Suppression of EAE and prevention of blood-brain barrier breakdown after vaccination with novel bifunctional peptide inhibitor

Neuropharmacology

Volumn 62, Issue 4, 2012, Pages 1874-1881

  Badawi, Ahmed H ^a   Kiptoo, Paul ^a   Wang, Wen Tung ^b   Choi, In Young ^b,c   Lee, Phil ^b,c   Vines, Charlotte M ^b   Siahaan, Teruna J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Antigen presenting cell; Bifunctional peptide inhibitor; Blood brain barrier; Experimental autoimmune encephalomyelitis; Magnetic resonance imaging; T cell

Indexed keywords

GADOLINIUM PENTETATE; PEPTIDE VACCINE; PROTEIN INHIBITOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG MECHANISM; FEMALE; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCORING SYSTEM; SPLEEN CELL; VACCINATION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; MICE; PEPTIDES; VACCINATION;

EID: 84856411455     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.12.013     Document Type: Article

References (45)

1. N.J. Abbott, L. Ronnback, and E. Hansson Astrocyte-endothelial interactions at the blood-brain barrier Nat. Rev. Neurosci. 7 2006 41 53 (Pubitemid 41828930)
2. X.F. Bai, F.D. Shi, B.G. Xiao, H.L. Li, P.H. van der Meide, and H. Link Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-beta mRNA J. Neuroimmunol. 80 1997 65 75 (Pubitemid 28015324)
3. B. Bielekova, and B.L. Becker Monoclonal antibodies in MS: mechanisms of action Neurology 74 Suppl. 1 2010 S31 S40
4. W. Cao, Y. Yang, Z. Wang, A. Liu, L. Fang, F. Wu, J. Hong, Y. Shi, S. Leung, C. Dong, and J.Z. Zhang Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease Immunity 35 2011 273 284
5. L.M. D'Cruz, and L. Klein Development and function of agonist-induced CD25 + Foxp3+ regulatory T cells in the absence of interleukin 2 signaling Nat. Immunol. 6 2005 1152 1159 (Pubitemid 41541793)
6. S. Floris, E.L. Blezer, G. Schreibelt, E. Dopp, S.M. van der Pol, I.L. Schadee-Eestermans, K. Nicolay, C.D. Dijkstra, and H.E. de Vries Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study Brain 127 2004 616 627 (Pubitemid 38295477)
7. J.D. Fontenot, J.P. Rasmussen, M.A. Gavin, and A.Y. Rudensky A function for interleukin 2 in Foxp3-expressing regulatory T cells Nat. Immunol. 6 2005 1142 1151 (Pubitemid 41541792)
8. A. Grakoui, S.K. Bromley, C. Sumen, M.M. Davis, A.S. Shaw, P.M. Allen, and M.L. Dustin The immunological synapse: a molecular machine controlling T cell activation Science 285 1999 221 227 (Pubitemid 29329988)
9. S. Haak, G. Gyulveszi, and B. Becher Th17 cells in autoimmune disease: changing the verdict Immunotherapy 1 2009 199 203
10. S. Haak, A.L. Croxford, K. Kreymborg, F.L. Heppner, S. Pouly, B. Becher, and A. Waisman IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice J. Clin. Invest. 119 2009 61 69
11. C.J. Hedegaard, M. Krakauer, K. Bendtzen, H. Lund, F. Sellebjerg, and C.H. Nielsen T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis Immunology 125 2008 161 169
12. J.D. Huber, K.A. Witt, S. Hom, R.D. Egleton, K.S. Mark, and T.P. Davis Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression Am. J. Physiol. Heart. Circ. Physiol. 280 2001 H1241 H1248
13. M.K. Jenkins, and J.G. Johnson Molecules involved in T-cell costimulation Curr. Opin. Immunol. 5 1993 361 367 (Pubitemid 23197447)
14. C.H. June, J.A. Bluestone, L.M. Nadler, and C.B. Thompson The B7 and CD28 receptor families Immunol. Today 15 1994 321 331 (Pubitemid 24231747)
15. N. Kobayashi, P. Kiptoo, H. Kobayashi, R. Ridwan, S. Brocke, and T.J. Siahaan Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor Clin. Immunol. 129 2008 69 79
16. N. Kobayashi, H. Kobayashi, L. Gu, T. Malefyt, and T.J. Siahaan Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor J. Pharmacol. Exp. Ther. 322 2007 879 886 (Pubitemid 47105795)
17. M. Larche, and D.C. Wraith Peptide-based therapeutic vaccines for allergic and autoimmune diseases Nat. Med. 11 2005 S69 S76
18. H. Lassmann Classification of demyelinating diseases at the interface between etiology and pathogenesis Curr. Opin. Neurol. 14 2001 253 258 (Pubitemid 32510587)
19. K.H. Lee, A.D. Holdorf, M.L. Dustin, A.C. Chan, P.M. Allen, and A.S. Shaw T cell receptor signaling precedes immunological synapse formation Science 295 2002 1539 1542 (Pubitemid 34174012)
20. R.S. Liblau, S.M. Singer, and H.O. McDevitt Th1 and Th2 CD4 + T cells in the pathogenesis of organ-specific autoimmune diseases Immunol. Today 16 1995 34 38
21. T.R. Malek The main function of IL-2 is to promote the development of T regulatory cells J. Leukoc. Biol. 74 2003 961 965 (Pubitemid 38040316)
22. P. Manikwar, P. Kiptoo, A.H. Badawi, B. Buyuktimkin, and T.J. Siahaan Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases Med. Res. Rev. 2011
23. B. Metzler, and D.C. Wraith Mucosal tolerance in a murine model of experimental autoimmune encephalomyelitis Ann. N. Y. Acad. Sci. 778 1996 228 242 (Pubitemid 26145549)
24. O. Meyer Oral immunomodulation therapy in rheumatoid arthritis Joint Bone Spine 67 2000 384 392
25. A. Minagar, and J.S. Alexander Blood-brain barrier disruption in multiple sclerosis Mult. Scler. 9 2003 540 549 (Pubitemid 37479401)
26. J.S. Murray, S. Oney, J.E. Page, A. Kratochvil-Stava, Y. Hu, I.T. Makagiansar, J.C. Brown, N. Kobayashi, and T.J. Siahaan Suppression of type 1 diabetes in NOD mice by bifunctional peptide inhibitor: modulation of the immunological synapse formation Chem. Biol. Drug Des. 70 2007 227 236 (Pubitemid 47305400)
27. R.A. O'Connor, C.T. Prendergast, C.A. Sabatos, C.W. Lau, M.D. Leech, D.C. Wraith, and S.M. Anderton Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis J. Immunol. 181 2008 3750 3754
28. C.T. Prendergast, and S.M. Anderton Immune cell entry to central nervous system - current understanding and prospective therapeutic targets Endocr. Metab. Immun. Disord. Drug Targets 9 2009 315 327
29. A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, and F. Sallusto C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE Nat. Immunol. 10 2009 514 523
30. R. Ridwan, P. Kiptoo, N. Kobayashi, S. Weir, M. Hughes, T. Williams, R. Soegianto, and T.J. Siahaan Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics J. Pharmacol. Exp. Ther. 332 2010 1136 1145
31. L. Santambrogio, A.K. Sato, F.R. Fischer, M.E. Dorf, and L.J. Stern Abundant empty class II MHC molecules on the surface of immature dendritic cells Proc. Natl. Acad. Sci. U.S.A. 96 1999 15050 15055 (Pubitemid 30019763)
32. D. Sun, M. Tani, T.A. Newman, K. Krivacic, M. Phillips, A. Chernosky, P. Gill, T. Wei, K.J. Griswold, R.M. Ransohoff, and R.O. Weller Role of chemokines, neuronal projections, and the blood-brain barrier in the enhancement of cerebral EAE following focal brain damage J. Neuropathol. Exp. Neurol. 59 2000 1031 1043 (Pubitemid 32006306)
33. S.A. Tibbetts, C. Chirathaworn, M. Nakashima, D.S. Jois, T.J. Siahaan, M.A. Chan, and S.H. Benedict Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture Transplantation 68 1999 685 692 (Pubitemid 29453447)
34. S.A. Tibbetts, D. Seetharama Jois, T.J. Siahaan, S.H. Benedict, and M.A. Chan Linear and cyclic LFA-1 and ICAM-1 peptides inhibit T cell adhesion and function Peptides 21 2000 1161 1167
35. J.R. Tonra, B.S. Reiseter, R. Kolbeck, K. Nagashima, R. Robertson, B. Keyt, and R.M. Lindsay Comparison of the timing of acute blood-brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis J. Comp. Neurol. 430 2001 131 144
36. S.Y. Tseng, and M.L. Dustin T-cell activation: a multidimensional signaling network Curr. Opin. Cell Biol. 14 2002 575 580 (Pubitemid 35247740)
37. V.K. Tuohy, Z. Lu, R.A. Sobel, R.A. Laursen, and M.B. Lees Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice J. Immunol. 142 1989 1523 1527 (Pubitemid 19086317)
38. S. Valitutti, M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton J. Exp. Med. 181 1995 577 584
39. P.A. van der Merwe Formation and function of the immunological synapse Curr. Opin. Immunol. 14 2002 293 298
40. D.C. Wraith Therapeutic peptide vaccines for treatment of autoimmune diseases Immunol. Lett. 122 2009 134 136
41. S. Youssef, O. Stuve, J.C. Patarroyo, P.J. Ruiz, J.L. Radosevich, E.M. Hur, M. Bravo, D.J. Mitchell, R.A. Sobel, L. Steinman, and S.S. Zamvil The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease Nature 420 2002 78 84 (Pubitemid 35291443)
42. H. Yusuf-Makagiansar, I.T. Makagiansar, and T.J. Siahaan Inhibition of the adherence of T-lymphocytes to epithelial cells by a cyclic peptide derived from inserted domain of lymphocyte function-associated antigen-1 Inflammation 25 2001 203 214 (Pubitemid 32493694)
43. H. Yusuf-Makagiansar, T.V. Yakovleva, B.A. Tejo, K. Jones, Y. Hu, G.M. Verkhivker, K.L. Audus, and T.J. Siahaan Sequence recognition of alpha-LFA-1-derived peptides by ICAM-1 cell receptors: inhibitors of T-cell adhesion Chem. Biol. Drug Des. 70 2007 237 246 (Pubitemid 47305397)
44. J. Zepp, L. Wu, and X. Li IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease Trends Immunol. 32 2011 232 239
45. H. Zhao, P. Kiptoo, T.D. Williams, T.J. Siahaan, and E.M. Topp Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model J. Control Release 141 2010 145 152