pp. 2154-2163
    • Balk, E.M.1    Tatsioni, A.2    Lichtenstein, A.H.3    Lau, J.4    Pittas, A.G.5
  • 52
    • 0034486659 scopus 로고    scopus 로고
    • Selenium: An insulin-mimetic
    • Stapleton, S. R. Selenium: An insulin-mimetic. Cell Mol. Life Sci., 2000, 57, 1874-1879.
    • (2000) Cell Mol. Life Sci. , vol.57 , pp. 1874-1879
    • Stapleton, S.R.1
  • 55
    • 0035168559 scopus 로고    scopus 로고
    • Dietary zinc supplementation attenuates hyperglycemia in db/db mice
    • Simon, S. F.; Taylor, C. G. Dietary zinc supplementation attenuates hyperglycemia in db/db mice. Exp. Biol. Med., 2001, 226, 43-51.
    • (2001) Exp. Biol. Med. , vol.226 , pp. 43-51
    • Simon, S.F.1    Taylor, C.G.2
  • 56
    • 84856435652 scopus 로고    scopus 로고
    • Zinc(II) complexes with anti-diabetic effect
    • Kojima Y.; Yoshikawa Y. Zinc(II) complexes with anti-diabetic effect. Vitamins, 2005, 79, 155-165.
    • (2005) Vitamins , vol.79 , pp. 155-165
    • Kojima, Y.1    Yoshikawa, Y.2
  • 57
    • 33750940955 scopus 로고    scopus 로고
    • Chemistry and biochemistry of insulin-mimetic vanadium and zinc complex. Trial for treatment of diabetes mellitus
    • Sakurai, H.; Katoh, A.; Yoshikawa, Y. Chemistry and biochemistry of insulin-mimetic vanadium and zinc complex. Trial for treatment of diabetes mellitus. Bull. Chem. Soc. Rev., 2006, 79, 1645-1664.
    • (2006) Bull. Chem. Soc. Rev , vol.79 , pp. 1645-1664
    • Sakurai, H.1    Katoh, A.2    Yoshikawa, Y.3
  • 58
    • 0036906288 scopus 로고    scopus 로고
    • New zinc(II) complexes with tetradentate amino acid derivatives: Structure characterization, solution chemistry, and in vitro insulinomimetic activity
    • Yoshikawa, Y.; Kawabe, K.; Tadokoro, M.; Suzuki, Y.; Yanagihara, N.; Nakayama, A.; Sakurai, H.; Kojima, Y. New zinc(II) complexes with tetradentate amino acid derivatives: Structure characterization, solution chemistry, and in vitro insulinomimetic activity. Bull. Chem. Soc. Jpn., 2002, 75, 2423-2432.
    • (2002) Bull. Chem. Soc. Jpn. , vol.75 , pp. 2423-2432
    • Yoshikawa, Y.1    Kawabe, K.2    Tadokoro, M.3    Suzuki, Y.4    Yanagihara, N.5    Nakayama, A.6    Sakurai, H.7    Kojima, Y.8
  • 59
    • 0034810531 scopus 로고    scopus 로고
    • Insulinomimetic bis(maltolato)zinc(II) complex: Blood glucose normalizing effect in KK-Ay mice with type 2 diabetes mellitus
    • Yoshikawa, Y.; Ueda, E.; Miyake, H.; Sakurai, H.; Kojima, Y. Insulinomimetic bis(maltolato)zinc(II) complex: blood glucose normalizing effect in KK-Ay mice with type 2 diabetes mellitus. Biochem. Biophys. Res. Commun., 2001, 281, 1190-1193.
    • (2001) Biochem. Biophys. Res. Commun , vol.281 , pp. 1190-1193
    • Yoshikawa, Y.1    Ueda, E.2    Miyake, H.3    Sakurai, H.4    Kojima, Y.5
  • 60
    • 22244460477 scopus 로고    scopus 로고
    • Highly potent insulin-mimetic zinc(II) complex with a Zn(S2O2) coordination mode: Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl -1,4-dihydropyridine-4-thionato)zinc(II)
    • Adachi, Y.; Yoshida, J.; Kodera, Y.; Sakurai, H. A Highly potent insulin-mimetic zinc(II) complex with a Zn(S2O2) coordination mode: Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl -1,4-dihydropyridine-4-thionato)zinc(II). Chem. Lett., 2005, 34, 656-657.
    • (2005) Chem. Lett. , vol.34 , pp. 656-657
    • Adachi, Y.1    Yoshida, J.2    Kodera, Y.3    Sakurai, H.A.4
  • 61
    • 20444400576 scopus 로고    scopus 로고
    • A family of insulinomimetic zinc(II) complexes of amino ligands with Zn(Nn) (n=3 and 4) coordination modes
    • Yoshikawa, Y.; Kondo, M.; Sakurai, H.; Kojima, Y. A family of insulinomimetic zinc(II) complexes of amino ligands with Zn(Nn) (n=3 and 4) coordination modes. J. Inorg. Biochem., 2005, 99, 1497-1503.
    • (2005) J. Inorg. Biochem. , vol.99 , pp. 1497-1503
    • Yoshikawa, Y.1    Kondo, M.2    Sakurai, H.3    Kojima, Y.4
  • 62
    • 46649084259 scopus 로고    scopus 로고
    • A [meso-tetrakis(4-sulfonatophenyl)porphyrinato] zinc(II) complex as an oral therapeutic for the treatment of type 2 diabetic KKAy mice
    • Saha, T. K.; Yoshikawa, Y.; Sakurai, H. A [meso-tetrakis(4-sulfonatophenyl)porphyrinato] zinc(II) complex as an oral therapeutic for the treatment of type 2 diabetic KKAy mice. ChemMed-Chem, 2007, 2, 218-225.
    • (2007) ChemMed-Chem , vol.2 , pp. 218-225
    • Saha, T.K.1    Yoshikawa, Y.2    Sakurai, H.3
  • 63
    • 33846211027 scopus 로고    scopus 로고
    • A new type of orally active anti-diabetic Zn(II)-dithiocarbamate complex
    • Yoshikawa, Y.; Adachi, Y.; Sakurai, H. A new type of orally active anti-diabetic Zn(II)-dithiocarbamate complex. Life Sci., 2007, 80, 759-766.
    • (2007) Life Sci , vol.80 , pp. 759-766
    • Yoshikawa, Y.1    Adachi, Y.2    Sakurai, H.3
  • 65
    • 0043023404 scopus 로고    scopus 로고
    • Anti-diabetes effect of Zn(II)/carnitine complex by oral administration
    • Yoshikawa, Y.; Ueda, E.; Sakurai, H.; Kojima, Y. Anti-diabetes effect of Zn(II)/carnitine complex by oral administration. Chem. Pharm. Bull., 2003, 51, 230-231.
    • (2003) Chem. Pharm. Bull. , vol.51 , pp. 230-231
    • Yoshikawa, Y.1    Ueda, E.2    Sakurai, H.3    Kojima, Y.4
  • 67
    • 0346848800 scopus 로고    scopus 로고
    • Anti-hyperglycemic activity of zinc plus cyclo (his-pro) in genetically diabetic Goto-Kakizaki and aged rats
    • Song, M. K.; Hwang, I. K.; Rosenthal, M. J.; Harris, D. M.; Yamaguchi, D. T.; Yip, I.; Go, V. L. Anti-hyperglycemic activity of zinc plus cyclo (his-pro) in genetically diabetic Goto-Kakizaki and aged rats. Exp. Biol. Med., 2003, 228, 1338-1345.
    • (2003) Exp. Biol. Med , vol.228 , pp. 1338-1345
    • Song, M.K.1    Hwang, I.K.2    Rosenthal, M.J.3    Harris, D.M.4    Yamaguchi, D.T.5    Yip, I.6    Go, V.L.7
  • 69
    • 62349093804 scopus 로고    scopus 로고
    • Evaluation of insulin-mimetic activities of vanadyl and zinc(II) complexes from the viewpoint of heterocyclic bidentate ligands
    • Katoh, A.; Matsumura, Y.; Yoshikawa, Y.; Yasui, H.; Sakurai, H. Evaluation of insulin-mimetic activities of vanadyl and zinc(II) complexes from the viewpoint of heterocyclic bidentate ligands. J. Inorg. Biochem., 2009, 103, 567-574.
    • (2009) J. Inorg. Biochem , vol.103 , pp. 567-574
    • Katoh, A.1    Matsumura, Y.2    Yoshikawa, Y.3    Yasui, H.4    Sakurai, H.5
  • 70
    • 84856475106 scopus 로고    scopus 로고
    • Zn organic compounds with hypoglycemic effect
    • Kojima, Y.; Sakurai, H. Zn organic compounds with hypoglycemic effect. JP Patent, 2001-220348.
    • JP Patent , pp. 2001-220348
    • Kojima, Y.1    Sakurai, H.2
  • 71
    • 65549129154 scopus 로고    scopus 로고
    • A zinc(II)/poly(gamma-glutamic acid) complex as an oral therapeutic for the treatment of type-2 diabetic KKAy mice
    • Karmaker, S.; Saha, T. K.; Yoshikawa, Y.; Sakurai, H. A zinc(II)/poly(gamma-glutamic acid) complex as an oral therapeutic for the treatment of type-2 diabetic KKAy mice. Macromol. Biosci., 2009, 9, 279-286.
    • (2009) Macromol. Biosci. , vol.9 , pp. 279-286
    • Karmaker, S.1    Saha, T.K.2    Yoshikawa, Y.3    Sakurai, H.4
  • 72
    • 0029988665 scopus 로고    scopus 로고
    • Antidiabetic activity of some oral hypoglycemic agents with metal ions on animal model
    • Narad, S. R.; Mishra, N. N; Pandey, P.; Kumar, A. Antidiabetic activity of some oral hypoglycemic agents with metal ions on animal model. Ind. J. Exp. Biol., 1996, 34, 81-82.
    • (1996) Ind. J. Exp. Biol , vol.34 , pp. 81-82
    • Narad, S.R.1    Mishra, N.N.2    Pandey, P.3    Kumar, A.4
  • 73
    • 40649101197 scopus 로고    scopus 로고
    • Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) schiff base complexes derived from salicylaldehyde and beta-alanine
    • Vanco, J.; Marek, J.; Trávnícek, Z.; Racanská, E.; Muselík, J.; Svajlenová, O. Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) schiff base complexes derived from salicylaldehyde and beta-alanine. J. Inorg. Biochem., 2008, 102, 595-605.
    • (2008) J. Inorg. Biochem. , vol.102 , pp. 595-605
    • Vanco, J.1    Marek, J.2    Trávnícek, Z.3    Racanská, E.4    Muselík, J.5    Svajlenová, O.6
  • 74
    • 0034094835 scopus 로고    scopus 로고
    • Zinc status in human immunodeficiency virus infection
    • Baum, M. K.; Shor-Posner, G.; Campa, A.; Zinc status in human immunodeficiency virus infection. J. Nutr., 2000, 130, 1421S-1423S.
    • (2000) J. Nutr , vol.130
    • Baum, M.K.1    Shor-Posner, G.2    Campa, A.3
  • 75
    • 0035130899 scopus 로고    scopus 로고
    • Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice
    • Ho, E.; Quan, H.; Tsai, Y. H.; Lai, W.; Bray, T. M. Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp. Biol. Med., 2001, 226, 103-111.
    • (2001) Exp. Biol. Med. , vol.226 , pp. 103-111
    • Ho, E.1    Quan, H.2    Tsai, Y.H.3    Lai, W.4    Bray, T.M.5
  • 76
    • 0035008149 scopus 로고    scopus 로고
    • Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes
    • Tang, X. H.; Shay, N. F. Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes. J. Nutr., 2001, 131, 1414-1420.
    • (2001) J. Nutr , vol.131 , pp. 1414-1420
    • Tang, X.H.1    Shay, N.F.2
  • 77
    • 0024441309 scopus 로고
    • 2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes
    • 2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes. J. Biol. Chem., 1989, 264, 16118-16122.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16118-16122
    • Ezaki, O.1
  • 78
    • 0042847299 scopus 로고    scopus 로고
    • Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
    • Wu, W.; Wang, X.; Zhang, W.; Reed, W.; Samet, J. M.; Whang, Y. E.; Ghio, A. J. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. J. Biol. Chem., 2003, 278, 28258-28263.
    • (2003) J. Biol. Chem , vol.278 , pp. 28258-28263
    • Wu, W.1    Wang, X.2    Zhang, W.3    Reed, W.4    Samet, J.M.5    Whang, Y.E.6    Ghio, A.J.7
  • 79
    • 24744446561 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases as target of the combined insulinomimetic effect of zinc and oxidants
    • Hasse, H.; Maret, W. Protein tyrosine phosphatases as target of the combined insulinomimetic effect of zinc and oxidants. Biometals, 2005, 18, 333-338.
    • (2005) Biometals , vol.18 , pp. 333-338
    • Hasse, H.1    Maret, W.2
  • 80
    • 21144431985 scopus 로고    scopus 로고
    • In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide
    • Ueda, E.; Yoshikawa, Y.; Sakurai, H.; Kojima, Y.; Kajiwara, N. M. In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide. Chem. Pharm. Bull., 2005, 53, 451-452.
    • (2005) Chem. Pharm. Bull. , vol.53 , pp. 451-452
    • Ueda, E.1    Yoshikawa, Y.2    Sakurai, H.3    Kojima, Y.4    Kajiwara, N.M.5
  • 81
    • 2542456412 scopus 로고    scopus 로고
    • The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes
    • Yoshikawa, Y.; Ueda, E.; Kojima, Y.; Sakurai, H. The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes. Life Sci., 2004, 75, 741-751.
    • (2004) Life Sci , vol.75 , pp. 741-751
    • Yoshikawa, Y.1    Ueda, E.2    Kojima, Y.3    Sakurai, H.4
  • 82
    • 33847419283 scopus 로고    scopus 로고
    • 2) enhances insulin signaling pathway in 3T3-L1 adipocytes
    • 2) enhances insulin signaling pathway in 3T3-L1 adipocytes. J Inorg. Biochem., 2007, 101, 692-699.
    • (2007) J Inorg. Biochem , vol.101 , pp. 692-699
    • Basuki, W.1    Hiromura, M.2    Sakurai, H.3
  • 83
    • 84856482613 scopus 로고    scopus 로고
    • Analysis of skin distribution of 65Zn in hairless mice treated with 65Zn-labeled zinc compounds by oral supplementation
    • Yasui, H.; Nishimura, H.; Haba, H.; Hirunuma, R.; Enomoto, S.; Sakurai, H. Analysis of skin distribution of 65Zn in hairless mice treated with 65Zn-labeled zinc compounds by oral supplementation. RIKEN Accel. Prog. Rep., 2005, 38, 119.
    • (2005) RIKEN Accel. Prog. Rep. , vol.38 , pp. 119
    • Yasui, H.1    Nishimura, H.2    Haba, H.3    Hirunuma, R.4    Enomoto, S.5    Sakurai, H.6
  • 84
    • 84856476599 scopus 로고    scopus 로고
    • Difference in property of skin penetration between 65Zn(II) ion and its complex topically applied on skin of live hairless mice
    • Yasui, H.; Nishimura, H.; Haba, H.; Enomoto, S.; Sakurai, H. Difference in property of skin penetration between 65Zn(II) ion and its complex topically applied on skin of live hairless mice. RIKEN Accel. Prog. Rep., 2006, 39, 118.
    • (2006) RIKEN Accel. Prog. Rep , vol.39 , pp. 118
    • Yasui, H.1    Nishimura, H.2    Haba, H.3    Enomoto, S.4    Sakurai, H.5
  • 85
    • 65549099521 scopus 로고    scopus 로고
    • Zinc and diabetes - clinical links and molecular mechanisms
    • Jansen, J.; Karges, W.; Rink, L. Zinc and diabetes - clinical links and molecular mechanisms. J. Nutr. Biochem., 2009, 20, 399-417.
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 399-417
    • Jansen, J.1    Karges, W.2    Rink, L.3
  • 87
    • 19444371720 scopus 로고    scopus 로고
    • Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle
    • Dokken, B. B.; Sloniger, J. A.; Henriksen, E. J. Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle. Am. J. Physiol., 2005, 288, E1188-E1194.
    • (2005) Am. J. Physiol. , vol.288
    • Dokken, B.B.1    Sloniger, J.A.2    Henriksen, E.J.3


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