Boon and bane of metal ions in medicine

Science

Volumn 300, Issue 5621, 2003, Pages 936-939

  Thompson, Katherine H ^a   Orvig, Chris ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; IRON; TOXICITY; ZINC;

METAL-BASED DRUGS;

MEDICINE;

AURANOFIN; BARIUM SULFATE; BISMUTH DERIVATIVE; BISMUTH SALICYLATE; CARBOPLATIN; CATALASE; CHELATING AGENT; CHROMIUM; CHROMIUM PICOLINATE; CISPLATIN; DIMERCAPROL; DRUG; GADOBENIC ACID; GALLIUM CITRATE GA 67; IRON; LEXIDRONAM SAMARIUM SM 153; LITHIUM CARBONATE; MACROCYCLIC COMPOUND; MANGANESE DERIVATIVE; MANGANESE SUPEROXIDE DISMUTASE; METAL ION; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MULTIVITAMIN; PENICILLAMINE; PENTETATE INDIUM IN 111; PLATINUM; SELENIUM; TRIENTINE; UNINDEXED DRUG; ZINC;

ION; MEDICINE; METAL;

ARTHRITIS; BIOAVAILABILITY; BIOLOGY; BIPOLAR DISORDER; BONE PAIN; CANCER; CATALYSIS; CHEMISTRY; CLINICAL TRIAL; DOSE RESPONSE; DRUG DESIGN; ELECTRONICS; GASTROINTESTINAL SYMPTOM; HUMAN; IMAGING; INTOXICATION; MEDICAL LITERATURE; MEDICINE; NONHUMAN; NUTRITIONAL DEFICIENCY; OVARY CANCER; OXIDATION REDUCTION STATE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; THERAPY; TRYPANOSOMIASIS; WILSON DISEASE;

ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CHELATING AGENTS; CHEMISTRY, PHARMACEUTICAL; CONTRAST MEDIA; CROSS-LINKING REAGENTS; DIAGNOSTIC IMAGING; DRUG DESIGN; HALF-LIFE; HUMANS; LIGANDS; MAGNETICS; METALS; MOLECULAR MIMICRY; OXIDATION-REDUCTION;

EID: 0037993828     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083004     Document Type: Review

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33. We thank E. Varty (Chemistry Department, University of British Columbia) for Fig. 1 and K.-F. Kreitner and EPIX Medical for Fig. 2.