Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes

Journal of Nutrition

Volumn 131, Issue 5, 2001, Pages 1414-1420

  Tang, X H ^a   Shay, N F ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Glucose transport; Insulin; Insulin signaling; Zinc

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CYTOCHALASIN D; GLUCOSE; INOSITOL PHOSPHATE; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; RECEPTOR SUBUNIT; TYROSINE; WORTMANNIN; ZINC;

ACTIN FILAMENT; ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; FIBROBLAST; GLUCOSE TRANSPORT; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION;

ANIMALIA;

EID: 0035008149     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.5.1414     Document Type: Article

References (42)

1. Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway
2. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane
3. Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells
4. Tyrosine phosphorylation of specific protein kinase C isoenzymes participates in insulin stimulation of glucose transport in primary cultures of rat skeletal muscle
5. Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3-L1 cells: Transfection studies suggest a role for PKC-zeta in glucose transport
6. Requirement of atypical protein kinase C-lambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes
7. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
8. Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes
9. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals
10. Bombesin and zinc enhance the synergistic mitogenic effects of insulin and phosphocholine by a MAP kinase-dependent mechanism in Swiss 3T3 cells
11. Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: Its role in zinc-induced neuronal death
12. Insulin-like effect of zinc on adipocytes
13. The mechanism of the insulin-like effects of ionic zinc
14. Zinc and diabetes mellitus
15. 2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes
16. Akt is a direct target of the phosphatidylinositide 3-kinase. Activation by growth factors, v-src and v-Ha-src, in sf9 and mammalian cells
17. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis
18. Zinc suppresses apoptosis of U937 cells induced by hydrogen peroxide through an increase of the Bcl-2/Bax ratio
19. Zinc may be a mediator of leptin production in humans
20. Insulin action and the insulin signaling network
21. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
22. Disruption of IRS-2 causes type 2 diabetes in mice
23. Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes
24. Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
25. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
26. Role of the actin cytoskeleton in insulin action
27. Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocyes
28. Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
29. Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote GLUT4 translocation in adipocytes
30. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
31. A wortmannin-sensitive phosphadylinositol 4-kinase that regulates hormone-sensitive pools of inositol-phospholipids
32. 2 activity in Swiss 3T3 cells
33. Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway
34. Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes
35. Signaling mechanisms that regulate glucose transport
36. G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes
37. Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells
38. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line
39. ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6
40. Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes
41. Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin
42. Akt-2 binds to GLUT4-containing vesicles and phosphorylates their component proteins in response to insulin