A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans

Eukaryotic Cell

Volumn 4, Issue 1, 2005, Pages 147-155

  Hsueh, Yen Ping ^a,b   Shen, Wei Chiang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; FUNGAL PROTEIN; PEPTIDE; PHEROMONE; STE6 PROTEIN, FUNGUS;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; CRYPTOCOCCUS NEOFORMANS; METABOLISM; MOLECULAR GENETICS; MUTATION; NORTHERN BLOTTING; PHYSIOLOGY; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SOUTHERN BLOTTING; TEMPERATURE; TIME;

ADENOSINE TRIPHOSPHATASES; ALLELES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CRYPTOCOCCUS NEOFORMANS; FUNGAL PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PHEROMONES; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TEMPERATURE; TIME FACTORS;

ASCOMYCOTA; BASIDIOMYCOTA; FILOBASIDIELLA NEOFORMANS; SACCHAROMYCES CEREVISIAE;

EID: 13744249299     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.4.1.147-155.2005     Document Type: Article

References (38)

1. Alspaugh, J. A., J. R. Perfect, and J. Heitman. 1997. Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP. Genes Dev. 11:3206-3217.
2. Brizzio, V., A. E. Gammie, G. Nijbroek, S. Michaelis, and M. D. Rose. 1996. Cell fusion during yeast mating requires high levels of a-factor mating pheromone. J. Cell Biol. 135:1727-1739.
3. Casadevall, A., and J. R. Perfect. 1998. Cryptococcus neoformans. ASM Press, Washington, D.C.
4. Chen, P., J. D. Choi, R. Wang, R. J. Cotter, and S. Michaelis. 1997. A novel a-factor-related peptide of Saccharomyces cerevisiae that exits the cell by a Ste6-independent mechanism. Mol. Biol. Cell 8:1273-1291.
5. Chen, P., S. K. Sapperstein, J. D. Choi, and S. Michaelis. 1997. Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor. J. Cell Biol. 136:251-269.
6. Christensen, P. U., J. Davey, and O. Nielsen. 1997. The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor. Mol. Gen. Genet. 255:226-236.
7. Chung, S., M. Karos, Y. C. Chang, J. Lukszo, B. L. Wickes, and K. J. Kwon-Chung. 2002. Molecular analysis of CPRα, a MATα-specific pheromone receptor gene of Cryptococcus neoformans. Eukaryot. Cell 1:432-439.
8. Davidson, R. C., J. R. Blankenship, P. R. Kraus, M. de Jesus Berrios, C. M. Hull, C. D'Souza, P. Wang, and J. Heitman. 2002. A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology 148:2607-2615.
9. Davidson, R. C., T. D. E. Moore, A. R. Odom, and J. Heitman. 2000. Characterization of the MFα pheromone of the human fungal pathogen Cryptococcus neoformans. Mol. Microbiol. 39:1-12.
10. Edman, J. C., and K. J. Kwon-Chung. 1990. Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation. Mol. Cell. Biol. 10:4538-4544.
11. Elia, L., and L. Marsh. 1996. Role of the ABC transporter Ste6 in cell fusion during yeast conjugation. J. Cell Biol. 135:741-751.
12. Fowler, T. J., S. M. DeSimone, M. F. Mitton, J. Kurjan, and C. A. Raper. 1999. Multiple sex pheromones and receptors of a mushroom-producing fungus elicit mating in yeast. Mol. Biol. Cell 10:2559-2572.
13. Guthrie, C., and G. R. Fink. 1991. Guide to yeast genetics and molecular biology. Academic Press, Inc., San Diego, Calif.
14. Hull, C. M., and J. Heitman. 2002. Genetics of Cryptococcus neoformans. Annu. Rev. Genet. 36:557-615.
15. Jackson, C. L., and L. H. Hartwell. 1990. Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating. Mol. Cell. Biol. 10:2202-2213.
16. Johnson, A. D. 1995. Molecular mechanisms of cell-type determination in budding yeast. Curr. Opin. Genet. Dev. 5:552-558.
17. Ketchum, C. J., W. K. Schmidt, G. V. Rajendrakumar, S. Michaelis, and P. C. Maloney. 2001. The yeast a-factor transporter Ste6, a member of the ABC superfamily, couples ATP hydrolysis to pheromone export. J. Biol. Chem. 276:29007-29011.
18. Kronstad, J. W., and C. Staben. 1997. Mating type in filamentous fungi. Annu. Rev. Genet. 31:245-276.
19. Kuchler, K., R. E. Sterne, and J. Thorner. 1989. Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO J. 8:3973-3984.
20. Kwon-Chung, K. J. 1976. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68:821-833.
21. Kwon-Chung, K. J. 1975. A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia 67:1197-1200.
22. Kwon-Chung, K. J., J. C. Edman, and B. L. Wickes. 1992. Genetic association of mating types and virulence in Cryptococcus neoformans. Infect. Immun. 60:602-605.
23. Lengeler, K. B., D. S. Fox, J. A. Fraser, A. Allen, K. Forrester, F. S. Dietrich, and J. Heitman. 2002. Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. Eukaryot. Cell 1:704-718.
24. Magee, B. B., M. Legrand, A. M. Alarco, M. Raymond, and P. T. Magee. 2002. Many of the genes required for mating in Saccharomyces cerevisiae are also required for mating in Candida albicans. Mol. Microbiol. 46:1345-1351.
25. McClelland, C. M., J. Fu, G. L. Woodlee, T. S. Seymour, and B. L. Wickes. 2002. Isolation and characterization of the Cryptococcus neoformans MATa pheromone gene. Genetics 160:935-947.
26. Michaelis, S. 1993. STE6, the yeast a-factor transporter. Semin. Cell Biol. 4:17-27.
27. Michaelis, S., P. Chen, C. Berkower, S. Sapperstein, and A. Kistler. 1992. Biogenesis of yeast a-factor involves prenylation, methylation and a novel export mechanism. Antonie Leeuwenhoek 61:115-117.
28. Michaelis, S., and I. Herskowitz. 1988. The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol. Cell. Biol. 8:1309-1318.
29. Moore, T. D. E., and J. C. Edman. 1993. The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol. Cell. Biol. 13:1962-1970.
30. Pitkin, J. W., D. G. Panaccione, and J. D. Walton. 1996. A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology 142:1557-1565.
31. Raymond, M., D. Dignard, A. M. Alarco, N. Mainville, B. B. Magee, and D. Y. Thomas. 1998. A Ste6/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor mating pheromone in Saccharomyces cerevisiae. Mol. Microbiol. 27:587-598.
32. Sapperstein, S., C. Berkower, and S. Michaelis. 1994. Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export. Mol. Cell. Biol. 14:1438-1449.
33. Shen, W.-C., R. C. Davidson, G. M. Cox, and J. Heitman. 2002. Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryot. Cell 1:366-377.
34. Taglicht, D., and S. Michaelis. 1998. Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease. Methods Enzymol. 292:130-162.
35. Toffaletti, D. L., T. H. Rude, S. A. Johnston, D. T. Durack, and J. R. Perfect. 1993. Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J. Bacteriol. 175:1405-1411.
36. Tscharke, R. L., M. Lazera, Y. C. Chang, B. L. Wickes, and K. J. Kwon-Chung. 2003. Haploid fruiting in Cryptococcus neoformans is not mating type α-specific. Fungal Genet. Biol. 39:230-237.
37. Wang, P., J. R. Perfect, and J. Heitman. 2000. The G-protein β subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. Mol. Cell. Biol. 20:352-362.
38. Wickes, B. L., M. E. Mayorga, U. Edman, and J. C. Edman. 1996. Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the α-mating type. Proc. Natl. Acad. Sci. USA 93:7327-7331.