Morphogenesis of Cryptococcus neoformans

Topics in Current Genetics

Volumn 22, Issue , 2012, Pages 197-223

  Ballou, Elizabeth R ^a   Alspaugh, J Andrew ^a   Nichols, Connie B ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84856438642     PISSN: 16102096     EISSN: 16106970     Source Type: Book Series    
DOI: 10.1007/978-3-642-22916-9_10     Document Type: Article

References (107)

1. Adams DJ (2004) Fungal cell wall chitinases and glucanases. Microbiology 150:2029-2035 (Pubitemid 39117618)
2. Alspaugh JA, Perfect JR, Heitman J (1997) Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev 11:3206-3217 (Pubitemid 27528060)
3. Alspaugh JA, Cavallo LM, Perfect JR, Heitman J (2000) RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Mol Microbiol 36:352-365 (Pubitemid 30229481)
4. Alspaugh JA, Pukkila-Worley R, Harashima T, Cavallo LM, Funnell D, Cox GM, Perfect JR, Kronstad JW, Heitman J (2002) Adenylyl cyclase functions downstream of the G-alpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell 1:75-84 (Pubitemid 36562350)
5. Bahn YS, Hicks JK, Giles SS, Cox GM, Heitman J (2004) Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMPprotein kinase A cascade. Eukaryot Cell 3:1476-1491 (Pubitemid 40025106)
6. Bahn YS, Cox GM, Perfect JR, Heitman J (2005a) Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. Curr Biol 15:2013-2020 (Pubitemid 41654624)
7. Bahn YS, Kojima K, Cox GM, Heitman J (2005b) Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell 16:2285-2300 (Pubitemid 40632212)
8. Baker RD, Haugen RK (1955) Tissue changes and tissue diagnosis in cryptococcosis: a study of twenty-six cases. Am J Clin Pathol 25:14-24
9. Baker LG, Specht CA, Donlin MJ, Lodge JK (2007) Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans. Eukaryot Cell 6:855-867 (Pubitemid 46835048)
10. Ballou ER, Nichols CB, Miglia KJ, Kozubowski L, Alspaugh JA (2010) Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. Mol Microbiol 75:763-780
11. Banuett F, Quintanilla RH Jr, Reynaga-Pena CG (2008) The machinery for cell polarity, cell morphogenesis, and the cytoskeleton in the Basidiomycete fungus Ustilago maydis - a survey of the genome sequence. Fungal Genet Biol 45:S3-S14
12. Bassilana M, Arkowitz RA (2006) Rac1 and Cdc42 have different roles in Candida albicans development. Eukaryot Cell 5:321-329 (Pubitemid 43262019)
13. Casselton LA, Olesnicky NS (1998) Molecular genetics of mating recognition in basidiomycete fungi. Microbiol Mol Biol Rev 62:55-70 (Pubitemid 28130796)
14. Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH (1994) Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell 79:131-141 (Pubitemid 24309519)
15. Chang YC, Miller GF, Kwon-Chung KJ (2003) Importance of a developmentally regulated pheromone receptor of Cryptococcus neoformans for virulence. Infect Immun 71:4953-4960 (Pubitemid 37070737)
16. Chant J (1999) Cell polarity in yeast. Annu Rev Cell Dev Biol 15:365-391 (Pubitemid 32250380)
17. Chant J, Pringle JR (1991) Budding and cell polarity in Saccharomyces cerevisiae. Curr Opin Genet Dev 1:342-350
18. Chuck SL, Sande MA (1989) Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med 321:794-799 (Pubitemid 19237427)
19. Cramer KL, Gerrald QD, Nichols CB, Price MS, Alspaugh JA (2006) The transcription factor Nrg1 mediates capsule, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryot Cell 5:1147-1156 (Pubitemid 44100712)
20. Cruz MC, Fox DS, Heitman J (2001) Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J 20:1020-1032 (Pubitemid 32186793)
21. Cvrckova F, Virgilio CD, Manser E, Pringle JR, Nasmyth K (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9:1817-1830
22. DSouza CA, Alspaugh JA, Yue C, Harashima T, Cox GM, Perfect JR, Heitman J (2001) Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol Cell Biol 21:3179-3191 (Pubitemid 32298384)
23. Davidson RC, Moore TD, Odom AR, Heitman J (2000) Characterization of the MFalpha pheromone of the human fungal pathogen Cryptococcus neoformans. Mol Microbiol 38:1017-1026 (Pubitemid 32009676)
24. Davidson RC, Nichols CB, Cox GM, Perfect JR, Heitman J (2003) A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. Mol Microbiol 49:469-485 (Pubitemid 36851201)
25. del Poeta M, Toffaletti DL, Rude TH, Sparks SD, Heitman J, Perfect JR (1999) Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein. Infect Immun 67:1812-1820 (Pubitemid 29144401)
26. Ekena JL, Stanton BC, Schiebe-Owens JA, Hull CM (2008) Sexual development in Cryptococcus neoformans requires CLP1, a target of the homeodomain transcription factors Sxi1alpha and Sxi2a. Eukaryot Cell 7:49-57 (Pubitemid 351959593)
27. Fazekas G, Schwarz J (1958) Histology of experimental murine Cryptococcosis. Am J Pathol 34:517-529
28. Feldmesser M, Kress Y, Casadevall A (2001) Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection. Microbiology 147:2355-2365 (Pubitemid 32785515)
29. Fox DS, Cox GM, Heitman J (2003) Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans. Eukaryot Cell 2:1025-1035 (Pubitemid 37298716)
30. Fraser JA, Diezmann S, Subaran RL, Allen A, Lengeler KB, Dietrich FS, Heitman J (2004) Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. PLoS Biol 2:e384
31. Fu J, Mares C, Lizcano A, Liu Y, Wickes BL (2011) Insertional mutagenesis combined with an inducible filamentation phenotype reveals a conserved STE50 homologue in Cryptococcus neoformans that is required for monokaryotic fruiting and sexual reproduction. Mol Microbiol 79:990-1007
32. Fujita A, Lord M, Hiroko T, Hiroko F, Chen T, Oka C, Misumi Y, Chant J (2004) Rax1, a protein required for the establishment of the bipolar budding pattern in yeast. Gene 327:161-169 (Pubitemid 38230112)
33. Giles SS, Dagenais TR, Botts MR, Keller NP, Hull CM (2009) Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infect Immun 77:3491-3500
34. Gladfelter AS, Bose I, Zyla TR, Bardes ES, Lew DJ (2002) Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p. J Cell Biol 156:315-326 (Pubitemid 34839912)
35. Golubev VI, Golubev NV (2003) A new basidiomycetous yeast species, Cryptococcus mycelialis, related to Holtermannia Saccardo et Traverso. Mikrobiologiia 72:822-827
36. Görlach J, Fox DS, Cutler NS, Cox GM, Perfect JR, Heitman J (2000) Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J 19:3618-3629 (Pubitemid 30462120)
37. Hanseman DV (1905) Uber eine bisher nicht beobachtete Gehriner Krankung durch Hefen. Verh Dtsch Ges Pathol 9:21-24
38. Ho J, Bretscher A (2001) Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway. Mol Biol Cell 12:1541-1555 (Pubitemid 33049712)
39. Hsueh YP, Shen WC (2005) A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans. Eukaryot Cell 4:147-155
40. Hsueh YP, Xue C, Heitman J (2007) G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Mol Biol Cell 18:3237-3249 (Pubitemid 47378667)
41. Hsueh YP, Xue C, Heitman J (2009) A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. EMBO J 28(9):1220-1233
42. Hull CM, Davidson RC, Heitman J (2002) Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. Genes Dev 16:3046-3060 (Pubitemid 35424192)
43. Hull CM, Cox GM, Heitman J (2004) The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. Infect Immun 72:3643-3645 (Pubitemid 38697795)
44. Idnurm A, Heitman J (2005) Light controls growth and development via a conserved pathway in the fungal kingdom. PLoS Biol 3:e95
45. Jung KW, Kim SY, Okagaki LH, Nielsen K, Bahn YS (2011) Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway. Fungal Genet Biol 48:154-165
46. Klengel T, Liang WJ, Chaloupka J, Ruoff C, Schroppel K, Naglik JR, Eckert SE, Mogensen EG, Haynes K, Tuite MF, Levin LR, Buck J, Muhlschlegel FA (2005) Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol 15:2021-2026 (Pubitemid 41654625)
47. Kopecka M, Gabriel M, Takeo K, Yamaguchi M, Svoboda A, Ohkusu M, Hata K, Yoshida S (2001) Microtubules and actin cytoskeleton in Cryptococcus neoformans compared with ascomycetous budding and fission yeasts. Eur J Cell Biol 80:303-311 (Pubitemid 32390148)
48. Kozubowski L, Heitman J (2010) Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. Mol Microbiol 75:658-675
49. Kozubowski L, Lee SC, Heitman J (2009) Signalling pathways in the pathogenesis of Cryptococcus. Cell Microbiol 11:370-380
50. Kwon-Chung KJ (1975) A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia 67:1197-1200
51. Kwon-Chung KJ (1976) Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68:821-833
52. Kwon-Chung KJ, Bennett JE (1978) Distribution of a and a mating types of Cryptococcus neoformans among natural and clinical isolates. Am J Epidemiol 108:337-340 (Pubitemid 9154533)
53. Kwon-Chung KJ, Popkin TJ (1976) Ultrastructure of septal complex in Filobasidiella neoformans (Cryptococcus neoformans). J Bacteriol 126:524-528
54. Kwon-Chung KJ, Edman JC, Wickes BL (1992) Genetic association of mating types and virulence in Cryptococcus neoformans. Infect Immun 60:602-605
55. Leveleki L, Mahlert M, Sandrock B, Bolker M (2004) The PAK family kinase Cla4 is required for budding and morphogenesis in Ustilago maydis. Mol Microbiol 54:396-406 (Pubitemid 39388284)
56. Levin EA (1937) Torula infection of the central nervous system. Arch Intern Med 59:667-684
57. Li Y, Chang EC (2003) Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis. Genetics 165:477-488 (Pubitemid 37337618)
58. Li L, Shen G, Zhang ZG, Wang YL, Thompson JK, Wang P (2007) Canonical heterotrimeric G proteins regulating mating and virulence of Cryptococcus neoformans. Mol Biol Cell 18:4201-4209 (Pubitemid 350064226)
59. Lin X, Hull CM, Heitman J (2005) Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. Nature 434:1017-1021 (Pubitemid 40586049)
60. Lin X, Jackson JC, Feretzaki M, Xue C, Heitman J (2010) Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans. PLoS Genet 6:e1000953
61. Longtine MS, Theesfeld CL, McMillan JN, Weaver E, Pringle JR, Lew DJ (2000) Septindependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20:4049-4061 (Pubitemid 30314503)
62. Lurie HI, Shadomy HJ (1971) Morphological variations of a hypha-forming strain of Cryptococcus neoformans (Coward strain) in tissues of mice. Sabouraudia 9:10-14
63. Maeng S, Ko YJ, Kim GB, Jung KW, Floyd A, Heitman J, Bahn YS (2010) Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. Eukaryot Cell 9:360-378
64. Mochizuki T, Tanaka S, Watanabe S (1987) Ultrastructure of the mitotic apparatus in Cryptococcus neoformans. J Med Vet Mycol 25:223-233
65. Mogensen EG, Janbon G, Chaloupka J, Steegborn C, Fu MS, Moyrand F, Klengel T, Pearson DS, Geeves MA, Buck J, Levin LR, Muhlschlegel FA (2006) Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell 5:103-111 (Pubitemid 43113455)
66. Moore RT (2000) Cytology and ultrastructure of yeasts and yeastlike fungi. In: Kurtzman CP, Fell JW (eds) The yeasts: a taxonomic study. Elsevier Science, Amsterdam, pp 33-44
67. Moore TD, Edman JC (1993) The alpha-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol Cell Biol 13:1962-1970 (Pubitemid 23068136)
68. Nichols CB, Fraser JA, Heitman J (2004) PAK Kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. Mol Biol Cell 15:4476-4489 (Pubitemid 39299097)
69. Nichols CB, Perfect Z, Alspaugh JA (2007) A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. Mol Microbiol 63:1118-1130 (Pubitemid 46184517)
70. Nichols CB, Ferreyra J, Ballou ER, Alspaugh JA (2009) Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein. Eukaryot Cell 8:181-189
71. Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J (1997) Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J 16:2576-2589 (Pubitemid 27226197)
72. Ohkusu M, Hata K, Takeo K (2001a) Bud emergence is gradually delayed from S to G2 with progression of growth phase in Cryptococcus neoformans. FEMS Microbiol Lett 194:251-255 (Pubitemid 32332793)
73. Ohkusu M, Raclavsky V, Takeo K (2001b) Deficit in oxygen causes G(2) budding and unbudded G (2) arrest in Cryptococcus neoformans. FEMS Microbiol Lett 204:29-32 (Pubitemid 33000028)
74. Okagaki LH, Strain AK, Nielsen JN, Charlier C, Baltes NJ, Chretien F, Heitman J, Dromer F, Nielsen K (2010) Cryptococcal cell morphology affects host cell interactions and pathogenicity. PLoS Pathog 6:e1000953
75. Panepinto J, Liu L, Ramos J, Zhu X, Valyi-Nagy T, Eksi S, Fu J, Jaffe HA, Wickes B, Williamson PR (2005) The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans. J Clin Invest 115:632-641 (Pubitemid 40322237)
76. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM (2009) Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23:525-530
77. Park YD, Panepinto J, Shin S, Larsen P, Giles S, Williamson PR (2010) Mating pheromone in Cryptococcus neoformans is regulated by a transcriptional/degradative "futile" cycle. J Biol Chem 285:34746-34756
78. Price MS, Nichols CB, Alspaugh JA (2008) The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infect Immun 76:5729-5737
79. Pukkila-Worley R, Alspaugh JA (2004) Cyclic AMP signaling in Cryptococcus neoformans. FEMS Yeast Res 4:361-367 (Pubitemid 38156200)
80. Roemer T, Vallier L, Sheu Y, Snyder M (1998) The Spa2-related protein, Sph1p, is important for polarized growth in yeast. J Cell Sci 111:479-494 (Pubitemid 28098397)
81. Rutherford JC, Lin X, Nielsen K, Heitman J (2008) Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. Eukaryot Cell 7:237-246 (Pubitemid 351959690)
82. Sanders SL, Herskowitz I (1996) The BUD4 protein of yeast, required for axial budding, is localized to the mother/BUD neck in a cell cycle-dependent manner. J Cell Biol 134:413-427 (Pubitemid 26250709)
83. Staudt MW, Kruzel EK, Shimizu K, Hull CM (2010) Characterizing the role of the microtubule binding protein Bim1 in Cryptococcus neoformans. Fungal Genet Biol 47:310-317
84. Sukroongreung S, Kitiniyom K, Nilakul C, Tantimavanich S (1998) Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans. Med Mycol 36:419-424
85. Takeo K, Tanaka R, Miyaji M, Nishimura K (1995) Unbudded G2 as well as G1 arrest in the stationary phase of the basidiomycetous yeast Cryptococcus neoformans. FEMS Microbiol Lett 129:231-235
86. Takeo K, Ogura Y, Virtudazo E, Raclavsky V, Kawamoto S (2004) Isolation of a CDC28 homologue from Cryptococcus neoformans that is able to complement cdc28 temperaturesensitive mutants of Saccharomyces cerevisiae. FEMS Yeast Res 4:737-744 (Pubitemid 38490581)
87. Todd RL, Herrmann WW (1936) The life cycle of the organism causing yeast meningitis. J Bacteriol 32:89-101
88. Tscharke RL, Lazera M, Chang YC, Wickes BL, Kwon-Chung KJ (2003) Haploid fruiting in Cryptococcus neoformans is not mating type alpha-specific. Fungal Genet Biol 39:230-237 (Pubitemid 36918481)
89. Vallim MA, Nichols CB, Fernandes L, Cramer KL, Alspaugh JA (2005) A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. Eukaryot Cell 4:1066-1078 (Pubitemid 40817466)
90. Velagapudi R, Hsueh YP, Geunes-Boyer S, Wright JR, Heitman J (2009) Spores as infectious propagules of Cryptococcus neoformans. Infect Immun 77:4345-4355
91. Virtudazo EV, Kawamoto S, Ohkusu M, Aoki S, Sipiczki M, Takeo K (2010) The single Cdk1-G1 cyclin of Cryptococcus neoformans is not essential for cell cycle progression, but plays important roles in the proper commitment to DNA synthesis and bud emergence in this yeast. FEMS Yeast Res 10:605-618
92. Wang P, Nichols CB, Lengeler KB, Cardenas ME, Cox GM, Perfect JR, Heitman J (2002) Matingtype- specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. Eukaryot Cell 1:257-272 (Pubitemid 36562402)
93. Wang P, Cutler J, King J, Palmer D (2004) Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans. Eukaryot Cell 3:1028-1035 (Pubitemid 39098878)
94. Waugh MS, Vallim MA, Heitman J, Alspaugh JA (2003) Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. Fungal Genet Biol 38:110-121 (Pubitemid 36262918)
95. Weirich CS, Erzberger JP, Barral Y (2008) The septin family of GTPases: architecture and dynamics. Nat Rev Mol Cell Biol 9:478-489 (Pubitemid 351733401)
96. Wickes BL, Mayorga ME, Edman U, Edman JC (1996) Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type. Proc Natl Acad Sci USA 93:7327-7331 (Pubitemid 26243549)
97. Wickes BL, Edman U, Edman JC (1997) The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific. Mol Microbiol 26:951-960 (Pubitemid 27507879)
98. Xue C, Bahn YS, Cox GM, Heitman J (2006) G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol Biol Cell 17:667-679 (Pubitemid 43191102)
99. Xue C, Tada Y, Dong X, Heitman J (2007) The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants. Cell Host Microbe 1:263-273 (Pubitemid 46865607)
100. Xue C, Hsueh YP, Chen L, Heitman J (2008a) The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans. Mol Microbiol 70:379-395
101. Xue C, Hsueh YP, Heitman J (2008b) Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol Rev 32:1010-1032
102. Xue C, Liu T, Chen L, Li W, Liu I, Kronstad JW, Seyfang A, Heitman J (2010a) Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. MBio 1(1):e00084-10
103. Xue C, Wang Y, Hsueh YP (2010b) Assessment of constitutive activity of a G protein-coupled receptor, CPR2, in Cryptococcus neoformans by heterologous and homologous methods. Methods Enzymol 484:397-412
104. Yamaguchi M, Ohkusu M, Biswas SK, Kawamoto S (2007) Cytological study of cell cycle of the pathogenic yeast Cryptococcus neoformans. Nihon Ishinkin Gakkai Zasshi 48:147-152 (Pubitemid 350224114)
105. Yamaguchi M, Biswas SK, Ohkusu M, Takeo K (2009) Dynamics of the spindle pole body of the pathogenic yeast Cryptococcus neoformans examined by freeze-substitution electron microscopy. FEMS Microbiol Lett 296:257-265
106. Yue C, Cavallo LM, Alspaugh JA, Wang P, Cox GM, Perfect JR, Heitman J (1999) The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics 153:1601-1615
107. Zaragoza O, Garcia-Rodas R, Nosanchuk JD, Cuenca-Estrella M, Rodriguez-Tudela JL, Casadevall A (2010) Fungal cell gigantism during mammalian infection. PLoS Pathog 6:e1000945