Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans

Fungal Genetics and Biology

Volumn 38, Issue 1, 2003, Pages 110-121

  Waugh, Michael S ^a   Vallim, Marcelo A ^a   Heitman, Joseph ^a   Alspaugh, J Andrew ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Fungi; MAP kinase; Signal transduction

Indexed keywords

ELEMENT; FUNGAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE; RAS PROTEIN; RAS1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONGENIC STRAIN; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DIFFERENTIATION; DOWNSTREAM PROCESSING; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS HYPHAE; GENE CONTROL; GENE DISRUPTION; GENETIC EPISTASIS; HIGH TEMPERATURE; MATING; MORPHOGENESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REGULATORY MECHANISM; SEROTYPE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

CROSSES, GENETIC; CRYPTOCOCCUS NEOFORMANS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MAP KINASE SIGNALING SYSTEM; PHEROMONES; RAS PROTEINS; SIGNAL TRANSDUCTION;

FILOBASIDIELLA NEOFORMANS; FUNGI;

EID: 0037332235     PISSN: 10871845     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1087-1845(02)00518-2     Document Type: Article

References (42)

1. Alspaugh J.A., Perfect J.R., Heitman J. Cryptococcus neoformans mating and virulence are regulated by the G-protein. α subunit Gpa1 and cAMP Genes Dev. 11:1997;3206-3217.
2. Alspaugh J.A., Cavallo L.M., Perfect J.R., Heitman J. RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Mol. Microbiol. 36:2000;352-365.
3. Alspaugh J.A., Pukkila-Worley R., Harashima T., Cavallo L.M., Funnell D., Cox G.M., Perfect J.R., Kronstad J.W., Heitman J. Adenylyl cyclase functions downstream of the G. α protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans Eukaryotic Cell. 1:2002;75-84.
4. Campbell S.L., Khosravi-Far R., Rossman K.L., Clark G.J., Der C.J. Increasing complexity of Ras signaling. Oncogene. 17:1998;1395-1413.
5. Chang Y.C., Wickes B.L., Miller G.F., Penoyer L.A., Kwon-Chung K.J. Cryptococcus neoformans STE12. α regulates virulence but is not essential for mating J. Exp. Med. 191:2000;871-882.
6. Choy E., Chiu V.K., Silletti J., Feoktistov M., Morimoto T., Michaelson D., Ivanov I.E., Philips M.R. Endomembrane trafficking of Ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 98:1999;69-80.
7. Davidson R.C., Cruz M.C., Sia R.A.L., Allen B.M., Alspaugh J.A., Heitman J. Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. Fungal Genet. Biol. 29:2000;38-48.
8. Engelberg D., Klein C., Martinetto H., Struhl K., Karin M. The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell. 77:1994;381-390.
9. Granger D.L., Perfect J.R., Durack D.T. Virulence of Cryptococcus neoformans: regulation of capsule synthesis by carbon dioxide. J. Clin. Invest. 76:1985;508-516.
10. Ho J., Bretscher A. Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway. Mol. Biol. Cell. 12:2001;1541-1555.
11. Hughes D.A. Control of signal transduction and morphogenesis by Ras. Cell Biol. 6:1995;89-94.
12. Jiang Y., Davis C., Broach J.R. Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway. EMBO J. 17:1998;6942-6951.
13. Kataoka T., Powers S., McGill C., Fasano O., Strathern J., Broach J., Wigler M. Genetic analysis of yeast RAS1 and RAS2 genes. Cell. 37:1984;437-445.
14. Kwon-Chung K.J. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia. 68:1976;821-833.
15. Kwon-Chung K.J., Bennett J.E. Medical Mycology. 1992;Lea & Febiger, Malvern, PA.
16. Kwon-Chung K.J., Edman J.C., Wickes B.L. Genetic association of mating types and virulence in Cryptococcus neoformans. Infect. Immun. 60:1992;602-605.
17. Leberer E., Harcus D., Dignard D., Johnson L., Ushinsky S., Thomas D.Y., Schröppel K. Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans. Mol. Microbiol. 42:2001;673-687.
18. Lorenz M.C., Heitman J. Yeast pseudohyphal growth is regulated by Gpa2, a G protein. α homolog EMBO J. 16:1997;7008-7018.
19. Ma H., Kunes S., Schatz P.J., Botstein D. Plasmid construction by homologous recombination in yeast. Gene. 58:1987;201-216.
20. Mitchell T.G., Perfect J.R. Cryptococcosis in the era of AIDS - 100 years after the discovery of Cryptococcus neoformans. Clin. Microbiol. Rev. 8:1995;515-548.
21. Moore T.D.E., Edman J.C. The. α -mating type locus of Cryptococcus neoformans contains a peptide pheromone gene Mol. Cell. Biol. 13:1993;1962-1970.
22. Mösch H.U., Roberts R.L., Fink G.R. Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 93:1996;5352-5356.
23. Mösch H.-U., Kubler E., Krappmann S., Fink G.R., Braus G.H. Crosstalk between the Ras2p-controlled mitogen-activated protein kinase and cAMP pathways during invasive growth of Saccharomyces cerevisiae. Mol. Biol. Cell. 10:1999;1325-1335.
24. Nielsen O., Davey J., Egel R. The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription. EMBO J. 11:1992;1391-1395.
25. Papadaki P., Pizon V., Onken B., Chang E.C. Two Ras pathways in fission yeast are differentially regulated by two Ras guanine nucleotide exchange factors. Mol. Cell. Biol. 22:2002;4598-4606.
26. Perfect J.R., Toffaletti D.L., Rude T.H. The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61:1993;4446-4451.
27. Pitkin J.W., Panaccione D.G., Walton J.D. A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology. 142:1996;1557-1565.
28. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Shah-Mahoney N., Hampton T., Vidaver R., Ratner D. Blocking the ends of transforming DNA enhances gene targeting in Dictyostelium. Gene. 203:1997;33-41.
30. Shen W.-C., Davidson R.C., Cox G.M., Heitman J. Pheromones control mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryotic Cell. 1:2002;366-377.
31. Sherman F. Getting started with yeast. Guthrie C., Fink G.R. Methods in Enzymology. vol. 194:1991;3-21 Academic Press, San Diego, CA.
32. Sudarshan S., Davidson R.C., Heitman J., Alspaugh J.A. Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. Fungal Genet. Biol. 27:1999;36-48.
33. Thevelein J.M. Signal transduction. Yeast. 10:1994;1753-1790.
34. Toda T., Uno I., Ishikawa T., Powers S., Kataoka T., Broek D., Cameron S., Broach J., Matsumoto K., Wigler M. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell. 40:1985;27-36.
35. Toffaletti D.L., Rude T.H., Johnston S.A., Durack D.T., Perfect J.R. Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J. Bacteriol. 175:1993;1405-1411.
36. Tolkacheva T., McNamara P., Piekarz E., Courchesne W. Cloning of a Cryptococcus neoformans gene, GPA1, encoding a G-protein. α -subunit homolog Infect. Immun. 62:1994;2849-2856.
37. Wang P., Nichols C.B., Lengeler K.B., Cardenas M.E., Cox G.M., Perfect J.R., Heitman J. Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neofromans. Eukaryotic Cell. 1:2002;257-272.
38. Wang P., Perfect J.R., Heitman J. The G-protein. β subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans Mol. Cell. Biol. 20:2000;352-362.
39. Waugh M.S., Nichols C.B., DeCesare C.M., Cox G.M., Heitman J., Alspaugh J.A. Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. Microbiology. 148:2002;191-201.
40. Wickes B.L., Mayorga M.E., Edman U., Edman J.C. Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the a-mating type. Proc. Natl. Acad. Sci. USA. 93:1996;7327-7331.
41. Wickes B.L., Edman U., Edman J.C. The Cryptococcus neoformans STE12. α gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific Mol. Microbiol. 26:1997;951-960.
42. Yue C., Cavallo L.M., Alspaugh J.A., Wang P., Cox G.M., Perfect J.R., Heitman J. The STE12. α homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans Genetics. 153:1999;1601-1615.